6 completed, 4 withdrawn, 3 terminated, 2 recruiting. 18 Phase 2, 4 Phase 1, 1 Phase 3.
Follow Brain Edema: new trials by email Literature Review of Brain Edema trials Research Report on Brain Edema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases Recombinant Human Endostatin (Endostar) - Lung Cancer (Non-Small Cell), Radiation | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 49 | 2026-09-01 | 2026-10-01 |
| Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema Salovum/SPC flakes - Glioblastoma, Cerebral Metastases | Phase 2 | Recruiting | Peter Siesjö | 20 | 2024-01-27 | 2025-01-27 |
| Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury ABX-101 1mg, ABX-101 2mg - Traumatic Brain Injury, Cerebral Edema | Phase 2 | Unknown | Abalonex, LLC | 45 | 2023-12-01 | 2023-10-23 |
| A Trial of HRS8179 on Brain Swelling After Large Hemispheric Infarction HRS8179, Placebo - Brain Swelling, Large Hemispheric Infarction | Phase 2 | Completed | Beijing Suncadia Pharmaceuticals Co., Ltd | 40 | 2023-04-07 | 2025-01-06 |
| Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) MW189, Saline - Intracerebral Hemorrhage | Phase 2 | Active not recruiting | Johns Hopkins University | 120 | 2022-10-10 | 2026-04-02 |
| Antisecretory Factor In Severe Traumatic Brain Injury Salovum, Placebo egg yolk powder - Traumatic Brain Injury | Phase 2 | Recruiting | Peter Siesjö | 20 | 2020-03-10 | 2026-01-21 |
| Antisecretory Factor in Primary Glioblastoma 1 Salovum - Glioblastoma, Cerebral Edema | Phase 1 / Phase 2 | Completed | Peter Siesjö | 8 | 2019-09-01 | 2021-04-28 |
| Anti-secretory Factor as a Treatment for Adults With Severe Traumatic Head Injury Salovum - Head Trauma, Intensive Care Neurological Disorder | Phase 2 | Withdrawn | Peter Siesjö | 2018-03-01 | 2018-12-12 | |
| Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism Glibenclamide, Placebo - Acute Stroke | Phase 2 / Phase 3 | Completed | Nanfang Hospital, Southern Medical University | 306 | 2018-01-01 | 2023-06-12 |
| Glyburide vs Placebo as Prophylaxis Against Cerebral Edema in Patients Receiving Radiosurgery for Brain Metastases (RAD 1502/UAB 1593) Glyburide, Placebo - Cerebral Edema, Brain Metastases | Phase 1 / Phase 2 | Terminated | University of Alabama at Birmingham | 1 | 2017-08-16 | 2022-09-21 |
| Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access Intraosseous, Hypertonic saline - Stroke, Intracranial Hypotension | Phase 2 | Completed | Ohio State University | 6 | 2017-04-21 | 2019-07-09 |
| Sevoflurane in Subarachnoidal Haemorrhage Sevoflurane, Propofol, Midazolam - Subarachnoid Haemorrhage (SAH) | Phase 2 | Withdrawn | University of Zurich | 2015-11-01 | 2020-06-02 | |
| Study of Stroke Related Edema Treatments Conivaptan, Hypertonic saline, Mannitol - Acute Cerebrovascular Accident, Cerebral Edema | Phase 2 | Withdrawn | University of Florida | 2015-09-01 | 2016-12-14 | |
| Histamine Glutamate Antagonism in Stroke Diphenhydramine, Pantoprazole, Famotidine - Acute Cerebrovascular Accident, Cerebral Edema | Phase 2 | Completed | University of Florida | 3 | 2014-12-01 | 2015-12-15 |
| Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium) - Traumatic Brain Injury, Subdural Hematoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2012-07-01 | 2016-12-12 | |
| Tolerability Study of Xerecept® in Pediatric Patients XERECEPT - Brain Edema, Brain Tumor | Phase 1 / Phase 2 | Terminated | Celtic Pharma Development Services | 15 | 2010-06-01 | 2013-07-30 |
| Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants Therapeutic Hypothermia, Standard of Care Therapy - Urea Cycle Disorders, Organic Acidemias | Phase 2 | Completed | Uta Lichter-Konecki | 5 | 2007-08-01 | 2015-06-01 |
| Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme Boswellia serrata extract, cyanocobalamin - Brain and Central Nervous System Tumors, Cerebral Edema | Phase 2 | Terminated | Ali Altunkaya | 12 | 2004-09-01 | 2019-04-30 |
Brain Injuries, Traumatic (4) · Stroke (4) · Glioblastoma (3) · Brain Diseases (2) · Brain Injuries (2) · Brain Neoplasms (2) · Craniocerebral Trauma (2) · Ischemic Stroke (2) · Argininosuccinic Aciduria (1) · Astrocytoma (1) · Brain Contusion (1) · Carbamoyl-Phosphate Synthase I Deficiency Disease (1) · Carcinoma, Non-Small-Cell Lung (1) · Central Nervous System Diseases (1)
Central Nervous System Diseases (17) · Nervous System Diseases (17) · Brain Diseases (16) · Cardiovascular Diseases (7) · Cerebrovascular Disorders (7) · Vascular Diseases (7) · Neoplasms (6) · Neoplasms by Site (5) · Pathological Conditions, Signs and Symptoms (5) · Trauma, Nervous System (5) · Nervous System Neoplasms (4) · Pathologic Processes (4) · Wounds and Injuries (4) · Brain Injuries (3) · Central Nervous System Neoplasms (3)
Saline Solution, Hypertonic (3) · Glyburide (2) · Mannitol (2) · Sodium Chloride (2) · antisecretory factor (2) · Acetazolamide (1) · Continuous Renal Replacement Therapy (1) · Cool-Down Exercise (1) · Corticotropin-Releasing Hormone (1) · Cryotherapy (1) · Dextromethorphan (1) · Dialysis (1) · Diphenhydramine (1) · Endostatins (1) · Famotidine (1)
Peter Siesjö (4) · University of Florida (2) · Abalonex, LLC (1) · Ali Altunkaya (1) · Beijing Suncadia Pharmaceuticals Co., Ltd (1) · Celtic Pharma Development Services (1) · Jiangmen Central Hospital (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Nanfang Hospital, Southern Medical University (1) · Ohio State University (1) · University of Alabama at Birmingham (1) · University of Zurich (1) · Uta Lichter-Konecki (1)
United States (7) · Sweden (3) · China (2) · Switzerland (1)
Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · David Cederberg, Consultant (1) · Emanuela Keller, MD Prof. (1) · Glen Stevens, DO, PhD (1) · Linda Van Eldik (1) · Michael F Waters, MD (1) · Sameer A Sheth, MD PhD (1) · Stewart Goldman, MD (1) · Suyue Pan, M.D., Ph.D. (1) · Uta Lichter-Konecki, MD, PhD (1) · Vishnumurthy S Hedna, MD (1) · Vishnumurthy Shushuthra Hedna, MD (1)
PMID 32527232, PMID 36803465, PMID 37919545, PMID 37965431, PMID 39920739, PMID 40236420, PMID 41040632
2019 (1), R01AG069930 (1), R21CA107277 (1)