Ocular Hypertension: Clinical Trials

1273 completed, 371 unknown, 179 recruiting, 127 terminated. 781 Not applicable, 281 Phase 4, 247 Phase 3, 230 Phase 2, 117 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	781	Completed 376, Unknown 169, Recruiting 91, Terminated 57, Not yet recruiting 27, Withdrawn 27, Active not recruiting 24, Enrolling by invitation 7, Suspended 3
Phase 4	281	Completed 195, Unknown 32, Terminated 19, Recruiting 15, Withdrawn 9, Not yet recruiting 6, Active not recruiting 5
Phase 3	247	Completed 184, Unknown 23, Terminated 13, Recruiting 12, Withdrawn 8, Active not recruiting 2, Not yet recruiting 2, Suspended 2, Enrolling by invitation 1
Phase 2	230	Completed 173, Unknown 23, Recruiting 10, Terminated 8, Active not recruiting 7, Withdrawn 5, Not yet recruiting 2, Enrolling by invitation 1, Suspended 1
Phase 1	117	Completed 72, Unknown 18, Recruiting 7, Active not recruiting 6, Terminated 6, Not yet recruiting 3, Withdrawn 3, Enrolling by invitation 1, Suspended 1
Early Phase 1	13	Completed 8, Unknown 3, Active not recruiting 1, Recruiting 1

Follow Ocular Hypertension: new trials by email Literature Review of Ocular Hypertension trials Research Report on Ocular Hypertension

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution - Glaucoma, Glaucoma, Open-Angle	Phase 4	Not yet recruiting	Tulane University	60	2027-11-01	2026-10-13
Know Your Pressures NYC Virtual Automated Navigator Intervention with Health Education, Usual Care - Glaucoma, Hypertension	Not applicable	Not yet recruiting	Columbia University	7085	2027-07-01	2026-08-25
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial) Nicotinamide, Standard Glaucoma Therapy - Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)	Phase 2	Not yet recruiting	University of Chicago	96	2027-06-01	2026-10-13
Eye Health Intervention Study in Upper Manhattan Intervention, Usual Care - Glaucoma, Suspect, Diabetic Retinopathy	Not applicable	Withdrawn	Columbia University		2027-04-01	2026-05-29
AI-Assisted vs Conventional Teleglaucoma Referral AI-Assisted Teleglaucoma Referral Pathway, Conventional Teleglaucoma Referral Pathway - Glaucoma	Not applicable	Not yet recruiting	University of Southern California	1386	2027-01-01	2026-11-05
Glaucoma Drop Aids Part 2 Nanodropper - Glaucoma, Intraocular Pressure	Not applicable	Not yet recruiting	Boston Medical Center	80	2027-01-01	2026-10-30
PureSee EDOF Versus ZCB00 Monofocal IOLs in Mild-to-Moderate Glaucoma TECNIS PureSee Intraocular Lens, TECNIS ZCB00 Monofocal Intraocular Lens - Primary Open-Angle Glaucoma		Not yet recruiting	Mann Eye Institute	100	2026-12-02	2026-11-09
VGFTe-(HD)-OD-2566: Adjunctive Aflibercept Ahmed Glaucoma Valve (AAA) Study Aflibercept Injection, Ahmed Tube Surgery - Glaucoma	Phase 2	Not yet recruiting	University of Miami	100	2026-12-01	2026-10-23
Effect of Late Ripcord Removal From Glaucoma Drainage Device Ripcord removal - GLAUCOMA 1, OPEN ANGLE, D (Disorder), Glaucoma	Not applicable	Recruiting	Duke University	80	2026-12-01	2026-11-09
GlaukomAI: Clinical Validation of an AI System for Early Glaucoma Screening GlaukomAI (Sens-vue GlaukomAI) - Glaucoma	Not applicable	Not yet recruiting	Fondazione G.B. Bietti, IRCCS	1200	2026-12-01	2026-11-12
Impact of Meditation on Reducing Stress in Glaucoma Patients: An Electronic Feasibility Study Meditation + Usual Care - Glaucoma	Not applicable	Not yet recruiting	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	158	2026-11-01	2026-08-18
Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment Active hf-tRNS., Placebo/sham hf-tRNS - Retinitis Pigmentosa (RP), Rod Cone Dystrophy	Not applicable	Recruiting	University of Waterloo	20	2026-11-01	2026-11-03
PAUL® Glaucoma Implant Safety and Effectiveness Study PAUL® Glaucoma Implant - Refractory Glaucoma	Not applicable	Not yet recruiting	Clinical Research Consultants, Inc.	65	2026-11-01	2026-10-30
A Phase 2a Study Comparing the Efficacy, Safety and Tolerability of Pregabalin Eye Drops Comparing With Timolol Eye Drops in Adults With Glaucoma or High Eye Pressure. Arm 1: TB0001 ophthalmic solution 0.9%, Arm 2: TB0001 ophthalmic solution 1.2%, TB0001 ophthalmic solution 1.5% - Primary Open - Angle Glaucoma (POAG), Ocular Hypertension (OHT)	Phase 2	Recruiting	Tavo Biotherapeutics	96	2026-10-23	2026-11-03
Baerveldt Versus Paul Study Baerveldt Glaucoma Implant, Paul Glaucoma Implant - Glaucoma	Phase 4	Not yet recruiting	University of Sydney	150	2026-10-12	2026-08-03
A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage ASP2767, Sham ASP2767, Prophylactic Regimen A - Glaucoma	Phase 1 / Phase 2	Recruiting	Astellas Pharma Global Development, Inc.	156	2026-10-07	2026-10-22
Switching From Preserved Glaucoma Therapy to Preservative-Free ZOLYMBUS preservative free ZOLYMBUS™ 0.01%. - Eye Drops Self-instillation, Glaucoma	Phase 4	Not yet recruiting	Southern College of Optometry	40	2026-10-05	2026-09-28
Iopidine to Decrease Intraocular Pressure Rise After Injections Apraclonidine 1.0% ophthalmic solution - Macular Degeneration, Diabetic Retinopathy	Phase 4	Not yet recruiting	Retina Consultants of Delmarva	120	2026-10-01	2026-10-23
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed. GORE Glaucoma Drainage Implant - Glaucoma, Primary Open Angle	Not applicable	Not yet recruiting	Gore Ophthalmic	70	2026-10-01	2026-10-19
Eplerenone and IOP in Healthy Adults Eplerenone, Microcrystalline Cellulose NF (placebo) - Intraocular Pressure (IOP), Healthy Adult	Phase 1	Not yet recruiting	University of Florida	30	2026-10-01	2026-08-31

Showing 20 of 2159. Sign in to see all of them.

Narrower conditions

Glaucoma (1364)  ·  Glaucoma, Open-Angle (920)  ·  Cataract (106)  ·  Glaucoma, Angle-Closure (87)  ·  Low Tension Glaucoma (65)  ·  Eye Diseases (54)  ·  Diabetic Retinopathy (49)  ·  Macular Degeneration (47)  ·  Exfoliation Syndrome (42)  ·  Glaucoma, Neovascular (39)  ·  Hydrophthalmos (37)  ·  Hypertension (30)  ·  Retinal Diseases (23)  ·  Patient Compliance (20)

Broader conditions

Eye Diseases (2105)  ·  Glaucoma (755)  ·  Lens Diseases (109)  ·  Cardiovascular Diseases (101)  ·  Vascular Diseases (100)  ·  Nervous System Diseases (86)  ·  Retinal Diseases (84)  ·  Optic Nerve Diseases (72)  ·  Pathological Conditions, Signs and Symptoms (69)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (64)  ·  Uveal Diseases (60)  ·  Endocrine System Diseases (57)  ·  Retinal Degeneration (56)  ·  Behavior (50)

Interventions

Latanoprost (167)  ·  Timolol (130)  ·  Travoprost (105)  ·  Ophthalmic Solutions (85)  ·  Bimatoprost (84)  ·  Trabeculectomy (75)  ·  Brimonidine Tartrate (63)  ·  brinzolamide (57)  ·  dorzolamide (40)  ·  dorzolamide-timolol combination (39)  ·  Phacoemulsification (37)  ·  Cataract Extraction (32)  ·  Mitomycin (30)  ·  Duotrav (24)  ·  netarsudil (22)

Sponsors

Alcon Research (135)  ·  Allergan (90)  ·  Glaukos Corporation (48)  ·  Wills Eye (48)  ·  Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (27)  ·  Aerie Pharmaceuticals (25)  ·  Medical University of Vienna (24)  ·  Sensimed AG (23)  ·  Sun Yat-sen University (23)  ·  Universitaire Ziekenhuizen KU Leuven (20)  ·  University of Zurich (20)  ·  Zhongshan Ophthalmic Center, Sun Yat-sen University (19)  ·  Aristotle University Of Thessaloniki (17)  ·  Duke University (17)  ·  Johns Hopkins University (16)

Countries

United States (747)  ·  Canada (116)  ·  China (115)  ·  Germany (102)  ·  France (78)  ·  Egypt (77)  ·  United Kingdom (75)  ·  Italy (74)  ·  Spain (69)  ·  Switzerland (61)  ·  Austria (55)  ·  South Korea (54)  ·  Belgium (45)  ·  Israel (38)  ·  Singapore (36)

Top investigators

Ingeborg Stalmans, MD, PhD (9)  ·  Anastasios G Konstas, MD, PhD (7)  ·  George L Spaeth, MD (7)  ·  Robert Ritch, MD (7)  ·  Theresa Heah, MD (7)  ·  William C. Stewart, MD (7)  ·  Zubair Hussain, PhD (7)  ·  Gong Je Seong, MD, PhD (6)  ·  Jeffrey L Goldberg, MD, PhD (6)

Results publications

PMID 35943114, PMID 36912740, PMID 10937547, PMID 24974815, PMID 17122118, PMID 12049574, PMID 19427617, PMID 24210765, PMID 35643967, PMID 40408035, PMID 11772581, PMID 12365904, PMID 16249960, PMID 16488940, PMID 17159450, PMID 19277230, PMID 19476406, PMID 19855289, PMID 22427577, PMID 22607109, PMID 23557744, PMID 23746612, PMID 25336577, PMID 25358735, PMID 25533656, PMID 26199618, PMID 26604914, PMID 26674779, PMID 26891880, PMID 27117781, PMID 27769587, PMID 27857759, PMID 27904503, PMID 28551166, PMID 29194198, PMID 29267575, PMID 29477688, PMID 29613978, PMID 31294768, PMID 31727428, PMID 32166538, PMID 32277009, PMID 34003939, PMID 34433548, PMID 34707360, PMID 35076329, PMID 36122660, PMID 36378864, PMID 37010901, PMID 37793935

NIH funding

2014 (5), 2018 (5), 2008 (4), 2015 (4), 2019 (4), 2009 (3), 2023 (3), 2016 (2), P30AG022838 (2), R01EY013178 (2), R01EY022124 (2), R01EY023285 (2), U01DP006820 (2), UL1TR001082 (2), 2017 (1)