Spondylarthritis: Clinical Trials

714 completed, 176 unknown, 145 recruiting, 69 not yet recruiting. 270 Not applicable, 207 Phase 3, 134 Phase 2, 133 Phase 4, 53 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	270	Completed 139, Unknown 45, Recruiting 37, Not yet recruiting 19, Active not recruiting 14, Terminated 7, Withdrawn 4, Enrolling by invitation 3, Suspended 2
Phase 3	207	Completed 151, Active not recruiting 19, Terminated 11, Unknown 9, Recruiting 8, Not yet recruiting 4, Withdrawn 4, Enrolling by invitation 1
Phase 2	134	Completed 62, Unknown 23, Terminated 21, Recruiting 11, Not yet recruiting 6, Withdrawn 6, Active not recruiting 4, Enrolling by invitation 1
Phase 4	133	Completed 70, Unknown 22, Recruiting 14, Terminated 8, Not yet recruiting 7, Withdrawn 7, Active not recruiting 4, Enrolling by invitation 1
Phase 1	53	Completed 26, Recruiting 8, Not yet recruiting 6, Terminated 6, Unknown 3, Withdrawn 2, Active not recruiting 1, Enrolling by invitation 1
Early Phase 1	6	Unknown 3, Completed 1, Terminated 1, Withdrawn 1

Follow Spondylarthritis: new trials by email Literature Review of Spondylarthritis trials Research Report on Spondylarthritis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Extension Study of Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis (CDDY391A12201-extension) DDY391 - Moderate to Severe Psoriatic Arthritis	Phase 2	Not yet recruiting	Novartis Pharmaceuticals	88	2027-02-10	2026-11-06
A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis	Phase 3	Not yet recruiting	Takeda	644	2027-01-11	2026-10-27
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis Patient-Reported Outcomes Dashboard With Goal Setting - Arthritis, Psoriatic (PsA), Arthritis, Rheumatoid (RA)	Not applicable	Not yet recruiting	Northwestern University	160	2027-01-01	2026-10-15
Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease	Phase 3	Not yet recruiting	Bristol-Myers Squibb	2300	2026-12-31	2026-09-03
Apremilast and Adalimumab in Psoriatic Arthritis Patients Adalimumab, Apremilast - Psoriatic Arthritis, Ultrasound Assessment	Not applicable	Not yet recruiting	Tanta University	60	2026-12-30	2026-09-08
Phase 2 Trial of FT2109 for the Treatment of Psoriatic Arthritis FT2109 Dosing Regimen 1, FT2109 Dosing Regimen 2, Matching Placebo - Psoriatic Arthritis (PsA)	Phase 2	Not yet recruiting	Forward Therapeutics	210	2026-12-01	2026-10-09
Effects of Land- and Water-Based Exercise in Axial Spondyloarthritis Land-Based Combined Exercise Program, Aquatic Combined Exercise Program, Home Exercise Program - Axial Spondyloarthritis and Ankylosing Spondylitis	Not applicable	Not yet recruiting	Izmir University of Economics	50	2026-12-01	2026-09-22
Phase Ia Study of MST-931 in Healthy Adult Subjects MST-931, MST-931 Placebo - Ankylosing Spondylitis (AS)	Phase 1	Recruiting	Mabsoft Therapeutics (Shanghai) Co., Ltd.	32	2026-11-30	2026-11-03
Comparing the Extent to Which Apremilast is Made Available in the Body After Administration as an Extended-release or Immediate-release Formulation Apremilast XR, Apremilast IR - Psoriasis, Arthritis, Psoriatic	Phase 1	Not yet recruiting	Amgen	114	2026-11-18	2026-11-02
Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic		Recruiting	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	225	2026-11-09	2026-11-12
A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis Secukinumab (IL-17i ), Upadacitinib (JAKi) - Axial Spondyloarthritis (AxSpA)	Phase 4	Not yet recruiting	The University of Texas Health Science Center, Houston	40	2026-11-01	2026-10-14
Posture Exercises in Ankylosing Spondylitis Standard Breathing Exercise Program, Posture-Focused Exercise Program - Ankylosing Spondylitis (AS)	Not applicable	Not yet recruiting	Mustafa Akça	54	2026-11-01	2026-10-16
A Study of GKL-006Allo Injection in Patients With Ankylosing Spondylitis GKL-006Allo - Ankylosing Spondylitis	Phase 1	Not yet recruiting	Beijing Gene Key Life Technology Co., Ltd	12	2026-11-01	2026-11-04
SLAMF1 Gene Expression in Ankylosing Spondylitis Ankylosing Spondylitis		Not yet recruiting	Assiut University	100	2026-10-30	2026-10-30
Corrective Spinal Surgery for Severe Spinal Curvature in People With Ankylosing Spondylitis pedicle subtraction osteotomy - Ankylosing Spondylitis	Not applicable	Not yet recruiting	China-Japan Friendship Hospital	35	2026-10-30	2026-11-12
Ivarmacitinib With or Without Celecoxib for Ankylosing Spondylitis Ivarmacitinib with celecoxib, Ivarmacitinib Monotherapy - Ankylosing Spondylitis (AS)	Phase 4	Not yet recruiting	Peking University Third Hospital	138	2026-10-25	2026-10-27
RENEW Intervention for Axial Spondyloarthritis RENEW - Axial Spondyloarthritis	Not applicable	Recruiting	University of Michigan	40	2026-10-22	2026-10-29
A Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis DDY391, Placebo - Moderate to Severe Psoriatic Arthritis	Phase 2	Recruiting	Novartis Pharmaceuticals	220	2026-10-19	2026-11-09
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes		Not yet recruiting	Assiut University	150	2026-10-01	2026-09-09
Evaluation of Serum IL-41 Level in Patients With Ankylosing Spondylitis and Psoriatic Arthritis IL 41 - Ankylosing Spondylitis, Psoriasis		Not yet recruiting	Assiut University	90	2026-10-01	2026-07-21

Showing 20 of 1272. Sign in to see all of them.

Narrower conditions

Arthritis, Psoriatic (595)  ·  Spondylitis, Ankylosing (524)  ·  Arthritis, Rheumatoid (267)  ·  Axial Spondyloarthritis (178)  ·  Psoriasis (141)  ·  Arthritis (85)  ·  Crohn Disease (67)  ·  Spondylarthropathies (67)  ·  Colitis, Ulcerative (48)  ·  Lupus Erythematosus, Systemic (44)  ·  Motor Activity (32)  ·  Non-Radiographic Axial Spondyloarthritis (32)  ·  Inflammatory Bowel Diseases (30)  ·  Arthritis, Juvenile (29)

Broader conditions

Bone Diseases (1269)  ·  Spinal Diseases (1265)  ·  Musculoskeletal Diseases (1264)  ·  Joint Diseases (1257)  ·  Spondylitis (1248)  ·  Arthritis (1187)  ·  Spondylarthropathies (1089)  ·  Skin and Connective Tissue Diseases (707)  ·  Ankylosis (652)  ·  Skin Diseases (614)  ·  Skin Diseases, Papulosquamous (606)  ·  Axial Spondyloarthritis (476)  ·  Psoriasis (467)  ·  Immune System Diseases (300)

Interventions

Etanercept (81)  ·  Adalimumab (75)  ·  secukinumab (58)  ·  Infliximab (52)  ·  golimumab (37)  ·  Methotrexate (34)  ·  apremilast (26)  ·  bimekizumab (21)  ·  tofacitinib (21)  ·  Blood Specimen Collection (19)  ·  Ustekinumab (19)  ·  guselkumab (19)  ·  ixekizumab (18)  ·  Surveys and Questionnaires (16)  ·  Certolizumab Pegol (15)

Sponsors

Novartis Pharmaceuticals (48)  ·  Pfizer (39)  ·  AbbVie (36)  ·  Assistance Publique - Hôpitaux de Paris (27)  ·  Amgen (24)  ·  Janssen Research & Development, LLC (23)  ·  Wyeth is now a wholly owned subsidiary of Pfizer (21)  ·  Charite University, Berlin, Germany (19)  ·  Merck Sharp & Dohme LLC (18)  ·  UCB Biopharma SRL (18)  ·  AbbVie (prior sponsor, Abbott) (14)  ·  Diakonhjemmet Hospital (14)  ·  Eli Lilly and Company (13)  ·  National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (13)  ·  Assiut University (12)

Countries

United States (281)  ·  France (220)  ·  Germany (186)  ·  United Kingdom (145)  ·  Spain (143)  ·  Canada (140)  ·  Turkey (Türkiye) (135)  ·  Poland (132)  ·  China (125)  ·  Czechia (115)  ·  Italy (94)  ·  Russia (94)  ·  Belgium (93)  ·  Hungary (92)  ·  Australia (81)

Top investigators

Joachim Sieper, MD (6)  ·  Lai Shan Tam, MD (4)

Results publications

PMID 40194794, PMID 41807031, PMID 31203228, PMID 37316690, PMID 38446397, PMID 41965705, PMID 42386286, PMID 34618347, PMID 35305260, PMID 38488975, PMID 38488976, PMID 39120849, PMID 30473179, PMID 33722947, PMID 34795065, PMID 35393269, PMID 36178584, PMID 36642439, PMID 36792107, PMID 37906417, PMID 37982966, PMID 38683479, PMID 39120848, PMID 39624020, PMID 40241921, PMID 40875187, PMID 41039829, PMID 19297344, PMID 30018799, PMID 30739254, PMID 31077258, PMID 31112005, PMID 31909868, PMID 31964419, PMID 32006348, PMID 32352653, PMID 32816215, PMID 33227175, PMID 33351179, PMID 34536218, PMID 34773130, PMID 34870800, PMID 35429281, PMID 36058784, PMID 36282526, PMID 36526796, PMID 36754548, PMID 36931693, PMID 36958766, PMID 36995469

NIH funding

2015 (19), 2016 (16), 2017 (16), 2023 (16), 2009 (14), 2014 (11), 2018 (10), 2019 (9), 2025 (7), 2008 (4), 2005 (3), K08CA237619 (1), K23HL152013 (1), KL2TR003168 (1), P20GM130414 (1)