1991 completed, 574 unknown, 341 recruiting, 283 terminated. 877 Not applicable, 734 Phase 2, 460 Phase 1, 432 Phase 3, 253 Phase 4.
Follow Retinal Diseases: new trials by email Literature Review of Retinal Diseases trials Research Report on Retinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss Personalised Remapping Training, RSVP personalized remappi, Reading text in the wild with remapping - Macular Degeneration, Central Visual Impairment | Not applicable | Not yet recruiting | University of Minnesota | 100 | 2027-06-01 | 2026-07-07 |
| Eye Health Intervention Study in Upper Manhattan Intervention, Usual Care - Glaucoma, Suspect, Diabetic Retinopathy | Not applicable | Withdrawn | Columbia University | 2027-04-01 | 2026-05-29 | |
| Non-invasive Ultrasound Retinal Stimulation for Vision Restoration Non-invasive ultrasound retinal stimulation Device - Age-Related Macular Degeneration, Retinitis Pigmentosa | Not applicable | Not yet recruiting | University of Southern California | 5 | 2027-01-10 | 2026-01-08 |
| MIND-AMD Study: a Multidisciplinary Investigation of Neuroretinal Damage in Age-related Macular Degeneration. Age-Related (Dry) Macular Degeneration, Age-Related Macular Degeneration (AMD) | Not yet recruiting | IRCCS San Raffaele | 160 | 2027-01-02 | 2026-09-29 | |
| Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells - Extremely Premature Infant, Anemia Neonatal | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 176 | 2027-01-01 | 2026-03-31 |
| Prevalence of Age-Related Macular Degeneration in Assiut University Hospitals OCT - clear - Age-Related Macular Degeneration (AMD) | Not yet recruiting | Assiut University | 90 | 2027-01-01 | 2026-10-21 | |
| 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome N-acetylcysteine amide, Placebo - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Not yet recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-12-01 | 2026-07-01 |
| Faricimab for Chronic Central Serous Chorioretinopathy: A Randomized Sham-Controlled Trial Faricimab, Sham - Central Serous Chorioretinopathy (CSC) | Phase 2 | Not yet recruiting | Singapore National Eye Centre | 50 | 2026-12-01 | 2026-07-02 |
| The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative Vitreoretinopathy Topotecan - Proliferative Vitreoretinopathy, Proliferative Vitreo-Retinopathy | Phase 1 | Not yet recruiting | Massachusetts Eye and Ear Infirmary | 50 | 2026-12-01 | 2026-10-16 |
| Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care Ultra-widefield Optical Coherence Tomography (UWF-OCT), Wide-field ophthalmic imaging system - Retinopathy of Prematurity (ROP) | Not applicable | Recruiting | Duke University | 175 | 2026-12-01 | 2026-09-17 |
| OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal Retinal Detachment, Macular Edema | Not yet recruiting | Assiut University | 30 | 2026-11-01 | 2026-10-08 | |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Phase 2a Study to Evaluate the Efficacy and Safety of SCAI-005 Ophthalmic Solution in Subjects With Neovascular Age-related Macular Degeneration SCAI-005 0.04% 2drops TID, SCAI-005 0.08% 2drops TID, Placebo 2drops TID - wetAMD, Age Related Macular Degeneration | Phase 2 | Not yet recruiting | SCAI Therapeutics | 50 | 2026-11-01 | 2026-05-26 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-02) OLN324, Aflibercept - Diabetic Macular Edema (DME) | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 450 | 2026-10-15 | 2026-09-25 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-03) OLN324, Aflibercept - Diabetic Macular Edema (DME) | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 450 | 2026-10-15 | 2026-09-25 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-05) OLN324, Ranibizumab - Wet Age-related Macular Degeneration | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 400 | 2026-10-15 | 2026-09-11 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-04) OLN324, Aflibercept - Wet Age Related Macular Degeneration | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 500 | 2026-10-15 | 2026-09-11 |
| Imaging and Predictive Modelling of Proliferative Vitreoretinopathy. Proliferative Vitreoretinopathy | Enrolling by invitation | University College, London | 100 | 2026-10-12 | 2026-07-02 | |
| OCTA Evaluated the Efficacy of Glucocorticoid Retrobulbar Injection in Retinal Photo-injury retrobulbar injection of glucocorticoid - Retinal Light Damage, Photic Retinopathy | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2026-10-09 | 2026-10-09 | |
| A Multicenter Randomized Double-Blind Trial of Chrocare CDSS for Integrated Management of Type 2 Diabetes AI large language model-based clinical decision support system, Standard diabetes integrated management formulated by endocrinologists - Type 2 Diabetes (T2DM), Diabetic Nephropathies | Not applicable | Not yet recruiting | Shanghai Jiao Tong University School of Medicine | 1200 | 2026-10-08 | 2026-09-22 |
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Macular Degeneration (1170) · Diabetic Retinopathy (683) · Macular Edema (418) · Retinal Vein Occlusion (275) · Retinitis Pigmentosa (267) · Diabetes Mellitus (199) · Geographic Atrophy (178) · Retinopathy of Prematurity (167) · Retinal Detachment (162) · Choroidal Neovascularization (153) · Eye Diseases (138) · Retinal Perforations (137) · Retinal Degeneration (130) · Epiretinal Membrane (123)
Eye Diseases (3464) · Retinal Degeneration (1881) · Cardiovascular Diseases (1017) · Vascular Diseases (1009) · Endocrine System Diseases (767) · Diabetic Angiopathies (679) · Diabetes Complications (673) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (639) · Pathological Conditions, Signs and Symptoms (573) · Eye Diseases, Hereditary (559) · Diabetes Mellitus (554) · Macular Degeneration (527) · Genetic Diseases, Inborn (460) · Nervous System Diseases (354)
Ranibizumab (336) · aflibercept (206) · Bevacizumab (126) · salicylhydroxamic acid (79) · Dexamethasone (61) · Calcium Dobesilate (54) · Triamcinolone Acetonide (51) · Vitrectomy (49) · Tomography, Optical Coherence (42) · Verteporfin (34) · pegaptanib (29) · Ganciclovir (27) · Carboplatin (26) · brolucizumab (25) · Intravitreal Injections (24)
National Eye Institute (NEI) (121) · Novartis Pharmaceuticals (79) · Bayer (53) · Medical University of Vienna (41) · Allergan (39) · Johns Hopkins University (32) · Sun Yat-sen University (32) · Hoffmann-La Roche (30) · Shahid Beheshti University of Medical Sciences (27) · Genentech, Inc. (26) · Alcon Research (25) · Asociación para Evitar la Ceguera en México (25) · Duke University (25) · Association for Innovation and Biomedical Research on Light and Image (24) · University of Sao Paulo (24)
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Emily Y Chew, M.D. (11) · Hamid Ahmadieh, MD (11) · Peter A Campochiaro, MD (10) · Hugo Quiroz-Mercado, MD (9) · Pablo Velazquez-Martin, MD (9) · Jason Hsu, MD (8) · Cynthia A Toth, MD (7)
PMID 37314061, PMID 40522203, PMID 37702300, PMID 32408387, PMID 32374423, PMID 32573764, PMID 36912792, PMID 40547876, PMID 22281388, PMID 23049090, PMID 25458728, PMID 26089210, PMID 30957581, PMID 32844399, PMID 34934034, PMID 39758130, PMID 21571677, PMID 23084240, PMID 23706949, PMID 24768239, PMID 25439614, PMID 25677668, PMID 30194931, PMID 31042791, PMID 32633861, PMID 33206392, PMID 33331670, PMID 35085502, PMID 36246941, PMID 36774994, PMID 37260074, PMID 37261916, PMID 38254722, PMID 39102242, PMID 39207600, PMID 11297486, PMID 15808240, PMID 17021318, PMID 17021319, PMID 18441312, PMID 19255158, PMID 19365036, PMID 19506188, PMID 19953081, PMID 20008710, PMID 20189654, PMID 20378094, PMID 20427088, PMID 20580421, PMID 20683380
2014 (18), 2019 (17), 2018 (14), U10EY014231 (9), 2017 (8), U10EY018817 (8), 2009 (7), 2016 (7), 2025 (7), 2015 (6), U10EY014229 (6), U10HD021385 (5), U10HD027851 (5), U10HD027853 (5), U10HD027856 (5)