18 completed, 3 not yet recruiting, 3 unknown, 2 recruiting. 10 Not applicable, 9 Phase 1, 9 Phase 2, 6 Phase 4, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remimazolam-Flumazenil Versus Sevoflurane for Hysteroscopic Day Surgery Remimazolam, Flumazenil, Sevoflurane - Hysteroscopy, Ambulatory Surgery | Phase 4 | Not yet recruiting | Chung-Ang University Gwangmyeong Hospital | 124 | 2026-06-01 | 2026-06-23 |
| Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy Flumazenil, Electroconvulsive therapy (ECT) - Depression - Major Depressive Disorder, Bipolar Disorder (BD) | Not applicable | Recruiting | Anders Jørgensen | 145 | 2026-01-15 | 2026-06-01 |
| The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hip Arthroplasty Under Spinal Anesthesia remimazolam sedation reversal with flumazenil, placebo - Postoperative Delirium, Sedation | Phase 4 | Not yet recruiting | Medical University of Gdansk | 150 | 2026-01-01 | 2026-01-06 |
| Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery Remimazolam with Flumazenil, Propofol - Emergence Agitation | Not applicable | Not yet recruiting | Seoul National University Hospital | 204 | 2026-01-01 | 2025-12-04 |
| Effect of Remazolam on Anesthesia Recovery in Patients Undergoing Fundus Surgery ciprofol, Remazolam, Flumazenil - Remazolam Anesthesia, Postoperative Recovery | Early Phase 1 | Unknown | Sichuan Provincial People's Hospital | 93 | 2024-06-01 | 2024-05-20 |
| Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam Flumazenil, normal saline - Flumazenil Adverse Reaction, Remimazolam | Not applicable | Recruiting | Pusan National University Yangsan Hospital | 24 | 2023-09-19 | 2025-09-12 |
| Finding ED90 of Flumazenil for Selective Improvement of Respiratory Distress by Remimazolam Flumazenil - Stomach Neoplasm | Not applicable | Completed | Yonsei University | 60 | 2023-08-23 | 2024-08-20 |
| Impact of Flumazenil on the Emergence Delirium Flumazenil - Anesthesia, General | Phase 4 | Completed | Korea University Guro Hospital | 68 | 2023-03-05 | 2023-09-06 |
| Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia Remimazolam, Flumazenil, Propofol - Hip Fracture | Phase 4 | Completed | Central South University | 136 | 2023-02-01 | 2024-07-24 |
| Comparison of Remimazolam With Flumazenil vs. Propofol During RFCA for Atrial Fibrillation Remimazolam Besylate, Flumazenil, Propofol - Recovery | Not applicable | Completed | Seoul National University Hospital | 54 | 2022-08-02 | 2023-11-22 |
| Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO], Flumazenil, Propofol - Recovery | Not applicable | Completed | Seoul National University Hospital | 66 | 2022-08-02 | 2023-01-13 |
| Reversal of Remimazolam by a Single Dose of Flumazenil Flumazenil - Flumazenil Adverse Reaction, Ambulatory Surgery | Not applicable | Completed | Konkuk University Medical Center | 224 | 2022-08-02 | 2023-05-19 |
| Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy Remimazolam, Propofol, Rocuronium - Endobronchial Metastases, Bronchoesophageal Fistula | Phase 4 | Completed | Zhejiang Cancer Hospital | 34 | 2021-01-04 | 2022-10-26 |
| GABA Antagonist to Improve Reversal of Anesthesia With High-density EEG Surveillance flumazenil, Placebos - Moderate Sedation, Colonoscopy | Not applicable | Unknown | National Taiwan University Hospital | 60 | 2020-03-25 | 2020-04-01 |
| Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination Flumazenil, Naloxone - Brain Death, Anoxic Brain Injury | Early Phase 1 | Withdrawn | Prisma Health-Midlands | 2019-01-01 | 2024-10-31 | |
| Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm Flumazenil, Placebo - Parkinson Disease | Phase 1 / Phase 2 | Completed | University of Michigan | 36 | 2018-03-09 | 2022-09-27 |
| Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Exposure Flumazenil, Placebo - Hypoactive Delirium | Phase 4 | Terminated | University of California, Davis | 22 | 2016-03-01 | 2020-07-23 |
| A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness Polypharmacy using FDA-approved products, Median Nerve Stimulation (MNS), Nutraceutical Supplementation - Brain Injury | Phase 1 / Phase 2 | Unknown | International Brain Research Foundation | 30 | 2016-03-01 | 2016-09-02 |
| Electro-acupuncture and Flumazenil's Effect on Sedation Flumazenil, Acupuncture - Acupuncture, General Anaesthesia | Not applicable | Completed | Dr. Yin Liu | 80 | 2015-01-01 | 2016-02-24 |
| Treatment of Hepatic Encephalopathy With Flumazenil and Change in Cortical GABA Levels in MRS Flumazenil, Placebo - Hepatic Encephalopathy, Liver Cirrhosis | Phase 1 / Phase 2 | Withdrawn | Yale University | 2014-06-01 | 2020-07-07 |
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Emergence Delirium (3) · Anxiety Disorders (2) · Delirium (2) · Alcoholism (1) · Bipolar Disorder (1) · Brain Death (1) · Brain Injuries (1) · Coma (1) · Consciousness Disorders (1) · Death (1) · Depressive Disorder, Major (1) · Disorders of Excessive Somnolence (1) · Heart Arrest (1) · Hepatic Encephalopathy (1) · Hip Fractures (1)
Seoul National University Hospital (3) · AstraZeneca (2) · Coeruleus Ltd. (2) · Yale University (2) · Anders Jørgensen (1) · Central South University (1) · Chung-Ang University Gwangmyeong Hospital (1) · Dr. Yin Liu (1) · International Brain Research Foundation (1) · Konkuk University Medical Center (1) · Korea University Guro Hospital (1) · Lynn Marie Trotti (1) · Medical University of Gdansk (1) · Medical University of South Carolina (1) · National Taiwan University Hospital (1)
United States (10) · South Korea (7) · China (3) · Israel (2) · Sweden (2) · Brazil (1) · Denmark (1) · Taiwan (1)
Bo Fransson (2) · Eva Taavo (2) · Yunseok Jeon, MD, PhD (2) · Byung Gun Lim, MD, PhD (1) · Hochang B Lee, MD (1) · James G Sullivan, MD (1) · Jeremiah J Duby, PharmD, BCPS (1) · Jiwon Han (1) · Kendra J Schomer, PharmD (1) · Lynn Marie Trotti, MD (1) · Nicolaas I Bohnen, MD, PhD (1) · Peter M Milgrom, DDS (1) · Philip A Defina, Ph.D. (1) · Raymond F Anton, MD (1)
PMID 28013354, PMID 42802645, PMID 17585216, PMID 19593171, PMID 21631542, PMID 23411725, PMID 32417976, PMID 38205822, PMID 38831029
2025 (1), P30DK034989 (1), R01DA008265 (1), R01NS099535 (1), U54DE014254 (1)