27 completed, 26 unknown, 15 recruiting, 5 not yet recruiting. 44 Not applicable, 6 Phase 2, 3 Phase 3, 1 Early Phase 1, 1 Phase 1.
Follow Disorder of Consciousness: new trials by email Literature Review of Disorder of Consciousness trials Research Report on Disorder of Consciousness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal Assessment Electrostimulation at the Twelve Hand Jing-Well Points - Disorder of Consciousness | Not applicable | Not yet recruiting | The Third People's Hospital of Huizhou | 66 | 2026-12-23 | 2026-09-02 |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC) Live Music Therapy, Recorded Music - Disorder of Consciousness, Acquired Brain Injury | Not applicable | Recruiting | Murdoch Childrens Research Institute | 10 | 2026-09-01 | 2026-09-02 |
| Auditory Processing in DOC Patients Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG) - Disorder of Consciousness, Unresponsive Wakefulness Syndrome | Not yet recruiting | BDH-Klinik Hessisch Oldendorf | 42 | 2026-04-15 | 2026-03-06 | |
| Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan - Coma, Cardiac Arrest | Not applicable | Recruiting | University Hospital, Toulouse | 263 | 2026-03-16 | 2026-06-29 |
| Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches Multidisciplinary neurorehabilitation - Disorder of Consciousness | Recruiting | IRCCS Centro Neurolesi Bonino Pulejo | 140 | 2026-01-16 | 2026-05-27 | |
| Alpha tACS for Disorders of Consciousness : a Single Case Experimental Design Transcranial alternating current stimulation (tACS) - Disorder of Consciousness | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 5 | 2026-01-01 | 2025-10-09 |
| Vagal Nerve Stimulation to Treat Disorders of Consciousness stimulated group, Sham (No Treatment) - Disorder of Consciousness | Not applicable | Not yet recruiting | Fondazione IRCCS San Gerardo dei Tintori | 106 | 2025-09-01 | 2025-07-22 |
| Study on the Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Consciousness Disorders TI Stimulation, Sham Stimulation - Disorder of Consciousness, Temporal Interference Stimulation | Not applicable | Recruiting | Huashan Hospital | 20 | 2025-04-21 | 2025-12-16 |
| Efficacy and Safety of Spinal Cord Stimulation in Patients With Spinal Cord Stimulation SCS Stimulation, Sham Stimulation - Disorder of Consciousness, Spinal Cord Stimulation | Not applicable | Recruiting | Huashan Hospital | 50 | 2025-01-10 | 2025-01-07 |
| Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial ErigoBasic or ErigoPro®, Traditional Verticalization - Acquired Brain Injury, Disorder of Consciousness | Not applicable | Recruiting | Anna Estraneo | 118 | 2024-12-02 | 2026-09-10 |
| Effects of rTMS With Different Stimulation Spots in Patients With Disorders of Consciousness active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation - Disorder of Consciousness | Not applicable | Unknown | Zhujiang Hospital | 84 | 2024-07-30 | 2024-07-30 |
| rTMS and EEG in DOC Patients Sham Stimulation for Crossover Study, DLPFC Stimulation for Crossover Study, AG Stimulation for Crossover Study - Disorder of Consciousness | Not applicable | Unknown | University of Liege | 90 | 2024-07-01 | 2023-12-12 |
| Improving the Diagnostic Accuracy of Children with DoC (IDeAl DesiRE) Acquired Brain Injury, Disorder of Consciousness | Recruiting | IRCCS Eugenio Medea | 113 | 2024-05-20 | 2024-12-16 | |
| Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Disorder of Consciousness Use of "expressive" sounds, Having benefited from a prognostic evaluation by event related potentials (without sound research methods, only neutral sounds) - Disorder of Consciousness | Recruiting | Assistance Publique - Hôpitaux de Paris | 114 | 2024-03-25 | 2025-09-12 | |
| Electro-acupuncture to Treat Disorder of Consciousness Electroacupuncture, Sham electroacupuncture - Disorder of Consciousness, Electroacupuncture | Not applicable | Unknown | The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine | 50 | 2024-01-01 | 2024-09-19 |
| Safety and Efficacy of tDCS in Pediatric DoC tDCS, sham tDCS - Disorder of Consciousness | Not applicable | Withdrawn | Giovanna Cristella | 2024-01-01 | 2024-09-19 | |
| Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness Active Transcranial alternative current stimulation, SHAM Transcranial alternative current stimulation - Brain Injury Traumatic Severe, Disorder of Consciousness | Not applicable | Unknown | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 138 | 2023-09-01 | 2023-04-27 |
| Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness Cerebrolysin, Control - Disorder of Consciousness, Hemorrhagic Stroke | Phase 4 | Recruiting | Konkuk University Medical Center | 12 | 2023-06-01 | 2026-05-11 |
| tDCS and rTMS in Patients With Early Disorders of Consciousness tDCS, rTMS - Disorder of Consciousness, Stroke | Not applicable | Unknown | Xuanwu Hospital, Beijing | 120 | 2023-05-01 | 2023-04-26 |
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Consciousness Disorders (80) · Persistent Vegetative State (22) · Brain Injuries (16) · Brain Injuries, Traumatic (11) · Coma (7) · Stroke (7) · Nervous System Diseases (4) · Disease (3) · Hypoxia-Ischemia, Brain (3) · Cognitive Dysfunction (2) · Heart Arrest (2) · Hydrocephalus (2) · Hypoxia, Brain (2) · Pain (2) · Trauma, Nervous System (2)
Mental Disorders (80) · Neurobehavioral Manifestations (80) · Neurologic Manifestations (80) · Pathological Conditions, Signs and Symptoms (80) · Signs and Symptoms (80) · Neurocognitive Disorders (79) · Nervous System Diseases (76) · Brain Diseases (46) · Central Nervous System Diseases (45) · Unconsciousness (25) · Craniocerebral Trauma (23) · Wounds and Injuries (23) · Brain Damage, Chronic (22) · Trauma, Nervous System (22) · Cardiovascular Diseases (10)
Transcranial Direct Current Stimulation (10) · Amantadine (2) · Apomorphine (2) · Rehabilitation (2) · Transcranial Magnetic Stimulation (2) · Acoustic Stimulation (1) · Animal Assisted Therapy (1) · Brain-Derived Neurotrophic Factor (1) · Cerebrospinal Fluid Shunts (1) · Control Groups (1) · Cross-Over Studies (1) · Diffusion Tensor Imaging (1) · Electroacupuncture (1) · Electroencephalography (1) · Eye-Tracking Technology (1)
First Affiliated Hospital of Zhejiang University (8) · University of Liege (8) · Hangzhou Normal University (4) · BDH-Klinik Hessisch Oldendorf (3) · Huashan Hospital (3) · Xijing Hospital (3) · Xuanwu Hospital, Beijing (3) · Fondazione Don Carlo Gnocchi ETS (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Groupe Hospitalier Pitie-Salpetriere (2) · Hospitales Nisa (2) · Massachusetts General Hospital (2) · Qiuyou Xie (2) · University Hospital, Toulouse (2) · Anna Estraneo (1)
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Benyan Luo (4) · Haibo Di, Pro. (3) · Benyan Luo, PhD (2) · Jens D Rollnik, MD (2) · Lionel Naccache, MD, PhD (2) · Luca Padua, MD, phD (2) · Melanie Boltzmann, PhD (2) · Nicolas Lejeune (2) · Steven Laureys, M.D., Ph.D. (2) · Xuehai Wu, Ph.D. (2) · Alain Cariou, MD, PhD (1) · Alberto Addis, MD (1) · Alison Fox-Robichaud, MD (1) · Annerose Mengel, attending physician (1) · Aurore Thibaut (1)
PMID 19954851, PMID 10869046, PMID 19150228, PMID 21112421, PMID 21876461, PMID 22224835, PMID 27567470, PMID 28575667, PMID 28901969, PMID 29770146, PMID 30089618, PMID 30098791, PMID 30233062, PMID 30405513, PMID 30941094, PMID 31003899, PMID 31308848, PMID 31320356, PMID 31401074, PMID 31574106, PMID 32001008, PMID 32484029, PMID 32792456, PMID 32919461, PMID 32982941, PMID 33214317, PMID 33455998, PMID 34154980, PMID 35302854, PMID 35773500, PMID 36467262, PMID 36522680, PMID 36817874, PMID 36873436, PMID 37005647, PMID 37178149, PMID 37545735, PMID 37608315, PMID 37857775, PMID 38362860, PMID 38734048, PMID 38820520, PMID 38991682, PMID 39300529, PMID 39337015, PMID 39624459, PMID 39627786, PMID 40275709, PMID 41419503, PMID 41714857
F32MH123001 (1), K23NS136745 (1)