4 completed, 2 recruiting, 1 not yet recruiting. 7 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 7 | Completed 4, Recruiting 2, Not yet recruiting 1 |
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control) - Metabolic Syndrome, Vascular Injury | Early Phase 1 | Not yet recruiting | Gary Van Guilder | 68 | 2026-10-01 | 2025-02-13 |
| Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM Insulin aspart - Gestational Diabetes, Endothelial Dysfunction | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 40 | 2024-10-01 | 2026-10-29 |
| Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use Placebo, Salsalate 750 MG Oral Tablet [DISALCID] - Electronic Cigarette Use, Endothelial Dysfunction | Early Phase 1 | Recruiting | University of Iowa | 24 | 2024-08-15 | 2026-10-29 |
| Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study Experimental: Nitrate-containing, Placebo: Nitrate-depleted - Aging, Arterial Stiffness | Early Phase 1 | Completed | Gary L. Pierce, PhD | 16 | 2018-11-01 | 2026-03-04 |
| Acute Effects of E-Cigarette Aerosol Inhalation Electronic Cigarette Aerosol - Endothelial Dysfunction, Biochemical Markers | Early Phase 1 | Completed | University of Pennsylvania | 31 | 2018-05-22 | 2024-05-08 |
| Endothelial Function in Human Arteries L-arginine - Endothelial Dysfunction | Early Phase 1 | Completed | The Cleveland Clinic | 25 | 2009-09-01 | 2017-03-07 |
| Leptin Infusion and Endothelial Vasomotor Response Leptin infusion plus vasodilators in healthy men, Leptin infusion in healthy men, Vasodilators in CAD patients - Endothelial Dysfunction, Obesity | Early Phase 1 | Completed | Stefan Soderberg | 103 | 2006-01-01 | 2023-05-09 |
Inflammation (2) · Aneurysm (1) · Cerebral Small Vessel Diseases (1) · Cognitive Dysfunction (1) · Diabetes, Gestational (1) · Hyperemia (1) · Hypertension (1) · Metabolic Syndrome (1) · Obesity (1) · Peripheral Vascular Diseases (1) · Reperfusion Injury (1) · Sedentary Behavior (1) · Vaping (1) · Vascular System Injuries (1)
Cardiovascular Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Vascular Diseases (4) · Nutritional and Metabolic Diseases (3) · Pathologic Processes (3) · Behavior (2) · Glucose Metabolism Disorders (2) · Metabolic Diseases (2) · Body Weight (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Cerebrovascular Disorders (1) · Cognition Disorders (1) · Diabetes Mellitus (1) · Endocrine System Diseases (1)
Acetylcholine (1) · Arginine (1) · Bradykinin (1) · Insulin Aspart (1) · Ischemic Preconditioning (1) · Nitric Oxide (1) · Nitroprusside (1) · Single Person (1) · Substance P (1) · Tablets (1) · Vasodilator Agents (1) · Verapamil (1) · salicylsalicylic acid (1)
Anna Stanhewicz, PhD (1) · Gary L. Pierce, PhD (1) · Gary Van Guilder (1) · Stefan Soderberg (1) · The Cleveland Clinic (1) · University of Iowa (1) · University of Pennsylvania (1)
United States (5) · Sweden (1) · United Kingdom (1)
Felix W. Wehrli, PhD (1) · Gary Pierce, PhD (1) · Vikram Kashyap, MD (1)
PMID 23830159, PMID 28366306, PMID 31042077, PMID 31429679, PMID 32528311, PMID 32538283, PMID 33216614, PMID 40066842
F31HL177925 (1), R01HL139358 (1)