388 completed, 121 unknown, 106 recruiting, 65 terminated. 306 Not applicable, 139 Phase 2, 68 Phase 1, 64 Phase 3, 33 Phase 4.
Follow Laryngeal Diseases: new trials by email Literature Review of Laryngeal Diseases trials Research Report on Laryngeal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Personalized Voice Restoration Device for Patients With Laryngectomy Surface Electromyography - Dysphonia, Aphonia | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 100 | 2027-12-01 | 2026-06-16 |
| Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2027-02-13 | 2026-09-03 |
| Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia - Cough, Vocal Cord Atrophy | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 200 | 2027-01-01 | 2026-06-16 |
| Effect Of Intracuff Dexamethasone On Postoperative Sore Throat In Patients Undergoing Laparoscopic Cholecystectomy Dexamethasone (0.1 mg/kg), Normal Saline (0.9% NaCl) - Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Not yet recruiting | B.P. Koirala Institute of Health Sciences | 40 | 2027-01-01 | 2026-08-24 |
| Single Dose 4-Aminopyridine for Diagnosing Recurrent Laryngeal Nerve Paralysis Continuity After Trauma 4-Aminopyridine - Vocal Cord Paralysis, Recurrent Laryngeal Nerve Palsy | Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 50 | 2026-12-01 | 2026-09-21 |
| Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires - Presbylarynx, Aspiration | Not applicable | Not yet recruiting | University of California, San Francisco | 40 | 2026-11-01 | 2026-09-18 |
| Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP) PRGN-2012, Bevacizumab - Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV) | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 50 | 2026-10-28 | 2026-10-23 |
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-10-28 | 2026-10-23 |
| Irrigation Fluid Volume, Tube Cuff Pressure, and Neck Swelling During Shoulder Arthroscopy Elective Shoulder Arthroscopy - Shoulder Arthroscopy, Endotracheal Tube Cuff Pressure | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 60 | 2026-10-15 | 2026-10-01 | |
| Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction Fosamprenavir Calcium, Placebo - Laryngopharyngeal Reflux | Phase 2 | Recruiting | Medical College of Wisconsin | 104 | 2026-10-01 | 2026-09-10 |
| Extended-release Sodium Oxybate (Lumryz) in Spasmodic Dysphonia and Voice Tremor sodium oxybate - Spasmodic Dysphonia, Laryngeal Dystonia | Phase 1 | Not yet recruiting | Kristina Simonyan | 8 | 2026-10-01 | 2026-04-28 |
| Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma Panitumumab-IRDye800, [18F]NOTA-ABY-030 - HNSCC,Larynx, Pharynx and Oral Cavity, Squamous Cell Carcinoma | Phase 1 | Recruiting | Vanderbilt-Ingram Cancer Center | 30 | 2026-10-01 | 2026-10-19 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-09-30 | 2026-08-13 |
| Effects of Video LMA Cuff Pressure in Tympanoplasty. Oropharyngeal Leak Pressure, Airway Management | Not yet recruiting | Samsun University | 48 | 2026-09-25 | 2026-09-30 | |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC Ficerafusp alfa, Pembrolizumab (KEYTRUDA®) - Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 2 | Recruiting | Bicara Therapeutics | 160 | 2026-09-01 | 2026-10-13 |
| Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery Intraoperative laryngeal nerve monitor - Unilateral Vocal Cord Paralysis, Unilateral Vocal Cord Paresis | Not applicable | Not yet recruiting | University of Alberta | 90 | 2026-09-01 | 2026-05-22 |
| Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Recruiting | Erasmus Medical Center | 30 | 2026-09-01 | 2026-09-02 |
| Active vs. Passive VR During Office-based ENT Procedures Passive virtual reality headset or goggles, Active virtual reality headset or goggles - Pain, Anxiety | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 132 | 2026-09-01 | 2026-08-17 |
| Effects of Therapeutic Exercise With and Without Nerve Stimulation on Dysphonia in Post Thyroidectomy Patients therapeutic exercise, therapeutic exercise + transcutaneous nerve stimulation - Post-Thyroidectomy Dysphonia | Not applicable | Not yet recruiting | University of Lahore | 60 | 2026-09-01 | 2026-09-09 |
Showing 20 of 779. Sign in to see all of them.
Laryngeal Neoplasms (256) · Head and Neck Neoplasms (132) · Hypopharyngeal Neoplasms (120) · Dysphonia (116) · Mouth Neoplasms (111) · Oropharyngeal Neoplasms (108) · Squamous Cell Carcinoma of Head and Neck (84) · Voice Disorders (69) · Vocal Cord Paralysis (57) · Laryngopharyngeal Reflux (53) · Hoarseness (51) · Nasopharyngeal Neoplasms (45) · Deglutition Disorders (39) · Carcinoma (36)
Respiratory Tract Diseases (779) · Otorhinolaryngologic Diseases (739) · Pathological Conditions, Signs and Symptoms (352) · Neoplasms by Site (321) · Signs and Symptoms (314) · Neoplasms (307) · Nervous System Diseases (300) · Neurologic Manifestations (281) · Otorhinolaryngologic Neoplasms (260) · Respiratory Tract Neoplasms (259) · Pharyngeal Diseases (220) · Stomatognathic Diseases (206) · Head and Neck Neoplasms (186) · Digestive System Diseases (150)
Cisplatin (47) · Radiotherapy (30) · Cetuximab (27) · Magnetic Resonance Spectroscopy (19) · pembrolizumab (17) · Docetaxel (16) · Fluorouracil (16) · Carboplatin (15) · Dexamethasone (15) · Specimen Handling (15) · Radiotherapy, Intensity-Modulated (14) · 1,2-diaminocyclohexaneplatinum II citrate (10) · Drug Therapy (9) · Lansoprazole (9) · Laryngoscopy (9)
National Cancer Institute (NCI) (19) · Mayo Clinic (10) · Emory University (9) · M.D. Anderson Cancer Center (9) · University Hospital Ostrava (9) · Memorial Sloan Kettering Cancer Center (8) · National Institute of Neurological Disorders and Stroke (NINDS) (8) · Seoul National University Hospital (8) · University of California, San Francisco (8) · Washington University School of Medicine (8) · University of Chicago (7) · University of Minnesota (7) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (6) · Massachusetts Eye and Ear Infirmary (6) · Roswell Park Cancer Institute (6)
United States (336) · France (50) · Turkey (Türkiye) (37) · China (35) · Canada (30) · Italy (29) · United Kingdom (28) · South Korea (27) · Germany (24) · Taiwan (21) · Belgium (20) · Egypt (17) · Netherlands (17) · Spain (17) · Poland (16)
Kristina Simonyan, MD, PhD (9) · Adam Luginbuhl, MD (3) · Clark Rosen, MD (3) · Frans JM Hilgers, MD, PhD (3) · Jennifer Johnson, MD, PhD (3) · Andrew Sikora, MD, PhD (2) · Benjamin Lallemant, MD (2) · Bo Chawes, PhD (2) · Carter Van Waes, M.D. (2) · Ching-Ting Tan, MD, PhD (2) · Christian Debry, MD (2) · David Lott, MD (2) · Edward J. Damrose MD, FACS (2)
PMID 19140539, PMID 26679193, PMID 26787799, PMID 27939583, PMID 28674168, PMID 29408585, PMID 39740942, PMID 10562789, PMID 10924966, PMID 11127145, PMID 11190378, PMID 11391740, PMID 11432181, PMID 11566828, PMID 11725167, PMID 11804862, PMID 12150380, PMID 12161727, PMID 12434607, PMID 14511925, PMID 14557228, PMID 14668816, PMID 14718713, PMID 15051621, PMID 15210907, PMID 15225175, PMID 15387083, PMID 16112543, PMID 16481828, PMID 16537737, PMID 16597660, PMID 16672085, PMID 16794899, PMID 16823067, PMID 16849759, PMID 16855994, PMID 16931978, PMID 17044539, PMID 17293228, PMID 17537681, PMID 17589721, PMID 17709149, PMID 17721405, PMID 17767636, PMID 17822322, PMID 17906496, PMID 17922287, PMID 18315632, PMID 18334848, PMID 19018337
2023 (4), P30CA138292 (4), U10CA180820 (4), U10CA180868 (4), 2019 (2), P30CA015083 (2), P30CA016056 (2), R01DC012545 (2), UM1CA186690 (2), 2008 (1), 2014 (1), 2015 (1), 2016 (1), 2025 (1), K01AT004415 (1)