9 completed, 4 terminated, 4 unknown, 2 recruiting. 20 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 9, Terminated 4, Unknown 4, Recruiting 2, Not yet recruiting 1 |
| Phase 3 | 3 | Unknown 2, Completed 1 |
| Phase 1 | 1 | Completed 1 |
Follow Bone Diseases, Infectious: new trials by email Literature Review of Bone Diseases, Infectious trials Research Report on Bone Diseases, Infectious
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EFFICACY AND SAFETY OF ZOLEDRONATE VERSUS PLACEBO ON PAIN AT WEEK 12 IN PEDIATRIC PATIENTS WITH CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS Zoledronic Acid / Zoledronate 4 MG/100 ML Intravenous Solution, NaCL 0.9% Intravenous Solution - Osteomyelitis Chronic | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-09-15 | 2026-06-25 |
| A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers. STIMULAN VG, Standard of Care - Pressure Ulcer, Stage IV, Osteomyelitis | Phase 2 | Recruiting | Biocomposites Ltd | 60 | 2025-06-15 | 2026-05-06 |
| Fecal Microbiota Transplantation in Axial Spondyloarthritis FMT, Placebo - Axial Spondyloarthritis, Ankylosing Spondylitis | Phase 2 | Recruiting | University Hospital of North Norway | 99 | 2024-06-01 | 2026-08-14 |
| Oral Vitamin D and Toll Like Receptor in Spondylitis Tuberculosis 400 IU, 5000 IU, 10000 IU - Spondylitis, Tuberculosis | Phase 2 / Phase 3 | Unknown | Hasanuddin University | 37 | 2022-07-01 | 2022-05-17 |
| Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis Bacteriophage Therapy, Placebo - Osteomyelitis, Diabetic Foot Osteomyelitis | Phase 2 | Terminated | Adaptive Phage Therapeutics, Inc. | 41 | 2021-11-24 | 2025-08-19 |
| Tofacitinib for Reduction of Spinal Inflammation in Patients With Psoriatic ArthritiS PresenTing With Axial InvOlvement Tofacitinib 5 MG Oral Tablet [Xeljanz], Placebo oral tablet - Psoriatic Arthritis, Spondylitis | Phase 2 | Unknown | Charite University, Berlin, Germany | 80 | 2020-08-04 | 2022-07-26 |
| Individualizing Anti-Inflammatory Medications for Adults With Axial Spondyloarthritis: A Series of N-of 1 Trials Celecoxib, Naproxen, Meloxicam - Axial Spondyloarthritis | Phase 2 | Terminated | The University of Texas Health Science Center, Houston | 42 | 2020-06-25 | 2025-08-13 |
| Effectivity of Mesenchymal Stem Cell on Vertebral Bone Defect Due to Mycobaterium Tuberculosis Infection Mesenchymal Stem cell + Nacl 0.9%, NaCl 0.9% - Spinal Tuberculosis, Mesenchymal Stem Cell | Phase 2 | Unknown | Ahmad Jabir Rahyussalim | 20 | 2017-05-21 | 2020-08-03 |
| Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Dalbavancin, Standard of Care - Osteomyelitis | Phase 2 | Terminated | Allergan | 1 | 2017-05-15 | 2018-09-26 |
| Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections (OTTER) Tedizolid - Bone and Joint Infection | Phase 2 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 44 | 2017-02-06 | 2023-12-13 |
| A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis Intravenous infusion of MSCs, Etanercept - Spondylitis, Spondylitis, Ankylosing | Phase 2 / Phase 3 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 250 | 2016-06-01 | 2016-06-24 |
| Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Bone Sites MBN-101, Placebo - Bacterial Infection | Phase 2 | Completed | Microbion Corporation | 29 | 2016-05-24 | 2021-09-30 |
| Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Participants With Osteomyelitis Dalbavancin, Comparator - Osteomyelitis | Phase 2 | Completed | Durata Therapeutics Inc., an affiliate of Allergan plc | 80 | 2016-03-15 | 2019-01-04 |
| Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections sodium fusidate - Refractory Bone or Joint Infections | Phase 2 / Phase 3 | Completed | Arrevus Inc. | 30 | 2015-12-01 | 2020-01-30 |
| Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Ceftaroline Fosamil - Hematogenously Acquired Staphylococcus Aureus Osteomyelitis, Bone Infection | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 11 | 2015-06-03 | 2021-11-02 |
| Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis Intravenous Antibacterial Agent, Oral Antibacterial Agent - Osteomyelitis | Phase 2 | Terminated | Loyola University | 30 | 2014-03-19 | 2018-07-19 |
| Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis Tofacitinib 2 mg, Tofacitinib 5 mg, Tofacitinib 10 mg - Ankylosing Spondylitis | Phase 2 | Completed | Pfizer | 208 | 2013-04-01 | 2016-06-10 |
| Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Feraheme, Magnetic Resonance Imaging (MRI) scan - Bone Cancer, Chondrosarcoma | Phase 2 | Completed | Heike E Daldrup-Link | 32 | 2011-08-01 | 2023-12-27 |
| Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci daptomycin, vancomycin, teicoplanin - Osteomyelitis | Phase 2 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 75 | 2007-06-26 | 2018-01-31 |
| Blocking Tumor Necrosis Factor in Ankylosing Spondylitis Anti-Tumor Necrosis Factor - Spondylitis, Ankylosing | Phase 2 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 42 | 1999-10-01 | 2007-01-04 |
Osteomyelitis (12) · Spondylitis (7) · Spondylitis, Ankylosing (4) · Spondylarthritis (3) · Arthritis (2) · Axial Spondyloarthritis (2) · Diabetes Mellitus (2) · Musculoskeletal Diseases (2) · Spinal Diseases (2) · Spondylarthropathies (2) · Ankylosis (1) · Arthritis, Psoriatic (1) · Bacterial Infections (1) · Bone Diseases (1) · Bone Neoplasms (1)
Bone Diseases (19) · Infections (19) · Musculoskeletal Diseases (18) · Spinal Diseases (6) · Joint Diseases (5) · Ankylosis (4) · Arthritis (4) · Spondylarthropathies (4) · Axial Spondyloarthritis (3) · Bacterial Infections and Mycoses (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Spondylarthritis (3) · Actinomycetales Infections (2)
Daptomycin (2) · Standard of Care (2) · Vancomycin (2) · dalbavancin (2) · tofacitinib (2) · Anti-Bacterial Agents (1) · Aztreonam (1) · Cefepime (1) · Ceftaroline (1) · Celecoxib (1) · Cholecalciferol (1) · Ciprofloxacin (1) · Clindamycin (1) · Etanercept (1) · Ferrosoferric Oxide (1)
Adaptive Phage Therapeutics, Inc. (1) · Ahmad Jabir Rahyussalim (1) · Allergan (1) · Arrevus Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Baylor College of Medicine (1) · Biocomposites Ltd (1) · Charite University, Berlin, Germany (1) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · Durata Therapeutics Inc., an affiliate of Allergan plc (1) · Hasanuddin University (1) · Heike E Daldrup-Link (1) · Loyola University (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · Microbion Corporation (1)
United States (13) · Germany (2) · Indonesia (2) · Russia (2) · Canada (1) · China (1) · Czechia (1) · France (1) · Hungary (1) · Norway (1) · Poland (1) · South Korea (1) · Spain (1) · Taiwan (1) · Ukraine (1)
Alistair Wheeler, MD (1) · Andi Alfian Zainuddin, MD. Ph.D (1) · Brett Baker, MSc, DC (1) · Denis Poddubnyy, Prof (1) · Firdaus Hamid, MD. Ph.D (1) · Heike E Daldrup-Link, MD (1) · Jainal Arifin, MD (1) · John C. Davis, MD, MPH (1) · Loren G Miller, MD MPH (1) · Mark C Hwang, MD (1) · Michael Pinzur, M.D. (1) · Nasrum Massi, MD. Ph.D (1) · Neyssa Marina, MD (1) · Nitsan Halevy, MD (1)
PMID 22265264, PMID 22908174, PMID 28130206, PMID 29100842, PMID 29615661, PMID 30480772, PMID 30648126, PMID 32173258, PMID 32433595, PMID 34785545, PMID 36138330, PMID 37331992, PMID 37909386, PMID 38696034, PMID 38825359, PMID 39636343, PMID 39695887, PMID 40676732
2023 (1), KL2TR003168 (1)