5 completed, 3 terminated, 1 withdrawn. 9 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 5, Terminated 3, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Brain Edema: new trials by email Literature Review of Brain Edema trials Research Report on Brain Edema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| "The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients" Trimetazidine - Acute Ischemic Stroke | Phase 3 | Completed | Ain Shams University | 60 | 2024-09-01 | 2025-09-08 |
| Trial of Dexamethasone for Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema Dexamethasone Oral, Placebo oral tablet - Traumatic Brain Injury, Cerebral Edema | Phase 3 | Terminated | Jon Pérez Bárcena | 600 | 2020-07-24 | 2026-02-06 |
| Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction BIIB093, Placebo - Brain Edema, Stroke, Acute | Phase 3 | Terminated | Remedy Pharmaceuticals, Inc. | 535 | 2018-08-29 | 2024-11-25 |
| Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism Glibenclamide, Placebo - Acute Stroke | Phase 2 / Phase 3 | Completed | Nanfang Hospital, Southern Medical University | 306 | 2018-01-01 | 2023-06-12 |
| Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis 0.45% saline replacement fluid, 0.9% saline replacement fluid, 0.45% saline intravenous fluid - Cerebral Edema, Diabetic Ketoacidosis | Phase 3 | Completed | University of California, Davis | 1389 | 2010-11-01 | 2018-06-25 |
| XERECEPT® (hCRF) for Primary Glioma Patients Requiring Dexamethasone to Treat Peritumoral Brain Edema hCRF, placebo hCRF - Brain Edema, Brain Tumor | Phase 3 | Withdrawn | Celtic Pharma Development Services | 120 | 2006-01-01 | 2008-01-03 |
| An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies hCRF [XERECEPT (corticorelin acetate injection)] - Brain Edema, Brain Tumor | Phase 3 | Completed | Celtic Pharma Development Services | 112 | 2005-07-01 | 2012-08-31 |
| XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors hCRF, placebo hCRF - Brain Edema, Brain Tumor | Phase 3 | Completed | Celtic Pharma Development Services | 200 | 2004-05-01 | 2014-08-13 |
| Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Decompressive hemicraniectomy and duraplasty, hemicraniectomy - Malignant Middle Cerebral Artery Infarction | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 60 | 2001-12-01 | 2008-01-17 |
Edema (4) · Astrocytoma (3) · Brain Neoplasms (3) · Ischemic Stroke (2) · Stroke (2) · Brain Diseases (1) · Brain Injuries, Traumatic (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Cerebrovascular Disorders (1) · Contusions (1) · Diabetic Ketoacidosis (1) · Infarction (1) · Vascular Diseases (1)
Nervous System Diseases (9) · Brain Diseases (8) · Central Nervous System Diseases (8) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (4) · Central Nervous System Neoplasms (3) · Glioma (3) · Neoplasms (3) · Neoplasms by Histologic Type (3) · Neoplasms by Site (3) · Neoplasms, Germ Cell and Embryonal (3) · Neoplasms, Glandular and Epithelial (3) · Neoplasms, Nerve Tissue (3) · Neoplasms, Neuroepithelial (3) · Nervous System Neoplasms (3)
Corticotropin-Releasing Hormone (3) · Glyburide (2) · Dexamethasone (1) · Trimetazidine (1)
Celtic Pharma Development Services (3) · Ain Shams University (1) · Assistance Publique - Hôpitaux de Paris (1) · Jon Pérez Bárcena (1) · Nanfang Hospital, Southern Medical University (1) · Remedy Pharmaceuticals, Inc. (1) · University of California, Davis (1)
United States (5) · Canada (4) · China (2) · France (2) · Spain (2) · Australia (1) · Belgium (1) · Brazil (1) · Croatia (1) · Czechia (1) · Denmark (1) · Egypt (1) · Finland (1) · Germany (1) · Hungary (1)
William Shapiro, MD (3) · Nathan Kuppermann, MD, MPH (1) · Nicole S Glaser, MD (1) · Suyue Pan, M.D., Ph.D. (1)
PMID 17303527, PMID 23382470, PMID 32527232, PMID 33546038, PMID 37449423, PMID 37965431, PMID 39577921
2017 (1), 2019 (1), U01HD062417 (1)