11 completed, 4 recruiting, 3 terminated, 2 not yet recruiting. 11 Not applicable, 2 Phase 3, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 6, Recruiting 3, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 2 | Terminated 2 |
| Early Phase 1 | 1 | Active not recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Complex Regional Pain Syndrome (CRPS): new trials by email Literature Review of Complex Regional Pain Syndrome (CRPS) trials Research Report on Complex Regional Pain Syndrome (CRPS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Validity and Reliability of the Turkish Version of the Revised Bath CRPS Body Perception Disturbance Scale Complex Regional Pain Syndrome (CRPS) | Not yet recruiting | Izmir Democracy University | 42 | 2026-11-15 | 2026-10-06 | |
| Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients transcranial alternating current stimulation (tACS) - Complex Regional Pain Syndrome (CRPS) | Not applicable | Recruiting | The Cleveland Clinic | 30 | 2026-10-01 | 2026-08-28 |
| Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome transcranial direct current stimulation, Placebo - Complex Regional Pain Syndrome (CRPS) | Not applicable | Recruiting | Polyclinique de l'Europe | 32 | 2026-04-01 | 2026-06-18 |
| Peripersonal Space Representation in Upper Limb Segmental Exclusion Reachability Judgment Task in VR. - Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS) | Recruiting | Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est | 60 | 2025-12-04 | 2026-03-16 | |
| Effects of Motor Imagery Technique With and Without Virtual Reality on Pain Intensity ,Functional Disability and Quality of Life in Patient With Post Stroke Shoulder Hand Syndrome motor imagery with virtual reality, motor imagery alone - Complex Regional Pain Syndrome (CRPS), Shoulder Hand Syndrome | Not applicable | Completed | Green International University | 40 | 2025-11-02 | 2026-05-28 |
| Reducing Pain in Complex Regional Pain Syndrome Using Personalized Brain Stimulation: A Feasibility Study Repetitive transcranial magnetic stimulation - Complex Regional Pain Syndrome (CRPS) | Not applicable | Not yet recruiting | McMaster University | 10 | 2025-07-01 | 2025-05-23 |
| Relationship Between Complex Regional Pain Syndrome and Magnesium Depletion Score scoring - Complex Regional Pain Syndrome (CRPS) | Completed | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization | 117 | 2025-01-01 | 2025-07-30 | |
| Preceding Pain and Development of Additional Pain in Patients With CRPS Complex Regional Pain Syndrome (CRPS) | Completed | Walton Centre NHS Foundation Trust | 705 | 2024-10-30 | 2026-10-13 | |
| Two Point Discrimination Two-point discrimination training, One-point discrimination training - Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS) | Early Phase 1 | Active not recruiting | Children's Hospital Medical Center, Cincinnati | 60 | 2018-07-21 | 2025-01-06 |
| Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 267 | 2018-05-31 | 2020-08-05 |
| Efficacy and Safety of Intravenous Neridronic Acid in CRPS Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 182 | 2018-05-30 | 2020-08-06 |
| A Study to Confirm the Safety of High Frequency DRG Stimulator in Patients With Chronic Lower Limb Pain GiMer Medical MN 1000 External Stimulator - Failed Back Surgery Syndrome, Complex Regional Pain Syndrome (CRPS) | Not applicable | Completed | GiMer Medical | 10 | 2017-03-03 | 2021-01-22 |
| Clinical and Cerebral Changes Following Multifaceted Rehabilitation of Complex Regional Pain Syndrome Individualized CRPS Rehabilitation - Complex Regional Pain Syndrome (CRPS) | Not applicable | Recruiting | University Hospital of North Norway | 12 | 2016-09-01 | 2026-10-08 |
| TARGET Post-Approval Study Dorsal Root Ganglion (DRG) Stimulation (Axium™ Neurostimulator System), Dorsal Root Ganglion (DRG) Stimulation (Proclaim™ Neurostimulator System) - Complex Regional Pain Syndrome (CRPS) | Completed | Abbott Medical Devices | 426 | 2016-08-23 | 2024-07-08 | |
| High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System High frequency stimulation, Low frequency stimulation - Chronic Pain, Low Back Pain | Phase 4 | Completed | The Center for Clinical Research, Winston-Salem, NC | 22 | 2014-10-01 | 2016-10-25 |
| Transcranial Magnetic Stimulation (TMS) for CRPS Transcranial Magnetic Stimulation (TMS) - Complex Regional Pain Syndrome (CRPS) | Not applicable | Completed | Stanford University | 20 | 2014-02-01 | 2017-05-15 |
| TMS for CRPS - Pilot Study Transcranial Magnetic Stimulation - Complex Regional Pain Syndrome (CRPS) | Not applicable | Completed | Stanford University | 4 | 2013-07-01 | 2017-05-10 |
| Mechanism and Treatment of Sympathetically Maintained Pain phenylephrine and clonidine, punch biopsy - Complex Regional Pain Syndrome (CRPS) | Not applicable | Terminated | The Cleveland Clinic | 128 | 2012-08-01 | 2021-01-13 |
| Effects of Pennsaid on Clinical Neuropathic Pain Pennsaid, Placebo (2.3% DMSO solution) - Neuralgia, Postherpetic Neuralgia | Not applicable | Completed | Massachusetts General Hospital | 35 | 2011-11-01 | 2017-02-06 |
| Spinal Cord Stimulation and Functional MRI Complex Regional Pain Syndrome (CRPS), Neuropathic Leg Pain | Completed | Vibhor Krishna | 10 | 2011-09-01 | 2019-09-23 |
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Complex Regional Pain Syndromes (21) · Chronic Pain (4) · Reflex Sympathetic Dystrophy (4) · Fibromyalgia (3) · Pain (3) · Low Back Pain (2) · Agnosia (1) · Anxiety Disorders (1) · Behavior (1) · Ehlers-Danlos Syndrome (1) · Facial Pain (1) · Failed Back Surgery Syndrome (1) · Headache Disorders (1) · Irritable Bowel Syndrome (1) · Migraine Disorders (1)
Autonomic Nervous System Diseases (21) · Nervous System Diseases (21) · Neuromuscular Diseases (21) · Peripheral Nervous System Diseases (21) · Neurologic Manifestations (7) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Pain (4) · Back Pain (3) · Muscular Diseases (3) · Musculoskeletal Diseases (3) · Rheumatic Diseases (3) · Behavior (1) · Brain Diseases (1) · Cardiovascular Diseases (1)
Transcranial Magnetic Stimulation (3) · 6-amino-1-hydroxyhexane-1,1-diphosphonate (2) · Transcranial Direct Current Stimulation (2) · Clonidine (1) · Diclofenac (1) · Educational Status (1) · Palliative Care (1) · Phenylephrine (1)
Grünenthal GmbH (2) · Stanford University (2) · The Cleveland Clinic (2) · Abbott Medical Devices (1) · Children's Hospital Medical Center, Cincinnati (1) · GiMer Medical (1) · Green International University (1) · Izmir Democracy University (1) · Massachusetts General Hospital (1) · McMaster University (1) · Polyclinique de l'Europe (1) · Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization (1) · The Center for Clinical Research, Winston-Salem, NC (1) · Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est (1) · University Hospital of North Norway (1)
United States (12) · France (3) · Canada (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Australia (1) · Czechia (1) · Germany (1) · New Zealand (1) · Norway (1) · Pakistan (1) · Poland (1) · Serbia (1) · Slovakia (1) · South Korea (1)
Aimee J Nelson, PhD (1) · Andreas Goebel (1) · Ann Jannu, PhD, CCRP (1) · James M North, MD (1) · Jianren Mao, M.D., Ph.D. (1) · Lena Danielsson, PhD (1) · Lonnie K. Zeltzer, MD (1) · Robert C Coghill, Ph.D. (1) · Vibhor Krishna, MD (1)
PMID 21600053, PMID 35579382, PMID 41925129
2016 (1), 2017 (1), R21AT013595 (1)