73 completed, 44 unknown, 31 recruiting, 24 terminated. 88 Not applicable, 10 Phase 3, 8 Phase 2, 7 Phase 4, 4 Phase 1.
Follow Hydrocephalus: new trials by email Literature Review of Hydrocephalus trials Research Report on Hydrocephalus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP - Normal Pressure Hydrocephalus, Hakim Syndrome | Not applicable | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 660 | 2027-08-01 | 2026-05-07 |
| Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage Sirolimus (Rapamune®) - Post-hemorrhagic Hydrocephalus (PHH) | Phase 1 / Phase 2 | Not yet recruiting | Massachusetts General Hospital | 15 | 2027-01-01 | 2026-06-25 |
| Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury Acute Brain Injury, Traumatic Brain Injury | Not yet recruiting | Virginia Commonwealth University | 220 | 2026-11-30 | 2026-08-19 | |
| Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar Puncture Idiopathic Normal Pressure Hydrocephalus, Normal Pressure Hydrocephalus | Not yet recruiting | Assiut University | 40 | 2026-10-01 | 2026-09-22 | |
| A Prospective Study Comparing CSF Shunt Flow Between "Virtual Off" and "Flow Permissive" Shunt Valve Settings Using a Wireless, Noninvasive Shunt Flow Sensor Rhaeos Shunt Monitoring System (RSMS), ShuntCheck III - Hydrocephalus | Not applicable | Not yet recruiting | Rhaeos, Inc. | 85 | 2026-09-08 | 2026-09-11 |
| Ultrasound and Photoacoustic Imaging of Hydrocephalus in Pediatric Patients PAUS imaging - Hydrocephalus in Infants, Hydrocephalus in Children | Not applicable | Not yet recruiting | Michael McDowell | 250 | 2026-09-01 | 2026-08-25 |
| Role of Endoscopic Third Ventriculostomy Imanagement of Hydrocephalus in Pediatric Age Group; Clinical and Surgical Outcome Fenestration of the floor of the third ventricle, Endoscopic third ventriculostomy of the brain third ventricle, Endoscopic third ventriculostomy - Hydrocephalus | Not applicable | Not yet recruiting | Sohag University | 30 | 2026-07-12 | 2026-07-13 |
| Efficacy of Combined Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Treatment of Hydrocephalus Combined endoscopic third ventriculostomy & coroid plexus cauterization - Paediatric Hydrocephalus | Not applicable | Not yet recruiting | Assiut University | 90 | 2026-07-01 | 2026-07-30 |
| Strategies for Weaning From External Ventricular Drainage Direct clamping of external ventricular drain, Progressive (gradual) weaning of external ventricular drain - Subarachnoid Hemorrhage, Hydrocephalus | Not applicable | Not yet recruiting | University Hospital, Angers | 170 | 2026-07-01 | 2026-06-05 |
| Study of Shunt Flow Under Different Valve Settings Using a Wireless Sensor Rhaeos Shunt Monitoring System (RSMS), ShuntCheck III - Hydrocephalus | Not applicable | Not yet recruiting | Rhaeos, Inc. | 85 | 2026-06-30 | 2026-07-01 |
| UVC in Prevention of Surgical Wound Infection UVC Irradiation - Hydrocephalus | Not applicable | Not yet recruiting | Ville Leinonen | 75 | 2026-06-04 | 2026-05-20 |
| Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials Intellidrop Automated CSF Drainage System - NPH (Normal Pressure Hydrocephalus) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 10 | 2026-05-14 | 2026-06-02 |
| Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies Topical Vancomycin Powder, Standard Perioperative Care - Hydrocephalus, Ventriculoperitoneal Shunt Infection | Phase 4 | Not yet recruiting | Assiut University | 164 | 2026-05-01 | 2026-04-23 |
| Ultrasound (US) Guided External Ventricular Catheter Placement Catheter Placement with Solopass System - Hydrocephalus | Not applicable | Recruiting | Milton S. Hershey Medical Center | 10 | 2026-04-01 | 2026-06-05 |
| Simultaneous Vs Staged VPS and CP :A Multi-cnter RCT. Time of choosing VPS and VP - Ventriculoperitoneal Shunt (VPS), Cranioplasty | Not applicable | Not yet recruiting | Anhui Provincial Hospital | 300 | 2026-04-01 | 2026-03-10 |
| Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation Cefazolin antibiotic prophylaxis - Hydrocephaly, CSF Shunts | Not applicable | Recruiting | University Hospital, Strasbourg, France | 15 | 2026-02-01 | 2026-08-20 |
| Flow Detection in Open and Closed Shunt Valve Periods Rhaeos Shunt Monitoring System - Hydrocephalus | Not applicable | Recruiting | Rhaeos, Inc. | 55 | 2026-01-27 | 2026-03-18 |
| Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement Device wireless thermal anisotropy measurement device - Hydrocephalus | Not applicable | Recruiting | Rhaeos, Inc. | 28 | 2025-11-10 | 2026-08-25 |
| Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus Intervention group "Virtual OFF", Control group (no change in shunt setting) - Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus | Not applicable | Not yet recruiting | Göteborg University | 60 | 2025-09-15 | 2025-09-15 |
| Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus Cerebrospinal fluid drainge - Normal Pressure Hydrocephalus | Not applicable | Recruiting | Chungnam National University Hospital | 22 | 2025-09-11 | 2026-09-21 |
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Hydrocephalus, Normal Pressure (63) · Subarachnoid Hemorrhage (16) · Brain Neoplasms (11) · Intracranial Hypertension (10) · Brain Injuries (9) · Brain Injuries, Traumatic (6) · Cerebral Hemorrhage (6) · Dementia (6) · Vasospasm, Intracranial (6) · Alzheimer Disease (5) · Brain Diseases (5) · Parkinson Disease (5) · Stroke (5) · Epilepsy (4)
Central Nervous System Diseases (209) · Nervous System Diseases (208) · Brain Diseases (206) · Pathological Conditions, Signs and Symptoms (53) · Cardiovascular Diseases (37) · Vascular Diseases (35) · Pathologic Processes (34) · Cerebrovascular Disorders (30) · Hemorrhage (23) · Mental Disorders (23) · Signs and Symptoms (22) · Wounds and Injuries (21) · Intracranial Hemorrhages (19) · Trauma, Nervous System (19)
Ventriculoperitoneal Shunt (8) · Ventriculostomy (7) · Spinal Puncture (3) · Acetazolamide (2) · Cerebrospinal Fluid Shunts (2) · Dexmedetomidine (2) · Hydrodynamics (2) · Sirolimus (2) · Surgical Procedures, Operative (2) · flutemetamol (2) · Anesthesia, General (1) · Anti-Bacterial Agents (1) · Cerebrovascular Circulation (1) · Control Groups (1) · Diagnostic Imaging (1)
Rhaeos, Inc. (15) · Assiut University (6) · Centre Hospitalier Universitaire, Amiens (5) · CereVasc Inc (5) · Integra LifeSciences Corporation (5) · NeuroDx Development (5) · Umeå University (5) · Copenhagen University Hospital, Rigshospitalet (4) · Transonic Systems Inc. (4) · University Hospital, Toulouse (4) · Yonsei University (4) · Boston Children's Hospital (3) · Codman & Shurtleff (3) · Dartmouth-Hitchcock Medical Center (3) · Insel Gruppe AG, University Hospital Bern (3)
United States (83) · France (20) · China (14) · Sweden (12) · Germany (10) · Canada (8) · Switzerland (8) · Denmark (6) · Spain (6) · Czechia (5) · Italy (5) · South Korea (5) · United Kingdom (5) · Argentina (4) · Finland (4)
Bruce A Kaufman, MD (3) · Cornelis J Drost, BS, MS (3) · Miroslav Cihlo, M.D. (3) · Abhaya Kulkarni, MD (2) · Hua Tang, MD (2) · Jan Malm, MD, PhD (2) · Johan Virhammar, MD, PhD (2) · John Kestle, MD (2) · Kim A Mansfield, MS (2) · Michael A Williams, MD (2) · Naomi Abel, MD (2) · Pei-Yi Lin, PhD (2) · Sam Browd, MD, PhD (2) · Aarti Sarwal, MD (1) · Alex Novak, MSc (1)
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R44NS049680 (4), 1RC1NS068943-01 (1), 2019 (1), 5UG3NS130338 (1), K99HD083512 (1), R01EB004632 (1), R43NS067770 (1), R44NS067772 (1), R44NS074486 (1), U01NS107486 (1)