111 completed, 18 unknown, 11 recruiting, 6 terminated. 157 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 157 | Completed 111, Unknown 18, Recruiting 11, Terminated 6, Not yet recruiting 5, Active not recruiting 2, Suspended 2, Withdrawn 2 |
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Propionic Acid Supplementation on Endothelial Function Sodium Propionate, Placebo - Cardiovascular Diseases, Endothelial Dysfunction | Not applicable | Not yet recruiting | Medical College of Wisconsin | 20 | 2029-07-01 | 2026-10-30 |
| Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes MitoQ (mitoquinol mesylate), Placebo - Type 2 Diabetes (T2DM), Endothelial Dysfunction | Not applicable | Not yet recruiting | Medical College of Wisconsin | 40 | 2027-10-01 | 2026-10-30 |
| Sacha Inchi-CoQ10 Supplementation and Cardiovascular Health Sacha-Q10 Plus, Placebo - Cardiovascular Disease (CVD), Elevated Cardiovascular Risk | Not applicable | Not yet recruiting | Hospital Pengajar Universiti Putra Malaysia | 60 | 2026-10-01 | 2026-08-28 |
| Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling - Pregnancy, Gestational Diabetes Mellitus (GDM) | Not applicable | Not yet recruiting | University of Salamanca | 60 | 2026-09-01 | 2026-06-18 |
| Huangqi Gegen Decoction for Endothelial Function in Type 2 Diabetes at Very High ASCVD Risk Huangqi Gegen Decoction Granules, Placebo Granules, Conventional Treatment - Type 2 Diabetes Mellitus, Endothelial Dysfunction | Not applicable | Active not recruiting | Putuo Hospital, Shanghai University of Traditional Chinese Medicine | 90 | 2026-08-04 | 2026-08-20 |
| Resveratrol for Endothelial Dysfunction and Metabolic Control in Type 2 Diabetes Resveratrol, Placebo - Type 2 Diabetes Mellitus, Endothelial Dysfunction | Not applicable | Completed | Universitas Sriwijaya | 48 | 2026-05-01 | 2026-06-16 |
| Impact of Garlic on the Clinical Outcome in Chronic Hemodialysis Patients Dried garlic powder (Garlic extract) - Allium sativum. - Hemodialysis, Endothelial Dysfunction | Not applicable | Completed | Ain Shams University | 58 | 2025-10-01 | 2026-03-10 |
| NightWare and Cardiovascular Health in Veterans With PTSD NightWare - Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases | Not applicable | Recruiting | VA Office of Research and Development | 125 | 2025-09-10 | 2026-10-08 |
| EndoPAT Device for Endothelial Dysfunction in ED Daily low-dose PDE5 inhibitor therapy, Testosterone therapy as per clinical guidelines. - Erectile Dysfunction, Hypogonadism, Male | Not applicable | Recruiting | University of California, Irvine | 120 | 2025-08-13 | 2026-02-02 |
| NightWare and Cardiovascular Health in Women With PTSD NightWare, Sham NightWare - Post Traumatic Stress Disorder, Cardiovascular Diseases | Not applicable | Recruiting | University of Colorado, Denver | 36 | 2025-08-06 | 2026-11-06 |
| ACEs, SIRT1, and Premature Vascular Aging in Humans Nicotinamide Riboside, Placebo - Adverse Childhood Experiences, Endothelial Dysfunction | Not applicable | Recruiting | University of Wisconsin, Madison | 30 | 2025-03-27 | 2026-08-19 |
| Centella Asiatica in Older Adults Centella Asiatica, Placebo Comparator - Endothelial Dysfunction | Not applicable | Completed | National University of Natural Medicine | 23 | 2025-02-01 | 2026-07-01 |
| Physical Activity and Cardiovascular Risk Training group, Physical activity orientation group - Rheumatoid Arthritis, Chronic Kidney Diseases | Not applicable | Not yet recruiting | University of Franche-Comté | 105 | 2024-09-01 | 2024-06-05 |
| Effects of Anesthesia Technique on Endothelial Function Group GA, Group IB - Endothelial Dysfunction, Ischemia Reperfusion | Not applicable | Completed | Bagcilar Training and Research Hospital | 106 | 2024-08-25 | 2026-05-07 |
| The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies Cognitive Behavioral Therapy for Insomnia (CBT-i) - Adverse Childhood Experiences, Vascular Dilatation | Not applicable | Suspended | University of Wisconsin, Madison | 70 | 2024-05-01 | 2026-10-29 |
| Onco-Vascular Exer-Study Exercise training - Breast Cancer, Vascular Disease，Peripheral | Not applicable | Completed | Cristian Alvarez | 30 | 2024-04-01 | 2025-01-22 |
| Effects of Krill Oil on Intestinal Integrity Markers in Elite Rowers. THYROX (Atlantic krill oil, Placebo - Endothelial Dysfunction | Not applicable | Unknown | Poznan University of Physical Education | 30 | 2024-03-23 | 2024-03-18 |
| Impact of the Mandibular Advancement Device on Sleep Apnea During CPAP Withdrawal Mandibular advancement device treatment - Sleep Apnea, Obstructive, Endothelial Dysfunction | Not applicable | Recruiting | University Hospital, Angers | 40 | 2024-03-05 | 2026-04-06 |
| Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II Treatment: additional albumin during cardiopulmonary bypass, control: additional ringers during cardiopulmonary bypass - Endothelial Dysfunction, Hemolysis | Not applicable | Unknown | Amsterdam UMC, location VUmc | 64 | 2023-10-15 | 2023-04-26 |
| The Effect of NADPH Oxidase and Creatine Supplementation on Microvascular Blood Flow Regulation Creatine Monohydrate, Maltodextrin (Placebo) - Endothelial Dysfunction | Not applicable | Completed | Florida State University | 9 | 2023-08-29 | 2024-05-16 |
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Cardiovascular Diseases (23) · Hypertension (19) · Inflammation (18) · Diabetes Mellitus, Type 2 (9) · Motor Activity (7) · Obesity (7) · Atherosclerosis (5) · Coronary Artery Disease (5) · Insulin Resistance (5) · Metabolic Syndrome (5) · Renal Insufficiency, Chronic (5) · Primary Dysautonomias (4) · COVID-19 (3) · Diabetes Mellitus (3) · Dyslipidemias (3)
Pathological Conditions, Signs and Symptoms (47) · Nutritional and Metabolic Diseases (40) · Cardiovascular Diseases (39) · Vascular Diseases (39) · Pathologic Processes (32) · Metabolic Diseases (31) · Glucose Metabolism Disorders (22) · Urogenital Diseases (19) · Endocrine System Diseases (17) · Signs and Symptoms (17) · Female Urogenital Diseases and Pregnancy Complications (16) · Male Urogenital Diseases (14) · Arterial Occlusive Diseases (13) · Arteriosclerosis (13) · Female Urogenital Diseases (13)
Exercise (9) · Resveratrol (4) · Estradiol (3) · maltodextrin (3) · Acetylcholine (2) · Adenosine (2) · Anthropometry (2) · Blood Pressure (2) · Blood Specimen Collection (2) · Creatine (2) · Electrocardiography (2) · Eplerenone (2) · mitoquinone (2) · phenolic acid (2) · Absorptiometry, Photon (1)
University of Colorado, Denver (6) · University of Edinburgh (5) · McMaster University (4) · Wageningen University (4) · Florida State University (3) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (3) · Medical College of Wisconsin (3) · Société des Produits Nestlé (SPN) (3) · Amsterdam UMC, location VUmc (2) · Assistance Publique - Hôpitaux de Paris (2) · Brigham and Women's Hospital (2) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (2) · Colorado State University (2) · Cristian Alvarez (2) · Indiana University (2)
United States (61) · United Kingdom (11) · Italy (8) · Netherlands (8) · Canada (6) · Belgium (5) · Brazil (5) · France (5) · Sweden (5) · Australia (4) · Denmark (4) · Chile (3) · Germany (3) · Russia (3) · Spain (3)
Maureen J MacDonald, PhD (4) · Anders Blomberg, MD PhD (3) · Amir Lerman, MD (2) · David E Newby, PhD FRCP (2) · Kerrie L Moreau, PhD (2) · Kerry L Hildreth, MD (2) · Leslie Tan (2) · Nathaniel Jenkins, PhD (2) · Rodrigo Araneda, PhD (2) · Alan Barker, PhD (1) · Anders B. Jensen, Professor (1)
PMID 37843843, PMID 41264372, PMID 17488800, PMID 18606901, PMID 18636958, PMID 20216298, PMID 20923960, PMID 21968545, PMID 22162245, PMID 22504483, PMID 22713099, PMID 23076403, PMID 23184900, PMID 23405070, PMID 23505057, PMID 23525434, PMID 23684677, PMID 23977055, PMID 24399113, PMID 24667535, PMID 24782198, PMID 24782475, PMID 24920698, PMID 25786484, PMID 25934864, PMID 25972527, PMID 26080804, PMID 26206681, PMID 26394828, PMID 26437603, PMID 26439537, PMID 26764881, PMID 26787561, PMID 27270841, PMID 27286178, PMID 27418688, PMID 27765765, PMID 28153005, PMID 28167186, PMID 28448534, PMID 28755406, PMID 28922226, PMID 29357033, PMID 29858417, PMID 30113522, PMID 30246635, PMID 30335579, PMID 30398646, PMID 30428890, PMID 30479642
UL1TR001082 (2), I01CX002762 (1), P20GM103418 (1), R01AG031750 (1), R01HL072711 (1), R01HL092954 (1), R01HL116470 (1), R01HL122472 (1), R01HL167788 (1), R21AG075544 (1), R21AT004265 (1), R21HL145002 (1), R56HL114073 (1)