146 completed, 46 recruiting, 43 unknown, 30 terminated. 94 Not applicable, 63 Phase 2, 45 Phase 1, 22 Phase 3, 9 Phase 4.
Follow Bone Neoplasms: new trials by email Literature Review of Bone Neoplasms trials Research Report on Bone Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-08-26 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-08-26 |
| Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration - Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone | Not applicable | Not yet recruiting | City of Hope Medical Center | 50 | 2027-01-10 | 2026-07-16 |
| Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors. Dinutuximab beta, Sirolimus and Irinotecan - Osteosarcomas, Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 89 | 2026-10-01 | 2026-10-01 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-09-30 | 2026-08-13 |
| Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions. Endoscopic Endonasal Approach for Skull Base Lesions. - Skull Base Neoplasms | Not applicable | Not yet recruiting | Assiut University | 30 | 2026-09-01 | 2026-08-26 |
| Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma Proton Therapy (Adaptive) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not applicable | Recruiting | St. Jude Children's Research Hospital | 100 | 2026-08-20 | 2026-08-21 |
| Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot Intervention Exercise Triage and Personalized Exercise Program - Sarcoma, Bone Sarcoma | Not applicable | Recruiting | Dana-Farber Cancer Institute | 40 | 2026-08-01 | 2026-08-26 |
| "Exercise Intervention to Increase Physical Activity in Young Sarcoma Survivors (Sport Ist Herzenssache)" Individualized Exercise Program - Bone Sarcoma, Soft Tissue Sarcoma (STS) | Not applicable | Not yet recruiting | Universität Duisburg-Essen | 46 | 2026-08-01 | 2026-07-27 |
| Stress and Anxiety Before Biopsy, After Biopsy Results, and During Treatment in Patients With Suspected Bone or Soft Tissue Cancer Routine Diagnostic and Treatment Pathway - Bone Neoplasms, Soft Tissue Neoplasms | Recruiting | Istanbul University | 100 | 2026-07-20 | 2026-07-27 | |
| Functional and Aesthetic Comparison of Surgical Nasal Reconstruction Versus Nasal Prosthesis (Epithesis) After Total or Subtotal Nasal Amputation SCHNOS score - Nose Cancer, Rhinectomy | Not yet recruiting | Hôpital NOVO | 20 | 2026-07-01 | 2026-07-01 | |
| EVERolimus and LenvAtinib Versus Everolimus for Bone Sarcoma Everolimus and Lenvatinib, Everolimus - Neoplasms of Bone and Articular Cartilage With Unspecified Anatomical Site | Phase 2 | Not yet recruiting | Yonsei University | 94 | 2026-07-01 | 2026-06-02 |
| Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis) | Recruiting | Mark C Burgmans, MD PhD | 2000 | 2026-07-01 | 2026-09-01 | |
| Predicting Allograft Volume in Orthopedic Oncology: Hemielipsoid Formula vs Intraoperative Fluid-Fill Measurement Hemielipsoid Formula-Based Preoperative and Intraoperative Bone Defect Volume Estimation - Bone Neoplasms, Musculoskeletal Neoplasms | Active not recruiting | Sakarya University | 40 | 2026-06-01 | 2026-06-30 | |
| Neoadjuvant Radiotherapy and Surgery for High-Risk Localized Ewing Sarcoma Ewing Sarcoma, Bone Neoplasms | Not yet recruiting | Peking University People's Hospital | 55 | 2026-06-01 | 2026-06-02 | |
| Treatment of Truncated ALK-positive Bone Cancer Using Crizotinib (Xalkori) or Alectinib (Alecensa) Alectinib - Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | China Medical University Hospital | 10 | 2026-05-15 | 2026-05-11 |
| U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures Percutaneous procedure in the MSK structures of the pelvis and/or the spine - Bone Tumor, Osteoporosis | Not applicable | Recruiting | Precision IO Group | 60 | 2026-04-28 | 2026-07-20 |
| Preoperative Immunonutrition in Patients With Bone and Soft Tissue Sarcomas Forticare Advanced oral nutritional supplement - Bone Sarcoma, Soft Tissue Sarcoma | Not applicable | Recruiting | St. Anne's University Hospital Brno, Czech Republic | 100 | 2026-04-01 | 2026-05-27 |
| The Effect of Preoperative Intravenous Ferric Derisomaltose and EPO and Tranexamic Acid in Patients With Preoperative Anemia or Iron Deficiency in Bone Tumor isomaltose iron - Anemia | Phase 4 | Not yet recruiting | Tang Xiaodong | 160 | 2026-01-01 | 2026-01-02 |
| Evaluation of Tumor Resection and Reconstruction With Prosthetic Implants Bone Tumor | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 100 | 2026-01-01 | 2026-01-13 |
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Sarcoma (74) · Osteosarcoma (43) · Neoplasms (39) · Neoplasm Metastasis (35) · Breast Neoplasms (29) · Sarcoma, Ewing (25) · Lung Neoplasms (21) · Skull Base Neoplasms (20) · Prostatic Neoplasms (18) · Pain (17) · Spinal Neoplasms (17) · Brain Neoplasms (14) · Head and Neck Neoplasms (14) · Chondrosarcoma (13)
Neoplasms by Site (323) · Musculoskeletal Diseases (322) · Bone Diseases (317) · Neoplasms (285) · Neoplasms by Histologic Type (133) · Neoplasms, Connective and Soft Tissue (104) · Pathological Conditions, Signs and Symptoms (70) · Neoplasms, Connective Tissue (62) · Neoplasms, Bone Tissue (56) · Skull Neoplasms (54) · Pathologic Processes (53) · Nervous System Diseases (44) · Respiratory Tract Diseases (38) · Respiratory Tract Neoplasms (36)
Gemcitabine (8) · Ibandronic Acid (8) · Cyclophosphamide (6) · Doxorubicin (6) · Irinotecan (5) · Radiotherapy (5) · Zoledronic Acid (5) · pembrolizumab (5) · Indocyanine Green (4) · Magnetic Resonance Spectroscopy (4) · Nivolumab (4) · Radiation (4) · Radiosurgery (4) · 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione (3) · Cisplatin (3)
M.D. Anderson Cancer Center (12) · Istituto Ortopedico Rizzoli (11) · Hoffmann-La Roche (8) · Assiut University (6) · InSightec (6) · National Cancer Institute (NCI) (6) · Stanford University (6) · Memorial Sloan Kettering Cancer Center (5) · Cairo University (4) · Fondation Ophtalmologique Adolphe de Rothschild (4) · Massachusetts General Hospital (4) · Peking University Third Hospital (4) · Central Hospital, Nancy, France (3) · Costantino Errani (3) · Grupo Espanol de Investigacion en Sarcomas (3)
United States (138) · France (33) · China (29) · Italy (27) · Egypt (21) · Canada (18) · Spain (12) · United Kingdom (11) · Germany (10) · Russia (10) · Netherlands (9) · Australia (8) · Poland (8) · Taiwan (8) · Belgium (7)
Amol J. Ghia, MD (2) · Antonio Casado (2) · Claudia Valverde (2) · Daniel Prevedello, MD (2) · Davide Donati, MD (2) · Ezequiel Goldschmidt, MD, PhD (2) · Hannu T Aro, MD, PhD (2) · Jerry Matteo, MD (2) · John Livingston, MD (2) · Josefina Cruz (2) · Lu Xie, M.D. (2)
PMID 31401903, PMID 38597586, PMID 10449559, PMID 12943357, PMID 14722039, PMID 15519876, PMID 17562049, PMID 18769654, PMID 19246088, PMID 19451429, PMID 19650013, PMID 20041484, PMID 20592851, PMID 20592852, PMID 20830768, PMID 20851113, PMID 21912321, PMID 22225488, PMID 22285199, PMID 22443312, PMID 22790224, PMID 22858054, PMID 23446769, PMID 23573135, PMID 23715582, PMID 24037083, PMID 24249538, PMID 24327518, PMID 24760791, PMID 24904885, PMID 25135035, PMID 25745609, PMID 25838377, PMID 26331920, PMID 27052019, PMID 27424289, PMID 27458288, PMID 27488294, PMID 27891264, PMID 27932229, PMID 27974040, PMID 28053024, PMID 28295221, PMID 28494338, PMID 28590796, PMID 28640703, PMID 28672195, PMID 28735378, PMID 28811848, PMID 28934351
P30CA014089 (2), 2017 (1), P30CA008748 (1), P30CA015704 (1), P30CA016672 (1), P30CA033572 (1), P30CA060553 (1), P50AR054041 (1), R01AG060920 (1), R01CA264248 (1), R01GM114102 (1), R01HL147155 (1), R01NS052274 (1), R37CA256867 (1), R61CA280978 (1)