49 completed. 49 Phase 2, 10 Phase 1, 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 49 | Completed 49 |
| Phase 1 | 10 | Completed 10 |
| Phase 3 | 8 | Completed 8 |
Follow Congestive Heart Failure: new trials by email Literature Review of Congestive Heart Failure trials Research Report on Congestive Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic BMS-986231, Furosemide, Placebo - Cardiac Failure, Myocardial Failure | Phase 2 | Completed | Bristol-Myers Squibb | 23 | 2019-01-17 | 2021-02-26 |
| Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs Allogeneic Derived Cells, Placebo/Control Arm - Congestive Heart Failure, Heart Failure, Diastolic | Phase 2 | Completed | Cedars-Sinai Medical Center | 27 | 2017-07-12 | 2024-07-25 |
| Sub-Q Versus IV Furosemide in Acute Heart Failure Furosemide Injection Solution (SCP-101), Furosemide Injection Solution, USP - Congestive Heart Failure | Phase 2 / Phase 3 | Completed | Johns Hopkins University | 40 | 2016-02-01 | 2017-12-18 |
| The Use of Intranasal Fentanyl for the Treatment of Incident Dyspnea in Congestive Heart Failure: A Prospective Trial fentanyl - Dyspnea, Congestive Heart Failure | Phase 2 | Completed | St. Boniface Hospital | 8 | 2015-10-01 | 2017-09-28 |
| Vitamin D3 Supplementation for Heart Failure Patients Placebo Comparator: Sugar Pill, Vitamin D3 (cholecalciferol) - Heart Failure, Vitamin D Deficiency | Phase 2 | Completed | Heidi Moretti, MS, RD | 40 | 2012-08-01 | 2017-04-26 |
| Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) Study Vagus Nerve Stimulation (VNS) - Congestive Heart Failure | Phase 1 / Phase 2 | Completed | Cyberonics, Inc. | 60 | 2012-07-01 | 2015-02-19 |
| Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure Nesiritide, Tadalafil, Placebo - Congestive Heart Failure | Phase 1 / Phase 2 | Completed | Mayo Clinic | 43 | 2012-02-01 | 2018-03-22 |
| Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction Isosorbide Dinitrate, Isosorbide Dinitrate + Hydralazine, Placebo - Heart Failure, Congestive Heart Failure | Phase 2 | Completed | Corporal Michael J. Crescenz VA Medical Center | 44 | 2012-01-01 | 2022-06-21 |
| Liraglutide and Heart Failure in Type 2 Diabetes liraglutide, glimepiride, Metformin - Congestive Heart Failure, Type 2 Diabetes Mellitus | Phase 2 | Completed | Thomas Nystrom | 62 | 2012-01-01 | 2016-09-01 |
| Blood Pressure Reduction in Heart Failure Hydralazine/amlodipine, Placebo - Heart Failure, Cardiac Failure | Phase 2 / Phase 3 | Completed | University of Sao Paulo | 21 | 2011-01-01 | 2014-06-10 |
| Safety Study of GE-145 320 mg I/mL Injection vs. Iopamidol 370 mg I/mL in Elderly Subjects Undergoing Coronary Procedure GE-145 - Chronic Renal Insufficiency, Diabete Mellitus | Phase 2 | Completed | GE Healthcare | 284 | 2010-11-01 | 2018-08-29 |
| Care Guides in the Primary Care Office (Phase II) education and care guide, education only - Diabetes, Hypertension | Phase 2 | Completed | Allina Health System | 2135 | 2010-07-01 | 2019-04-08 |
| AC6 Gene Transfer for CHF Ad5.hAC6, Sucrose (3%) - Congestive Heart Failure | Phase 1 / Phase 2 | Completed | Hammond, H. Kirk, M.D. | 56 | 2010-07-01 | 2018-02-09 |
| Study to Evaluate the Effects of Oral Administration of Lixivaptan in Patients With Congestive Heart Failure Lixivaptan, Placebo - Congestive Heart Failure | Phase 2 | Completed | CardioKine Inc. | 170 | 2010-01-01 | 2011-06-28 |
| Evaluation of a Diagnostic Feature in a Cardiac Resynchronization Therapy (CRT) Device Paradym CRT + Physiological Diagnosis (PhD) - Congestive Heart Failure | Phase 2 | Completed | ELA Medical, Inc. | 520 | 2009-09-01 | 2014-05-15 |
| Intensive Glycemic Control for Congestive Heart Failure Exacerbation Intravenous insulin, Subcutaneous insulin - Congestive Heart Failure, Diabetes Mellitus | Phase 2 | Completed | Kathleen Dungan | 74 | 2009-01-01 | 2018-01-02 |
| Glycemic Control and Variability for Congestive Heart Failure Exacerbation Intravenous insulin, Subcutaneous insulin - Congestive Heart Failure, Diabetes Mellitus | Phase 1 / Phase 2 | Completed | Kathleen Dungan | 75 | 2009-01-01 | 2013-12-31 |
| Autologous Mesenchymal Stromal Cell Therapy in Heart Failure Mesenchymal stromal cell, Saline - Congestive Heart Failure | Phase 1 / Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 59 | 2008-09-01 | 2015-03-17 |
| Efficiency Study of Triple-Site Cardiac Resynchronization in Patients With Heart Failure Cardiac resynchronization pacemaker (InSync Sentry or Concerto, Medtronic, Minneapolis, MN,USA) with two intracardiac leads, Triple-site cardiac resynchronization - Congestive Heart Failure, Heart Disease | Phase 2 / Phase 3 | Completed | Silesian Centre for Heart Diseases | 100 | 2008-02-01 | 2016-04-13 |
| Interventricular Delay of Lumax HF-T for Heart Failure Optimized interventricular delay biventricular pacing - Congestive Heart Failure | Phase 2 | Completed | Biotronik, Inc. | 122 | 2007-07-01 | 2010-01-26 |
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Heart Failure (49) · Diabetes Mellitus (5) · Renal Insufficiency (3) · Anemia (2) · Cardiomyopathies (2) · Hyperglycemia (2) · Myocardial Infarction (2) · Myocardial Ischemia (2) · Adenoviridae Infections (1) · Angina Pectoris (1) · Angina, Unstable (1) · Chest Pain (1) · Chronic Disease (1) · Coronary Disease (1) · Diabetes Mellitus, Type 2 (1)
Cardiovascular Diseases (49) · Heart Diseases (48) · Nutritional and Metabolic Diseases (8) · Glucose Metabolism Disorders (7) · Metabolic Diseases (7) · Pathological Conditions, Signs and Symptoms (7) · Endocrine System Diseases (6) · Pathologic Processes (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Kidney Diseases (4) · Male Urogenital Diseases (4) · Signs and Symptoms (4) · Urogenital Diseases (4) · Urologic Diseases (4)
Natriuretic Peptide, Brain (5) · Darbepoetin alfa (2) · Furosemide (2) · Hydralazine (2) · Sodium Chloride (2) · Tolvaptan (2) · 5-(formyl-(3-(formyl-(3,5-bis (2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl) amino)-2-hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide (1) · Acupuncture Therapy (1) · Allopurinol (1) · Amlodipine (1) · Cardiac Resynchronization Therapy (1) · Cholecalciferol (1) · Defibrillators (1) · Educational Status (1) · Endothelium-Dependent Relaxing Factors (1)
Boston Scientific Corporation (3) · Amgen (2) · Horng Chen (2) · Johns Hopkins University (2) · Kathleen Dungan (2) · Otsuka Pharmaceutical Development & Commercialization, Inc. (2) · Advanz Pharma (1) · Allina Health System (1) · AstraZeneca (1) · Bio-Medisinsk Innovasjon (1) · Biotronik, Inc. (1) · Brigham and Women's Hospital (1) · Bristol-Myers Squibb (1) · CardioKine Inc. (1) · Cedars-Sinai Medical Center (1)
United States (32) · Germany (4) · United Kingdom (3) · Canada (2) · Denmark (2) · Brazil (1) · India (1) · Norway (1) · Poland (1) · Sweden (1) · Switzerland (1)
Horng H. Chen, M.D. (2) · Kathleen M Dungan, MD (2) · Amit Patel, MD (1) · Andreas M Zeiher, MD (1) · Anju Nohria, MD (1) · Boris Nasseri, MD (1) · Bradley D Berry, MD (1) · Christian Torp-Pedersen, Dr. Med (1) · Christof Stamm, MD (1) · Clyde W Yancy, MD (1) · David R Murray, MD (1) · Dirk H Walter, MD (1) · Edimar A Bocchi, Prof. (1)
PMID 15152059, PMID 15319045, PMID 16796497, PMID 17543634, PMID 18549913, PMID 19204305, PMID 19567409, PMID 19919976, PMID 21411144, PMID 22156953, PMID 22361399, PMID 22510424, PMID 22651239, PMID 22728580, PMID 22936827, PMID 22980293, PMID 23122795, PMID 23487543, PMID 23592107, PMID 23922063, PMID 24497345, PMID 24626998, PMID 25187002, PMID 25319879, PMID 25926562, PMID 26601770, PMID 27221316, PMID 27437887, PMID 28219917, PMID 29084522, PMID 29226816, PMID 29548934, PMID 30764699, PMID 31168885, PMID 31909303, PMID 33590355, PMID 34405565, PMID 34920733, PMID 35360224, PMID 35490339, PMID 37349083
P01HL076611 (3), UL1RR024150 (3), R01HL084155 (2), 2004 (1), 2005 (1), 2018 (1), K23DK080891 (1), P01HL066941 (1), R01HL036634 (1), R01HL061912 (1), R21AG043802 (1), R21DK081877 (1)