7 completed, 2 unknown, 1 terminated, 1 withdrawn. 6 Not applicable, 3 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 3, Unknown 2, Withdrawn 1 |
| Phase 4 | 3 | Completed 2, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Punctal Plugs: new trials by email Literature Review of Punctal Plugs trials Research Report on Punctal Plugs
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| OTX-DED for the Short-term Treatment of the Symptoms of Dry Eye Disease (DED) OTX-DED, Controlled Insertion, Collagen Punctal Plug - Dry Eye Syndromes, Eye Diseases | Phase 2 | Completed | Ocular Therapeutix, Inc. | 100 | 2023-05-11 | 2024-07-10 |
| Alveolar Ridge Preservation in Molar Extraction Sockets With an Open Healed Collagen Membrane: A Randomized Clinical Trial. membrane guided regeneration, collagen plug - Tooth Extraction | Not applicable | Unknown | National Taiwan University Hospital | 30 | 2021-04-15 | 2023-02-06 |
| Safety and Efficacy of Dexamethasone Ophthalmic Insert (Dextenza®) in the Management of Clinically Significant Dry Eye Sustained Release Dexamethasone, 0.4 mg, E-Caprolactone-L-Lactide copolymer (PCL) punctal plug - Dry Eye | Phase 4 | Terminated | Johns Hopkins University | 77 | 2021-03-16 | 2024-03-15 |
| Quality of Life Improvement in Dry Eye Patients After Intense Pulsed Light Therapy Compared to Punctal Plugs IPL therapy, Punctal plugs - Evaporative Dry Eye | Not applicable | Completed | Tanta University | 30 | 2020-12-01 | 2022-04-18 |
| The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal Injection Punctal plug - Dry Eye Syndromes, Dry Eye | Not applicable | Completed | University of Oklahoma | 126 | 2019-06-01 | 2023-12-07 |
| Outcome of Omega 3 FA and Punctal Plugs on Ocular Surface Disease Omega 3, punctal plug - Ocular Surface Disease | Phase 4 | Completed | Benha University | 90 | 2018-07-02 | 2019-11-26 |
| Punctal Plugs and Iodine Related Discomfort Punctal plug - Dry Eye Syndromes | Not applicable | Withdrawn | University of New Mexico | 2017-07-26 | 2024-03-13 | |
| A Comparison Between Bandage Contact Lens, Punctal Plugs and Standard Measures in Preventing Corneal Injuries contact lens, punctal plug - Contact Lens and Punctal Plug in Preventing Corneal Injuries | Not applicable | Unknown | Rabin Medical Center | 105 | 2015-05-01 | 2013-10-11 |
| Safety and Efficacy of Punctal Plug Insertion in Patients With Dry Eye Punctal Plug - Dry Eye | Phase 4 | Completed | Allergan | 30 | 2012-10-01 | 2019-04-17 |
| Long-term Follow-up of Anal Fistula Plug Biodesign® anal fistula plug - Anal Fistula | Completed | Region Skane | 95 | 2006-05-01 | 2019-05-23 | |
| Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion Punctal plugs, punctal cautery, Punctal Plug, Punctal thermocauterization, Silicone plug or thermodynamic hydrophobic acrylic plug - Dry Eye Syndrome | Not applicable | Completed | Lahey Clinic | 55 | 2003-07-01 | 2009-05-25 |
Dry Eye Syndromes (7) · Corneal Injuries (1) · Eye Diseases (1) · Rectal Fistula (1)
Allergan (1) · Benha University (1) · Johns Hopkins University (1) · Lahey Clinic (1) · National Taiwan University Hospital (1) · Ocular Therapeutix, Inc. (1) · Rabin Medical Center (1) · Region Skane (1) · Tanta University (1) · University of New Mexico (1) · University of Oklahoma (1)
United States (5) · Egypt (1) · Israel (1) · Singapore (1) · Sweden (1) · Taiwan (1) · United Arab Emirates (1)
Esen Akpek, MD (1) · Jennifer Nelson, COA, ROUB (1) · Jonathan Cohen, MD Prof (1) · Marianne Starck, MD, PhD (1) · Sarkis H. Soukiasian, M.D. (1) · Vinay Shah, MD (1)
PMID 11408145, PMID 19694608, PMID 25325851, PMID 27088009, PMID 27442130, PMID 37203207, PMID 38492864