5 completed, 2 unknown, 1 active not recruiting, 1 recruiting. 2 Phase 2, 1 Early Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Active not recruiting 1, Completed 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Blood Brain Barrier Defect: new trials by email Literature Review of Blood Brain Barrier Defect trials Research Report on Blood Brain Barrier Defect
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium laboratory biomarker analysis, 3D-CAM/CAM-ICU - Delirium - Postoperative, Neuronal Damage | Recruiting | Medical University of Vienna | 1170 | 2026-01-12 | 2026-02-17 | |
| The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI - Major Depressive Disorder, Inflammation | Unknown | Lithuanian University of Health Sciences | 150 | 2022-06-01 | 2024-01-12 | |
| MRI Study of Blood-brain Barrier Function in CADASIL MRI - Cadasil, Blood Brain Barrier Defect | Unknown | Peking University First Hospital | 100 | 2021-04-01 | 2023-06-13 | |
| The Importance of Sleep Quality and the Blood-brain Barrier in Cognitive Disorders and Alzheimer's Disease Diagnostic Test - Blood Brain Barrier Defect, Sleep Deprivation | Withdrawn | Charite University, Berlin, Germany | 2019-09-12 | 2022-07-27 | ||
| Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH) Minocyclin - Aneurysm, Ruptured, Vasospasm, Intracranial | Phase 2 | Active not recruiting | University of Southern California | 20 | 2019-07-01 | 2023-02-10 |
| Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery Dexmedetomidine, Saline - Endothelial Dysfunction, Blood Brain Barrier Defect | Phase 4 | Completed | The First Affiliated Hospital of Anhui Medical University | 464 | 2019-07-01 | 2021-02-10 |
| Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) gadopiclenol, Gadobutrol 1Mmol/mL Solution for Injection Vial - CNS Lesion, Blood Brain Barrier Defect | Phase 3 | Completed | Guerbet | 260 | 2019-06-03 | 2025-09-22 |
| Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury Traumatic Brain Injury, Blood Brain Barrier Defect | Completed | Nova Scotia Health Authority | 2 | 2017-08-03 | 2023-02-02 | |
| P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) P03277, Gadobenate dimeglumine, MRI - CNS Lesion, Blood Brain Barrier Defect | Phase 2 | Completed | Guerbet | 312 | 2016-06-01 | 2021-10-25 |
| Brain Interstitium Temozolomide Concentration Pre and Post Regadenoson Administration Regadenoson, Temozolomide, Microdialysis catheter - Blood Brain Barrier Defect | Early Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 6 | 2015-02-01 | 2018-11-20 |
Inflammation (2) · Alzheimer Disease (1) · Aneurysm, Ruptured (1) · Brain Injuries, Traumatic (1) · CADASIL (1) · Cognitive Dysfunction (1) · Depressive Disorder, Major (1) · Emergence Delirium (1) · Endotoxemia (1) · Genetic Predisposition to Disease (1) · Postoperative Cognitive Complications (1) · Postoperative Complications (1) · Sleep Apnea Syndromes (1) · Sleep Deprivation (1) · Vasospasm, Intracranial (1)
Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Mental Disorders (4) · Neurocognitive Disorders (4) · Pathologic Processes (4) · Cardiovascular Diseases (2) · Cerebrovascular Disorders (2) · Cognition Disorders (2) · Dementia (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Vascular Diseases (2) · Aneurysm (1)
gadopiclenol (2) · Dexmedetomidine (1) · Diagnostic Tests, Routine (1) · Minocycline (1) · Sodium Chloride (1) · Solutions (1) · Temozolomide (1) · gadobenic acid (1) · gadobutrol (1) · regadenoson (1)
Guerbet (2) · Charite University, Berlin, Germany (1) · Lithuanian University of Health Sciences (1) · Medical University of Vienna (1) · Nova Scotia Health Authority (1) · Peking University First Hospital (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · The First Affiliated Hospital of Anhui Medical University (1) · University of Southern California (1)
United States (4) · Belgium (2) · China (2) · Germany (2) · Hungary (2) · Italy (2) · Mexico (2) · Poland (2) · South Korea (2) · Austria (1) · Canada (1) · Czechia (1) · France (1) · Lithuania (1) · Spain (1)
Christian Reiterer, PD DDr. (1) · David B. Clarke, MD, PhD (1) · Lorie Loevner, MD (1) · Stuart Grossman, MD (1) · Vesta Steibliene, PhD, MD (1) · Xinqi Cheng, PhD (1)