25 completed, 12 recruiting, 6 unknown, 4 terminated. 27 Phase 4, 7 Phase 3, 6 Phase 1, 5 Early Phase 1, 5 Not applicable.
Follow Nitrofurantoin: new trials by email Literature Review of Nitrofurantoin trials Research Report on Nitrofurantoin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate Pivmecillinam Versus Nitrofurantoin in Female Adolescents 12 to Less Than 18 Years of Age With Uncomplicated Urinary Tract Infection Pivya (Pivmecillinam 185 mg), Nitrofurantoin 100 mg (nitrofurantoin monohydrate/macrocrystalline capsule) - Uncomplicated Urinary Tract Infections | Phase 2 | Not yet recruiting | Alembic Therapeutics | 100 | 2026-10-24 | 2026-10-13 |
| Prophylactic Antibiotics for Outpatient Urethral Bulking Bactrim (800/160 mg), Keflex (500 mg), Cipro (250 mg), or Macrobid (100mg) - Urinary Tract Infections, Stress Urinary Incontinence | Phase 4 | Recruiting | University of Miami | 150 | 2026-08-19 | 2026-10-29 |
| Self-Start Triage Model for Post-Botox® Lower Urinary Tract Symptoms Macrobid® Capsules 100 mg, Standard Medical Care (SMC) - Overactive Bladder | Early Phase 1 | Recruiting | The Cleveland Clinic | 260 | 2026-07-31 | 2026-08-03 |
| Daily Nitrofurantoin Versus Bladder Fulguration Plus Daily Nitrofurantoin for Women With Recurrent Urinary Tract Infections Electrofulguration (EF), Nitrofurantoin (NF) - Recurrent UTIs, Cystitis Recurrent | Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 104 | 2026-04-06 | 2026-07-23 |
| The Effect of Different Intra-canal Medications on Postoperative Pain ibuprofen, Nitrofurantoin, Calcium Hydroxide - Pulp Necrosis, Apical Periodontitis | Early Phase 1 | Recruiting | Cairo University | 111 | 2025-12-15 | 2026-07-21 |
| Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries Oral nitrofurantoin monohydrate/macrocrystals, Placebo - Preterm Birth, Small for Gestational Age (SGA) | Phase 3 | Recruiting | NICHD Global Network for Women's and Children's Health | 1134 | 2025-12-08 | 2026-01-22 |
| Urine Alkalinization for UTI in Women: RCT potassium citrate, Nitrofurantoin - UTI - Urinary Tract Infection | Not applicable | Not yet recruiting | Assiut University | 50 | 2025-10-15 | 2025-10-02 |
| Assessing the Utility of Prophylactic Antibiotics at Time of Urethral Bulking Using Bulkamid (Bulkamid Study) Bactrim or Macrobid, Placebo - Stress Urinary Incontinence | Phase 4 | Recruiting | Ohio State University | 138 | 2025-09-15 | 2026-10-13 |
| Microbiome-Modulating Prophylaxis RCT: Antibiotic vs Gynoflor in Postmenopausal Women With Recurrent Cystitis Nitrofurantoin, Gynoflor - Cystitis, Recurrent, Urinary Tract Infections | Phase 4 | Recruiting | Mahidol University | 100 | 2025-09-11 | 2025-09-25 |
| Comparison of Inter-appointment Pain Reduction During Root Canal Treatment in Symptomatic Apical Periodontitis by Using Intracanal Medicaments; Chlorhexidine Gel and Single Antibiotic Paste Nitrofurantoin Chlorhexidine gel, Nitrofurantoin 100 MG - Intracanal Medicament | Phase 1 / Phase 2 | Enrolling by invitation | Altamash Institute of Dental Medicine | 220 | 2025-05-20 | 2025-09-30 |
| Intravesical Gentamicin to Prevent Recurrent UTI Gentamicin, Nitrofurantoin - Recurrent Uti | Phase 4 | Completed | Women and Infants Hospital of Rhode Island | 20 | 2025-04-28 | 2026-04-15 |
| An Open Clinical Trial of the Safety and Efficacy of the Drug Fluorothiazinone, 300 Mg Tablets with the Participation of Adult Patients with Chronic Bacterial Cystitis" Fluorothiazinone, tablets 300 mg, Nitrofurantoin 100 MG - P. Aeruginosa, Baumannii | Phase 3 | Not yet recruiting | Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation | 280 | 2025-02-17 | 2025-02-07 |
| Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis Pivmecillinam, Amoxicillin clavulanic acid, Amoxicillin - Cystectomy, Bladder Cancer Requiring Cystectomy | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 248 | 2025-01-07 | 2025-01-09 |
| COMPARISON OF NITROFURANTOIN WITH FOSFOMYCIN in TREATING CYSTITIS IN WOMEN Nitrofurantoin 100 MG, Fosfomycin - Urinary Tract Infections | Phase 4 | Unknown | Shalamar Institute of Health Sciences | 392 | 2025-01-01 | 2024-07-24 |
| Bladder Botox UTI Antibiotic Prophylaxis Nitrofurantoin 100 MG - Overactive Bladder, Bladder Pain Syndrome | Phase 4 | Recruiting | Walter Reed National Military Medical Center | 100 | 2024-04-04 | 2025-02-19 |
| Role of Prophylactic Postoperative Antibiotics in HoLEP Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination - Benign Prostatic Hyperplasia, Urinary Tract Infections | Phase 4 | Withdrawn | Baylor Research Institute | 2023-03-01 | 2026-02-12 | |
| A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis) Gepotidacin, Nitrofurantoin, Placebo - Urinary Tract Infections | Phase 3 | Completed | GlaxoSmithKline | 380 | 2023-01-11 | 2025-03-17 |
| Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study Ialuril 50ml Prefill, Nitrofurantoin - Recurrent Urinary Tract Infection | Phase 4 | Recruiting | Radboud University Medical Center | 100 | 2022-10-20 | 2024-11-18 |
| Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA Nitrofurantoin - Antibiotic Prophylaxis | Phase 4 | Recruiting | Atlantic Health System | 140 | 2022-08-16 | 2024-03-27 |
| The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste Nitrofurantoin, Double Antibiotic - Pain, Symptomatic Irreversible Pulpitis | Phase 4 | Completed | Altamash Institute of Dental Medicine | 60 | 2022-08-01 | 2022-10-31 |
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Urinary Tract Infections (30) · Cystitis (4) · Urinary Incontinence, Stress (3) · Bacteriuria (2) · Dental Pulp Necrosis (2) · Infections (2) · Nephrolithiasis (2) · Pelvic Organ Prolapse (2) · Recurrence (2) · Urinary Bladder, Overactive (2) · Urinary Incontinence (2) · Calculi (1) · Cystitis, Interstitial (1) · Escherichia coli Infections (1) · Hematuria (1)
GlaxoSmithKline (4) · Altamash Institute of Dental Medicine (3) · Mylan Pharmaceuticals Inc (3) · Cairo University (2) · University of California, San Diego (2) · Wake Forest University Health Sciences (2) · Alembic Therapeutics (1) · Assiut University (1) · Atlantic Health System (1) · Baylor Research Institute (1) · Children's Hospital, Dziekanów Leśny, Poland (1) · Copenhagen University Hospital, Rigshospitalet (1) · Duke University (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina (1)
United States (30) · India (4) · Pakistan (4) · Poland (3) · Bulgaria (2) · Canada (2) · Egypt (2) · Israel (2) · Mexico (2) · Netherlands (2) · Spain (2) · United Kingdom (2) · Australia (1) · Bangladesh (1) · China (1)
Thomas S Clark, M.D. (3) · Aleksandra M Zurowska, Professor (1) · Amr Darwish, Lecturer (1) · Arturo Mendoza Valdes, MD (1) · Audrey N Schuetz, MD (1) · Ben Chew, MD (1) · Carolyn Botros, DO (1) · Cindy Amundsen, MD (1) · Daniel L Jackson, M.D. (1) · Daniel L Miller, MD MPH (1) · David Seligson, MD (1) · Deborah Lightner, MD (1)
PMID 20570319, PMID 34978887, PMID 36255258, PMID 36271314, PMID 38342126, PMID 40372095, PMID 40924001, PMID 40924012, PMID 41399629, PMID 41495938, PMID 42682990, PMID 15276398, PMID 15840453, PMID 17313438, PMID 17998493, PMID 18280509, PMID 19588358, PMID 21247286, PMID 21567157, PMID 21944106, PMID 22530208, PMID 23611930, PMID 24463669, PMID 29710295, PMID 31503155, PMID 33369488, PMID 33620905, PMID 34824124, PMID 35349162, PMID 37702442, PMID 39836173, PMID 40279497, PMID 40722189, PMID 42026010, PMID 4902833, PMID 8948280
2018 (1), R01DK140224 (1)