864 completed, 328 unknown, 177 recruiting, 106 terminated. 733 Not applicable, 178 Phase 2, 117 Phase 3, 114 Phase 1, 109 Phase 4.
Follow Peripheral Arterial Disease: new trials by email Literature Review of Peripheral Arterial Disease trials Research Report on Peripheral Arterial Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease FGF-1, Placebo - Peripheral Arterial Disease, Stenosis | Phase 1 / Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 24 | 2028-10-15 | 2026-08-19 |
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent Restenosis Drug-Coated Balloon-First Strategy, Eluvia Drug-Eluting Stent-First Strategy - Femoropopliteal In-Stent Restenosis (ISR) | Not yet recruiting | Chunshui He | 600 | 2027-01-01 | 2026-09-16 | |
| FRAME, External Support for Lower Limb Autologous Grafts FRAME - Peripheral Arterial Disease, Peripheral Artery Disease | Not applicable | Suspended | Vascular Graft Solutions Ltd. | 30 | 2026-12-31 | 2025-02-04 |
| Spectroscopic Assessment of Tissue Oxygenation Changes During Vascular Surgery Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia | Not yet recruiting | Spectrocor | 30 | 2026-12-01 | 2026-08-26 | |
| DCB Outcomes After Non-Compliant Balloon Vessel Preparation With or Without Scoring in Patients With Femoropopliteal Arterial Disease Non-compliant Plain Balloon angioplasty (PBA), Non-compliant Scoring Balloon Angioplasty (SB) - Femoropopliteal Disease, Drug Coated Balloon | Not applicable | Not yet recruiting | Marc Sirvent | 142 | 2026-12-01 | 2026-10-07 |
| The NICE-PAD II Trial Nicotinamide Riboside (NR), Placebo - Peripheral Artery Disease (PAD) | Phase 3 | Not yet recruiting | Northwestern University | 250 | 2026-12-01 | 2026-08-24 |
| PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease | Not yet recruiting | Medical College of Wisconsin | 60 | 2026-12-01 | 2025-10-14 | |
| XPAD European Feasibility Study XPAD conduit - Peripheral Arterial Disease | Not applicable | Not yet recruiting | Xeltis | 15 | 2026-12-01 | 2026-07-21 |
| IV-X Medical Peripheral Intravascular Lithotripsy Study for PAD IV-X Medical IVL System - Peripheral Artery Disease (PAD) | Not applicable | Not yet recruiting | IVX Medical | 140 | 2026-12-01 | 2026-10-21 |
| Hemodynamic Characteristics of Peripheral Arterial Disease Using Computational Fluid Dynamics Computational Fluid Dynamics Simulation - Peripheral Arterial Disease | Not yet recruiting | Fudan University | 14 | 2026-11-01 | 2026-10-06 | |
| Clinical Value of CT Perfusion in Peripheral Artery Disease Peripheral Artery Disease (PAD), CT Perfusion | Not yet recruiting | Fudan University | 200 | 2026-11-01 | 2026-09-14 | |
| Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 180 | 2026-10-20 | 2026-09-18 |
| Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention ropivacaine - Postoperative Delirium (POD), Peripheral Arterial Disease | Not applicable | Not yet recruiting | Assiut University | 168 | 2026-10-01 | 2026-09-29 |
| LineMatrix® Biological Vascular Graft for Infra-renal Arterial Bypass or Replacement LineMatrix® Biological Vascular Graft - Peripheral Arterial Disease | Not applicable | Not yet recruiting | Shanghai Zhongshan Hospital | 15 | 2026-09-30 | 2026-07-30 |
| Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease Hybrid Cardiac Rehabilitation, Supervised Exercise Therapy - Peripheral Arterial Disease | Not applicable | Not yet recruiting | Biruni University | 40 | 2026-09-16 | 2026-04-24 |
| IV-X Medical First-in-Human Peripheral Intravascular Lithotripsy Study for PAD IV-X Medical IVL System - Peripheral Artery Disease | Not applicable | Active not recruiting | IVX Medical | 25 | 2026-09-15 | 2026-10-21 |
| Multimodal Physiologic State Intelligence Study OMNIPHYS Multimodal Ultrasound Imaging System - Heart Failure, Cardiomyopathies | Enrolling by invitation | Truway Health, Inc. | 25000 | 2026-09-02 | 2026-09-10 | |
| Rotational Atherectomy and Drug-Coated Balloon Angioplasty With Embolic Protection for Superficial Femoral Artery Occlusions Rotational Atherectomy With Distal Embolic Protection and Drug-Coated Balloon Angioplasty - Peripheral Artery Disease, Atherectomy in Diseased Lower Extremity Arteries | Not applicable | Not yet recruiting | Sakarya University | 60 | 2026-09-01 | 2026-09-04 |
| ORbital Atherectomy for Lesion Preparation in Patients With Chronic Limb-threatening ischEmia Stealth 360™ Peripheral Orbital Atherectomy System from Abbott - Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia | Recruiting | Cardiovascular and Interventional Radiological Society of Europe | 250 | 2026-08-31 | 2026-09-23 |
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Chronic Limb-Threatening Ischemia (353) · Intermittent Claudication (306) · Peripheral Vascular Diseases (205) · Atherosclerosis (111) · Cardiovascular Diseases (86) · Diabetes Mellitus (79) · Coronary Artery Disease (64) · Arterial Occlusive Diseases (60) · Vascular Diseases (57) · Motor Activity (48) · Diabetic Foot (44) · Myocardial Infarction (34) · Peripheral Arterial Occlusive Disease 1 (33) · Ischemia (32)
Vascular Diseases (1613) · Cardiovascular Diseases (1584) · Arteriosclerosis (1570) · Arterial Occlusive Diseases (1533) · Atherosclerosis (1474) · Peripheral Vascular Diseases (1465) · Pathological Conditions, Signs and Symptoms (764) · Pathologic Processes (464) · Disease Attributes (378) · Chronic Disease (371) · Ischemia (369) · Signs and Symptoms (355) · Endocrine System Diseases (138) · Nutritional and Metabolic Diseases (137)
Angioplasty (39) · Aspirin (38) · Exercise (35) · Clopidogrel (30) · Cilostazol (20) · Rivaroxaban (18) · Standard of Care (17) · Angioplasty, Balloon (16) · Atherectomy (13) · Stents (11) · Ticagrelor (11) · Control Groups (10) · Saline Solution (9) · Exercise Therapy (8) · Simvastatin (7)
University Hospital, Angers (29) · Northwestern University (26) · Medtronic Endovascular (22) · C. R. Bard (17) · Flanders Medical Research Program (17) · Abbott Medical Devices (16) · Spectranetics Corporation (16) · VA Office of Research and Development (16) · Cook Group Incorporated (14) · Biotronik AG (12) · University of Nebraska (12) · Boston Scientific Corporation (11) · W.L.Gore & Associates (11) · Yonsei University (11) · Bayer (10)
United States (554) · Germany (193) · France (140) · China (100) · Belgium (98) · United Kingdom (98) · Italy (96) · Austria (88) · Netherlands (57) · Canada (54) · Spain (52) · South Korea (50) · New Zealand (43) · Switzerland (43) · Australia (39)
Marc Bosiers, MD (14) · Koen Deloose, MD (12) · Mary McDermott, MD (10) · Thomas Zeller, MD (10) · Marianne Brodmann, MD (9) · Dierk Scheinert, MD (8) · Jihad Mustapha, MD (8) · Andrew Holden, MD (6) · Gunnar Tepe, MD (6) · Mary M McDermott, MD (5) · Pierre Abraham, MD, PhD (5) · Craig Walker, MD (4) · Kenneth Rosenfield, MD (4)
PMID 42573020, PMID 42035974, PMID 31567024, PMID 33025243, PMID 35802393, PMID 36588397, PMID 30690141, PMID 31543165, PMID 36137674, PMID 17223489, PMID 21262997, PMID 23583245, PMID 23915883, PMID 25237048, PMID 26062950, PMID 31926836, PMID 34167675, PMID 36645250, PMID 16242558, PMID 16449620, PMID 17140820, PMID 17848483, PMID 20484101, PMID 21123095, PMID 21146749, PMID 21873417, PMID 21953370, PMID 22169682, PMID 23050152, PMID 23797811, PMID 25472980, PMID 25499305, PMID 25908725, PMID 26490645, PMID 26861113, PMID 27388828, PMID 27840332, PMID 28393673, PMID 28411244, PMID 28729250, PMID 29132879, PMID 29132880, PMID 29301628, PMID 29326153, PMID 29976553, PMID 30786835, PMID 31159978, PMID 31195825, PMID 31912491, PMID 32390569
2009 (4), 2017 (4), 2023 (3), 2025 (3), 2005 (2), 2014 (2), R01HL098909 (2), 1IK2RX003546-01A2 (1), 1RC2HL101515-01 (1), 2004 (1), 2008 (1), 2016 (1), 2018 (1), 2019 (1), I01CX002150 (1)