366 completed, 102 unknown, 63 recruiting, 38 not yet recruiting. 135 Not applicable, 100 Phase 3, 72 Phase 4, 71 Phase 2, 22 Phase 1.
Follow Axial Spondyloarthritis: new trials by email Literature Review of Axial Spondyloarthritis trials Research Report on Axial Spondyloarthritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Land- and Water-Based Exercise in Axial Spondyloarthritis Land-Based Combined Exercise Program, Aquatic Combined Exercise Program, Home Exercise Program - Axial Spondyloarthritis and Ankylosing Spondylitis | Not applicable | Not yet recruiting | Izmir University of Economics | 50 | 2026-12-01 | 2026-09-22 |
| A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis Secukinumab (IL-17i ), Upadacitinib (JAKi) - Axial Spondyloarthritis (AxSpA) | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 40 | 2026-11-01 | 2026-10-14 |
| Posture Exercises in Ankylosing Spondylitis Standard Breathing Exercise Program, Posture-Focused Exercise Program - Ankylosing Spondylitis (AS) | Not applicable | Not yet recruiting | Mustafa Akça | 54 | 2026-11-01 | 2026-10-16 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-10-28 | 2026-10-23 | |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes | Not yet recruiting | Assiut University | 150 | 2026-10-01 | 2026-09-09 | |
| Evaluation of Serum IL-41 Level in Patients With Ankylosing Spondylitis and Psoriatic Arthritis IL 41 - Ankylosing Spondylitis, Psoriasis | Not yet recruiting | Assiut University | 90 | 2026-10-01 | 2026-07-21 | |
| Postural Biofeedback and Exercise in Axial Spondyloarthritis Standard Exercise Program, Wearable Postural Biofeedback - Axial Spondyloarthritis (AxSpA), Ankylosing Spondylitis (AS) | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 38 | 2026-10-01 | 2026-08-21 |
| A Study to Assess the Safety of Subcutaneous Secukinumab for Treatment in Adult Indian Participants With Axial Spondyloarthritis (axSpA), Ankylosing Spondylitis (AS), and Non-Radiographic Axial Spondyloarthritis (nr-axSpA) Axial Spondyloarthritis, Ankylosing Spondylitis | Not yet recruiting | Novartis Pharmaceuticals | 60 | 2026-09-30 | 2026-07-30 | |
| Controlled Reduction of AO Spine B3 Fractures in Ankylosing Spinal Disorders Using an Inflatable Positioning Device: Technical Note and Retrospective Single-centre Case Series Spine Fracture, Osteoporosis | Not yet recruiting | Diakonie-Klinikum Stuttgart | 23 | 2026-09-20 | 2026-09-29 | |
| Surface Topography and Radiographic Spinal Damage in Radiographic Axial Spondyloarthritis DIERS Formetric 4D surface topography - Axial Spondyloarthritis, Ankylosing Spondylitis | Recruiting | Ankara Etlik City Hospital | 53 | 2026-09-19 | 2026-10-02 | |
| Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for Efficacy vilamakitug, placebo - Axial Spondyloarthritis, Ankylosing Spondylitis | Phase 2 | Not yet recruiting | XBiotech, Inc. | 150 | 2026-09-01 | 2026-05-14 |
| RENEW Intervention for Axial Spondyloarthritis RENEW - Axial Spondyloarthritis | Not applicable | Not yet recruiting | University of Michigan | 40 | 2026-09-01 | 2026-09-23 |
| 15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis Osteoarthritis, Ankylosing Spondylitis | Not yet recruiting | Assiut University | 51 | 2026-08-02 | 2026-08-07 | |
| Safety and Efficacy of Allogeneic Bone Marrow MSCs in Ankylosing Spondylitis IV administration of CG-BM1, Placebo, CG-BM1 - Ankylosing Spondylitis | Phase 1 | Not yet recruiting | Eighth Affiliated Hospital, Sun Yat-sen University | 40 | 2026-07-01 | 2026-06-08 |
| Assessment of Peripheral Neuropathy in Ankylosing Spondylitis Nerve conduction study - Ankylosing Spondylitis, Peripheral Neuropathies | Not yet recruiting | Assiut University | 45 | 2026-06-30 | 2026-06-12 | |
| Efficacy of the Erector Spinae Plane Block for Persistent Back Pain in Patients With Ankylosing Spondylitis Erector spinae plane block(ESBP) - Ankylosing Spondylitis (AS), Back Pain | Not applicable | Recruiting | Marmara University | 15 | 2026-06-02 | 2026-06-08 |
| Expression of Tim-3 on Neutrophils in Ankylosing Spondylitis Ankylosing Spondylitis, AS | Not yet recruiting | Assiut University | 81 | 2026-06-01 | 2026-02-03 | |
| Physical Activity Through Health Technology in Axial Spondyloarthritis Physical activity program intervention, Usual Care Group - Axial Spondyloarthritis | Not applicable | Recruiting | University of Washington | 40 | 2026-06-01 | 2026-06-11 |
| The REFLECT Study- Flares in axSpA Axial Spondyloarthritis (AxSpA), Axial Spondyloarthritis, Non-Radiographic | Active not recruiting | Royal United Hospitals Bath NHS Foundation Trust | 40 | 2026-06-01 | 2026-07-07 | |
| Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis Upadacitinib 15 MG [Rinvoq] - Axial Spondylarthritis (axSpA) | Phase 4 | Not yet recruiting | CARE ARTHRITIS LTD. | 200 | 2026-05-01 | 2026-02-06 |
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Spondylitis, Ankylosing (517) · Arthritis, Rheumatoid (149) · Arthritis, Psoriatic (125) · Spondylarthritis (64) · Crohn Disease (45) · Arthritis (37) · Colitis, Ulcerative (32) · Non-Radiographic Axial Spondyloarthritis (32) · Psoriasis (32) · Spondylarthropathies (30) · Lupus Erythematosus, Systemic (28) · Motor Activity (19) · Spondylitis (19) · Osteoarthritis (17)
Ankylosis (643) · Bone Diseases (643) · Musculoskeletal Diseases (640) · Joint Diseases (639) · Spinal Diseases (638) · Spondylitis (626) · Spondylarthropathies (615) · Arthritis (608) · Spondylarthritis (581) · Skin and Connective Tissue Diseases (192) · Connective Tissue Diseases (163) · Immune System Diseases (162) · Rheumatic Diseases (153) · Autoimmune Diseases (146)
Etanercept (50) · Adalimumab (41) · Infliximab (36) · secukinumab (29) · golimumab (21) · Exercise (11) · Celecoxib (10) · Methotrexate (10) · Certolizumab Pegol (9) · upadacitinib (9) · Sulfasalazine (8) · bimekizumab (8) · ixekizumab (8) · tofacitinib (8) · Anti-Inflammatory Agents, Non-Steroidal (7)
Novartis Pharmaceuticals (24) · Pfizer (21) · AbbVie (18) · Charite University, Berlin, Germany (14) · Merck Sharp & Dohme LLC (14) · Wyeth is now a wholly owned subsidiary of Pfizer (14) · AbbVie (prior sponsor, Abbott) (11) · Assistance Publique - Hôpitaux de Paris (10) · UCB Biopharma SRL (9) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (8) · Sun Yat-sen University (8) · Abbott (7) · Assiut University (6) · Biocad (6) · Eli Lilly and Company (6)
United States (104) · Turkey (Türkiye) (97) · France (93) · China (83) · Germany (80) · United Kingdom (56) · Spain (53) · Netherlands (47) · Czechia (46) · Canada (44) · Poland (43) · Belgium (40) · South Korea (37) · Russia (35) · Hungary (27)
Joachim Sieper, MD (6) · Chunde Bao (3) · Finbar O'Shea (3) · Jieruo Gu, Prof (3) · Joachim Sieper, Prof. (3)
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