21 completed, 5 withdrawn, 4 active not recruiting, 4 recruiting. 17 Not applicable, 6 Phase 2, 5 Phase 1, 4 Phase 4.
Follow Degenerative Spondylolisthesis: new trials by email Literature Review of Degenerative Spondylolisthesis trials Research Report on Degenerative Spondylolisthesis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease Intraoperative Computed Tomography (O-arm) - Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability | Not yet recruiting | 4th Military Clinical Hospital with Polyclinic, Poland | 100 | 2026-08-01 | 2026-06-12 | |
| Assessing Safety of Cervical Spine Fusion With NMP® Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion - Degenerative Disc Disease, Degenerative Spondylolisthesis | Not yet recruiting | Red Rock Regeneration Inc. | 300 | 2026-01-15 | 2025-11-24 | |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| Restoring Segmental Lumbar Lordosis After Failed Previous Fusion at the Same Level Restoring segmental lordosis at the lumbar spine - Failed Back Surgery Syndrome, Degeneration Lumbar Spine | Not applicable | Active not recruiting | N.N. Priorov National Medical Research Center of Traumatology and Orthopedics | 20 | 2025-06-25 | 2026-07-02 |
| Degenerative Spondylolisthesis Accompanying LSS: Do We Need Fusion? Unilateral laminotomy decompression, Decompression and fusion - Degenerative Spondylolisthesis, Lumbar Spinal Stenosis | Completed | Kafrelsheikh University | 52 | 2025-01-01 | 2026-02-13 | |
| Mid- or High-flex Rods Versus Low-flex Rods of SpineShape System IV for Treatment of Degenerative Lumbar Spine Diseases SpineShape System IV straight rod elastic, SpineShape System IV straight rod medium, SpineShape System IV straight rod stiff - Degenerative Lumbar Spinal Stenosis, Facet Joint Arthrosis | Not applicable | Recruiting | SpineSave AG | 126 | 2024-06-04 | 2024-06-25 |
| Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol Degenerative Spondylolisthesis, Lumbar Spinal Stenosis | Recruiting | Beijing Friendship Hospital | 150 | 2024-03-01 | 2025-06-06 | |
| Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion - Degenerative Disc Disease, Degenerative Spondylolisthesis | Enrolling by invitation | Induce Biologics USA Inc. | 200 | 2024-01-04 | 2025-11-18 | |
| Short-term Clinical Outcome of Cortical Bone Trajectory Compared With the Traditional "Open" and Minimal Invasive Posterior Lumbar Interbody Fusion Posterior Lumbar Interbody Fusion (PLIF) - Degenerative Spondylolisthesis, Spondylolytic Spondylolisthesis | Recruiting | Jos M. A. Kuijlen | 180 | 2022-09-19 | 2025-05-04 | |
| Clinical Evaluation of Orion Lamina Cover in Patients Undergoing Lumbar Laminectomy With Instrumented Fusion Sham, ORION spinal lamina cover - Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis | Not applicable | Completed | Orion Biotech Inc. | 30 | 2022-03-30 | 2024-08-01 |
| Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline - Lumbar Spinal Stenosis, Lumbar Disc Herniation | Phase 4 | Recruiting | John O'Toole | 125 | 2022-02-01 | 2026-02-17 |
| TLIF Osteo3 ZP Putty Study (Also Known as the TOP Fusion Study) Osteo3 ZP Putty - Degenerative Disc Disease, Degenerative Spondylolisthesis | Not applicable | Completed | OssDsign | 17 | 2021-09-07 | 2024-07-10 |
| Instability in the Lumbar Spine of Patients With Age Related Changes and Narrowing of the Spinal Canal (Spinal Stenosis) decompression, fusion - Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis | Completed | Spine Centre of Southern Denmark | 235 | 2021-06-30 | 2021-12-14 | |
| XLIF Decade Plate System Study Degenerative Disc Disease, Degenerative Spondylolisthesis | Completed | NuVasive | 75 | 2021-04-12 | 2025-12-22 | |
| Re-operation Rates of Concorde Bullet Device Versus Conduit Titanium Interbody Graft for Lumbar Fusion Conduit Titanium Interbody Graft, Concorde Bullet Device - Degenerative Spondylolisthesis, Lumbar Spondylosis | Completed | Lahey Clinic | 100 | 2021-03-12 | 2024-07-03 | |
| Methadone for Spinal Fusion Surgery. Methadone, Morphine - Pain, Postoperative, Back Pain | Phase 4 | Terminated | University of Aarhus | 114 | 2021-02-26 | 2024-11-25 |
| Clinical Decision-Making and Virtual Reality Exercise VR skateboarding training - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Not applicable | Completed | National Taiwan University Hospital | 200 | 2021-01-01 | 2025-06-22 |
| First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS) AK1320 MS, Control - Degenerative Spondylolisthesis, Spinal Stenosis | Phase 1 | Terminated | Asahi Kasei Therapeutics Corporation | 30 | 2020-11-18 | 2024-03-06 |
| Lumbar Interbody Implant Study Degenerative Disc Disease, Degenerative Spondylolisthesis | Enrolling by invitation | NuVasive | 1050 | 2020-10-01 | 2025-12-22 | |
| Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion ART352-L - Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Unknown | Ankasa Regenerative Therapeutics, Inc. | 12 | 2020-09-30 | 2020-10-12 |
Showing 20 of 44. Sign in to see all of them.
Spinal Stenosis (23) · Intervertebral Disc Degeneration (19) · Spondylolisthesis (13) · Radiculopathy (3) · Back Pain (2) · Intervertebral Disc Displacement (2) · Spondylosis (2) · Agnosia (1) · Failed Back Surgery Syndrome (1) · Intervertebral disc disease (1) · Low Back Pain (1) · Pain (1) · Pain, Postoperative (1) · Pseudarthrosis (1) · Scoliosis (1)
Bone Diseases (38) · Musculoskeletal Diseases (38) · Spinal Diseases (38) · Spondylolysis (13) · Spondylosis (11) · Pathological Conditions, Signs and Symptoms (7) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Nervous System Diseases (4) · Neuromuscular Diseases (3) · Pain (3) · Peripheral Nervous System Diseases (3) · Back Pain (2) · Fractures, Bone (2) · Hernia (2)
Gene Fusion (5) · Decompression (3) · Clonidine (2) · N-methylpyrrolidone (2) · Spinal Fusion (2) · Transplantation, Autologous (2) · Anesthesia, Local (1) · Arthrodesis (1) · Epinephrine (1) · Laminectomy (1) · Methadone (1) · Morphine (1) · Ropivacaine (1) · Saline Solution (1) · Transplantation, Homologous (1)
Mesoblast, Ltd. (4) · NuVasive (3) · Lahey Clinic (2) · Zimmer Biomet (2) · 4th Military Clinical Hospital with Polyclinic, Poland (1) · Amedica Corporation (1) · Ankasa Regenerative Therapeutics, Inc. (1) · Asahi Kasei Therapeutics Corporation (1) · Beijing Friendship Hospital (1) · Bone and Joint Clinic of Baton Rouge (1) · Corewell Health East (1) · Empirical Spine, Inc. (1) · Haukeland University Hospital (1) · Induce Biologics USA Inc. (1) · Instituto Nacional de Rehabilitacion (1)
United States (20) · Canada (3) · Denmark (3) · Netherlands (3) · Switzerland (2) · Taiwan (2) · Australia (1) · China (1) · Egypt (1) · France (1) · Germany (1) · Hungary (1) · Mexico (1) · Norway (1) · Poland (1)
Kyle Malone, MS (3) · Roger Brown (3) · Christopher S Bailey, MD (1) · Clemens Weber, PhD, MD (1) · David S. Krum-Moeller, M.D. (1) · Donna Skerrett, MD (1) · Edilin Lopez, MD (1) · Eeric Truumees, MD (1) · Frode G Rekeland, MD (1) · Henrik Kehlet, M.D. (1) · Jad G Khalil, MD (1) · Joel Batts (1) · John O'Toole, MD (1) · Joon Y Lee, M.D. (1)
PMID 15995108, PMID 23948848, PMID 24568365, PMID 25238480, PMID 27548582, PMID 29957147, PMID 31451936, PMID 33792726, PMID 36152329, PMID 36477416, PMID 37395780, PMID 38127138, PMID 38974656, PMID 39134699, PMID 39868633, PMID 40050812, PMID 41034885, PMID 41196064