37 completed, 9 unknown, 5 withdrawn, 4 recruiting. 61 Phase 1, 22 Phase 2.
Follow Brain Damage, Chronic: new trials by email Literature Review of Brain Damage, Chronic trials Research Report on Brain Damage, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of Cultured Umbilical or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for CP Umbilical or placental derived mesenchymal stem cells - Cerebral Palsy | Phase 1 | Recruiting | The Foundation for Orthopaedics and Regenerative Medicine | 15 | 2026-12-01 | 2026-10-16 |
| Human Umbilical Cord Blood Infusion in Patients with Cerebral Palsy hUCB - Cerebral Palsy | Phase 1 | Not yet recruiting | StemCyte Taiwan Co., Ltd. | 12 | 2025-09-01 | 2025-02-27 |
| Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy Placebo for the AZA 10mg/m^2, Placebo for the AZA 20mg/m^2, Placebo for the AZA 35mg/m^2 - Cerebral Palsy, Contracture | Phase 1 | Enrolling by invitation | Shirley Ryan AbilityLab | 27 | 2025-07-01 | 2025-07-03 |
| Intrathecal Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells for Children With Cerebral Palsy allogeneic umbilical cord tissue-derived mesenchymal stromal cells (UCT-MSCs) - Cerebral Palsy (CP) | Phase 1 | Active not recruiting | Gadjah Mada University | 7 | 2024-12-01 | 2026-08-13 |
| Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy Trihexyphenidyl - Pediatric Disorder, Genetic Predisposition | Phase 1 | Recruiting | Children's Mercy Hospital Kansas City | 40 | 2024-10-15 | 2026-06-24 |
| Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities Sprint-Intensity Interval Training with Telecoaching - Cerebral Palsy | Phase 1 | Completed | University of Alabama at Birmingham | 42 | 2023-09-29 | 2026-04-02 |
| Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals MTR-601 - Muscle Spasticity, Hypertonia, Muscle | Phase 1 | Completed | Motric Bio | 89 | 2023-09-11 | 2026-06-05 |
| Tau And Connectomics In TES Study [18F] PI-2620 Tau Ligand - Chronic Traumatic Encephalopathy, Traumatic Encephalopathy | Phase 1 | Unknown | Macquarie University, Australia | 12 | 2023-02-03 | 2024-02-28 |
| Augmenting Ankle Plantarflexor Function in Cerebral Palsy Biomotum Spark: Robotic ankle assistance, Biomotum Spark: Robotic ankle resistance, Standard gait training - Cerebral Palsy | Phase 1 | Recruiting | Northern Arizona University | 36 | 2023-02-01 | 2026-03-03 |
| ADX-629 Therapy for Sjogren-Larsson Syndrome ADX-629 - Sjogren-Larsson Syndrome | Phase 1 / Phase 2 | Completed | University of Nebraska | 8 | 2023-01-02 | 2026-05-05 |
| Telehealth Virtual Reality Gaming on Cardiometabolic Health Among Youth With Cerebral Palsy Virtual Reality Exergaming - Cerebral Palsy | Phase 1 | Completed | University of Alabama at Birmingham | 32 | 2022-06-01 | 2026-10-08 |
| Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for CP cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells - Cerebral Palsy | Phase 1 | Recruiting | The Foundation for Orthopaedics and Regenerative Medicine | 15 | 2022-02-01 | 2026-10-20 |
| Stem Cell and Conditioned Medium for Cerebral Palsy Umbilical Cord Mesenchymal Stem Cells, Conditioned Medium, Standard Therapy - Cerebral Palsy | Phase 1 / Phase 2 | Active not recruiting | PT. Prodia Stem Cell Indonesia | 78 | 2021-10-13 | 2026-02-25 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| Noninvasive Spinal Neuromodulation Enables Locomotor Recovery in Individuals With Cerebral Palsy SCiP - Cerebral Palsy | Phase 1 | Unknown | SpineX Inc. | 50 | 2021-05-15 | 2023-04-04 |
| Development of a Robotic Ankle Assist Device Robotic Ankle Assist Device (RAAD) - Cerebral Palsy | Phase 1 | Completed | BiOMOTUM, Inc. | 31 | 2020-11-01 | 2025-04-04 |
| A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy HB-adMSCs - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Hope Biosciences LLC | 24 | 2020-01-01 | 2026-11-09 |
| A Study of UCB and MSCs in Children With CP: ACCeNT-CP Infusion of allogeneic umbilical cord blood, Infusion of MSCs - Cerebral Palsy | Phase 1 / Phase 2 | Completed | Joanne Kurtzberg, MD | 91 | 2018-04-10 | 2021-08-19 |
| Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness. Analgesic administration, Placebo administration - Disorders of Consciousness, Severe Brain Injury | Phase 1 | Completed | University of Liege | 19 | 2018-02-21 | 2021-05-03 |
| Clinical Effect and Safety of Autologous Umbilical Cord Blood Transfusion in the Treatment of Cerebral Palsy 0.9% Sodium Chloride, Autologous Umbilical Cord Blood - Safety Issues, Effect of Drugs | Phase 1 | Unknown | Guangdong Women and Children Hospital | 25 | 2017-10-10 | 2019-01-04 |
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Cerebral Palsy (52) · Brain Injuries (5) · Muscle Spasticity (5) · Persistent Vegetative State (5) · Stroke (4) · Brain Injuries, Traumatic (3) · Chronic Traumatic Encephalopathy (3) · Consciousness Disorders (3) · Spinal Cord Injuries (3) · Dystonia (2) · Ischemic Stroke (2) · Muscle Hypertonia (2) · Neuromuscular Diseases (2) · Paresis (2) · Alzheimer Disease (1)
Brain Diseases (61) · Central Nervous System Diseases (61) · Nervous System Diseases (61) · Pathological Conditions, Signs and Symptoms (23) · Neurologic Manifestations (17) · Signs and Symptoms (17) · Wounds and Injuries (13) · Trauma, Nervous System (12) · Craniocerebral Trauma (11) · Mental Disorders (11) · Neurobehavioral Manifestations (9) · Pathologic Processes (9) · Cardiovascular Diseases (8) · Cerebrovascular Disorders (8)
Sodium Chloride (3) · Exercise (2) · Granulocyte Colony-Stimulating Factor (2) · Standard of Care (2) · Stem Cell Transplantation (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · ADX-629 (1) · Azacitidine (1) · Baclofen (1) · Botulinum Toxins, Type A (1) · Culture Media, Conditioned (1) · Ensure Plus (1) · Equine-Assisted Therapy (1) · Erythropoietin (1) · Exercise Test (1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Hadassah Medical Organization (2) · Joanne Kurtzberg, MD (2) · National Institutes of Health Clinical Center (CC) (2) · Neurogen Brain and Spine Institute (2) · Royan Institute (2) · The Foundation for Orthopaedics and Regenerative Medicine (2) · University of Alabama at Birmingham (2) · University of Liege (2) · Acorda Therapeutics (1) · Aryn Knight (1) · Assaf-Harofeh Medical Center (1) · Augusta University (1) · BiOMOTUM, Inc. (1) · Bundang CHA Hospital (1)
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Diane L Damiano, Ph.D. (2) · Hamid Gourabi, PhD (2) · Joanne Kurtzberg, MD (2) · Nasser Aghdami, MD,PhD (2) · Alan Hand, MD (1) · Alexander A Ostanin, MD, PhD (1) · Ali Reza Zali, MD (1) · AliReza Zaali, MD (1) · Andrea Domenighetti, PhD (1) · Antonio Fiaschi, MD PhD (1) · Avraam Ploumis (1) · Byron Lai, PhD (1) · Chadwick Prodromos, MD (1) · Chang Yanqun, Phd (1) · Charles S Cox, MD (1)
PMID 15779003, PMID 23106988, PMID 24506509, PMID 24607242, PMID 25593079, PMID 28109298, PMID 28131322, PMID 28867665, PMID 30922152, PMID 32152173, PMID 35193825, PMID 35811372, PMID 35976192, PMID 36198701, PMID 37555886, PMID 38087394, PMID 38441939
R03HD107598 (1), R21HD054697 (1), R21HD109358 (1)