23 completed, 6 terminated, 6 unknown, 4 recruiting. 20 Not applicable, 10 Phase 3, 9 Phase 2, 2 Phase 4, 1 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CRPS-RISE Outcomes Registry Complex Regional Pain Syndrome I (CRPS I) | Recruiting | Ambros Therapeutics, Inc. | 270 | 2026-09-17 | 2026-09-29 | |
| Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) Neridronate, Placebo - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 270 | 2026-04-14 | 2026-10-29 |
| Effects of Task-Based Mirror Therapy for Post-stroke Shoulder-Hand Syndrome Task based mirror therapy, Conventional exercises - Stroke | Not applicable | Recruiting | Riphah International University | 34 | 2025-11-05 | 2026-02-24 |
| Effects of Motor Imagery Technique With and Without Virtual Reality on Pain Intensity ,Functional Disability and Quality of Life in Patient With Post Stroke Shoulder Hand Syndrome motor imagery with virtual reality, motor imagery alone - Complex Regional Pain Syndrome (CRPS), Shoulder Hand Syndrome | Not applicable | Completed | Green International University | 40 | 2025-11-02 | 2026-05-28 |
| Contribution of Immersive Virtual Reality to a Standardized Rehabilitation Program for Upper Limb Chronic Pain: A Single-Case Experimental Design Study H'ability - Complex Regional Pain Syndrome Type I of the Upper Limb | Not applicable | Completed | University Hospital, Angers | 13 | 2024-11-04 | 2026-06-17 |
| The Treatment of Shoulder-hand Syndrome in Hemiplegia Patients Dry Needling, Sham Kinesio taping, Kinesio Taping - Shoulder-hand Syndrome | Not applicable | Completed | Handan Central Hospital | 84 | 2023-11-01 | 2025-11-24 |
| Prism Adaptation Therapy for CRPS Type 1 The Prism Adaptation Therapy Group, The Control Group - Complex Regional Pain Syndrome I (CRPS I), Distal Radius Fracture | Not applicable | Completed | Ankara Etlik City Hospital | 54 | 2023-10-04 | 2026-01-28 |
| Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up Volar locking plate, external fixation - Radius Fracture Distal, Surgery | Not applicable | Unknown | Olof Skoldenberg | 203 | 2022-04-01 | 2022-05-12 |
| Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I) Non-invasive Neuromodulation - Type I Complex Regional Pain Syndrome | Not applicable | Recruiting | University of Las Palmas de Gran Canaria | 42 | 2022-03-28 | 2025-08-28 |
| Fu's Subcutaneous Needling Treatment for Hemiplegic Shoulder Pain Fu's subcutaneous needling (FSN), Rehabilitation - Hemiplegic Shoulder Pain | Not applicable | Completed | China Medical University Hospital | 48 | 2021-11-26 | 2025-04-24 |
| Peripheral Magnetic Stimulation to Treat Patient With Post-stroke Shoulder-hand Syndrome peripheral magnetic stimulation, physical therapy - Reflex Sympathetic Dystrophy of Upper Limb, Stroke | Not applicable | Completed | National Taiwan University Hospital | 25 | 2021-07-22 | 2026-10-16 |
| Embodied Virtual Reality for Chronic Pain Embodied virtual reality - Complex Regional Pain Syndromes, Complex Regional Pain Syndrome Type I of the Upper Limb | Not applicable | Completed | University of Zurich | 29 | 2021-05-31 | 2024-10-18 |
| MTPr With Shockwave on Pain & Function of SHS in Stroke Myofascial trigger points pressure (MTrP) release, Shockwave therapy application, conventional therapy - Stroke | Not applicable | Completed | October 6 University | 30 | 2019-10-01 | 2020-11-13 |
| Audio-Visual Relaxation Technology for Pediatric Amplified Musculoskeletal Pain Syndrome Oculus GO VR HMD, application Happy Place (© Mimerse), iPad, application Happy Place (© Mimerse) - Amplified Musculoskeletal Pain Syndrome, Reflex Sympathetic Dystrophy | Not applicable | Completed | Tufts Medical Center | 30 | 2018-12-20 | 2021-01-26 |
| Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 267 | 2018-05-31 | 2020-08-05 |
| Efficacy and Safety of Intravenous Neridronic Acid in CRPS Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 182 | 2018-05-30 | 2020-08-06 |
| Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Suprascapular and median nerve blocks - Shoulder Hand Syndrome, Complex Regional Pain Syndromes | Phase 4 | Completed | Ottawa Hospital Research Institute | 5 | 2017-10-15 | 2019-09-30 |
| CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation Sham nrTMS and open phase, Active nrTMS and open phase - Transcranial Magnetic Stimulation, Complex Regional Pain Syndrome of Upper Limb (Disorder) | Not applicable | Completed | Helsinki University Central Hospital | 62 | 2017-08-28 | 2024-07-03 |
| Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy Mirror therapy, Usual care - Reflex Sympathetic Dystrophy, Causalgia | Not applicable | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 34 | 2017-06-06 | 2021-01-20 |
| Single-port Thoracoscopic Sympathicotomy in Complex Regional Pain Syndrome Type I (CRPS) unilateral single-port VATS sympathicotomy - Complex Regional Pain Syndrome Type I of the Upper Limb | Not applicable | Withdrawn | University of Groningen | 2015-08-01 | 2016-02-09 |
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Complex Regional Pain Syndromes (23) · Pain (10) · Chronic Pain (6) · Neuralgia (6) · Causalgia (5) · Agnosia (3) · Stroke (3) · Edema (2) · Neuralgia, Postherpetic (2) · Peripheral Nervous System Diseases (2) · Wrist Fractures (2) · Autoimmune Diseases (1) · Charcot-Marie-Tooth Disease (1) · Diabetic Neuropathies (1)
Autonomic Nervous System Diseases (42) · Nervous System Diseases (42) · Neuromuscular Diseases (42) · Peripheral Nervous System Diseases (40) · Pathological Conditions, Signs and Symptoms (20) · Complex Regional Pain Syndromes (19) · Neurologic Manifestations (19) · Signs and Symptoms (19) · Pain (9) · Central Nervous System Diseases (4) · Neuralgia (4) · Wounds and Injuries (4) · Arm Injuries (3) · Brain Diseases (3) · Cardiovascular Diseases (3)
6-amino-1-hydroxyhexane-1,1-diphosphonate (4) · Lenalidomide (2) · Rehabilitation (2) · 1,10-phenanthroline-platinum(II)-ethylenediamine (1) · Acupuncture Therapy (1) · Ascorbic Acid (1) · Bupivacaine (1) · Capsaicin (1) · Diclofenac (1) · Drainage (1) · Dry Needling (1) · Ethosuximide (1) · External Fixators (1) · Immunoglobulins, Intravenous (1) · Mirror Movement Therapy (1)
Grünenthal GmbH (3) · Ruhr University of Bochum (3) · Ambros Therapeutics, Inc. (2) · Celgene Corporation (2) · National Institute of Nursing Research (NINR) (2) · Ankara Etlik City Hospital (1) · Axsome Therapeutics, Inc. (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · China Medical University Hospital (1) · Green International University (1) · Handan Central Hospital (1) · Helsinki University Central Hospital (1) · Jitka Fricova (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Massachusetts General Hospital (1)
United States (15) · Canada (6) · Germany (6) · France (3) · Netherlands (3) · United Kingdom (3) · Australia (2) · China (2) · Czechia (2) · Pakistan (2) · Spain (2) · Taiwan (2) · Austria (1) · Egypt (1) · Finland (1)
Christoph Maier, Prof. Dr. (2) · Barth L Wilsey, MD (1) · Binash Afzal, PHD (1) · Donald C Manning, MD, PhD (1) · Donald Manning, MD, PhD (1) · Eija Kalso, Professor (1) · Geoff A Bellingham, MD FRCPC (1) · Hanna Harno, MD, PhD (1) · Huang Zouqin, Dcctor (1) · Jeffrey J. Borckardt, Ph.D. (1)
PMID 10636366, PMID 12595868, PMID 12749974, PMID 18346583, PMID 20693883, PMID 22022040, PMID 22515496, PMID 23171669, PMID 24668314, PMID 25283471, PMID 25919011, PMID 26628523, PMID 27134626, PMID 28961359, PMID 40626344
2014 (1), 2016 (1), 2017 (1), K23NS050485 (1)