17 completed, 7 terminated, 6 recruiting, 3 active not recruiting. 11 Phase 1, 9 Early Phase 1, 9 Not applicable, 7 Phase 2.
Follow Acetylcholine: new trials by email Literature Review of Acetylcholine trials Research Report on Acetylcholine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Neurovascular Adaptations in Aging Women Norepinephrine, Isoproterenol, Acetylcholine - Women, Sympathetic Nervous System | Early Phase 1 | Recruiting | University of Missouri-Columbia | 64 | 2024-09-20 | 2025-11-26 |
| Role of Endothelial Function in SCI CVD Risk Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine - Spinal Cord Injuries, Cardiovascular Diseases | Recruiting | Craig Hospital | 60 | 2024-09-01 | 2024-08-20 | |
| Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation Acetylcholine - Endothelial Function | Early Phase 1 | Active not recruiting | University of Iowa | 56 | 2024-08-01 | 2026-10-29 |
| Estrogen and Microvascular Function Nω-nitro-L-arginine methyl ester (L-NAME), Acetylcholine, Sodium Nitroprusside - Estrogen, Cardiovascular Diseases | Active not recruiting | Medical College of Wisconsin | 45 | 2023-10-12 | 2026-07-29 | |
| Investigation of Endothelium-dependent Vasodilation in Human Gingiva Acetylcholine Chloride - Vasodilation, Oral Soft Tissue Conditions | Not applicable | Unknown | Semmelweis University | 80 | 2023-09-01 | 2024-06-12 |
| Role of NADPH Oxidase in Microvascular Dysfunction Following GDM Acetylcholine, Insulin aspart - Gestational Diabetes, Oxidative Stress | Early Phase 1 | Active not recruiting | Anna Stanhewicz, PhD | 40 | 2023-08-30 | 2026-07-29 |
| Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes Acetylcholine, insulin aspart - Gestational Diabetes, Vascular Endothelial Function | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 28 | 2023-07-01 | 2026-07-29 |
| Prenatal Aspirin and Postpartum Vascular Function Acetylcholine, Endothelin-1 - Preeclampsia, Microvascular Function | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 60 | 2023-01-03 | 2025-05-31 |
| Hot Flashes and Neurovascular Function in Women Sympathoexcitatory stressors, Sodium Nitroprusside, Acetylcholine - Hot Flashes, Menopause | Not applicable | Recruiting | Mayo Clinic | 120 | 2022-02-24 | 2026-06-12 |
| Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva Nitroglycerin, Acetylcholine - Vasodilatation, Oral Soft Tissue Conditions | Not applicable | Completed | Semmelweis University | 24 | 2020-09-15 | 2021-06-14 |
| The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels C-type natriuretic peptide (CNP), Saline, Acetylcholine - Ischaemia-reperfusion (IR) Injury | Not applicable | Withdrawn | Queen Mary University of London | 2020-01-01 | 2020-05-05 | |
| Targeting ER Stress in Vascular Dysfunction Acetylcholine, Sodium Nitroprusside, Ascorbic Acid - Vasodilation, Arterial Stiffness | Early Phase 1 | Terminated | Colorado State University | 17 | 2019-06-01 | 2025-04-08 |
| HeartPhone Cancer Survivors Trial 2019 HeartPhone app, Acetylcholine, Sodium Nitroprusside - Breast Cancer, Leukemia | Phase 1 / Phase 2 | Terminated | Penn State University | 2 | 2019-04-23 | 2026-02-27 |
| Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training Handgrip Exercise Training, Acetylcholine, Adenosine Triphosphate - Vasoconstriction, Vasodilation | Early Phase 1 | Withdrawn | Colorado State University | 2019-04-16 | 2021-08-02 | |
| The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood Flow Acetylcholine, Norepinephrine, Phenylephrine - Cardiovascular Diseases, Vascular Diseases | Not applicable | Terminated | University Hospital, Linkoeping | 31 | 2019-04-01 | 2026-05-13 |
| Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults Adenosine Triphosphate, Acetylcholine, Sodium Nitroprusside - Receptor Blockade | Early Phase 1 | Completed | Colorado State University | 9 | 2019-02-07 | 2021-07-27 |
| Anemia Study in Chronic Kidney Disease (CKD) : Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat -Forearm Blood Flow (ASCEND-FBF) Daprodustat, Darbepoetin alfa, Acetylcholine - Anaemia | Phase 2 | Terminated | GlaxoSmithKline | 6 | 2019-01-10 | 2024-03-27 |
| Pharmacodynamic Study to Assess the Effects of Repeated Dosing of SAR247799 on Endothelial Function in Patients With Type 2 Diabetes Mellitus SAR247799, Placebo, Sildenafil - Microvascular Coronary Artery Disease | Phase 1 | Completed | Sanofi | 54 | 2018-03-07 | 2022-04-25 |
| Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease. Darbepoetin Alfa, Acetylcholine, Noradrenaline - Cardiovascular Diseases, Chronic Kidney Disease | Completed | Cambridge University Hospitals NHS Foundation Trust | 29 | 2017-02-20 | 2024-02-07 | |
| Vascular Function and Uterine Fibroids Brachial artery catheter, Acetylcholine, Nitroprusside - Leiomyoma | Completed | Mayo Clinic | 28 | 2013-04-01 | 2018-03-02 |
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Aneurysm (6) · Cardiovascular Diseases (4) · Anemia, Sickle Cell (3) · Diabetes, Gestational (2) · Heart Failure (2) · Hypertension (2) · Inflammation (2) · Obesity (2) · Acquired Immunodeficiency Syndrome (1) · Anemia (1) · Ascorbic Acid Deficiency (1) · Atherosclerosis (1) · Breast Neoplasms (1) · Coronary Vasospasm (1) · Diabetes Mellitus, Type 2 (1)
National Heart, Lung, and Blood Institute (NHLBI) (4) · Anna Stanhewicz, PhD (3) · Colorado State University (3) · National Institutes of Health Clinical Center (CC) (3) · Mayo Clinic (2) · Radboud University Medical Center (2) · Semmelweis University (2) · Cambridge University Hospitals NHS Foundation Trust (1) · Craig Hospital (1) · D. Walter Wray (1) · Emory University (1) · Gladwin, Mark, MD (1) · GlaxoSmithKline (1) · Heidelberg University (1) · Mark Gladwin (1)
United States (25) · United Kingdom (6) · Germany (2) · Hungary (2) · Netherlands (2) · Sweden (2) · France (1)
Frank Dinenno, PhD (3) · John F Tisdale, M.D. (2) · Ahluwalia Amrita, BSc PhD (1) · Andrew Park, MD (1) · Arshed A Quyyumi, MD (1) · Catalin Toma, MD (1) · Daniel Wilhelms, Phd (1) · David W Wray, Ph.D. (1) · Gerard Rongen, MD, PhD (1) · Henry Masur, M.D. (1) · Joseph Cheriyan, MBCHB, MA, FRCP (1) · Juan C Kaski, MD (1)
PMID 11927685, PMID 12122152, PMID 12237259, PMID 12793996, PMID 15153776, PMID 15498811, PMID 15563538, PMID 21555712, PMID 23519586, PMID 24675657, PMID 24925526, PMID 25648989, PMID 26222884, PMID 33125753, PMID 35449189, PMID 35562729, PMID 36005278, PMID 40066842
2017 (2), R01HL169201 (2), 2018 (1), K01HL148144 (1), R01HL079115 (1), R01HL098032 (1)