13 recruiting, 9 completed, 5 unknown, 3 not yet recruiting. 7 Phase 2, 4 Not applicable, 1 Phase 1.
Follow CADASIL: new trials by email Literature Review of CADASIL trials Research Report on CADASIL
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Edaravone Dexborneol Sublingual Tablets for Blood-Brain Barrier Dysfunction in CADASIL Edaravone Dexborneol Sublingual Tablets - CADASIL | Phase 2 | Not yet recruiting | Huashan Hospital | 60 | 2026-07-01 | 2026-07-09 |
| Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2 Biocollection, Neurological evaluation and Biocollection - CADASIL, Cavernous Angioma | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 600 | 2026-06-30 | 2026-06-16 |
| Neurogenetic And Hemodynamic Of Migraine Aura And Pfo Intervention - Migraine With Aura | Recruiting | Azienda Usl di Bologna | 240 | 2025-11-24 | 2026-02-11 | |
| Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASIL Functional MRI at 3T - CADASIL | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 70 | 2025-04-01 | 2025-03-05 | |
| Effect of the Mediterranean Diet in Patients Affected by CADASIL and Cerebral Amyloid Angiopathy. Mediterranean Diet with Extra Virgin Olive Oil, Mediterranean Diet with Walnuts, Low-Fat Control Diet - Cerebral Amyloid Angiopathy, CAA - Cerebral Amyloid Angiopathy | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 86 | 2024-10-10 | 2026-09-01 | |
| CERebrolysin In CADASIL Cerebrolysin, 0.9 % NaCl - Cadasil | Phase 2 | Active not recruiting | Ever Neuro Pharma GmbH | 30 | 2023-11-29 | 2025-02-25 |
| AusCADASIL: An Australian Cohort of CADASIL Cadasil | Recruiting | Perminder Sachdev | 300 | 2023-11-25 | 2024-05-08 | |
| Genotype, Clinical Features and Imaging of Neuroradiological Abnormalities in CADASIL CADASIL, CADASIL (Diagnosis) | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 100 | 2023-11-21 | 2026-08-31 | |
| Long-term Prospective Study of Korean CADASIL Patients CADASIL, Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy | Recruiting | Jeju National University Hospital | 500 | 2023-07-10 | 2026-05-14 | |
| RAre, But Not aLone: a Large Italian Network to Empower the Impervious diaGNostic Pathway of Rare cerEbrovascular Diseases (ALIGNED) CADASIL, CADASIL (Diagnosis) | Completed | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 500 | 2023-05-01 | 2026-09-01 | |
| Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic Cerebral Small Vessel Disease Cerebrospinal fluid (CSF) sample and additional blood samples - Cerebral Small Vessel Diseases, CADASIL (Diagnosis) | Unknown | Assistance Publique - Hôpitaux de Paris | 90 | 2023-03-01 | 2023-03-31 | |
| Florida Cerebrovascular Disease Biorepository and Genomics Center Cerebrovascular Disease, Ischemic Stroke | Active not recruiting | Mayo Clinic | 72 | 2022-08-02 | 2026-09-03 | |
| Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study Study Procedures - CADASIL | Recruiting | University of Wisconsin, Madison | 660 | 2022-06-03 | 2026-01-15 | |
| Registry for CADASIL Registry - Cerebral Autosomal Dominant Ateriopathy With Subcortical Infarcts and Leukoencephalopathy | Recruiting | University of Wisconsin, Madison | 2500 | 2022-06-03 | 2026-10-23 | |
| Adrenomedullin for CADASIL Adrenomedullin - Cadasil | Phase 2 | Completed | National Cerebral and Cardiovascular Center, Japan | 60 | 2022-01-06 | 2023-10-10 |
| Safety and Efficacy of Fremanezumab for Migraine in Adult CADASIL Fremanezumab, Placebo - Cadasil, Migraine | Phase 2 | Withdrawn | Mayo Clinic | 2021-12-01 | 2022-02-28 | |
| MRI Study of Blood-brain Barrier Function in CADASIL MRI - Cadasil, Blood Brain Barrier Defect | Unknown | Peking University First Hospital | 100 | 2021-04-01 | 2023-06-13 | |
| Retina is a Marker for Cerebrovascular Heath Cilostazol - Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 100 | 2021-02-09 | 2026-08-03 |
| Efficacy and Safety of Tocotrienols in CADASIL HOV-12020 (Palm tocotrienols complex), Placebo - Cadasil | Phase 2 | Completed | Hovid Berhad | 50 | 2020-12-21 | 2026-02-02 |
| Prognosis of Cerebral Small Vessel Disease Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease | Recruiting | Insel Gruppe AG, University Hospital Bern | 900 | 2020-12-01 | 2023-03-08 |
Showing 20 of 33. Sign in to see all of them.
Cerebral Small Vessel Diseases (8) · Cognitive Dysfunction (4) · Dementia (4) · Leukoencephalopathies (4) · Stroke (4) · Dementia, Vascular (3) · Disease (3) · Adrenoleukodystrophy (2) · Aicardi-Goutieres syndrome (2) · Alexander Disease (2) · Alexanders leukodystrophy (2) · Allan-Herndon-Dudley syndrome (2) · Alzheimer Disease (2) · Attention Deficit Disorder with Hyperactivity (2)
Brain Diseases (33) · Brain Infarction (33) · Cardiovascular Diseases (33) · Central Nervous System Diseases (33) · Cerebral Arterial Diseases (33) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (33) · Genetic Diseases, Inborn (33) · Infarction (33) · Intracranial Arterial Diseases (33) · Ischemia (33) · Necrosis (33) · Pathologic Processes (33) · Pathological Conditions, Signs and Symptoms (33) · Vascular Diseases (33) · Brain Ischemia (32)
Methods (2) · Adrenomedullin (1) · Cilostazol (1) · Dabigatran (1) · Diet, Mediterranean (1) · Registries (1) · Sodium Chloride (1) · Tocotrienols (1) · Transcranial Direct Current Stimulation (1) · cerebrolysin (1) · erenumab (1) · fremanezumab (1)
Assistance Publique - Hôpitaux de Paris (4) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (3) · Mayo Clinic (3) · Children's Hospital of Philadelphia (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · MD Stem Cells (2) · University of Wisconsin, Madison (2) · Azienda Usl di Bologna (1) · Bin Cai (1) · Charite University, Berlin, Germany (1) · Ever Neuro Pharma GmbH (1) · Fondation Hôpital Saint-Joseph (1) · Hovid Berhad (1) · Huashan Hospital (1) · Insel Gruppe AG, University Hospital Bern (1)
United States (9) · France (5) · Italy (5) · China (3) · United Arab Emirates (2) · Australia (1) · Czechia (1) · Germany (1) · Japan (1) · South Korea (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Adeline Vanderver, MD (2) · Jeffrey Weiss, MD (2) · Steven Levy, MD (2) · David Ho (1) · David J Seiffge, Prof, MD (1) · Francesco Orzi, MD (1) · Hugues Chabriat, MD PhD (1) · James F Meschia (1) · James Meschia, MD (1) · Jane Paulsen, PhD (1) · Jane S Paulsen, PhD (1)
PMID 37652700, PMID 10356105, PMID 15364702, PMID 19933977, PMID 20386637, PMID 22133740, PMID 23867200, PMID 24578207, PMID 27844030, PMID 30009197, PMID 30237574, PMID 32342562, PMID 32749716, PMID 33712516, PMID 34881353, PMID 35617208, PMID 35781912, PMID 37236211, PMID 37982214, PMID 39392097, PMID 39493517, PMID 39499373, PMID 42005919, PMID 42856679, PMID 8878478, PMID 9818928
1RF1AG074608-01 (1), U01NS106845 (1), U54NS115052 (1)