53 completed, 25 unknown, 5 withdrawn, 4 recruiting. 95 Phase 2, 22 Phase 1, 12 Phase 3.
Follow Brain Damage, Chronic: new trials by email Literature Review of Brain Damage, Chronic trials Research Report on Brain Damage, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Leveraging Extended Reality Exergaming and Telehealth to Improve Physical Activity and Health in Children With Disabilities Extended Reality Exergaming - Cerebral Palsy (CP) | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 130 | 2026-12-01 | 2026-05-14 |
| Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy Smart Ankle-Foot Orthosis, 5-Azacitidine, Placebo - Cerebral Palsy | Phase 2 | Recruiting | Shirley Ryan AbilityLab | 60 | 2026-05-28 | 2026-06-01 |
| tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy tSCS, 5-Azacitidine, Mannitol - Cerebral Palsy | Phase 2 | Recruiting | Shirley Ryan AbilityLab | 80 | 2026-05-28 | 2026-05-29 |
| Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy Magnetic Spinal Stimulation - Spastic Cerebral Palsy, Dysarthria | Phase 2 / Phase 3 | Unknown | Sociedad Argenttina de Neuromodulación | 20 | 2024-11-18 | 2023-11-21 |
| Promoting Upright Mobility in Infants With Cerebral Palsy Using a Robotic Unweighting System BabyG - Cerebral Palsy, Physical Therapy Modalities | Phase 2 | Withdrawn | National Institutes of Health Clinical Center (CC) | 2024-09-11 | 2025-08-05 | |
| Wereables for Upper Limb Functionality in Hemiparesis WeFun-wearable activated, WeFun-wearable desactivated - Unilateral Cerebral Palsy | Phase 2 / Phase 3 | Recruiting | Universidade da Coruña | 40 | 2024-06-07 | 2025-03-12 |
| Upper Limb Somatosensory Discrimination Therapy and Dose-matched Motor Therapy in Children and Adolescents With Unilateral Cerebral Palsy Upper limb somatosensory discrimination therapy, Upper limb motor therapy - Cerebral Palsy, Spastic, Hemiplegic Cerebral Palsy | Phase 2 | Unknown | Hilde Feys | 50 | 2023-12-09 | 2024-02-07 |
| Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Metformin - Cerebral Palsy | Phase 2 | Completed | Holland Bloorview Kids Rehabilitation Hospital | 3 | 2023-11-14 | 2026-03-02 |
| Spinal Cord Innovation in Pediatrics (SCiP) to Treat SensoriMotor Function in Children Cerebral Palsy: Protocol for a Randomized Controlled Trial SCiP - Cerebral Palsy | Phase 2 | Unknown | SpineX Inc. | 60 | 2023-09-01 | 2023-02-09 |
| Therapeutic Photobiomodulation and Tretament of Spasticity Photobiomodulation, Institution's Standard Physiotherapy, Photobiomodulation Placebo - Muscle Spasticity, Cerebral Palsy | Phase 2 / Phase 3 | Completed | University of Nove de Julho | 12 | 2023-08-15 | 2026-05-01 |
| Magnesium Sulphate Neuroprotective Strategies for Preterm Deliveries Magnesium sulfate loading with maintenance dose, Magnesium sulfate loading dose only - Premature Birth, NEUROPROTECTION | Phase 2 / Phase 3 | Unknown | Zagazig University | 336 | 2023-01-20 | 2023-07-14 |
| ADX-629 Therapy for Sjogren-Larsson Syndrome ADX-629 - Sjogren-Larsson Syndrome | Phase 1 / Phase 2 | Completed | University of Nebraska | 8 | 2023-01-02 | 2026-05-05 |
| INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT) IncobotulinumtoxinA 100 UNT [Xeomin] - Spastic Cerebral Palsy | Phase 2 | Unknown | Universita di Verona | 30 | 2022-06-01 | 2022-04-22 |
| Short-term Pre-OPerative Durvalumab (MEDI 4736) in Early Small Triple Negative Breast Cancer Patients (POP-Durva) Durvalumab - Early Small (cT1N0) Triple Negative Breast Cancer | Phase 2 | Active not recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 200 | 2021-12-06 | 2026-08-05 |
| Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 2; Placebo - Spasticity, Cerebrovascular Accident | Phase 2 / Phase 3 | Terminated | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 32 | 2021-11-02 | 2026-05-27 |
| Stem Cell and Conditioned Medium for Cerebral Palsy Umbilical Cord Mesenchymal Stem Cells, Conditioned Medium, Standard Therapy - Cerebral Palsy | Phase 1 / Phase 2 | Active not recruiting | PT. Prodia Stem Cell Indonesia | 78 | 2021-10-13 | 2026-02-25 |
| Peripheral Modulation of Muscle Stiffness and Spasticity Hyaluronidase, Placebo - Muscle Spasticity | Phase 2 | Active not recruiting | Johns Hopkins University | 56 | 2021-10-11 | 2026-06-30 |
| Apomorphine in Severe Brain-injured Patients Apomorphine Hydrochloride 5mg/ml, Sodium chloride 9mg/ml - Disorder of Consciousness | Phase 2 / Phase 3 | Recruiting | University of Liege | 48 | 2021-06-18 | 2025-04-15 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| Treatment of Children With Cerebral Palsy With Autologous Umbilical Cord Blood, a Pilot Study Autologous umbilical cord blood transfusion, placebo - Cerebral Palsy | Phase 2 | Unknown | Sheba Medical Center | 72 | 2020-07-08 | 2021-01-20 |
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Cerebral Palsy (78) · Muscle Spasticity (11) · Persistent Vegetative State (10) · Brain Injuries, Traumatic (9) · Brain Injuries (6) · Consciousness Disorders (6) · Stroke (6) · Paresis (5) · Chronic Traumatic Encephalopathy (4) · Brain Injury, Chronic (3) · Amyotrophic Lateral Sclerosis (2) · Coma (2) · Dystonia (2) · Hypoxia-Ischemia, Brain (2) · Intracranial Hemorrhages (2)
Brain Diseases (95) · Central Nervous System Diseases (95) · Nervous System Diseases (95) · Pathological Conditions, Signs and Symptoms (43) · Signs and Symptoms (36) · Neurologic Manifestations (32) · Wounds and Injuries (18) · Craniocerebral Trauma (17) · Trauma, Nervous System (17) · Neurobehavioral Manifestations (15) · Mental Disorders (13) · Muscular Diseases (13) · Pathologic Processes (13) · Musculoskeletal Diseases (12)
Botulinum Toxins, Type A (5) · Sodium Chloride (4) · Standard of Care (4) · Apomorphine (3) · Granulocyte Colony-Stimulating Factor (3) · Saline Solution (3) · incobotulinumtoxinA (3) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (2) · Acupuncture Therapy (2) · Azacitidine (2) · Baclofen (2) · Constraint Induced Movement Therapy (2) · Hyperbaric Oxygenation (2) · Mannitol (2) · Physical Therapy Modalities (2)
Bundang CHA Hospital (3) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · University of Liege (3) · Hanyang University Seoul Hospital (2) · Holland Bloorview Kids Rehabilitation Hospital (2) · Joanne Kurtzberg, MD (2) · National Institutes of Health Clinical Center (CC) (2) · Shirley Ryan AbilityLab (2) · State-Financed Health Facility "Samara Regional Medical Center Dinasty" (2) · University of Calgary (2) · University of Oklahoma (2) · University of Southern California (2) · Vinmec Healthcare System (2) · Virginia Polytechnic Institute and State University (2) · Agency for Healthcare Research and Quality (AHRQ) (1)
United States (39) · South Korea (6) · Belgium (5) · Canada (4) · Russia (4) · Egypt (3) · Israel (3) · Spain (3) · Vietnam (3) · China (2) · France (2) · Iran (2) · Argentina (1) · Brazil (1) · Hong Kong (1)
Minyoung Kim, M.D., Ph.D. (3) · Charles S Cox, MD (2) · Darcy Fehlings, MD, MSc (2) · Diane L Damiano, Ph.D. (2) · Joanne Kurtzberg, MD (2) · Liem T Nguyen, MD., PhD. (2) · Steven Laureys, M.D., Ph.D. (2) · Adam Kirton, MD MSc FRCPC (1) · Adam Kirton, MD, MSc (1) · Ahmed M Kamel, M.D. (1) · Alexander A Ostanin, MD, PhD (1) · Ali Reza Moaeidi, MD (1) · Ali Reza Zali, MD (1) · Amirali Hamidieh, MD (1)
PMID 38114596, PMID 28403842, PMID 28688787, PMID 12529557, PMID 15037681, PMID 16108461, PMID 18065878, PMID 18676556, PMID 18990048, PMID 19416339, PMID 19811515, PMID 22071153, PMID 22541308, PMID 22747635, PMID 22776958, PMID 23106988, PMID 24100132, PMID 24607242, PMID 24909743, PMID 24969309, PMID 25113573, PMID 25157725, PMID 25534356, PMID 25593079, PMID 25863661, PMID 26745476, PMID 27029628, PMID 27187300, PMID 27927938, PMID 28109298, PMID 28867665, PMID 29080265, PMID 30107811, PMID 30782701, PMID 30941094, PMID 30969506, PMID 31438885, PMID 34362453, PMID 34484101, PMID 34649982, PMID 35351020, PMID 35811372, PMID 36477478, PMID 37555886, PMID 37564370, PMID 38087394, PMID 38409060, PMID 39624459, PMID 42156830, PMID 905874
2005 (1), P50AT000008 (1), R21AR051564 (1), R21HD054697 (1)