16 unknown, 12 completed, 7 recruiting, 4 not yet recruiting. 44 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 44 | Unknown 16, Completed 12, Recruiting 7, Not yet recruiting 4, Enrolling by invitation 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
Follow Disorder of Consciousness: new trials by email Literature Review of Disorder of Consciousness trials Research Report on Disorder of Consciousness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal Assessment Electrostimulation at the Twelve Hand Jing-Well Points - Disorder of Consciousness | Not applicable | Not yet recruiting | The Third People's Hospital of Huizhou | 66 | 2026-12-23 | 2026-09-02 |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC) Live Music Therapy, Recorded Music - Disorder of Consciousness, Acquired Brain Injury | Not applicable | Recruiting | Murdoch Childrens Research Institute | 10 | 2026-09-01 | 2026-09-02 |
| Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan - Coma, Cardiac Arrest | Not applicable | Recruiting | University Hospital, Toulouse | 263 | 2026-03-16 | 2026-06-29 |
| Alpha tACS for Disorders of Consciousness : a Single Case Experimental Design Transcranial alternating current stimulation (tACS) - Disorder of Consciousness | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 5 | 2026-01-01 | 2025-10-09 |
| Vagal Nerve Stimulation to Treat Disorders of Consciousness stimulated group, Sham (No Treatment) - Disorder of Consciousness | Not applicable | Not yet recruiting | Fondazione IRCCS San Gerardo dei Tintori | 106 | 2025-09-01 | 2025-07-22 |
| Study on the Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Consciousness Disorders TI Stimulation, Sham Stimulation - Disorder of Consciousness, Temporal Interference Stimulation | Not applicable | Recruiting | Huashan Hospital | 20 | 2025-04-21 | 2025-12-16 |
| Efficacy and Safety of Spinal Cord Stimulation in Patients With Spinal Cord Stimulation SCS Stimulation, Sham Stimulation - Disorder of Consciousness, Spinal Cord Stimulation | Not applicable | Recruiting | Huashan Hospital | 50 | 2025-01-10 | 2025-01-07 |
| Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial ErigoBasic or ErigoPro®, Traditional Verticalization - Acquired Brain Injury, Disorder of Consciousness | Not applicable | Recruiting | Anna Estraneo | 118 | 2024-12-02 | 2026-09-10 |
| Effects of rTMS With Different Stimulation Spots in Patients With Disorders of Consciousness active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation - Disorder of Consciousness | Not applicable | Unknown | Zhujiang Hospital | 84 | 2024-07-30 | 2024-07-30 |
| rTMS and EEG in DOC Patients Sham Stimulation for Crossover Study, DLPFC Stimulation for Crossover Study, AG Stimulation for Crossover Study - Disorder of Consciousness | Not applicable | Unknown | University of Liege | 90 | 2024-07-01 | 2023-12-12 |
| Electro-acupuncture to Treat Disorder of Consciousness Electroacupuncture, Sham electroacupuncture - Disorder of Consciousness, Electroacupuncture | Not applicable | Unknown | The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine | 50 | 2024-01-01 | 2024-09-19 |
| Safety and Efficacy of tDCS in Pediatric DoC tDCS, sham tDCS - Disorder of Consciousness | Not applicable | Withdrawn | Giovanna Cristella | 2024-01-01 | 2024-09-19 | |
| Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness Active Transcranial alternative current stimulation, SHAM Transcranial alternative current stimulation - Brain Injury Traumatic Severe, Disorder of Consciousness | Not applicable | Unknown | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 138 | 2023-09-01 | 2023-04-27 |
| tDCS and rTMS in Patients With Early Disorders of Consciousness tDCS, rTMS - Disorder of Consciousness, Stroke | Not applicable | Unknown | Xuanwu Hospital, Beijing | 120 | 2023-05-01 | 2023-04-26 |
| Prognostication of Recovery in Early Disorders of Consciousness Study Functional MRI (fMRI) - Disorder of Consciousness, Comatose | Not applicable | Enrolling by invitation | University of Pennsylvania | 150 | 2023-03-08 | 2026-07-30 |
| Hydrocephalus Treatment on Persistent Disorder of Consciousness Ventriculoperitoneal shunt - Disorder of Consciousness | Not applicable | Unknown | University Hospital, Toulouse | 20 | 2022-09-16 | 2024-02-28 |
| Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases Combinatory effect of music stimulation and neurostimulation - Disorder of Consciousness, Stroke | Not applicable | Recruiting | Istituti Clinici Scientifici Maugeri SpA | 90 | 2022-09-01 | 2025-06-04 |
| Personal Music for Disorders of Consciousness Listening to music - Disorder of Consciousness | Not applicable | Unknown | Qiuyou Xie | 45 | 2022-05-26 | 2023-01-23 |
| Cerebellar iTBS in Patients With Disorders of Consciousness iTBS stimulation, sham stimulation - Disorder of Consciousness, Vegetative State | Not applicable | Unknown | Xijing Hospital | 44 | 2022-04-29 | 2022-09-28 |
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Consciousness Disorders (44) · Brain Injuries (9) · Persistent Vegetative State (7) · Brain Injuries, Traumatic (6) · Stroke (5) · Coma (4) · Hydrocephalus (2) · Hypoxia, Brain (2) · Hypoxia-Ischemia, Brain (2) · Nervous System Diseases (2) · Aphasia (1) · Heart Arrest (1) · Motor Neuron Disease (1) · Pain (1) · Paralysis (1)
Mental Disorders (44) · Neurobehavioral Manifestations (44) · Neurocognitive Disorders (44) · Neurologic Manifestations (44) · Pathological Conditions, Signs and Symptoms (44) · Signs and Symptoms (44) · Nervous System Diseases (42) · Brain Diseases (23) · Central Nervous System Diseases (23) · Craniocerebral Trauma (14) · Trauma, Nervous System (14) · Wounds and Injuries (14) · Unconsciousness (9) · Brain Damage, Chronic (7) · Cardiovascular Diseases (6)
Transcranial Direct Current Stimulation (7) · Acoustic Stimulation (1) · Animal Assisted Therapy (1) · Cerebrospinal Fluid Shunts (1) · Control Groups (1) · Cross-Over Studies (1) · Electroacupuncture (1) · Electroencephalography (1) · MIME protocol (1) · Magnetic Resonance Imaging (1) · Melatonin (1) · Sound (1) · Spinal Cord Stimulation (1) · Standard of Care (1) · Transcranial Magnetic Stimulation (1)
First Affiliated Hospital of Zhejiang University (4) · University of Liege (4) · Huashan Hospital (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Qiuyou Xie (2) · University Hospital, Toulouse (2) · Xijing Hospital (2) · Xuanwu Hospital, Beijing (2) · Anna Estraneo (1) · BDH-Klinik Hessisch Oldendorf (1) · Casa Colina Hospital and Centers for Healthcare (1) · Centre Hospitalier Universitaire de Liege (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Fondazione IRCCS San Gerardo dei Tintori (1) · Giovanna Cristella (1)
China (14) · France (5) · Italy (5) · Belgium (3) · United States (3) · Germany (2) · Israel (2) · Australia (1) · Ireland (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Benyan Luo (3) · Lionel Naccache, MD, PhD (2) · Luca Padua, MD, phD (2) · Xuehai Wu, Ph.D. (2) · Alberto Addis, MD (1) · Aurore Thibaut (1) · Benyan Luo, PhD (1) · Bertrand Hermann, MD (1) · Caroline Schnakers, PhD (1) · Damien Coyle, PhD (1) · David J Fischer, MD (1) · Efraim Jaul, MD (1) · Fang Yuan, PhD (1)
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K23NS136745 (1)