88 completed, 22 unknown, 12 recruiting, 11 withdrawn. 148 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 148 | Completed 88, Unknown 22, Recruiting 12, Withdrawn 11, Terminated 10, Not yet recruiting 4, Active not recruiting 1 |
Follow Deglutition Disorders: new trials by email Literature Review of Deglutition Disorders trials Research Report on Deglutition Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity Placebo, Tirzepatide - Obese Adults | Phase 4 | Not yet recruiting | Mayo Clinic | 30 | 2026-10-26 | 2026-10-26 |
| Effect of Omeprazole on Gut Microbiota in Adults With Obesity and GERD Omeprazole, Standard Non-pharmacological Recommendations for GERD - Obesity & Overweight, Gastroesophageal Reflux Disease | Phase 4 | Not yet recruiting | Federal State Budgetary Scientific Institution | 26 | 2026-09-25 | 2026-10-01 |
| A Study to Evaluate Tegoprazan as a Diagnostic Tool for GERD Tegoprazan 50 mg, Placebo - GERD (Gastroesophageal Reflux Disease) | Phase 4 | Not yet recruiting | HK inno.N Corporation | 100 | 2026-09-01 | 2026-09-17 |
| Treatment of Gastroesophageal Reflux Disease in Infants Protein pump inhibitor., Mother or infant diet, Placebo - Gastroesophageal Reflux, Infant, Newborn, Diseases | Phase 4 | Recruiting | Odense University Hospital | 96 | 2025-10-27 | 2025-11-20 |
| Heartburn, Gastroesophageal Reflux Disease Zastaprazan, Esomeprazole - GERD | Phase 4 | Recruiting | Incheon St.Mary's Hospital | 160 | 2025-07-07 | 2025-12-23 |
| The Mechanism Versus PPI Trial Omeprazole 40 MG, Laryngeal Recalibration Therapy, GERD Lifestyle Recommendations - Laryngopharyngeal Reflux, Cough | Phase 4 | Recruiting | University of California, San Diego | 160 | 2025-06-04 | 2025-08-01 |
| Gastrointestinal Dysmotility on Aspiration Risk Prucalopride, Famotidine - Esophageal Motility Disorders, Gastric Motor Dysfunction | Phase 4 | Recruiting | Boston Children's Hospital | 120 | 2025-02-13 | 2026-08-03 |
| Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial Nerver growth factor (NGF) injection, Placebo injection, EA intervention - Ischemic Stroke, Dysphagia | Phase 4 | Recruiting | The Third Affiliated hospital of Zhejiang Chinese Medical University | 144 | 2024-12-01 | 2024-12-17 |
| Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE) Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT] - Eosinophilic Esophagitis (EoE) | Phase 4 | Recruiting | University of California, San Diego | 30 | 2024-11-10 | 2024-12-11 |
| The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease PPI (proton pump inhibitor), Probiotic, Zinc - Gastro-oesophageal Reflux Disease | Phase 4 | Not yet recruiting | Ain Shams University | 120 | 2024-11-01 | 2024-10-29 |
| Therapeutic Effect of Vonoprazan Versus Dexlansoprazole in Treatment of Gastroesophageal Reflux Disease Dexlansoprazole 60 mg, Vonoprazan 20 mg bid - Vonoprazan, Proton Pump Inhibitor | Phase 4 | Completed | Ayman Magd Eldin Mohammad Sadek | 136 | 2024-10-01 | 2025-02-27 |
| Clinical Study Evaluating The Role of Vonoprazan Versus Pantoprazole in Patients With Gastroesophageal Reflux Disease Vonoprazan 20 mg versus Pantoprazole 40 mg - Gastroesophageal Reflux Disease (GERD) | Phase 4 | Recruiting | Tanta University | 44 | 2024-09-18 | 2024-12-05 |
| Clinical Trial for the Comparative Evaluation of Acid Suppression and Symptom Management of Gastroesophageal Reflux Disease With the Administration of Tegoprazan or Pantoprazole Tegoprazan, Pantoprazole - Gastroesophageal Reflux Disease | Phase 4 | Recruiting | Carnot Laboratories | 128 | 2024-07-30 | 2025-07-23 |
| Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI) - Dysbiosis, Gastroesophageal Reflux Disease (GERD) | Phase 4 | Completed | Seoul National University Hospital | 80 | 2024-07-18 | 2026-10-01 |
| Famotidine and Antacids for Treatment of Dyspepsia Intravenous Famotidine, Oral Maalox/ Mylanta - Dyspepsia, GERD | Phase 4 | Recruiting | Stony Brook University | 80 | 2023-11-09 | 2026-06-02 |
| The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass upper endoscopy - Obesity, Gastric Reflux | Phase 4 | Recruiting | Prof Urs Zingg | 50 | 2023-11-01 | 2026-06-09 |
| Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRD Jinsang Liyan Capsule; Rabeprazole enteric-coated tablets., Jinsang Liyan Capsule placebo; Rabeprazole enteric-coated tablets. - Laryngopharyngeal Reflux | Phase 4 | Unknown | Tongji Hospital | 72 | 2023-07-01 | 2024-01-23 |
| Primary carE PPi dEprescRibing Trial de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate - Heartburn, Dyspepsia | Phase 4 | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 724 | 2023-05-12 | 2025-01-31 |
| VZV in the Enteric Nervous System: Pathogenesis and Consequences ValACYclovir 1000 MG, Shingrix - Achalasia | Phase 4 | Recruiting | Vanderbilt University Medical Center | 40 | 2023-03-27 | 2026-10-05 |
| A Study to Evaluate the Efficacy and Safety of Tegoprazan in GERD Patients With Nighttime Heartburn Tegoprazan, Esomeprazole - Gastroesophageal Reflux Disease | Phase 4 | Unknown | HK inno.N Corporation | 338 | 2023-03-24 | 2023-08-03 |
Showing 20 of 148. Sign in to see all of them.
Gastroesophageal Reflux (116) · Heartburn (18) · Laryngopharyngeal Reflux (11) · Esophageal Achalasia (7) · Dyspepsia (4) · Esophageal Motility Disorders (4) · Esophagitis, Peptic (4) · Non-Erosive Reflux Disease (4) · Esophagitis (3) · Obesity (3) · Cerebral Palsy (2) · Cough (2) · Dysphonia (2) · Eosinophilic Esophagitis (2)
Digestive System Diseases (148) · Esophageal Diseases (148) · Gastrointestinal Diseases (148) · Esophageal Motility Disorders (132) · Pathological Conditions, Signs and Symptoms (39) · Signs and Symptoms (32) · Respiratory Tract Diseases (23) · Otorhinolaryngologic Diseases (22) · Signs and Symptoms, Digestive (21) · Pharyngeal Diseases (15) · Gastroesophageal Reflux (11) · Laryngeal Diseases (11) · Nervous System Diseases (10) · Gastroenteritis (8)
Esomeprazole (36) · Lansoprazole (17) · Omeprazole (17) · Pantoprazole (13) · Rabeprazole (11) · Dexlansoprazole (7) · Proton Pump Inhibitors (5) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (3) · Domperidone (3) · tegoprazan (3) · Alginates (2) · Antacids (2) · BID protein, human (2) · Baclofen (2) · Citalopram (2)
AstraZeneca (23) · Takeda (6) · Universitaire Ziekenhuizen KU Leuven (6) · Neutec Ar-Ge San ve Tic A.Ş (4) · Chong Kun Dang Pharmaceutical (3) · Vanderbilt University Medical Center (3) · Boston Children's Hospital (2) · Emory University (2) · HK inno.N Corporation (2) · Mayo Clinic (2) · National Taiwan University Hospital (2) · University of California, San Diego (2) · Aboca Spa Societa' Agricola (1) · Advanced Center for Specialty Care (1) · Ain Shams University (1)
United States (46) · South Korea (9) · Belgium (8) · China (7) · Germany (7) · Italy (6) · Taiwan (6) · Turkey (Türkiye) (5) · Denmark (4) · Canada (3) · France (3) · Sweden (3) · Switzerland (3) · United Kingdom (3) · Argentina (2)
Paula Fernstrom (6) · Karthik Ravi, MD (2) · Nicholas Shaheen, MD, MPH (2) · Alasdair Barr, Ph.D (1) · Anand Jain, MD (1) · Andreas Franke, MD (1) · Anna Guillen, MD (1) · Aya Hany Abdel Aziz (1)
PMID 25478944, PMID 12161727, PMID 15519198, PMID 16481828, PMID 16882832, PMID 17305763, PMID 17331245, PMID 17377079, PMID 18279773, PMID 18493207, PMID 19114878, PMID 19210493, PMID 19236727, PMID 19445547, PMID 19601705, PMID 19925497, PMID 19960205, PMID 20132153, PMID 20456300, PMID 20540767, PMID 20551454, PMID 20578215, PMID 20706150, PMID 21028753, PMID 21083590, PMID 21083673, PMID 21288053, PMID 21317257, PMID 21347742, PMID 21546269, PMID 21908799, PMID 22429630, PMID 22759841, PMID 22813439, PMID 23432146, PMID 24083350, PMID 24917966, PMID 25304129, PMID 26121347, PMID 26121348, PMID 26422095, PMID 26422096, PMID 26559637, PMID 28119763, PMID 28567114, PMID 28607547, PMID 28780072, PMID 28894571, PMID 29024410, PMID 29739175
2014 (1), 2016 (1), K23DK115827 (1), K23DK131317 (1), R01DK139089 (1), R03DK145962 (1), R21DK077678 (1)