55 unknown, 12 completed, 5 not yet recruiting, 4 recruiting. 54 Phase 2, 10 Phase 3, 7 Phase 1, 6 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 54 | Unknown 38, Completed 7, Not yet recruiting 5, Recruiting 4 |
| Phase 3 | 10 | Unknown 8, Completed 2 |
| Phase 1 | 7 | Completed 3, Unknown 3, Terminated 1 |
| Phase 4 | 6 | Unknown 5, Completed 1 |
Follow Endostatins: new trials by email Literature Review of Endostatins trials Research Report on Endostatins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases Recombinant Human Endostatin (Endostar) - Lung Cancer (Non-Small Cell), Radiation | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 49 | 2026-09-01 | 2026-10-01 |
| Platinum-Free Regimen in Nasopharyngeal Carcinoma Endostar (recombinant human endostatin injection) - Nasopharyngeal Cancinoma (NPC) | Phase 2 | Not yet recruiting | Zhejiang Cancer Hospital | 145 | 2026-09-01 | 2026-08-31 |
| Efficacy and Safety of Sintilimab Combined with Nab-PP Plus Rh-endostatin in Locally Advanced/advanced and Recurrent Metastatic Squamous Non-small Cell Lung Cancer: a Single-arm, Multicenter Clinical Study Sintilimab, albumin-bound paclitaxel plus platinum agent (Nab-PP), and recombinant human endostatin - Squamous Non-Small Cell Lung Cancer SqNSCLC | Phase 2 | Not yet recruiting | Jian-Guo Zhou, MD, PhD | 32 | 2024-12-17 | 2024-12-27 |
| Local Injection and Systemic Therapy in the Treatment of NSCLC. Envafolimab, Recombinant human endostatin, recombinant human adenovirus type 5 - Non-small Cell Lung Cancer | Phase 2 | Not yet recruiting | Henan Cancer Hospital | 84 | 2024-10-08 | 2024-10-01 |
| GEP Combined With Radiotherapy in Non-locally Treatable Recurrent NPC GEP (Gemcitabine, Recombinant Human Endostatin, and Carrellizumab) Combined With High-low-dose Radiotherapy - Nasopharynx Cancer | Phase 2 | Not yet recruiting | Zhejiang Cancer Hospital | 41 | 2024-09-30 | 2024-09-25 |
| Tislelizumab Combined With Recombinant Human Endostatin Combined With Chemotherapy for Unresectable Stage III Non-small Cell Lung Cancer. neoadjuvant therapy:Tislelizumab With Recombinant human endostatin combined with Chemotherapy, surgery, Adjuvant therapy:Tislelizumab and Recombinant Human Endostatin Injection (Endostar) - Unresectable Non-small Cell Lung Cancer | Phase 2 | Recruiting | Hua Zhang | 36 | 2024-08-27 | 2025-07-15 |
| Endostar Combined With SBRT and Envafolimab in the Treatment of Advanced Gastrointestinal Tumors Envafolimab Injection, Endostar - Gastrointestinal Neoplasms | Phase 2 | Unknown | Nanjing First Hospital, Nanjing Medical University | 16 | 2024-02-21 | 2024-03-08 |
| Recombinant Human Endostatin Combined With Envafolimab and Synchronal Radiochemotherapy Recombinant Human Endostatin Injection - Locally Advanced Squamous Non-small Cell Lung Cancer | Phase 2 | Unknown | The First Affiliated Hospital of Xinxiang Medical College | 30 | 2024-02-18 | 2024-02-28 |
| Envafolimab Combined With Recombinant Human Endostatin and First-line Chemotherapy Treat of Advanced Mucosal Melanoma Envafolimab combined with recombinant human endostatin and first-line chemotherapy - Advanced Mucosal Melanoma | Phase 2 | Unknown | Fudan University | 46 | 2023-09-18 | 2023-09-18 |
| A Clinical Study of Recombinant Human Vascular Endothelial Inhibitor in Combination With PRaG for Advanced Refractory Non-small Cell Lung Cancer Radiotherapy, PD-1/PD-L1 inhibitor, Granulocyte-macrophage colony-stimulating factor subcutaneous injection - Advanced Solid Tumor, Refractory Tumor | Phase 2 | Unknown | Second Affiliated Hospital of Soochow University | 30 | 2023-06-16 | 2023-09-21 |
| Envafolimab Combined With Endostar and Concurrent Chemoradiotherapy for Locally Advanced Primary Cervical Cancer cis-platinum, radiation, Envafolimab Injection - Cervical Cancer | Unknown | Peking University Third Hospital | 30 | 2023-05-16 | 2023-05-30 | |
| Effect and Safety of Envafolimab Combined With Endostar/S-1 in Second-line of Advanced Non-small Cell Lung Cancer Envafolimab plus Endostar and S-1, Envafolimab plus Endostar, Envafolimab plus S-1 - Carcinoma, Non-Small-Cell Lung | Phase 2 | Unknown | Anhui Chest Hospital | 45 | 2022-09-18 | 2022-09-07 |
| Envafolimab Combined With Endostatin in Recurrent or Metastatic MSS-type Colorectal Cancer Envafolimab, recombinant human endostatin (endostatin) - Colorectal Neoplasms | Phase 2 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 30 | 2022-09-15 | 2022-09-22 |
| Radiotherapy Combined With Endostatin and Capecitabine for NPC Endostatin and Capecitabine - Nasopharyngeal Carcinoma | Phase 2 | Recruiting | Zhejiang Cancer Hospital | 41 | 2022-08-01 | 2022-08-24 |
| Recombinant Human Angioendostatin /PD-1 Mab Combined With First-line Chemotherapy in the Treatment of Driver Gene Negative Advanced NSCLC Endostatin - Non Small Cell Lung Cancer, Endostatin | Phase 2 | Unknown | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | 38 | 2022-07-20 | 2022-07-07 |
| Preoperative Short Course Radiotherapy With Envafolimab, Endostatin and SOX Regimen in Locally Advanced Gastric Envafolimab - Gastric/Gastroesophageal Junction Adenocarcinoma, Radiotherapy | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 35 | 2022-05-30 | 2022-05-24 |
| A Clinical Study of Immunotherapy Combined With Chemotherapy and Anti-angiogenic Therapy in Operable NSCLC envafolimab - Non-small Cell Lung Cancer | Phase 2 | Unknown | Second Xiangya Hospital of Central South University | 42 | 2022-05-15 | 2022-05-04 |
| Modified CV Regimen in Optic Pathway Glioma Carboplatin, Vincristine, Recombinant human endostatin - Optic Glioma, Pediatric Brain Tumor, Optic Nerve Glioma | Phase 2 | Recruiting | Beijing Sanbo Brain Hospital | 75 | 2022-04-13 | 2024-10-15 |
| Envafolimab Combined With Endostar and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer Envafolimab, Endostar, Nab paclitaxel - Advanced Pancreatic Cancer | Phase 2 | Unknown | The Affiliated Hospital of Xuzhou Medical University | 20 | 2022-04-01 | 2022-03-28 |
| Envafolimab Combined With Chemotherapy and Recombinant Human Endostatin in the First-line Treatment of Sq-NSCLC "Envafolimab" and "Chemotherapy" and "Recombinant Human Endostatin" - Squamous Non-small Cell Lung Cancer | Phase 2 | Unknown | Qilu Hospital of Shandong University | 46 | 2021-12-03 | 2022-02-17 |
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Carcinoma, Non-Small-Cell Lung (22) · Nasopharyngeal Carcinoma (7) · Breast Neoplasms (4) · Colorectal Neoplasms (4) · Lung Neoplasms (3) · Nasopharyngeal Neoplasms (3) · Uterine Cervical Neoplasms (3) · Head and Neck Neoplasms (2) · Neoplasms (2) · Recurrence (2) · Sarcoma (2) · Adenocarcinoma of Lung (1) · Adenoma, Islet Cell (1) · Adenoviridae Infections (1) · Brain Edema (1)
Zhejiang Cancer Hospital (9) · Sun Yat-sen University (4) · Fudan University (3) · Simcere Pharmaceutical Co., Ltd (3) · Tianjin Medical University Cancer Institute and Hospital (3) · Xijing Hospital (3) · Beijing Sanbo Brain Hospital (2) · Peking University Third Hospital (2) · Zhejiang University (2) · Affiliated Cancer Hospital & Institute of Guangzhou Medical University (1) · Anhui Chest Hospital (1) · Anhui Provincial Hospital (1) · Beijing Tiantan Hospital (1) · China International Medical Foundation (1) · China Medical University, China (1)
China (58) · United States (3)
Jianghao Chen, MD, PhD (2) · Ling Wang, MD (2) · Bin Li (1) · Degan Lu, professor (1) · Enxiao Li (1) · Fei Han, M.D., Ph.D. (1) · Fu Zhao (1) · Hanmei Lou, PHD (1) · Hongbo Wu, M.D. (1) · Hui Bu (1) · Huiqiang Huang, Ph.D (1) · James P. Thomas, MD, PhD (1) · Jianhua Chang, MD,PhD (1) · Jie He, M.D. & Ph.D. (1)
PMID 10640954, PMID 11212235, PMID 15172975, PMID 15746043, PMID 15752890, PMID 15920746, PMID 16012180, PMID 16139912, PMID 16807466, PMID 17426445, PMID 19564532, PMID 19692680, PMID 21108883, PMID 22209574, PMID 22496834, PMID 22537906, PMID 22562140, PMID 23670576, PMID 23693018, PMID 24662947, PMID 25198661, PMID 25244494, PMID 25497558, PMID 26434908, PMID 27067521, PMID 27566586, PMID 29238974, PMID 30773184, PMID 30850562, PMID 34154614, PMID 38700579, PMID 41049580, PMID 42291342
P30CA014520 (1)