11 completed, 6 unknown, 3 terminated, 2 recruiting. 6 Not applicable, 4 Phase 3, 2 Phase 2, 2 Phase 4, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 3, Unknown 2, Terminated 1 |
| Phase 3 | 4 | Completed 2, Terminated 2 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Unknown 1 |
Follow Eisenmenger Complex: new trials by email Literature Review of Eisenmenger Complex trials Research Report on Eisenmenger Complex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sota-ES - Sotatercept in Patients With Congenital Heart Disease and Eisenmenger´s Syndrome Sotatercept - Congenital Heart Disease (CHD), Eisenmenger Syndrome | Phase 2 | Not yet recruiting | Philipps University Marburg | 40 | 2026-09-01 | 2026-03-27 |
| A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy Sotatercept, vasodilator-based PAH therapy - Eisenmenger Syndrome, Pulmonary Arterial Hypertension of Congenital Heart Disease | Phase 4 | Recruiting | Kazuya Hosokawa | 36 | 2025-10-07 | 2026-01-21 |
| Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger Syndrome Pentoxifylline - Eisenmenger Syndrome | Not applicable | Unknown | University of Sao Paulo General Hospital | 48 | 2022-06-03 | 2023-12-15 |
| Real World Difference After Changing Medication From Nonselective to Selective Endothelin Receptor Antagonist in Stable Eisenmenger Syndrome Eisenmenger Complex | Unknown | Samsung Medical Center | 40 | 2021-02-04 | 2021-02-01 | |
| 4DFlow Magnetic Resonance Imaging in Patients With Pulmonary Hypertension Associated With Congenital Heart Disease 4D Flow magnetic resonance imagery, Cardiac catheterization - Congenital Heart Disease, Pulmonary Arterial Hypertension | Not applicable | Completed | Centre Chirurgical Marie Lannelongue | 50 | 2018-05-30 | 2026-05-01 |
| Six Minutes Walk Test and Shuttle Walk Test in Eisenmenger Syndrome Eisenmenger Complex, Pulmonary Hypertension | Unknown | Federal University of São Paulo | 60 | 2016-04-01 | 2016-04-27 | |
| Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome Macitentan 10 mg tablet, once daily. - Pulmonary Arterial Hypertension | Phase 3 | Terminated | Actelion | 217 | 2013-09-10 | 2019-04-16 |
| Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Transcather Valve Implantation - Eisenmenger Syndrome | Not applicable | Completed | University of California, Los Angeles | 90 | 2013-08-01 | 2019-04-30 |
| Sleep-disordered Breathing in Eisenmenger Syndrome Polysomnography - Eisenmenger Syndrome, Congenital Heart Disease | Completed | Copenhagen University Hospital, Rigshospitalet | 20 | 2013-06-01 | 2015-11-25 | |
| Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome Macitentan 10 mg, Placebo - Pulmonary Arterial Hypertension | Phase 3 | Completed | Actelion | 226 | 2013-05-21 | 2018-02-23 |
| Eisenmenger Syndrome in the Nordic Countries Eisenmenger Syndrome | Unknown | Copenhagen University Hospital, Rigshospitalet | 714 | 2012-10-01 | 2015-12-24 | |
| Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline Malate L-Citrulline Malate - Idiopathic Pulmonary Arterial Hypertension, Eisenmenger Syndrome | Early Phase 1 | Unknown | Masih Daneshvari Hospital | 25 | 2012-08-01 | 2013-08-12 |
| Eisenmenger Quality Enhancement Research Initiative Subjects with diagnosis of Eisenmenger Syndrome - Pulmonary Arterial Hypertension | Completed | Actelion | 193 | 2012-07-01 | 2025-02-03 | |
| Effects Oxygen Supplementation Determined Better Exercise Capacity in Eisenmenger Syndrome Oxygen Supplementation - Eisenmenger Complex, Hypertension, Pulmonary | Not applicable | Completed | Federal University of São Paulo | 30 | 2012-01-01 | 2016-01-25 |
| Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart Defects respiratory and exercise therapy - Pulmonary Arterial Hypertension, Eisenmenger Syndrome | Not applicable | Unknown | Heidelberg University | 50 | 2012-01-01 | 2022-07-14 |
| Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart Disease Iloprost - Pulmonary Arterial Hypertension, Congenital Heart Disease | Not applicable | Terminated | University of California, Los Angeles | 5 | 2011-06-01 | 2015-01-26 |
| Phosphodiesterase-5 Inhibitor in Eisenmenger Syndrome Tadalafil, placebo - Eisenmenger Syndrome | Phase 2 | Completed | Govind Ballabh Pant Hospital | 28 | 2008-02-01 | 2010-09-14 |
| Therapy of Pulmonary Arterial Hypertension (PAH) - Treatment With Sildenafil in Eisenmenger Patients Sildenafil, Placebo - Pulmonary Arterial Hypertension (PAH) | Phase 3 | Terminated | Competence Network for Congenital Heart Defects | 24 | 2007-12-01 | 2012-06-06 |
| The Effects of Inhaled Iloprost on Congenital Heart Disease With Eisenmenger Syndrome Eisenmenger's Syndrome | Completed | Gachon University Gil Medical Center | 12 | 2007-09-01 | 2011-01-26 | |
| COMPERA / COMPERA-KIDS Pulmonary Arterial Hypertension (PAH), Pulmonary Hypertension (PH) | Recruiting | Technische Universität Dresden | 14000 | 2007-07-01 | 2025-08-24 |
Showing 20 of 23. Sign in to see all of them.
Pulmonary Arterial Hypertension (10) · Heart Defects, Congenital (8) · Hypertension, Pulmonary (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Familial Primary Pulmonary Hypertension (1) · Hypertension (1) · Pulmonary Heart Disease (1) · Sleep Apnea Syndromes (1) · Thrombosis (1)
Cardiovascular Abnormalities (23) · Cardiovascular Diseases (23) · Congenital Abnormalities (23) · Heart Diseases (23) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (22) · Respiratory Tract Diseases (16) · Heart Defects, Congenital (15) · Lung Diseases (15) · Hypertension, Pulmonary (10) · Vascular Diseases (6) · Hypertension (5) · Apnea (1) · Dyssomnias (1) · Embolism and Thrombosis (1) · Nervous System Diseases (1)
ACE-011 (2) · Sildenafil Citrate (2) · macitentan (2) · Bosentan (1) · Cardiac Catheterization (1) · Exercise Therapy (1) · Iloprost (1) · Pentoxifylline (1) · Respiratory Rate (1) · Tablets (1) · Tadalafil (1)
Actelion (3) · Copenhagen University Hospital, Rigshospitalet (3) · Competence Network for Congenital Heart Defects (2) · Federal University of São Paulo (2) · University of California, Los Angeles (2) · Centre Chirurgical Marie Lannelongue (1) · Children's Healthcare of Atlanta (1) · Gachon University Gil Medical Center (1) · Govind Ballabh Pant Hospital (1) · Heidelberg University (1) · Kazuya Hosokawa (1) · Masih Daneshvari Hospital (1) · Philipps University Marburg (1) · Samsung Medical Center (1) · Technische Universität Dresden (1)
Germany (6) · United States (5) · France (3) · Austria (2) · Brazil (2) · Bulgaria (2) · Chile (2) · China (2) · Denmark (2) · Greece (2) · Malaysia (2) · Mexico (2) · Philippines (2) · Poland (2) · Portugal (2)
Ingram Schulze-Neick, MD (2) · Antonio Augusto Barbosa Lopes, MD (1) · Ardeschir H. Ghofrani, MD, PhD (1) · Christian Opitz, MD, PhD (1) · Dario Vizza, MD, PhD (1) · David Pittrow, MD, PhD (1) · Ekkehard Gruenig, MD (1) · Gary Palmer, MD, MBA (1) · Harald Kaemmerer, MD, PhD (1) · Jamil A Aboulhosn, MD (1) · Jamil A Aboulhosn, MD, FACC (1) · Karen Olsson, MD, PhD (1) · Laion Gonzaga, PT (1)
PMID 20202971, PMID 21914136, PMID 23164592, PMID 23720182, PMID 24081973, PMID 26630396, PMID 28775047, PMID 29368137, PMID 29450722, PMID 29599117, PMID 30337446, PMID 30586694, PMID 32414075, PMID 33581097, PMID 34737226, PMID 35070795, PMID 35777416, PMID 36333206, PMID 37105586, PMID 37462520, PMID 37802633, PMID 41819579