100 completed, 79 recruiting, 47 unknown, 20 active not recruiting. 93 Not applicable, 4 Phase 1, 4 Phase 4, 3 Phase 2, 2 Phase 3.
Follow Genetic Predisposition to Disease: new trials by email Literature Review of Genetic Predisposition to Disease trials Research Report on Genetic Predisposition to Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease Polygenic risk score - Coronary Heart Disease | Not yet recruiting | Medical College of Wisconsin | 200 | 2027-06-01 | 2026-05-04 | |
| Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx) - Heart Failure With Reduced Ejection Fraction | Phase 4 | Recruiting | University of Michigan | 100 | 2026-12-01 | 2026-10-15 |
| Effects of Sirolimus on Asymptomatic ApoE4 Carriers Sirolimus (rapamycin), Placebo - Genetic Predisposition to Disease, Healthy Volunteer | Phase 1 | Recruiting | University of Missouri-Columbia | 225 | 2026-12-01 | 2026-10-05 |
| Predicting Pre-dementia Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD) | Recruiting | Prevention Research Consortium Corp. | 100 | 2026-11-15 | 2026-09-22 | |
| The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans Exendin 9-39, Saline - Genetic Predisposition, Type2diabetes | Phase 2 | Not yet recruiting | Mayo Clinic | 80 | 2026-10-01 | 2026-01-30 |
| Genetic Investigation of Cancer Predisposition DNA or RNA Sequencing - Genetic Predisposition, Cancer | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 100 | 2026-10-01 | 2026-01-06 | |
| Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology Type 2 Diabetes Mellitus (T2DM), Chronic Pancreatitis | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 440 | 2026-09-01 | 2026-06-26 | |
| Genetic Architecture of Natriuretic Peptides and Blood Pressure Response Low Salt Diet, High Salt Diet, Saline Infusion - Hypertension (HTN), Cardiometabolic Diseases | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-09-01 | 2026-03-10 |
| Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool No Intervention: Observational Cohort - Optic Neuritis, Multiple Sclerosis | Not yet recruiting | King's College London | 180 | 2026-09-01 | 2026-07-15 | |
| Precure Targeted Accrual and Rapid Growth in Enrollment Trial Study Exposure, Environmental, Genetic Predisposition | Enrolling by invitation | Mayo Clinic | 100000 | 2026-08-07 | 2026-08-17 | |
| Non-Invasive Diagnostic Panel for MASLD in Children With Obesity Non-Invasive Multi-Parameter Diagnostic Panel - Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity | Not yet recruiting | Kayseri City Hospital | 180 | 2026-07-01 | 2026-07-30 | |
| Outcomes of Health Care Transition for AYA With a Cancer Predisposition Readiness Assessment, Transition Outcomes Survey A, Transition Outcomes Survey B - Genetic Predisposition | Recruiting | St. Jude Children's Research Hospital | 56 | 2026-06-16 | 2026-06-18 | |
| The Preventive Risk Outreach And Cascade Testing Minimally facilitated platform, AI-powered platform - Genetic Predisposition, Family Members | Not applicable | Not yet recruiting | Stanford University | 400 | 2026-06-01 | 2026-05-14 |
| Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3) Coronary Artery Disease, Atherosclerosis | Enrolling by invitation | Radboud University Medical Center | 250 | 2026-05-31 | 2026-08-13 | |
| Bundled Cancer Screening and Genetic Services Navigation Breast cancer screening navigation, Multicancer screening navigation, Usual care genetics referral - Breast Cancer Screening, Colon Cancer Screening | Not applicable | Recruiting | Georgetown University | 820 | 2026-05-06 | 2026-05-08 |
| Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. Semaglutide or Tirzepatide - Obesity (Disorder), Anti-obesity Agents | Recruiting | National and Kapodistrian University of Athens | 220 | 2026-04-22 | 2026-07-10 | |
| Study of a Polygenic Risk Score to Predict the Risk of Pancreatic Ductal Adenocarcinoma Blood sample collection - Pancreatic Ductal Adenocarcinoma (mPDAC) | Not applicable | Not yet recruiting | Catholic University of the Sacred Heart | 1140 | 2026-04-01 | 2026-04-08 |
| Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous Flap Viability in Breast Recon Minoxidil, Hair mousse - Breast Reconstruction, Perfusion; Complications | Phase 1 | Recruiting | Duke University | 25 | 2026-03-16 | 2026-07-08 |
| DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk Scores Wearable Electronic Devices, Polygenic Risk Score | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 10 | 2026-02-01 | 2026-01-23 | |
| Mayo Clinic Precure - Prospective Study Genetic Predisposition, Exposure, Environmental | Enrolling by invitation | Mayo Clinic | 100000 | 2026-01-19 | 2026-03-16 |
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Genetic Risk Score (52) · Breast Neoplasms (20) · Neoplasms (16) · Prostatic Neoplasms (15) · Diabetes Mellitus, Type 2 (14) · Genetic Diseases, Inborn (13) · Obesity (12) · Coronary Artery Disease (10) · Cardiovascular Diseases (8) · Ovarian Neoplasms (8) · Rare Diseases (8) · Hypertension (7) · Pancreatic Neoplasms (7) · Alzheimer Disease (6)
Pathological Conditions, Signs and Symptoms (284) · Disease Attributes (283) · Pathologic Processes (283) · Disease Susceptibility (280) · Neoplasms (66) · Neoplasms by Site (59) · Nutritional and Metabolic Diseases (47) · Endocrine System Diseases (43) · Urogenital Diseases (40) · Cardiovascular Diseases (37) · Metabolic Diseases (34) · Vascular Diseases (32) · Nervous System Diseases (29) · Signs and Symptoms (29)
Blood Specimen Collection (6) · Interviews as Topic (4) · Surveys and Questionnaires (4) · Genetic Testing (3) · Genome-Wide Association Study (3) · Biopsy (2) · Echocardiography (2) · Electrocardiography, Ambulatory (2) · Equipment and Supplies (2) · Exome (2) · Exome Sequencing (2) · High-Throughput Nucleotide Sequencing (2) · Sirolimus (2) · Specimen Handling (2) · Whole Genome Sequencing (2)
University Hospital Tuebingen (10) · National Institute of Environmental Health Sciences (NIEHS) (7) · Brigham and Women's Hospital (6) · St. Jude Children's Research Hospital (6) · Abramson Cancer Center at Penn Medicine (5) · Catholic University of the Sacred Heart (5) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5) · Massachusetts General Hospital (5) · The University of Hong Kong (5) · Mayo Clinic (4) · National Cancer Institute (NCI) (4) · University Hospital, Lille (4) · Assistance Publique - Hôpitaux de Paris (3) · Boston Children's Hospital (3) · Dana-Farber Cancer Institute (3)
United States (99) · Italy (27) · France (23) · United Kingdom (16) · Germany (15) · China (14) · Spain (11) · Switzerland (9) · Brazil (7) · Singapore (7) · Sweden (7) · Turkey (Türkiye) (7) · Canada (6) · Greece (6) · Poland (6)
Konstantinos N. Lazaridis, M.D. (3) · Robert C. Green, MD, MPH (3) · Ai-Ling Lin, PhD (2) · Angela R Bradbury, MD (2) · Katianne Sharp, PhD (2) · Keke Zhang, M.D. (2) · Kim E. Nichols, MD (2) · Magdi H Yacoub, FRS OM (2) · Pankaj Arora, MD, FAHA (2) · Paolo Della Bella, MD (2) · Tobias Haack, Dr. (2) · Wenwen He, M.D. (2) · Xiangjia Zhu, M.D. (2) · Yannis Manios, Professor (2)
PMID 15741351, PMID 16415884, PMID 16775236, PMID 17434869, PMID 18820647, PMID 19268270, PMID 19585618, PMID 19605829, PMID 20031626, PMID 20624171, PMID 20647424, PMID 20808246, PMID 20840664, PMID 20888433, PMID 21153533, PMID 21274322, PMID 21471568, PMID 21684333, PMID 21997396, PMID 22006311, PMID 22216169, PMID 22642073, PMID 22695330, PMID 22968341, PMID 23548751, PMID 23555274, PMID 23592667, PMID 23739212, PMID 23789315, PMID 23840612, PMID 23912809, PMID 24216218, PMID 24243635, PMID 24484606, PMID 24566154, PMID 24578078, PMID 24774647, PMID 24915259, PMID 25341628, PMID 25341889, PMID 25410576, PMID 25471927, PMID 25530085, PMID 25601634, PMID 25634646, PMID 25642295, PMID 25646330, PMID 25652150, PMID 25673413, PMID 25722272
2018 (2), R01HG002213 (2), I01CX002635 (1), I01HX003477 (1), K23DK131345 (1), K23NS097625 (1), P50CA091846 (1), R01CA074880 (1), R01CA129142 (1), R01CA301168 (1), R01DK128207 (1), R01ES016347 (1), R01HD039081 (1), R01HG011798 (1), R01HL098601 (1)