33 completed, 16 unknown, 10 recruiting, 8 terminated. 24 Phase 4, 20 Not applicable, 13 Phase 3, 11 Phase 2, 4 Phase 1.
Follow Proton Pump Inhibitors: new trials by email Literature Review of Proton Pump Inhibitors trials Research Report on Proton Pump Inhibitors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction Zastaprazan, Proton Pump Inhibitors (PPI) - Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding | Phase 3 | Recruiting | Samsung Medical Center | 5000 | 2026-06-23 | 2026-06-26 |
| Comparative Effectiveness of Alginate, Magaldrate, Sucralfate, Proton Pump Inhibitors, and Diet in Laryngopharyngeal Reflux Disease Alginate, Magaldrate, Sucralfate - Laryngopharyngeal Reflux Disease | Phase 4 | Not yet recruiting | University of Mons | 800 | 2026-05-01 | 2026-05-28 |
| Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection Vonoparazan, Vitamin D, Probiotic - HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection | Phase 2 | Recruiting | Tanta University | 132 | 2026-02-15 | 2026-09-09 |
| Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection zinc sulfate, Vonoprazan + amoxicillin + clarithromycin, proton pump inhibitor + amoxicillin - HELICOBACTER PYLORI INFECTIONS | Phase 3 | Recruiting | Tanta University | 88 | 2026-02-01 | 2026-09-09 |
| A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 414 | 2025-12-20 | 2026-03-06 |
| Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy Experimental (Health Canada Approved Proton Pump Inhibitors) - Primary Lung Cancer, Non Small Cell Lung Cancer | Phase 2 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 58 | 2025-10-02 | 2025-07-22 |
| The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON) Proton Pump Inhibitors - Pancreatic Walled-off Necrosis | Not applicable | Recruiting | Qilu Hospital of Shandong University | 120 | 2025-09-17 | 2026-08-10 |
| Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection Potassium-Competitive Acid Blocker, Proton Pump Inhibitor - Potassium-Competitive Acid Blocker, Proton Pump Inhibitor | Not applicable | Recruiting | Tanta University | 320 | 2025-09-11 | 2025-09-12 |
| Evaluate the Effects of Famotidine or Rabeprazole on the PK of Nirogacestat Nirogacestat, Nirogacestat and Famotidine, Nirogacestat and Rabeprazole - Healthy | Phase 1 | Completed | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 24 | 2025-08-21 | 2026-05-08 |
| Evaluation of the Efficacy and Safety of Eolo in Patients With NERD EOLO, PPI (proton pump inhibitor), Group C: Eolo - Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal | Not applicable | Completed | University of Bologna | 60 | 2025-05-30 | 2025-06-27 |
| Tegoprazan And Lansoprazole Effectiveness in Bleeding Peptic Ulcer Treatment Tegoprazan, Lansoprazole - Peptic Ulcer Bleeding | Not applicable | Recruiting | Mario Steffanus | 162 | 2025-05-01 | 2025-05-29 |
| The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease PPI (proton pump inhibitor), Probiotic, Zinc - Gastro-oesophageal Reflux Disease | Phase 4 | Not yet recruiting | Ain Shams University | 120 | 2024-11-01 | 2024-10-29 |
| Evaluation of the Efficacy of Local Budesonide Treatment in Children with Crohn's Disease Located in the Esophagus And/or Stomach And/or Duodenum budesonide, omeprazole (proton pump inhibitor) - Crohn Disease (CD) | Phase 2 / Phase 3 | Enrolling by invitation | Medical University of Warsaw | 114 | 2024-07-30 | 2024-12-06 |
| Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI) - Dysbiosis, Gastroesophageal Reflux Disease (GERD) | Phase 4 | Completed | Seoul National University Hospital | 80 | 2024-07-18 | 2026-10-01 |
| Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding Proton Pump Inhibitors, No Proton Pump Inhibitors - Upper Gastrointestinal Hemorrhage | Phase 4 | Not yet recruiting | West China Hospital | 672 | 2023-10-01 | 2023-09-28 |
| The PRO-SOma COla (PROSOCO) Study Proton Pump inhibitor, Placebo - Healthy | Not applicable | Unknown | University of Copenhagen | 11 | 2023-09-13 | 2023-11-07 |
| PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents Proton pump inhibitor, LAMS-implantation - Acute Pancreatitis | Completed | University Medical Center Goettingen | 893 | 2023-05-05 | 2025-06-15 | |
| Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery pantoprazole, Placebo - Postoperative Nausea and Vomiting | Phase 2 | Recruiting | United States Naval Medical Center, Portsmouth | 132 | 2022-08-26 | 2025-05-21 |
| Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury Proton pump inhibitor - Proton Pump Inhibitor, Acute Kidney Injury | Completed | Qianfoshan Hospital | 30000 | 2022-07-01 | 2023-11-18 | |
| Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial Placebo, Esomeprazole 20mg - Liver Cirrhosis | Phase 4 | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 476 | 2021-04-22 | 2025-04-24 |
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Gastroesophageal Reflux (17) · Stomach Neoplasms (6) · Peptic Ulcer (5) · Liver Cirrhosis (4) · Non-Erosive Reflux Disease (4) · Dyspepsia (3) · Gastrointestinal Hemorrhage (3) · Helicobacter Infections (3) · Barrett Esophagus (2) · Breast Neoplasms (2) · Cough (2) · Hemorrhage (2) · Hypertension, Portal (2) · Lymphoma, Non-Hodgkin (2) · Neoplasms (2)
National Taiwan University Hospital (6) · Shanghai Jiao Tong University School of Medicine (6) · Tanta University (4) · Samsung Medical Center (3) · National Cancer Center, Korea (2) · University of Pittsburgh (2) · AVM Biotechnology Inc (1) · Advanced Center for Specialty Care (1) · Ain Shams University (1) · Asan Medical Center (1) · Asian Institute of Gastroenterology, India (1) · Assiut University (1) · Brooklyn ImmunoTherapeutics, LLC (1) · Canadian Network for Observational Drug Effect Studies, CNODES (1) · Chinese PLA General Hospital (1)
United States (15) · China (11) · South Korea (10) · Taiwan (8) · Canada (6) · Egypt (5) · Germany (3) · Italy (3) · Denmark (2) · Poland (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Greece (1) · India (1)
Hong Lu, M.D. (3) · Jyh-Chin Yang, M.D.Ph.D. (3) · Abeer Salamah, Lecturer (1) · Alojz Ihan, MD, PhD (1) · Andrea Morgner-Miehlke, MD, PhD (1) · Anne Armstrong (1) · Ansgar W Lohse, MD (1) · Benny Dahl, MD (1) · Blair A Jobe, MD (1) · Carlo Calabrese, Prof of Gastroenterology, PI (1) · Casey Timmerman, DO (1) · Caterina B Bucca, MD (1) · Charles H. Goldsmith, PhD (1) · Chen-Chi Wu, MD (1)
PMID 15907550, PMID 17067919, PMID 18237386, PMID 18423628, PMID 21923713, PMID 23067033, PMID 23376004, PMID 23721547, PMID 23856153, PMID 25587615, PMID 26165736, PMID 26338726, PMID 28098408, PMID 28558708, PMID 28680717, PMID 29145971, PMID 29562147, PMID 30327875, PMID 31067538, PMID 32162821, PMID 32283700, PMID 32407890, PMID 32738599, PMID 32946931, PMID 34942310, PMID 34997989, PMID 35660509, PMID 35884067, PMID 35929980, PMID 36235778, PMID 37885233, PMID 40164133, PMID 40341536, PMID 9014926
2023 (2), 2014 (1), 2018 (1), 2019 (1)