89 completed, 23 unknown, 20 terminated, 16 recruiting. 165 Phase 3, 36 Phase 2.
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale | Phase 3 | Recruiting | Columbia University | 32 | 2026-10-15 | 2026-10-08 |
| A Trial to Assess the Efficacy and Safety of Engasertib in Participants With Moderate to Severe Hereditary Hemorrhagic Telangiectasia (HHT) Engasertib, Placebo - Hereditary Hemorrhagic Telangiectasia | Phase 3 | Recruiting | Vaderis Therapeutics AG | 240 | 2026-09-01 | 2026-09-17 |
| The Efficacy and Safety of Inpegsomatropin Injection in Children With Turner Syndrome (TS) and Short Stature Inpegsomatropin-Injection, Givopegsomatropin Solution Injection - Turner Syndrome | Phase 3 | Recruiting | Xiamen Amoytop Biotech Co., Ltd. | 84 | 2026-07-05 | 2026-07-22 |
| SGLT2 Inhibition With Empagliflozin in Fontan Circulatory Failure Empagliflozin 10 mg, Placebo - Congenital Heart Disease | Phase 3 | Recruiting | Subodh Verma | 410 | 2026-05-29 | 2026-09-02 |
| Evaluation of the Efficacy and Safety of THRV-1268 in Participants With Long QT Syndrome Type 2 (LQTS2) and Type 3 (LQTS3) baseline lead-in, THRV-1268 - Long QT Syndrome (LQTS) 2 | Phase 2 / Phase 3 | Recruiting | Thryv Therapeutics, Inc. | 84 | 2026-03-07 | 2026-09-21 |
| Efficacy and Safety of Anti-angiogenic Therapy With IV Bevacizumab in Patients With Symptomatic Cerebral Arteriovenous Malformations Bevacizumab, Placebo - Cerebral AV Malformation | Phase 2 / Phase 3 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 54 | 2026-01-16 | 2026-01-22 |
| Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders Lonapegsomatropin [SKYTROFA®], Somatropin Pen Injector - Turner Syndrome, Short Stature Homeobox Gene Mutation | Phase 3 | Recruiting | Ascendis Pharma A/S | 186 | 2025-12-12 | 2026-09-30 |
| Deep Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block in Pediatric Cardiac Patients Undergoing Primary Repair of Septal Defects Via Median Sternotomy Deep Parasternal intercostal plane block, Erector Spinae Plane Block, conventional analgesic regimen - Septal Defect | Phase 3 | Not yet recruiting | Ain Shams University | 45 | 2025-03-20 | 2025-03-13 |
| Effect of Sacubitril-Valsartan on Cardiac Structure and Function Entresto Pill, Placebo - Congenital Heart Disease | Phase 3 | Recruiting | Mayo Clinic | 45 | 2025-02-03 | 2026-10-09 |
| Prophylactic IV Paracetamol in Extremely Premature Infants Paracetamol (drug) - Patent Ductus Arteriosus in Preterm Infants, Patent Ductus Arteriosus After Premature Birth | Phase 2 / Phase 3 | Completed | Al-Quds University | 40 | 2025-01-01 | 2026-04-07 |
| Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention Azithromycin 40 MG/ML, Placebo - Tracheomalacia, Bronchopulmonary Dysplasia (BPD) | Phase 3 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 150 | 2024-09-01 | 2024-05-14 |
| SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations QTORIN 3.9% Rapamycin Anhydrous Gel - Microcystic Lymphatic Malformation | Phase 3 | Active not recruiting | Palvella Therapeutics, Inc. | 51 | 2024-07-31 | 2026-03-27 |
| A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections Mavorixafor, Placebo - Neutropenia | Phase 3 | Recruiting | X4 Pharmaceuticals | 176 | 2024-06-06 | 2026-08-06 |
| Comparative Effectiveness of Gadopiclenol for Evaluation of Adult Congenital Heart Anatomy and Hemodynamics Gadopiclenol, Gadobenate dimeglumine - Congenital Heart Disease | Phase 3 | Unknown | University of California, San Diego | 160 | 2024-05-01 | 2024-05-09 |
| Effects of Topical Lidocaine and Benzocaine on Pain Level and Injection Satisfaction Lidocaine Spray: Each ml contained 10 mg lidocaine and ethanol. Applied to the local site to provide anesthesia, Benzocaine spray, Placebo group (control arm) - Pain, Satisfaction | Phase 3 | Completed | TC Erciyes University | 60 | 2024-04-01 | 2025-12-01 |
| A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial) Losartan, Amlodipine, Placebo - Coarctation of Aorta, High Blood Pressure | Phase 3 | Recruiting | Mayo Clinic | 120 | 2024-04-01 | 2026-09-11 |
| Randomised Clinical Trial Comparing Drug-coated Balloon to Plain Balloon for All Peripheral AVF Stenosis Angioplasty of all peripheral AVF stenosis - Arteriovenous Fistula, Arteriovenous Fistula Stenosis | Phase 3 | Recruiting | Singapore General Hospital | 94 | 2024-01-04 | 2024-08-14 |
| PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years Transcatheter PFO closure, Oral Anticoagulant, Direct-Acting, Antiplatelet therapy - Cryptogenic Ischemic Stroke, Patent Foramen Ovale | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 792 | 2023-07-07 | 2026-03-24 |
| Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease Sildenafil, Placebos - Single-ventricle, Pulmonary Hypertension | Phase 3 | Withdrawn | University Hospital, Montpellier | 2023-06-01 | 2023-05-15 |
Showing 20 of 165. Sign in to see all of them.
Heart Defects, Congenital (47) · Ductus Arteriosus, Patent (19) · Turner Syndrome (14) · Foramen Ovale, Patent (10) · Arteriovenous Fistula (9) · Marfan Syndrome (9) · Noonan Syndrome (9) · Telangiectasia, Hereditary Hemorrhagic (9) · Genetic Diseases, Inborn (7) · Heart Septal Defects, Atrial (7) · Univentricular Heart (7) · Epistaxis (6) · Heart Failure (6) · Migraine Disorders (6) · Premature Birth (6)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (165) · Congenital Abnormalities (164) · Cardiovascular Diseases (162) · Heart Diseases (124) · Heart Defects, Congenital (85) · Vascular Diseases (42) · Pathological Conditions, Signs and Symptoms (32) · Genetic Diseases, Inborn (29) · Female Urogenital Diseases and Pregnancy Complications (28) · Urogenital Diseases (28) · Musculoskeletal Diseases (25) · Vascular Malformations (24) · Female Urogenital Diseases (22) · Male Urogenital Diseases (22)
Human Growth Hormone (11) · Acetaminophen (7) · Ibuprofen (7) · Losartan (7) · Atenolol (5) · Sirolimus (5) · Clopidogrel (4) · Indomethacin (4) · Nitric Oxide (4) · Sildenafil Citrate (4) · Sodium Chloride (4) · Triiodothyronine (4) · macitentan (4) · Bevacizumab (3) · Cardiopulmonary Bypass (3)
Novo Nordisk A/S (8) · Assistance Publique - Hôpitaux de Paris (5) · Actelion (4) · Carelon Research (3) · Competence Network for Congenital Heart Defects (3) · Hospices Civils de Lyon (3) · Mayo Clinic (3) · National Cardiovascular Center Harapan Kita Hospital Indonesia (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Sanofi (3) · Asklepion Pharmaceuticals, LLC (2) · Boston Children's Hospital (2) · Cardiox Corporation (2) · Children's Hospital Medical Center, Cincinnati (2) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (2)
United States (71) · France (31) · Canada (20) · United Kingdom (19) · Germany (18) · China (16) · Spain (16) · Italy (14) · Netherlands (14) · Belgium (12) · Israel (10) · Malaysia (10) · Poland (10) · Austria (8) · Russia (8)
Brian McCrindle, MD (2) · Cathy Hammerman, MD (2) · Christoph Male, Prof,MD,PhD (2) · Ida Jovanovic, Prof,MD,PhD (2) · LuAnn Minich, MD (2) · Mark Reisman, MD (2) · Michael Burch, Prof,MD,PhD (2) · Michael Portman, MD (2) · Michiel Dalinghaus, MD,PhD (2) · Sriram Iyer, MD (2) · Vladimir Lomivorotov, PhD (2) · Adelina Pellicer, PhDMD (1)
PMID 17911499, PMID 22065264, PMID 23258386, PMID 36567000, PMID 38825327, PMID 11430325, PMID 12622582, PMID 15784709, PMID 16203673, PMID 16601194, PMID 16647401, PMID 16757526, PMID 16765134, PMID 16769377, PMID 17188612, PMID 17188619, PMID 17210844, PMID 17307535, PMID 17606845, PMID 17962585, PMID 18242267, PMID 18245398, PMID 18341239, PMID 18628265, PMID 19081394, PMID 19117897, PMID 19430350, PMID 19619781, PMID 19953376, PMID 20202971, PMID 20405117, PMID 20453699, PMID 20606124, PMID 20619242, PMID 20625111, PMID 20628774, PMID 20733274, PMID 20837917, PMID 21051670, PMID 21094951, PMID 21163497, PMID 21315203, PMID 21317433, PMID 21576655, PMID 21619701, PMID 21727276, PMID 21784436, PMID 21875911, PMID 22089267, PMID 22192662
2016 (4), U01HL068270 (3), 2004 (2), 2008 (2), 2015 (2), 2017 (2), 2023 (2), R01HL162830 (2), U01HL068269 (2), U01HL068279 (2), U01HL068281 (2), U01HL068285 (2), U01HL068288 (2), U01HL068290 (2), U01HL068292 (2)