36 completed, 16 unknown, 12 recruiting, 5 active not recruiting. 29 Not applicable, 4 Phase 3, 3 Phase 4, 2 Phase 2, 1 Early Phase 1.
Follow Ehlers-Danlos Syndrome: new trials by email Literature Review of Ehlers-Danlos Syndrome trials Research Report on Ehlers-Danlos Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Exercise and Lifestyle Programme for Adults With Vascular Ehlers-Danlos Syndrome: A Feasibility Study Co-designed exercise-based lifestyle intervention - Vascular Ehlers Danlos Syndrome | Not applicable | Not yet recruiting | Sheffield Hallam University | 40 | 2027-03-01 | 2026-07-13 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution - Ehlers-Danlos Syndrome, Low Back Pain | Phase 3 | Withdrawn | Tulane University | 2026-10-05 | 2026-10-08 | |
| COG+OT Telerehabilitation for Adults With Subjective Cognitive Complaints COG+OT Telerehabilitation - Subjective Cognitive Complaints, Ehlers-Danlos Syndrome | Not applicable | Not yet recruiting | Medical University of South Carolina | 16 | 2026-10-01 | 2026-09-21 |
| STABLE Pilates for Hypermobility Pilates, Education - Ehlers-Danlos Syndrome (EDS), Hypermobile EDS (hEDS) | Not applicable | Recruiting | Brigham and Women's Hospital | 100 | 2026-07-09 | 2026-08-19 |
| Hamstring Strengthening in Hypermobile Conditions Progressive resistance exercise with an emphasis on eccentric hamstring loading. - Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome | Not applicable | Not yet recruiting | University of Calgary | 20 | 2026-06-01 | 2026-06-04 |
| Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01) Ehlers-Danlos Syndrome, Hypermobile, Chronic Pain | Recruiting | Centre Medical ISM (Integrative Systemic Medicine) | 25 | 2026-05-26 | 2026-06-15 | |
| PregnAncy-Related Aortic DISsEction in China Intervention strategies including medication or surgery - Pregnancy Complication, Aortic Dissection | Recruiting | DeltaHealth Hospital · Shanghai | 500 | 2026-03-17 | 2026-07-17 | |
| Metabolic Phenotyping in vEDS No intervention, observational - Vascular Ehlers-Danlos Syndrome, Vascular Ehlers Danlos Syndrome | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 15 | 2026-03-05 | 2026-04-08 | |
| Multicentre Longitudinal Study of Bone Mineralisation Characteristics in Marfan Syndrome and Ehlers-Danlos Syndrome Marfan Syndrome, Ehlers-Danlos Syndrome (EDS) | Not yet recruiting | IRCCS Policlinico S. Donato | 150 | 2025-10-31 | 2025-09-12 | |
| 3D Printed Orthosis for Wrist Instability for Ehlers-Danlos Syndrome Patient 3D scanned and 3D printed wrist hand orthosis - Ehlers-Danlos Syndrome Hypermobility Type (hEDS) | Completed | ELewis | 2 | 2025-08-21 | 2026-09-14 | |
| Impact of Ehlers-Danlos Syndrome on Gynaecological Health Ehlers-Danlos Syndrome (EDS) | Recruiting | University Hospital, Rouen | 156 | 2025-07-07 | 2026-06-10 | |
| National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry whole genome sequencing - Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated | Recruiting | Hospital do Coracao | 1211 | 2025-04-30 | 2026-05-08 | |
| Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome. Enzastaurin, Placebo - Vascular Ehlers-Danlos Syndrome | Phase 3 | Suspended | Aytu BioPharma, Inc. | 260 | 2025-01-01 | 2024-03-08 |
| Evaluation of the Effects of Cross Linking on the Biomechanical Characteristics of Skin Samples From Patients With Classic or Hypermobile Ehlers-Danlos Syndrome skin biopsy - Ehlers-Danlos Syndrome | Not applicable | Unknown | GCS Ramsay Santé pour l'Enseignement et la Recherche | 28 | 2024-09-03 | 2024-06-24 |
| ABVN Phase 2 - EDS Wearable Device ML1101 Stimulus Isolator, Cardiowatch Bracelet - Ehlers-Danlos Syndrome, Healthy Subjects | Not applicable | Completed | Indiana University | 58 | 2024-07-30 | 2026-10-02 |
| The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil - Collagen Degeneration, Wrinkle | Not applicable | Unknown | Integrative Skin Science and Research | 90 | 2024-07-22 | 2024-08-28 |
| Group Coaching Study for Life Goals Group Coaching - Students, Spinal Cord Injury | Not applicable | Enrolling by invitation | Thomas Jefferson University | 100 | 2024-07-01 | 2025-07-24 |
| FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases Alpha-Thalassemia, Beta-Thalassemia | Unknown | xCures | 1000 | 2024-06-10 | 2024-11-14 | |
| Heart Coherence Training on Vascular Ehlers-Danlos Syndrome Patients Heartmath Intervention, Control Group - Vascular Ehlers-Danlos Syndrome | Not applicable | Recruiting | Baylor College of Medicine | 40 | 2024-04-01 | 2024-07-01 |
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Ehlers-Danlos Syndrome, Type IV (16) · Marfan Syndrome (14) · Ehlers-Danlos syndrome type 3 (11) · Loeys-Dietz Syndrome (8) · Aortic Dissection (5) · Fatigue (5) · Pain (5) · Postural Orthostatic Tachycardia Syndrome (5) · Autonomic Nervous System Diseases (4) · Chronic Pain (4) · Joint Instability (4) · Rare Diseases (4) · Aortic Aneurysm, Thoracic (3) · Bicuspid Aortic Valve Disease (3)
Congenital Abnormalities (78) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (78) · Hematologic Diseases (78) · Hemic and Lymphatic Diseases (78) · Hemorrhagic Disorders (78) · Hemostatic Disorders (78) · Skin Abnormalities (78) · Skin Diseases (78) · Skin Diseases, Genetic (78) · Skin and Connective Tissue Diseases (78) · Vascular Diseases (78) · Cardiovascular Diseases (77) · Genetic Diseases, Inborn (77) · Collagen Diseases (76) · Connective Tissue Diseases (75)
Lidocaine (3) · Sodium Chloride (3) · Celiprolol (2) · Glucose (2) · Anti-Inflammatory Agents (1) · BID protein, human (1) · Bupivacaine (1) · Castor Oil (1) · Control Groups (1) · Diet (1) · Drug Implants (1) · Educational Status (1) · Exercise (1) · Exercise Movement Techniques (1) · Genotype (1)
Assistance Publique - Hôpitaux de Paris (4) · University Health Network, Toronto (4) · Genetic Disease Investigators (3) · IRCCS Policlinico S. Donato (3) · GCS Ramsay Santé pour l'Enseignement et la Recherche (2) · Hospices Civils de Lyon (2) · Integrative Skin Science and Research (2) · Medical University of South Carolina (2) · National Human Genome Research Institute (NHGRI) (2) · University of Calgary (2) · University of Zurich (2) · Acer Therapeutics Inc. (1) · Andres Schanzer (1) · Aytu BioPharma, Inc. (1) · Baylor College of Medicine (1)
United States (32) · France (17) · Canada (6) · Italy (4) · United Kingdom (4) · Switzerland (2) · Brazil (1) · China (1) · Denmark (1) · Germany (1) · Spain (1) · Sweden (1)
Diana L Driscoll, O.D. (2) · Satish R Raj, MD MSCI (2) · Adam Strange (1) · Amanda J Miller, Ph.D. (1) · Amel Karaa, MD (1) · Andrea Maier, Dr. (1) · Andres Schanzer, MD (1) · Andrew Brodbelt (1) · Anne Blanchard, MD (1) · Barbara Kroner, PhD, MPH (1) · Benjamin Landis, MD (1) · Beth Darnall, PhD (1) · Boris Bienvenu (1) · Carlos Rafael Ramirez Paesano, MD (1) · Cheryl L. Maslen, Ph.D. (1)
PMID 20825986, PMID 19699898, PMID 21982653, PMID 22104675, PMID 23444191, PMID 23630948, PMID 25595400, PMID 28073822, PMID 32249045, PMID 35816681, PMID 35941284, PMID 36384183, PMID 36526308, PMID 37059239, PMID 37261636, PMID 37330702, PMID 37406924, PMID 38353245, PMID 38989575, PMID 39762099, PMID 39906986, PMID 39963789, PMID 40629345, PMID 41495090, PMID 41775498, PMID 42363793
1OT2OD028183-01 (1), 2015 (1), 268201000048C-5-0-1 (1), N01HV681997 (1), UL1TR001082 (1)