25 completed, 7 unknown, 2 recruiting, 2 terminated. 38 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 38 | Completed 25, Unknown 7, Recruiting 2, Terminated 2, Not yet recruiting 1, Withdrawn 1 |
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neurovascular Effects of Empagliflozin Empagliflozin (EMPA), Placebo - Blood Pressure, Endothelial Dysfunction | Phase 4 | Not yet recruiting | Kanokwan Bunsawat | 100 | 2026-09-01 | 2026-09-02 |
| Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation Atorvastatin 20mg - Cerebrovascular Event, Stent Stenosis | Phase 4 | Recruiting | Duan Chuanzhi | 354 | 2024-07-30 | 2026-03-03 |
| SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery Vericiguat, Placebo - Endothelial Dysfunction, Vascular Diseases | Phase 4 | Recruiting | Vanderbilt University Medical Center | 170 | 2023-05-19 | 2026-08-06 |
| Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes Dapagliflozin, Placebo - Diabetes Mellitus, Type 2, Endothelial Dysfunction | Phase 4 | Terminated | Boston University | 4 | 2022-05-31 | 2026-02-11 |
| Endothelial Protection in Convalescent COVID-19 Patients Sulodexide - Endothelial Dysfunction, Inflammation | Phase 4 | Terminated | Pirogov Russian National Research Medical University | 2 | 2022-04-01 | 2025-06-13 |
| Novel Therapeutics and Endothelial Dysfunction in T1DM Patients Semaglutide Pen Injector [Ozempic], Empagliflozin 10 MG - Endothelial Dysfunction, Diabetes Mellitus, Type 1 | Phase 4 | Completed | General and Teaching Hospital Celje | 90 | 2021-12-15 | 2023-05-12 |
| Effect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With Hypertension berberine hydrochloride, lifestyle intervention group - Hypertension, Endothelial Dysfunction | Phase 4 | Unknown | Jun Tao | 30 | 2020-10-22 | 2021-03-10 |
| Anti-Inflammatory Drug and Endothelial Function Hydroxychloroquine, Placebo oral tablet - Cardiovascular Diseases, Endothelial Dysfunction | Phase 4 | Unknown | Instituto de Cardiologia do Rio Grande do Sul | 50 | 2019-07-01 | 2019-11-13 |
| Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery Dexmedetomidine, Saline - Endothelial Dysfunction, Blood Brain Barrier Defect | Phase 4 | Completed | The First Affiliated Hospital of Anhui Medical University | 464 | 2019-07-01 | 2021-02-10 |
| Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial) Stent implantation in the infart-related artery in patients with ST elevation myocardial infarction - Endothelial Dysfunction, Coronary Microvascular Disease | Phase 4 | Completed | Institut d'Investigació Biomèdica de Bellvitge | 60 | 2018-11-05 | 2020-10-26 |
| Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis Methotrexate, Sulfasalazine, Other DMARDs - Rheumatoid Arthritis, Stiffness, Aortic | Phase 4 | Completed | Flinders University | 124 | 2017-10-01 | 2025-02-26 |
| Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD Sodium Chloride 0.9% Intravenous Solution, Ferinject - Renal Anemia, Iron Toxicity | Phase 4 | Unknown | Carol Davila University of Medicine and Pharmacy | 40 | 2017-09-20 | 2022-08-16 |
| Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments Paroxetine, Placebo oral capsule - Postmenopausal Flushing, Cardiovascular Risk Factor | Phase 4 | Completed | Rio de Janeiro State University | 140 | 2016-03-01 | 2018-04-12 |
| Peripheral Endothelial Function Assessment of Patients on Ticagrelor vs. Clopidogrel Who Have Undergone PCI Ticagrelor, Clopidogrel - Myocardial Ischemia, Coronary Artery Disease | Phase 4 | Completed | University Hospital of Limerick | 61 | 2015-07-01 | 2016-03-11 |
| Effect of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation Ticagrelor, Clopidogrel - Endothelial Dysfunction, Vascular Inflammation | Phase 4 | Unknown | Kiyuk Chang | 38 | 2015-01-01 | 2016-07-06 |
| Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) OctaplasLG®, Fresh frozen plasma - Aortic Aneurysm, Thoracic, Endothelial Dysfunction | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 44 | 2014-11-01 | 2016-12-20 |
| Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Isosorbide-5-mononitrate - Endothelial Dysfunction, Bone Disease | Phase 4 | Withdrawn | Tameside Hospital NHS Foundation Trust | 2014-10-01 | 2019-09-11 | |
| Vildagliptin vs. Glibenclamide in Endothelial Function in Type 2 Diabetes and Hypertension Glibenclamide, Vildagliptin - Type 2 Diabetes Mellitus, Hypertension | Phase 4 | Completed | Dr. José Fernando Vilela-Martin MD PhD | 50 | 2013-07-01 | 2016-08-16 |
| CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Nebivolol, Continuous positive airway pressure (CPAP) - Hypertension, Endothelial Dysfunction | Phase 4 | Unknown | Universitaire Ziekenhuizen KU Leuven | 36 | 2013-02-01 | 2013-01-18 |
| Functional Change in Endothelium After Cardiac cAtheterization, With and Without Music Therapy Music therapy - Coronary Artery Disease, Endothelial Dysfunction | Phase 4 | Completed | Emmanouil Brilakis | 70 | 2012-06-01 | 2013-10-29 |
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Inflammation (6) · Diabetes Mellitus, Type 2 (5) · Hypertension (5) · Coronary Artery Disease (4) · Atherosclerosis (3) · Diabetes Mellitus (3) · Multiple Endocrine Neoplasia Type 1 (3) · Obesity (3) · Sexual Dysfunction, Physiological (3) · Cardiovascular Diseases (2) · Ischemic Stroke (2) · Myocardial Infarction (2) · Acute Coronary Syndrome (1) · Anemia (1) · Aortic Aneurysm, Thoracic (1)
Cardiovascular Diseases (19) · Vascular Diseases (18) · Pathological Conditions, Signs and Symptoms (11) · Endocrine System Diseases (10) · Nutritional and Metabolic Diseases (10) · Pathologic Processes (10) · Glucose Metabolism Disorders (7) · Heart Diseases (7) · Metabolic Diseases (7) · Nervous System Diseases (6) · Arterial Occlusive Diseases (5) · Arteriosclerosis (5) · Genital Diseases (5) · Myocardial Ischemia (5) · Urogenital Diseases (5)
Atorvastatin (4) · Clopidogrel (2) · Rosuvastatin Calcium (2) · Sodium Chloride (2) · Ticagrelor (2) · empagliflozin (2) · Aspirin (1) · Cilostazol (1) · Continuous Positive Airway Pressure (1) · Dexmedetomidine (1) · Diet (1) · Exercise (1) · Ezetimibe (1) · Glyburide (1) · Hydroxychloroquine (1)
Changi General Hospital (3) · Rio de Janeiro State University (2) · Ajou University School of Medicine (1) · Boston University (1) · Brasilia Heart Study Group (1) · Carol Davila University of Medicine and Pharmacy (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dr. José Fernando Vilela-Martin MD PhD (1) · Duan Chuanzhi (1) · Emmanouil Brilakis (1) · Flinders University (1) · General and Teaching Hospital Celje (1) · Hippocration General Hospital (1) · Hospital Universitario Pedro Ernesto (1) · Institut d'Investigació Biomèdica de Bellvitge (1)
Brazil (6) · United States (5) · China (3) · Netherlands (3) · Singapore (3) · Denmark (2) · Italy (2) · South Korea (2) · Australia (1) · Belgium (1) · Germany (1) · Greece (1) · Ireland (1) · Mexico (1) · Romania (1)
A IM Hoepelman, MD, PhD (1) · Alin O Stirban, Dr (1) · Andrea Lenzi, MD, PhD (1) · Andrei C Sposito, MD, PhD (1) · Andrej Janez, prof PhD (1) · Andy IM Hoepelman, MD (1) · Angelo Avogaro, M.D. (1) · Catharina Belge, M.D., Ph.D. (1) · Chuanzhi Duan, MD (1) · Ciciliana MZ Rech (1) · Cristina Capusa, Assoc. Prof. (1) · Denis Martinez (1) · Dimitris Tousoulis (1) · Edward Jude, MD, MRCP (1) · Emmanouil S Brilakis, MD, PhD (1)
PMID 10634801, PMID 11498461, PMID 20837928, PMID 21349594, PMID 21372302, PMID 21730307, PMID 21885990, PMID 21920481, PMID 22192670, PMID 22472556, PMID 22474419, PMID 22496161, PMID 23635309, PMID 23735418, PMID 24462073, PMID 24933032, PMID 25355814, PMID 25722222, PMID 26178526, PMID 26312070, PMID 26590269, PMID 27300170, PMID 28851320, PMID 29146831, PMID 29327999, PMID 29770748, PMID 29863610, PMID 30094725, PMID 30565953, PMID 31102457, PMID 31352800, PMID 31504418, PMID 33221242, PMID 33447904, PMID 33640311, PMID 34535165, PMID 34991791, PMID 35292570, PMID 36375835, PMID 36700744, PMID 37324979, PMID 38198155, PMID 38719444, PMID 39387403, PMID 40742006
2015 (1), R01HL164909 (1)