25 completed, 12 terminated, 6 unknown, 4 recruiting. 13 Phase 4, 11 Phase 3, 10 Phase 2, 7 Phase 1, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy - Febrile Neutropenia (FN), Pediatric Cancer | Phase 4 | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 136 | 2026-06-01 | 2026-05-15 |
| A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients Vancomycin, Piperacillin-tazobactam, Cefepime - Acute Kidney Injury | Phase 4 | Recruiting | University of Pennsylvania | 750 | 2026-01-28 | 2026-02-13 |
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-09-04 |
| A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI cefepime and enmetazobactam combination - Complicated Urinary Tract Infection | Phase 2 | Recruiting | Orchid Pharma Europe GmbH | 40 | 2023-09-11 | 2026-08-20 |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Cefepime and Unictam on Preventing Post-Cesarean Surgical Site Infections Cefepime 1000 MG, Ampicillin-sulbactam - Cesarean Section; Infection | Phase 3 | Unknown | Beni-Suef University | 213 | 2023-01-01 | 2023-09-21 |
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline - Endocarditis | Phase 4 | Terminated | West Virginia University | 5 | 2022-03-16 | 2026-05-05 |
| BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia Cefepime, Meropenem, or Piperacillin/Tazobactam - Pneumonia | Phase 4 | Terminated | University of Florida | 35 | 2021-12-17 | 2023-12-12 |
| Early Antibiotics After Aspiration in ICU Patients Ceftriaxone, Amoxicillin clavulanic acid, Cefepime - Aspiration, Aspiration Pneumonia | Phase 4 | Terminated | UConn Health | 5 | 2021-11-30 | 2025-12-30 |
| Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia Piperacillin and Tazobactam for Injection, Cefepime Injection, Ceftazidime Injection - Febrile Neutropenia | Phase 4 | Completed | Murdoch Childrens Research Institute | 55 | 2021-11-15 | 2026-03-20 |
| PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN Imipenem/Cilastatin/Relebactam, Cefepime, Meropenem - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 2 | Completed | M.D. Anderson Cancer Center | 100 | 2021-09-14 | 2026-04-06 |
| Antibiotics Continuous Infusion at Home Cefepime, Piperacillin/tazobactam, Meropenem - Severe Bacterial Infections | Phase 1 | Unknown | Ospedale San Carlo Borromeo | 50 | 2021-09-01 | 2021-03-25 |
| Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®) Continuous venovenous hemodiafiltration with high adsorption membrane (oXiris®), Antibiotics - Hemodiafiltration, Sepsis | Completed | Hospital Universitari de Bellvitge | 20 | 2021-01-01 | 2023-10-10 | |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| Antibiotic Profile of Pathogenic Bacteria Isolated in Public Hospitals in Northern Jordan ciprofloxacin - Bacterial Infections, Antibiotic Resistant Infection | Completed | Yarmouk University | 24 | 2019-08-01 | 2021-11-04 | |
| Single Dose Cefepime Versus Cefuroxime Plus Metronidazole as a Prophylactic Antibiotic During Emergency Intrapartum Cesarean Section Cefepime, Cefuroxime plus Metronidazole - Emergency Cesarean Section, Infection Wound | Phase 2 / Phase 3 | Unknown | Assiut University | 500 | 2019-07-01 | 2019-07-05 |
| Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patients Piperacillin-Tazobactam 4 g-0.5 g, Cefepime 2000 mg, Meropenem 1000 mg - Febrile Neutropenia | Phase 4 | Unknown | Hospital Universitari de Bellvitge | 150 | 2019-06-05 | 2021-02-12 |
| Safety and Pharmacokinetics of VNRX-5133 in the Epithelial Lining Fluid of Healthy Adult Subjects VNRX-5133 + cefepime - Healthy Subjects | Phase 1 | Completed | Venatorx Pharmaceuticals, Inc. | 20 | 2019-03-14 | 2019-05-06 |
| Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever Ceftazidime Injection, Cefepime Injection - Neutropenia, Febrile, Leukemia | Phase 4 | Completed | Universitas Indonesia | 72 | 2019-03-01 | 2019-12-06 |
| A Study the Population Pharmacokinetics of Children of Infectious Disease in Central Nervous System Children with the usage of anti-infective drugs - Central Nervous System Infection | Unknown | Wei Zhao | 800 | 2019-01-01 | 2019-05-23 |
Showing 20 of 49. Sign in to see all of them.
Febrile Neutropenia (7) · Neutropenia (6) · Pneumonia (5) · Sepsis (5) · Neoplasms (4) · Urinary Tract Infections (4) · Bacteremia (3) · Fever (3) · Infections (3) · Acute Kidney Injury (2) · Arrhythmias, Cardiac (2) · Bacterial Infections (2) · Burkitt Lymphoma (2) · Central Nervous System Infections (2) · Critical Illness (2)
Allecra (3) · Wockhardt (3) · Hospital Universitari de Bellvitge (2) · Janssen Research & Development, LLC (2) · M.D. Anderson Cancer Center (2) · West Virginia University (2) · Assiut University (1) · Basilea Pharmaceutica (1) · Beni-Suef University (1) · CPL Associates (1) · Center for Supporting Hematology-Oncology Trials (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Universitaire de Besancon (1) · Chulalongkorn University (1) · Daniel Benjamin (1)
United States (25) · Poland (6) · Spain (6) · Czechia (5) · Hungary (5) · France (4) · Ukraine (4) · Argentina (3) · Colombia (3) · Latvia (3) · Lithuania (3) · Mexico (3) · Russia (3) · Slovakia (3) · Brazil (2)
Issam I Raad (2) · Alina Tone, MD (1) · Alvaro Ruiz, MD; MSc (1) · Arif R. Sarwari, MD, MSc, MBA (1) · Brandon Oto (1) · Carlota Gudiol, PhD (1) · Charles Peloquin (1) · Chi Hornik (1) · Chi Hornik, PharmD (1) · David A Khan, MD (1) · David Melnick, M.D. (1) · David Seligson, MD (1) · Dr Ankur Jindal, MD (1)
PMID 15276398, PMID 15327406, PMID 15840453, PMID 19588358, PMID 20350927, PMID 20458318, PMID 20594297, PMID 21649882, PMID 22530208, PMID 23317527, PMID 24614374, PMID 24949994, PMID 25414157, PMID 26039810, PMID 26474358, PMID 26926644, PMID 27522443, PMID 28101605, PMID 28137820, PMID 28288784, PMID 28290120, PMID 28601833, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29677389, PMID 29937192, PMID 30397067, PMID 30790601, PMID 31317556, PMID 31331757, PMID 31332068, PMID 31335570, PMID 31548185, PMID 31814149, PMID 31833540, PMID 32011685, PMID 32222460, PMID 32324313, PMID 32423462, PMID 32497307, PMID 33029806, PMID 33903114, PMID 34302290, PMID 34687548, PMID 34768176, PMID 35370711, PMID 35491971, PMID 35663286
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