Ocular Hypertension: Clinical Trials

1269 completed, 374 unknown, 174 recruiting, 126 terminated. 776 Not applicable, 280 Phase 4, 247 Phase 3, 228 Phase 2, 117 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	776	Completed 375, Unknown 171, Recruiting 86, Terminated 56, Not yet recruiting 28, Withdrawn 27, Active not recruiting 23, Enrolling by invitation 7, Suspended 3
Phase 4	280	Completed 195, Unknown 32, Terminated 19, Recruiting 15, Withdrawn 9, Active not recruiting 5, Not yet recruiting 5
Phase 3	247	Completed 184, Unknown 23, Terminated 13, Recruiting 12, Withdrawn 8, Active not recruiting 2, Not yet recruiting 2, Suspended 2, Enrolling by invitation 1
Phase 2	228	Completed 172, Unknown 23, Recruiting 9, Active not recruiting 8, Terminated 8, Withdrawn 5, Enrolling by invitation 1, Not yet recruiting 1, Suspended 1
Phase 1	117	Completed 72, Unknown 18, Recruiting 7, Active not recruiting 6, Terminated 6, Not yet recruiting 3, Withdrawn 3, Enrolling by invitation 1, Suspended 1
Early Phase 1	13	Completed 8, Unknown 3, Active not recruiting 1, Recruiting 1

Follow this condition Literature Review of Ocular Hypertension trials Research Report on Ocular Hypertension

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution - Glaucoma, Glaucoma, Open-Angle	Phase 4	Not yet recruiting	Tulane University	60	2027-11-01	2026-10-13
Know Your Pressures NYC Virtual Automated Navigator Intervention with Health Education, Usual Care - Glaucoma, Hypertension	Not applicable	Not yet recruiting	Columbia University	7085	2027-07-01	2026-08-25
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial) Nicotinamide, Standard Glaucoma Therapy - Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)	Phase 2	Not yet recruiting	University of Chicago	96	2027-06-01	2026-10-13
Eye Health Intervention Study in Upper Manhattan Intervention, Usual Care - Glaucoma, Suspect, Diabetic Retinopathy	Not applicable	Withdrawn	Columbia University		2027-04-01	2026-05-29
Impact of Meditation on Reducing Stress in Glaucoma Patients: An Electronic Feasibility Study Meditation + Usual Care - Glaucoma	Not applicable	Not yet recruiting	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	158	2026-11-01	2026-08-18
Baerveldt Versus Paul Study Baerveldt Glaucoma Implant, Paul Glaucoma Implant - Glaucoma	Phase 4	Not yet recruiting	University of Sydney	150	2026-10-12	2026-08-03
Switching From Preserved Glaucoma Therapy to Preservative-Free ZOLYMBUS preservative free ZOLYMBUS™ 0.01%. - Eye Drops Self-instillation, Glaucoma	Phase 4	Not yet recruiting	Southern College of Optometry	40	2026-10-05	2026-09-28
Eplerenone and IOP in Healthy Adults Eplerenone, Microcrystalline Cellulose NF (placebo) - Intraocular Pressure (IOP), Healthy Adult	Phase 1	Not yet recruiting	University of Florida	30	2026-10-01	2026-08-31
GlaukomAI: Clinical Validation of an AI System for Early Glaucoma Screening GlaukomAI (Sens-vue GlaukomAI) - Glaucoma	Not applicable	Not yet recruiting	Fondazione G.B. Bietti, IRCCS	1200	2026-10-01	2026-09-04
Glaucoma Drop Aids Part 2 Nanodropper - Glaucoma, Intraocular Pressure	Not applicable	Not yet recruiting	Boston Medical Center	80	2026-10-01	2026-07-28
Adaptive Optics OCT Evaluation of Rhopressa's Effects on the Retinal Ganglion Cells in Glaucoma Patients Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Timolol Maleate 0.25% Ophthalmic Solution - Open Angle Glaucoma (OAG), Glaucoma	Phase 4	Recruiting	Brett King	13	2026-10-01	2026-09-29
Trabeculectomy Versus MicroShunt Implantation in Glaucoma Surgery (TIGER) Preserflo MicroShunt, Trabeculectomy - Glaucoma	Not applicable	Not yet recruiting	Oslo University Hospital	100	2026-10-01	2026-10-09
Combined Phacoemulsification-Goniotomy in Primary Open-Angle and Primary Angle-Closure Glaucoma Combined Phacoemulsification and Goniotomy - Primary Open-Angle Glaucoma, Primary Angle-Closure Glaucoma	Not applicable	Not yet recruiting	Assiut University	70	2026-10-01	2026-09-16
Changes in Intraocular Pressure After Intravitreal Injection Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration		Not yet recruiting	Assiut University	50	2026-10-01	2026-09-17
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed. GORE Glaucoma Drainage Implant - Glaucoma, Primary Open Angle	Not applicable	Not yet recruiting	Gore Ophthalmic	70	2026-10-01	2026-10-19
Visual Function and Exercise in Glaucoma Patients answer questionnaire - Glaucoma, Exercise		Not yet recruiting	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	100	2026-09-30	2026-09-17
Ocular Surface Disease in Glaucoma Patients on Long-Term Therapy Glaucoma, Ocular Surface Disease		Not yet recruiting	Assiut University	55	2026-09-26	2026-09-28
Comparative Study of the Tomey FT-1000, and Goldmann Applanation Tonometer (GAT) Non Contact Tonometer and Applanation Tonometer - Glaucoma		Recruiting	Tomey Corporation	30	2026-09-23	2026-10-06
Efficacy and Safety of a Releasable Intraluminal Suture Technique to Reduce Hypotony Following Glaucoma Surgery Using the Preserflo Device Classical surgery, Intraluminal suture - Glaucoma	Not applicable	Recruiting	Hôpital Privé de la Baie	192	2026-09-17	2026-10-02
Optimizing Graft Selection in Glaucoma Surgery: A Comparative Study of Sclera, Pericardium, and Corneal Tissue MicroShunt with Scleral Patch Graft, MicroShunt with Corneal Patch Graft, MicroShunt with Pericardial Patch Graft - Glaucoma	Not applicable	Not yet recruiting	University of Alberta	180	2026-09-15	2026-07-24

Showing 20 of 2149. Sign in to see all of them.

Narrower conditions

Glaucoma (1357)  ·  Glaucoma, Open-Angle (917)  ·  Cataract (105)  ·  Glaucoma, Angle-Closure (86)  ·  Low Tension Glaucoma (65)  ·  Eye Diseases (54)  ·  Diabetic Retinopathy (48)  ·  Macular Degeneration (46)  ·  Exfoliation Syndrome (42)  ·  Glaucoma, Neovascular (39)  ·  Hydrophthalmos (37)  ·  Hypertension (30)  ·  Retinal Diseases (23)  ·  Patient Compliance (20)

Broader conditions

Eye Diseases (2095)  ·  Glaucoma (752)  ·  Lens Diseases (108)  ·  Cardiovascular Diseases (100)  ·  Vascular Diseases (99)  ·  Nervous System Diseases (86)  ·  Retinal Diseases (83)  ·  Optic Nerve Diseases (72)  ·  Pathological Conditions, Signs and Symptoms (69)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (64)  ·  Uveal Diseases (60)  ·  Endocrine System Diseases (56)  ·  Retinal Degeneration (55)  ·  Behavior (50)

Interventions

Latanoprost (167)  ·  Timolol (129)  ·  Travoprost (105)  ·  Bimatoprost (84)  ·  Ophthalmic Solutions (83)  ·  Trabeculectomy (75)  ·  Brimonidine Tartrate (63)  ·  brinzolamide (57)  ·  dorzolamide (40)  ·  dorzolamide-timolol combination (39)  ·  Phacoemulsification (37)  ·  Cataract Extraction (32)  ·  Mitomycin (30)  ·  Duotrav (24)  ·  netarsudil (22)

Sponsors

Alcon Research (135)  ·  Allergan (90)  ·  Glaukos Corporation (48)  ·  Wills Eye (48)  ·  Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (27)  ·  Aerie Pharmaceuticals (25)  ·  Medical University of Vienna (24)  ·  Sensimed AG (23)  ·  Sun Yat-sen University (23)  ·  Universitaire Ziekenhuizen KU Leuven (20)  ·  University of Zurich (20)  ·  Zhongshan Ophthalmic Center, Sun Yat-sen University (19)  ·  Aristotle University Of Thessaloniki (17)  ·  Duke University (17)  ·  Johns Hopkins University (16)

Countries

United States (743)  ·  Canada (116)  ·  China (114)  ·  Germany (102)  ·  France (78)  ·  Egypt (76)  ·  United Kingdom (75)  ·  Italy (74)  ·  Spain (69)  ·  Switzerland (61)  ·  Austria (54)  ·  South Korea (54)  ·  Belgium (45)  ·  Israel (38)  ·  Singapore (36)

Top investigators

Ingeborg Stalmans, MD, PhD (9)  ·  Anastasios G Konstas, MD, PhD (7)  ·  George L Spaeth, MD (7)  ·  Robert Ritch, MD (7)  ·  Theresa Heah, MD (7)  ·  William C. Stewart, MD (7)  ·  Zubair Hussain, PhD (7)  ·  Gong Je Seong, MD, PhD (6)  ·  Jeffrey L Goldberg, MD, PhD (6)

Results publications

PMID 35943114, PMID 36912740, PMID 10937547, PMID 24974815, PMID 17122118, PMID 12049574, PMID 19427617, PMID 24210765, PMID 35643967, PMID 40408035, PMID 11772581, PMID 12365904, PMID 16249960, PMID 16488940, PMID 17159450, PMID 19277230, PMID 19476406, PMID 19855289, PMID 22427577, PMID 22607109, PMID 23557744, PMID 23746612, PMID 25336577, PMID 25358735, PMID 25533656, PMID 26199618, PMID 26604914, PMID 26674779, PMID 26891880, PMID 27117781, PMID 27769587, PMID 27857759, PMID 27904503, PMID 28551166, PMID 29194198, PMID 29267575, PMID 29477688, PMID 29613978, PMID 31294768, PMID 31727428, PMID 32166538, PMID 32277009, PMID 34003939, PMID 34433548, PMID 34707360, PMID 35076329, PMID 36122660, PMID 36378864, PMID 37010901, PMID 37793935

NIH funding

2014 (5), 2018 (5), 2008 (4), 2015 (4), 2019 (4), 2009 (3), 2023 (3), 2016 (2), P30AG022838 (2), R01EY013178 (2), R01EY022124 (2), R01EY023285 (2), U01DP006820 (2), UL1TR001082 (2), 2017 (1)