130 completed, 57 recruiting, 29 unknown, 17 terminated. 133 Not applicable, 38 Phase 2, 14 Phase 1, 11 Phase 3, 5 Phase 4.
Follow Essential Tremor: new trials by email Literature Review of Essential Tremor trials Research Report on Essential Tremor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Encora X1™ in a Real World Observational Study Encora X1 - Essential Tremor | Recruiting | Encora, Inc. | 1000 | 2026-11-01 | 2026-11-05 | |
| Effects of Microelectrode-based Brain Stimulation in Humans High Definition Brain Stimulation (HDBS) - Essential Tremor, Parkinsons Disease (PD) | Not applicable | Recruiting | Lund University | 12 | 2026-10-15 | 2026-11-03 |
| Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation Cobenfy KarXT pill (50/20 mg), Placebo - Epilepsy, Essential Tremor | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 30 | 2026-10-01 | 2026-07-23 |
| Image-Guided DBS Programming programming a, programming b - Essential Tremor | Not applicable | Not yet recruiting | University of Pennsylvania | 20 | 2026-09-01 | 2026-08-06 |
| Cerebellar Research in Ultrasound Stimulation Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox - Essential Tremor | Not applicable | Not yet recruiting | KU Leuven | 60 | 2026-06-01 | 2026-04-02 |
| Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor Transcranial temporal interference stimulation, Tremor monitoring through Inertial Measurement Units (IMUs) - Essential Tremor | Not applicable | Not yet recruiting | University Hospital, Geneva | 6 | 2026-05-26 | 2026-05-01 |
| Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor Low Intensity Focused Ultrasound (LIFU) - Essential Tremor | Early Phase 1 | Recruiting | University of California, Los Angeles | 20 | 2026-05-01 | 2026-05-20 |
| Neuromodulation Strategies for Treatment-Resistant Essential Tremor Using Chronos™ DBS Continuous, Continuous + High Frequency Cycling, High Frequency - Essential Tremor | Not applicable | Not yet recruiting | University of British Columbia | 5 | 2026-04-01 | 2025-12-24 |
| Motor and Non-Motor Effects of Low-Intensity Focused Ultrasound (LIFU) as a Neuromodulation Tool in Essential Tremor Low-Intensity Focused Ultrasound (LIFU) - NeuroFUS PRO - Essential Tremor (ET) | Phase 1 / Phase 2 | Not yet recruiting | University of Sao Paulo General Hospital | 20 | 2026-03-17 | 2026-03-19 |
| Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus - Parkinson's Disease (PD), Essential Tremor | Not applicable | Recruiting | Boston University Charles River Campus | 80 | 2026-02-18 | 2026-03-09 |
| Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease Essential Tremor, Movement Disorders, Essential Tremor | Recruiting | CND Life Sciences | 300 | 2026-02-18 | 2026-11-04 | |
| Magnetoencephalography (MEG) Pilot Study MRI and fMRI scans, MEG, Sensor-based motor assessments - Essential Tremor | Not applicable | Recruiting | University of Florida | 10 | 2026-02-17 | 2026-09-30 |
| Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor Deep Brain Stimulation - Tremor, Essential Tremor | Phase 1 | Recruiting | The Cleveland Clinic | 12 | 2026-01-15 | 2026-07-10 |
| Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor. Dual-site repetitive transcranial magnetic stimulation (rTMS) of the supplementary motor area and cerebellum, Transcranial Magnetic Stimulation Sham - Essential Tremor | Phase 1 / Phase 2 | Recruiting | São Paulo State University | 36 | 2026-01-15 | 2026-01-21 |
| Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness Study Transcutaneous Afferent Patterned Stimulation - Essential Tremor | Not applicable | Recruiting | Ruijin Hospital | 50 | 2025-12-15 | 2026-08-19 |
| LIFUS For Neurological Disorders LIFUS, Sham LIFUS - Parkinson's Disease (PD), Essential Tremor | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2025-12-02 | 2026-08-13 |
| Analysis of Clinical Outcomes in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Tremor Essential Tremor, Essential Tremor, Movement Disorders | Recruiting | Sunnybrook Health Sciences Centre | 240 | 2025-10-01 | 2025-10-08 | |
| Attention and Eye Movement in Parkinson's Disease Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS - Essential Tremor, Parkinson's Disease (PD) | Not applicable | Recruiting | University of Nebraska | 138 | 2025-09-22 | 2026-05-05 |
| Proof of Concept Study on BP1.4979 Effect on Essential Tremor BP1.4979, Placebo - Essential Tremor | Phase 2 | Recruiting | Bioprojet | 50 | 2025-09-17 | 2025-12-16 |
| Developing a New LIFU Neuromodulation Method to Suppress Tremor Transcranial focused ultrasound stimulation, Sham stimulation - Essential Tremor | Phase 2 | Not yet recruiting | University of Calgary | 20 | 2025-09-15 | 2025-08-05 |
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PMID 35995551, PMID 21594724, PMID 11391740, PMID 12566335, PMID 14718713, PMID 15210907, PMID 17784944, PMID 19452239, PMID 19940187, PMID 20175185, PMID 20201005, PMID 20926368, PMID 21384292, PMID 22454323, PMID 23408867, PMID 23550093, PMID 23944301, PMID 24112892, PMID 26046412, PMID 26881179, PMID 26927672, PMID 27014033, PMID 27231659, PMID 27557301, PMID 27720703, PMID 28007690, PMID 28747452, PMID 30761078, PMID 31244760, PMID 31748250, PMID 32651242, PMID 32815611, PMID 33510610, PMID 34454047, PMID 34513166, PMID 34715657, PMID 35088733, PMID 35932269, PMID 36404213, PMID 36603216, PMID 36702499, PMID 36711127, PMID 37097344, PMID 37365210, PMID 37456281, PMID 37637850, PMID 37722831, PMID 38227538, PMID 38237402, PMID 38411747
1UH3NS109845-01 (1), 2016 (1), 5UH3NS095553-04 (1), 5UH3NS109845-02 (1), F31NS115363 (1), P20GM130447 (1), R01DC022949 (1), R01EB006136 (1), R01NS073683 (1), R01NS075321 (1), R01NS094607 (1), R01NS097437 (1), R01NS097782 (1), R01NS125386 (1), R03DC012429 (1)