20 terminated. 20 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Terminated 20 |
| Phase 2 | 5 | Terminated 5 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects L-citrulline, Plasmalyte A - Ventricular Septal Defect, Atrioventricular Septal Defect | Phase 3 | Terminated | Asklepion Pharmaceuticals, LLC | 64 | 2022-06-29 | 2024-09-19 |
| Specialized Pacing for Patients With Congenital Heart Disease Closed loop stimulation, Standard rate response - Congenital Heart Disease, Bradycardia Sinus | Phase 2 / Phase 3 | Terminated | University of California, Los Angeles | 4 | 2021-05-09 | 2023-01-20 |
| Propranolol for Epistaxis in Hereditary Hemorrhagic Telangiectasia Patients Propranolol treatment, Placebo - Hereditary Hemorrhagic Telangiectasia, Osler Weber Rendu Disease | Phase 3 | Terminated | University Hospital, Bordeaux | 15 | 2020-06-23 | 2026-06-23 |
| An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients. macitentan 10 mg - Congenital Heart Disease With Fontan Circulation | Phase 3 | Terminated | Actelion | 112 | 2019-04-11 | 2023-03-07 |
| Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants Fenoldopam, 0.9%NS - Patent Ductus Arteriosus (PDA), Acute Kidney Injury (AKI) | Phase 2 / Phase 3 | Terminated | Medical College of Wisconsin | 1 | 2019-02-06 | 2022-09-16 |
| Colchicine in Postoperative Fontan Patients Colchicine - Single-ventricle, Heart Diseases | Phase 2 / Phase 3 | Terminated | University of Michigan | 11 | 2018-08-29 | 2022-05-09 |
| Acetaminophen vs Indomethacin in Treating hsPDA Indomethacin, Acetaminophen - Patent Ductus Arteriosus | Phase 3 | Terminated | University of Tennessee | 37 | 2016-06-01 | 2019-12-03 |
| Effect of Eleclazine on Shortening of the QT Interval, Safety, and Tolerability in Adults With Long QT Syndrome Type 3 Eleclazine, Eleclazine placebo - Long QT Syndrome Type 3 | Phase 3 | Terminated | Gilead Sciences | 41 | 2014-12-17 | 2018-01-12 |
| Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Bevacizumab, placebo - Hereditary Hemorrhagic Telangiectasia, Epistaxis | Phase 2 / Phase 3 | Terminated | Hospices Civils de Lyon | 80 | 2014-04-01 | 2015-11-20 |
| Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome Macitentan 10 mg tablet, once daily. - Pulmonary Arterial Hypertension | Phase 3 | Terminated | Actelion | 217 | 2013-09-10 | 2019-04-16 |
| Right to Left Cardiac Shunt Detection Flow Detection System - Right to Left Shunt, Patent Foramen Ovale | Phase 3 | Terminated | Cardiox Corporation | 141 | 2012-11-01 | 2015-11-13 |
| Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study) Atenolol, Telmisartan - Cardiac Disease | Phase 3 | Terminated | Hamilton Health Sciences Corporation | 85 | 2011-06-01 | 2019-09-18 |
| Cardiox Shunt Detection Technology Study Cardiox FDS - Patent Foramen Ovale | Phase 3 | Terminated | Cardiox Corporation | 71 | 2011-04-01 | 2013-01-09 |
| Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome placebo, Losartan - Marfan Syndrome | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 303 | 2008-09-01 | 2015-11-04 |
| An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants Indomethacin - Patent Ductus Arteriosus | Phase 2 / Phase 3 | Terminated | University of Calgary | 9 | 2008-08-01 | 2016-08-18 |
| Therapy of Pulmonary Arterial Hypertension (PAH) - Treatment With Sildenafil in Eisenmenger Patients Sildenafil, Placebo - Pulmonary Arterial Hypertension (PAH) | Phase 3 | Terminated | Competence Network for Congenital Heart Defects | 24 | 2007-12-01 | 2012-06-06 |
| Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot Dobutamin - Tetralogy of Fallot | Phase 3 | Terminated | Competence Network for Congenital Heart Defects | 53 | 2007-11-01 | 2012-06-06 |
| Effects of PTH Replacement on Bone in Hypoparathyroidism PTH 1-34 - Hypoparathyroidism, DiGeorge Syndrome | Phase 3 | Terminated | National Institute of Dental and Craniofacial Research (NIDCR) | 46 | 2006-10-30 | 2019-08-28 |
| ESCAPE Migraine Trial PFO Closure with Premere investigational device., Medical management/current medications per standard of care by personal physician. - Migraine Disorders, Heart Septal Defects, Atrial | Phase 3 | Terminated | Abbott Medical Devices | 168 | 2005-11-01 | 2019-02-04 |
| Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation Enalapril, Placebo - Heart Defects, Congenital, Heart Septal Defects, Ventricular | Phase 3 | Terminated | University of Utah | 5 | 2004-12-01 | 2014-03-13 |
Ductus Arteriosus, Patent (3) · Foramen Ovale, Patent (3) · Eisenmenger Complex (2) · Epistaxis (2) · Heart Defects, Congenital (2) · Heart Diseases (2) · Heart Septal Defects, Atrial (2) · Heart Septal Defects, Ventricular (2) · Migraine Disorders (2) · Pulmonary Arterial Hypertension (2) · Telangiectasia, Hereditary Hemorrhagic (2) · Univentricular Heart (2) · Acute Kidney Injury (1) · Aortic Aneurysm, Thoracic (1) · Atrioventricular Septal Defect (1)
Cardiovascular Diseases (20) · Congenital Abnormalities (20) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (20) · Heart Defects, Congenital (16) · Heart Diseases (16) · Heart Septal Defects (5) · Respiratory Tract Diseases (5) · Vascular Diseases (5) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Hemic and Lymphatic Diseases (3) · Abnormalities, Multiple (2) · Arrhythmias, Cardiac (2) · Brain Diseases (2)
Indomethacin (2) · macitentan (2) · Acetaminophen (1) · Atenolol (1) · Bevacizumab (1) · Citrulline (1) · Colchicine (1) · Dobutamine (1) · Enalapril (1) · Fenoldopam (1) · Losartan (1) · Parathyroid Hormone (1) · Plasmalyte A (1) · Saline Solution (1) · Sildenafil Citrate (1)
Actelion (2) · Cardiox Corporation (2) · Competence Network for Congenital Heart Defects (2) · Abbott Medical Devices (1) · Asklepion Pharmaceuticals, LLC (1) · Assistance Publique - Hôpitaux de Paris (1) · Gilead Sciences (1) · Hamilton Health Sciences Corporation (1) · Hospices Civils de Lyon (1) · Medical College of Wisconsin (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1) · University Hospital, Bordeaux (1) · University of Calgary (1) · University of California, Los Angeles (1) · University of Michigan (1)
United States (13) · France (6) · Canada (5) · Germany (4) · United Kingdom (3) · China (2) · Poland (2) · Australia (1) · Austria (1) · Bulgaria (1) · Chile (1) · Czechia (1) · Denmark (1) · Greece (1) · Israel (1)
Amuchou S Soraisham, MD, DM (1) · Christopher Mastropietro, MD, FCCM (1) · David Dodick, MD (1) · Gurdyal Kalsi, MD, MFPM (1) · Ingram Schulze-Neick, MD (1) · Jeffrey Segar, MD (1) · Judith Therrien, MD (1) · LuAnn Minich, MD (1) · Michael W Jopling, MD (1) · Philipp Beerbaum, MD (1) · Rachel I Gafni, M.D. (1)
PMID 18628265, PMID 20619242, PMID 21094951, PMID 21163497, PMID 21315203, PMID 22065264, PMID 23258386, PMID 24223740, PMID 24854626, PMID 25313847, PMID 25653299, PMID 25935877, PMID 26052700, PMID 26168357, PMID 26244949, PMID 26283668, PMID 26672023, PMID 27599328, PMID 39607014, PMID 39625244, PMID 4418268, PMID 6338474, PMID 6343572
2014 (1), 2016 (1), 2018 (1), U01HL068269 (1), U01HL068270 (1), U01HL068279 (1), U01HL068281 (1), U01HL068285 (1), U01HL068288 (1), U01HL068290 (1), U01HL068292 (1)