60 completed, 9 unknown, 3 recruiting, 3 terminated. 52 Not applicable, 7 Phase 1, 7 Phase 4, 4 Phase 2, 1 Phase 3.
Follow Endotoxemia: new trials by email Literature Review of Endotoxemia trials Research Report on Endotoxemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation Efferon LPS, Toramyxin PMX 20R, Jafron HA 330 - Septic Shock | Not applicable | Not yet recruiting | Moscow Multidisciplinary Clinical Center "Kommunarka" | 76 | 2026-06-25 | 2026-07-02 |
| OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH) - Sepsis, Septic Shock | Recruiting | Pauls Stradins Clinical University Hospital | 29 | 2026-03-01 | 2026-02-19 | |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause). Capsules containing plant extracts, including resveratrol, ellagic acid and isoflavones, Consumption of placebo - Menopause Related Conditions, Cardiovascular Risk | Not applicable | Active not recruiting | National Research Council, Spain | 90 | 2024-01-15 | 2025-09-19 |
| Different Dietary Patterns Dietary intervention - Diet, Healthy, Endotoxemia | Not applicable | Unknown | University of Vienna | 16 | 2023-10-20 | 2025-04-15 |
| Elevated Levels of Antibodies to Endotoxin Core in Hemodialysis Patients With Peripheral Artery Disease Endotoxemia, Peripheral Arterial Disease | Completed | Tungs' Taichung Metroharbour Hospital | 155 | 2023-05-03 | 2024-03-01 | |
| The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains. 2000 meter ergometer test - Endothelial Dysfunction | Completed | Poznan University of Physical Education | 13 | 2023-05-01 | 2024-05-07 | |
| Dietary Intervention to Reduce Metabolic Endotoxemia AIA-D, CONV-D - Endotoxemia, Intestinal Microbiota | Not applicable | Completed | Centro de Investigación en Alimentación y Desarrollo A.C. | 72 | 2023-04-14 | 2024-02-07 |
| The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI - Major Depressive Disorder, Inflammation | Unknown | Lithuanian University of Health Sciences | 150 | 2022-06-01 | 2024-01-12 | |
| Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components Whole Wheat Bread, White Bread (control) - PreDiabetes, Dysbiosis | Not applicable | Active not recruiting | Ohio State University | 65 | 2022-01-27 | 2025-11-20 |
| Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS) hemoperfusion with polymyxin B - Multiple Organ Dysfunction With Severe Endotoxemia | Not applicable | Recruiting | Petrovsky National Research Centre of Surgery | 20 | 2021-11-01 | 2024-11-25 |
| The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric Surgery probiotic supplementation, placebo - Bariatric Surgery Candidate, Dysbiosis | Not applicable | Unknown | Medical University of Gdansk | 80 | 2021-08-02 | 2022-06-07 |
| Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes Rifaximin, Placebo - Liver Cirrhosis, Coagulation Disorder | Phase 4 | Terminated | University of Roma La Sapienza | 20 | 2021-04-03 | 2024-10-08 |
| Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function Dietary intervention 1, Dietary Intervention 2, Dietary Intervention 3 - Dietary Habits, Endotoxemia | Not applicable | Completed | University of Vienna | 18 | 2021-03-01 | 2023-11-01 |
| Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in Humans Camu camu, Placebo - Overweight, Microtia | Not applicable | Completed | Laval University | 35 | 2020-10-31 | 2022-10-04 |
| Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention bioactive components fortified food products intake (biscuits and cookies), control food products intake (biscuits and cookies) - Cardiometabolic Risk, Abdominal Obesity | Not applicable | Completed | Hospices Civils de Lyon | 62 | 2020-01-21 | 2025-09-25 |
| Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge - Septic Shock, Endotoxemia | Not applicable | Completed | Spectral Diagnostics (US) Inc. | 157 | 2020-01-09 | 2026-10-13 |
| Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic Syndrome Maple syrup, Placebo - Overweight, Microbiota | Not applicable | Completed | Laval University | 47 | 2019-09-03 | 2024-04-15 |
| Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome Green Tea Extract, Placebo - Dysbiosis, Endotoxemia | Not applicable | Completed | Ohio State University | 46 | 2019-07-01 | 2025-12-19 |
Showing 20 of 80. Sign in to see all of them.
Inflammation (23) · Sepsis (14) · Insulin Resistance (7) · Shock, Septic (7) · Obesity (6) · Metabolic Syndrome (5) · Overweight (4) · Diabetes Mellitus, Type 2 (3) · Dysbiosis (3) · Feeding Behavior (3) · Liver Cirrhosis (3) · Hyperglycemia (2) · Non-alcoholic Fatty Liver Disease (2) · Alcohol Drinking (1)
Pathologic Processes (80) · Pathological Conditions, Signs and Symptoms (80) · Toxemia (80) · Bacteremia (79) · Infections (79) · Systemic Inflammatory Response Syndrome (79) · Sepsis (66) · Inflammation (57) · Nutritional and Metabolic Diseases (19) · Signs and Symptoms (15) · Metabolic Diseases (12) · Body Weight (11) · Nutrition Disorders (11) · Overnutrition (11) · Glucose Metabolism Disorders (10)
Endotoxins (11) · Lipopolysaccharides (10) · Whey (4) · endotoxin, Escherichia coli (4) · Diet Therapy (3) · Aspirin (2) · Complement C1 Inhibitor Protein (2) · Rifaximin (2) · Sodium Chloride (2) · Tea (2) · microcrystalline cellulose (2) · 20-aldehyde leukotriene B4 (1) · 3-(2,4-dimethoxybenzylidene)anabaseine (1) · Arginine Vasopressin (1) · Atazanavir Sulfate (1)
Radboud University Medical Center (21) · University of Aarhus (5) · Copenhagen University Hospital, Rigshospitalet (4) · Laval University (4) · Ohio State University (4) · Spectral Diagnostics (US) Inc. (4) · Medical University of Vienna (3) · University of Vienna (3) · Hospices Civils de Lyon (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Bernd Jilma (1) · Centre de Recherche en Nutrition Humaine Rhone-Alpe (1) · Centro de Investigación en Alimentación y Desarrollo A.C. (1) · Critical Therapeutics (1) · Danisco (1)
Netherlands (21) · United States (11) · Denmark (10) · Austria (8) · Canada (5) · France (4) · China (2) · Italy (2) · Mexico (2) · Poland (2) · Russia (2) · Belgium (1) · Finland (1) · Latvia (1) · Lithuania (1)
Niels Moeller, Professor (5) · Peter Pickkers, MD, PhD (5) · Anne Sofie Andreasen, MD (3) · Richard Bruno, PhD, RD (3) · Bernd Jilma, MD (2) · Aila Rissanen, MD (1) · Aldo Torre-Delgadillo, M.D., M.Sc. (1) · Alec Wittek, M.D. (1) · Bart P Ramakers, MD (1) · Bente K Pedersen, MD, DMSc (1) · Boushra Dalile, PhD (1) · Christa Firbas, MD (1) · Denis Protsenko, MD, PHD (1)
PMID 40517600, PMID 16864730, PMID 18433844, PMID 20444270, PMID 21211004, PMID 21931634, PMID 22129171, PMID 22162470, PMID 22822024, PMID 22992437, PMID 23235199, PMID 24684464, PMID 24916483, PMID 25916910, PMID 26151336, PMID 27307305, PMID 27810310, PMID 27816052, PMID 28515092, PMID 28545546, PMID 30260393, PMID 30304428, PMID 30418539, PMID 30470853, PMID 30525950, PMID 30919998, PMID 31008870, PMID 33483132, PMID 33693737, PMID 34566840, PMID 34837121, PMID 35213875, PMID 37261364, PMID 37892479, PMID 38214917, PMID 38430822, PMID 39163971, PMID 39168095, PMID 39565757, PMID 39710576, PMID 40670486, PMID 41068905, PMID 41837287, PMID 41887242, PMID 42729417
2014 (2), 2016 (1), 2023 (1)