104 completed. 104 Phase 2, 23 Phase 1, 11 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 104 | Completed 104 |
| Phase 1 | 23 | Completed 23 |
| Phase 3 | 11 | Completed 11 |
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BCAAs in Concussion 2.0 BCAA, Placebo - Concussion, Brain, Concussion, Mild | Phase 2 | Completed | Akiva Cohen | 17 | 2025-04-01 | 2026-09-03 |
| Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial Cannabidiol, Placebo - Brain Injuries, Traumatic | Phase 2 | Completed | University of Colorado, Denver | 43 | 2023-04-11 | 2025-12-17 |
| Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin melatonin, placebo - Traumatic Brain Injury, Critical Illness | Phase 2 | Completed | Oregon Health and Science University | 21 | 2023-01-02 | 2025-08-20 |
| Cold-stored Platelet Early Intervention in TBI Cold Stored Platelets, Standard Care - Traumatic Brain Injury | Phase 2 | Completed | Jason Sperry | 100 | 2022-03-21 | 2025-05-11 |
| Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors The combined supplement of Ascorbic acid, Thiamine, and Cortisol, Placebo - Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome | Phase 2 | Completed | Asan Medical Center | 160 | 2021-12-31 | 2025-06-11 |
| Outcomes of Autologous Bone Marrow-derived Mononuclear Cell Transplantation in the Management of Neurological Sequelae autologous bone marrow-derived mononuclear cell transplantation, Rehabilitation therapy - Sequelae of Injuries of Head | Phase 1 / Phase 2 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 50 | 2021-04-01 | 2024-10-01 |
| Ghrelin (OXE--103) for Acute Concussion Management Ghrelin (OXE-103), Placebo - Concussion, Brain, Traumatic Brain Injury | Phase 2 | Completed | Michael Rippee | 23 | 2020-10-20 | 2024-05-21 |
| Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest Methylprednisolone, Isotonic saline - Out-Of-Hospital Cardiac Arrest, Cardiac Arrest | Phase 2 | Completed | Christian Hassager | 158 | 2020-10-10 | 2023-03-29 |
| A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy HB-adMSCs - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Hope Biosciences LLC | 24 | 2020-01-01 | 2026-01-15 |
| Vitamin C in Post-cardiac Arrest Vitamin C, Thiamine, Placebos - Cardiac Arrest | Phase 2 | Completed | Amsterdam UMC, location VUmc | 270 | 2019-10-07 | 2025-03-10 |
| Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients N-Acetyl cysteine - Traumatic Brain Injury | Phase 2 | Completed | HonorHealth Research Institute | 92 | 2019-09-01 | 2026-05-01 |
| RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD) Reconsolidation of Traumatic Memories (RTM), Prolonged Exposure (PE) - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 / Phase 3 | Completed | Uniformed Services University of the Health Sciences | 94 | 2019-06-12 | 2025-07-15 |
| Evaluation the Effects of French Maritime Pine Bark Extract on the Clinical Status in Traumatic Brain Injury Patients Dietary Supplement (OLIGOPIN), Placebo - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Mashhad University of Medical Sciences | 67 | 2019-04-14 | 2020-05-21 |
| Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache AMG 334 - Post-Traumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Completed | Danish Headache Center | 100 | 2019-04-05 | 2020-02-10 |
| Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study Tranexamic Acid, Placebo - Brain Injuries, Wounds and Injuries | Phase 2 | Completed | Daniel Nishijima, MD, MAS | 31 | 2019-03-04 | 2021-09-05 |
| 3MDR to Treat PTSD With mTBI (3MDR) Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) Therapy - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 | Completed | Walter Reed National Military Medical Center | 20 | 2019-01-11 | 2025-07-18 |
| Effects of Peer Mentoring on Caregivers of Patients With Acquired Brain Injury one-to-one peer mentoring - Acquired Brain Injury, Family Members | Phase 2 | Completed | Shepherd Center, Atlanta GA | 41 | 2019-01-08 | 2021-04-20 |
| Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Bromocriptine 5 MG, Acetaminophen 650 MG - Subarachnoid Hemorrhage, Subdural Hematoma | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 47 | 2018-11-30 | 2021-06-24 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury Placebo, AVP-786-28, AVP-786-42.63 - Neurobehavioral Disinhibition | Phase 2 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 168 | 2017-05-30 | 2025-10-29 |
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Brain Injuries, Traumatic (68) · Brain Concussion (10) · Stroke (9) · Post-Concussion Syndrome (8) · Post-Traumatic Headache (5) · Stress Disorders, Post-Traumatic (5) · Cerebral Palsy (4) · Headache (4) · Trauma, Nervous System (4) · Wounds and Injuries (4) · Chronic Traumatic Encephalopathy (3) · Consciousness Disorders (3) · Heart Arrest (3) · Post-Cardiac Arrest Syndrome (3)
Nervous System Diseases (104) · Brain Diseases (103) · Central Nervous System Diseases (102) · Craniocerebral Trauma (99) · Trauma, Nervous System (98) · Wounds and Injuries (98) · Pathological Conditions, Signs and Symptoms (37) · Signs and Symptoms (25) · Cardiovascular Diseases (19) · Vascular Diseases (18) · Mental Disorders (17) · Pathologic Processes (17) · Cerebrovascular Disorders (15) · Neurologic Manifestations (15)
Sodium Chloride (6) · Hyperbaric Oxygenation (5) · Saline Solution (5) · Acetylcysteine (4) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3) · Acetaminophen (2) · Ascorbic Acid (2) · Hydrocortisone (2) · Magnetic Resonance Spectroscopy (2) · Melatonin (2) · Methylphenidate (2) · Oxyhemoglobins (2) · Sertraline (2) · Standard of Care (2) · Therapeutics (2)
University of Washington (4) · National Institutes of Health Clinical Center (CC) (3) · The University of Texas Health Science Center, Houston (3) · University of Pennsylvania (3) · Avid Radiopharmaceuticals (2) · Neuren Pharmaceuticals Limited (2) · U.S. Army Medical Research and Development Command (2) · Uniformed Services University of the Health Sciences (2) · University of British Columbia (2) · University of Calgary (2) · University of California, San Francisco (2) · University of Magdeburg (2) · University of Pittsburgh (2) · University of Sao Paulo (2) · VA Office of Research and Development (2)
United States (71) · Canada (8) · Denmark (4) · Germany (3) · United Kingdom (3) · Australia (2) · Brazil (2) · Iran (2) · New Zealand (2) · Spain (2) · Austria (1) · Belgium (1) · China (1) · France (1) · Israel (1)
Charles S Cox, Jr., M.D. (2) · Charles S Cox, MD (2) · Eric M Wassermann, M.D. (2) · Jeanne M Hoffman, PhD (2) · Leighton Chan, M.D. (2) · Lindell K. Weaver, MD (2) · Ramon R. Diaz-Arrastia, MD, PhD (2) · Ross R Bullock, M.D., PhD (2) · Alexander A Ostanin, MD, PhD (1) · Alice Rose (1) · Allen Lamb, DO (1) · Allen Thornton (1) · Allen W Brown, MD (1) · Angelique ME Spoelstra-de Man, Dr. (1)
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