981 completed, 215 unknown, 166 terminated, 155 recruiting. 412 Phase 2, 311 Not applicable, 256 Phase 3, 251 Phase 1, 150 Phase 4.
Follow Macular Degeneration: new trials by email Literature Review of Macular Degeneration trials Research Report on Macular Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss Personalised Remapping Training, RSVP personalized remappi, Reading text in the wild with remapping - Macular Degeneration, Central Visual Impairment | Not applicable | Not yet recruiting | University of Minnesota | 100 | 2027-06-01 | 2026-07-07 |
| Non-invasive Ultrasound Retinal Stimulation for Vision Restoration Non-invasive ultrasound retinal stimulation Device - Age-Related Macular Degeneration, Retinitis Pigmentosa | Not applicable | Not yet recruiting | University of Southern California | 5 | 2027-01-10 | 2026-01-08 |
| MIND-AMD Study: a Multidisciplinary Investigation of Neuroretinal Damage in Age-related Macular Degeneration. Age-Related (Dry) Macular Degeneration, Age-Related Macular Degeneration (AMD) | Not yet recruiting | IRCCS San Raffaele | 160 | 2027-01-02 | 2026-09-29 | |
| Prevalence of Age-Related Macular Degeneration in Assiut University Hospitals OCT - clear - Age-Related Macular Degeneration (AMD) | Not yet recruiting | Assiut University | 90 | 2027-01-01 | 2026-10-21 | |
| OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal Retinal Detachment, Macular Edema | Not yet recruiting | Assiut University | 30 | 2026-11-01 | 2026-10-08 | |
| Phase 2a Study to Evaluate the Efficacy and Safety of SCAI-005 Ophthalmic Solution in Subjects With Neovascular Age-related Macular Degeneration SCAI-005 0.04% 2drops TID, SCAI-005 0.08% 2drops TID, Placebo 2drops TID - wetAMD, Age Related Macular Degeneration | Phase 2 | Not yet recruiting | SCAI Therapeutics | 50 | 2026-11-01 | 2026-05-26 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-05) OLN324, Ranibizumab - Wet Age-related Macular Degeneration | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 400 | 2026-10-15 | 2026-09-11 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-04) OLN324, Aflibercept - Wet Age Related Macular Degeneration | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 500 | 2026-10-15 | 2026-09-11 |
| Photobiomodulation Laser for Reticular Pseudodrusen in Age-Related Macular Degeneration Photobiomodulation Therapy, Sham Photobiomodulation - AMD - Age-Related Macular Degeneration | Not applicable | Not yet recruiting | Fondazione G.B. Bietti, IRCCS | 67 | 2026-10-01 | 2026-09-04 |
| Iopidine to Decrease Intraocular Pressure Rise After Injections Apraclonidine 1.0% ophthalmic solution - Macular Degeneration, Diabetic Retinopathy | Phase 4 | Not yet recruiting | Retina Consultants of Delmarva | 120 | 2026-10-01 | 2026-10-23 |
| An Open-label Extension Study of the Long-Term Safety of Vonaprument (ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA) Vonaprument - Geographic Atrophy | Phase 3 | Not yet recruiting | Annexon, Inc. | 605 | 2026-09-30 | 2026-09-08 |
| Evaluation of PAN-90806 Eye Drops in Healthy Subjects PAN-90806 Ophthalmic Solution, Vehicle Ophthalmic Solution - Wet Age Related Macular Degeneration, Neovascular (Wet) Age-Related Macular Degeneration | Phase 1 | Not yet recruiting | Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. | 20 | 2026-09-30 | 2026-08-14 |
| Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) Sub-study Adaptive Optics Scanning Light Ophthalmoscopy, Microperimetry, Optical Coherence Tomography - Geographic Atrophy | Not applicable | Enrolling by invitation | University of Wisconsin, Madison | 10 | 2026-09-29 | 2026-09-01 |
| A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration BRX011, Placebo - Geographic Atrophy | Phase 1 / Phase 2 | Recruiting | Biojiva LLC | 152 | 2026-09-29 | 2026-09-23 |
| Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study Repeated intravitreal anti-VEGF injection with eyelid speculum - Blepharoptosis, Age-Related Macular Degeneration | Recruiting | Abdulkadir Küçük | 60 | 2026-09-25 | 2026-10-22 | |
| A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005) MK-8748, Aflibercept - Diabetic Retinopathy, Macular Edema | Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 1104 | 2026-09-25 | 2026-10-23 |
| A Study in Adults With Geographic Atrophy STL303, Placebo - Geographic Atrophy | Phase 2 | Recruiting | Sitala Bio LTD | 300 | 2026-09-11 | 2026-09-21 |
| A Study to Evaluate the Efficacy and Safety of VIS-101 in Participants With Neovascular Age-Related Macular Degeneration VIS-101 6.0mg Low concentration, VIS-101 6.0mg High concentration, VIS-101 9.0mg High concentration - Neovascular Age Related Macular Degeneration(nAMD) | Phase 2 | Not yet recruiting | Everest Medicines (China) Co.,Ltd. | 244 | 2026-09-01 | 2026-09-10 |
| A Phase 1, First-in-Human Study of CITY-RBP4 in Healthy Volunteers and STGD1 Participants CITY-RBP4, Placebo - Stargardt Disease 1, STGD1 | Phase 1 | Recruiting | City Therapeutics | 48 | 2026-09-01 | 2026-09-23 |
| Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma Center Animated Videos - Diabetic Retinopathy (DR), Macular Edema (ME) | Not applicable | Not yet recruiting | University of California, San Francisco | 150 | 2026-09-01 | 2026-07-22 |
Showing 20 of 1697. Sign in to see all of them.
Macular Edema (418) · Geographic Atrophy (178) · Diabetic Retinopathy (152) · Retinal Vein Occlusion (152) · Choroidal Neovascularization (138) · Retinal Diseases (99) · Wet Macular Degeneration (93) · Vision Disorders (69) · Eye Diseases (68) · Retinal Degeneration (67) · Stargardt Disease (66) · Diabetes Mellitus (64) · Glaucoma (47) · Cataract (44)
Retinal Degeneration (1630) · Eye Diseases (1629) · Retinal Diseases (1598) · Pathological Conditions, Signs and Symptoms (300) · Cardiovascular Diseases (291) · Vascular Diseases (291) · Uveal Diseases (204) · Endocrine System Diseases (197) · Pathologic Processes (189) · Metaplasia (163) · Choroid Diseases (157) · Diabetes Complications (153) · Embolism and Thrombosis (152) · Thrombosis (152)
Ranibizumab (263) · aflibercept (151) · Bevacizumab (81) · salicylhydroxamic acid (55) · Dexamethasone (51) · Calcium Dobesilate (40) · Triamcinolone Acetonide (33) · Verteporfin (32) · pegaptanib (26) · brolucizumab (22) · Triamcinolone (20) · Tomography, Optical Coherence (16) · Photochemotherapy (14) · Lutein (13) · faricimab (13)
National Eye Institute (NEI) (78) · Novartis Pharmaceuticals (66) · Bayer (38) · Allergan (37) · Medical University of Vienna (27) · Genentech, Inc. (25) · Notal Vision Ltd. (21) · Alcon Research (20) · Hoffmann-La Roche (16) · Johns Hopkins University (16) · Pfizer (16) · Duke University (13) · GlaxoSmithKline (12) · The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery (12) · Regeneron Pharmaceuticals (11)
United States (769) · Germany (154) · France (153) · United Kingdom (144) · Italy (118) · Canada (111) · Australia (102) · Spain (100) · Austria (98) · China (89) · Israel (76) · Hungary (69) · Switzerland (64) · Poland (63) · Czechia (62)
Emily Y Chew, M.D. (9) · Pablo Velazquez-Martin, MD (6) · Peter A Campochiaro, MD (5) · Thomas Ciulla, MD (5) · Joel Naor, MD (4)
PMID 37314061, PMID 37702300, PMID 32374423, PMID 22281388, PMID 25458728, PMID 30957581, PMID 32844399, PMID 34934034, PMID 39758130, PMID 23084240, PMID 23706949, PMID 25677668, PMID 33206392, PMID 33331670, PMID 35085502, PMID 36246941, PMID 36912792, PMID 39102242, PMID 39207600, PMID 11297486, PMID 15808240, PMID 17021318, PMID 17021319, PMID 19255158, PMID 19365036, PMID 19506188, PMID 20189654, PMID 20378094, PMID 20683380, PMID 20688734, PMID 20920825, PMID 21296824, PMID 21320967, PMID 21546089, PMID 21794843, PMID 22234714, PMID 22559899, PMID 22965590, PMID 23009891, PMID 23361508, PMID 23415775, PMID 23453513, PMID 23699977, PMID 23745581, PMID 24113783, PMID 24310343, PMID 24385141, PMID 24768239, PMID 24896137, PMID 25104651
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