Peripheral Vascular Diseases: Clinical Trials

1103 completed, 409 unknown, 195 recruiting, 135 terminated. 882 Not applicable, 229 Phase 2, 172 Phase 3, 145 Phase 4, 140 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	882	Completed 461, Unknown 161, Recruiting 100, Terminated 54, Not yet recruiting 37, Active not recruiting 36, Withdrawn 27, Suspended 4, Enrolling by invitation 2
Phase 2	229	Completed 134, Unknown 49, Terminated 22, Withdrawn 9, Recruiting 7, Not yet recruiting 6, Active not recruiting 2
Phase 3	172	Completed 101, Unknown 32, Terminated 17, Recruiting 11, Not yet recruiting 4, Withdrawn 4, Active not recruiting 3
Phase 4	145	Completed 81, Unknown 32, Terminated 13, Recruiting 9, Withdrawn 5, Not yet recruiting 3, Active not recruiting 1, Suspended 1
Phase 1	140	Completed 80, Unknown 34, Terminated 10, Withdrawn 8, Not yet recruiting 3, Active not recruiting 2, Recruiting 2, Enrolling by invitation 1
Early Phase 1	24	Completed 12, Unknown 5, Not yet recruiting 2, Recruiting 2, Enrolling by invitation 1, Terminated 1, Withdrawn 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease FGF-1, Placebo - Peripheral Arterial Disease, Stenosis	Phase 1 / Phase 2	Not yet recruiting	Venturis Therapeutics, Inc.	24	2028-10-15	2026-08-19
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease	Early Phase 1	Not yet recruiting	Milton S. Hershey Medical Center	30	2027-12-01	2026-03-17
Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent Restenosis Drug-Coated Balloon-First Strategy, Eluvia Drug-Eluting Stent-First Strategy - Femoropopliteal In-Stent Restenosis (ISR)		Not yet recruiting	Chunshui He	600	2027-01-01	2026-09-16
Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's Disease BOTOX INJECTION - Buerger Disease, Raynaud Syndrome	Phase 3	Not yet recruiting	University Hospital, Toulouse	8	2027-01-01	2026-07-23
FRAME, External Support for Lower Limb Autologous Grafts FRAME - Peripheral Arterial Disease, Peripheral Artery Disease	Not applicable	Suspended	Vascular Graft Solutions Ltd.	30	2026-12-31	2025-02-04
Spectroscopic Assessment of Tissue Oxygenation Changes During Vascular Surgery Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia		Not yet recruiting	Spectrocor	30	2026-12-01	2026-08-26
DCB Outcomes After Non-Compliant Balloon Vessel Preparation With or Without Scoring in Patients With Femoropopliteal Arterial Disease Non-compliant Plain Balloon angioplasty (PBA), Non-compliant Scoring Balloon Angioplasty (SB) - Femoropopliteal Disease, Drug Coated Balloon	Not applicable	Not yet recruiting	Marc Sirvent	142	2026-12-01	2026-10-07
The NICE-PAD II Trial Nicotinamide Riboside (NR), Placebo - Peripheral Artery Disease (PAD)	Phase 3	Not yet recruiting	Northwestern University	250	2026-12-01	2026-08-24
PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease		Not yet recruiting	Medical College of Wisconsin	60	2026-12-01	2025-10-14
XPAD European Feasibility Study XPAD conduit - Peripheral Arterial Disease	Not applicable	Not yet recruiting	Xeltis	15	2026-12-01	2026-07-21
IV-X Medical Peripheral Intravascular Lithotripsy Study for PAD IV-X Medical IVL System - Peripheral Artery Disease (PAD)	Not applicable	Not yet recruiting	IVX Medical	140	2026-12-01	2026-10-21
Hemodynamic Characteristics of Peripheral Arterial Disease Using Computational Fluid Dynamics Computational Fluid Dynamics Simulation - Peripheral Arterial Disease		Not yet recruiting	Fudan University	14	2026-11-01	2026-10-06
Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis	Phase 4	Not yet recruiting	Jay C. Buckey Jr.	100	2026-11-01	2026-09-09
Clinical Value of CT Perfusion in Peripheral Artery Disease Peripheral Artery Disease (PAD), CT Perfusion		Not yet recruiting	Fudan University	200	2026-11-01	2026-09-14
A Study of LIQ861 (Inhaled Treprostinil) in Adults With Systemic Sclerosis Who Have Symptomatic Raynaud's Phenomenon Attacks LIQ861 (treprostinil) inhalation powder - Dose Titration Arm, LIQ861 (treprostinil) inhalation powder - fixed dose arm - Raynaud's Phenomenon Secondary to Systemic Sclerosis	Phase 2	Not yet recruiting	Liquidia Technologies, Inc.	75	2026-10-26	2026-08-07
Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer	Phase 4	Not yet recruiting	First Affiliated Hospital of Wenzhou Medical University	180	2026-10-20	2026-09-18
Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention ropivacaine - Postoperative Delirium (POD), Peripheral Arterial Disease	Not applicable	Not yet recruiting	Assiut University	168	2026-10-01	2026-09-29
LineMatrix® Biological Vascular Graft for Infra-renal Arterial Bypass or Replacement LineMatrix® Biological Vascular Graft - Peripheral Arterial Disease	Not applicable	Not yet recruiting	Shanghai Zhongshan Hospital	15	2026-09-30	2026-07-30
Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease Hybrid Cardiac Rehabilitation, Supervised Exercise Therapy - Peripheral Arterial Disease	Not applicable	Not yet recruiting	Biruni University	40	2026-09-16	2026-04-24
IV-X Medical First-in-Human Peripheral Intravascular Lithotripsy Study for PAD IV-X Medical IVL System - Peripheral Artery Disease	Not applicable	Active not recruiting	IVX Medical	25	2026-09-15	2026-10-21

Showing 20 of 2068. Sign in to see all of them.

Narrower conditions

Peripheral Arterial Disease (1356)  ·  Chronic Limb-Threatening Ischemia (353)  ·  Intermittent Claudication (306)  ·  Atherosclerosis (127)  ·  Cardiovascular Diseases (121)  ·  Diabetes Mellitus (105)  ·  Raynaud Disease (80)  ·  Coronary Artery Disease (78)  ·  Arterial Occlusive Diseases (73)  ·  Vascular Diseases (68)  ·  Diabetic Foot (56)  ·  Stroke (50)  ·  Motor Activity (49)  ·  Ischemia (46)

Broader conditions

Vascular Diseases (2000)  ·  Cardiovascular Diseases (1947)  ·  Arteriosclerosis (1597)  ·  Arterial Occlusive Diseases (1559)  ·  Atherosclerosis (1474)  ·  Pathological Conditions, Signs and Symptoms (840)  ·  Pathologic Processes (519)  ·  Disease Attributes (388)  ·  Signs and Symptoms (382)  ·  Ischemia (379)  ·  Chronic Disease (377)  ·  Peripheral Arterial Disease (314)  ·  Endocrine System Diseases (181)  ·  Nutritional and Metabolic Diseases (181)

Interventions

Angioplasty (43)  ·  Aspirin (43)  ·  Exercise (37)  ·  Clopidogrel (36)  ·  Cilostazol (24)  ·  Rivaroxaban (20)  ·  Angioplasty, Balloon (18)  ·  Standard of Care (18)  ·  Stents (16)  ·  Atherectomy (14)  ·  Saline Solution (14)  ·  Sodium Chloride (14)  ·  Ticagrelor (13)  ·  Control Groups (11)  ·  Exercise Therapy (8)

Sponsors

Northwestern University (30)  ·  University Hospital, Angers (30)  ·  Medtronic Endovascular (24)  ·  Flanders Medical Research Program (22)  ·  Abbott Medical Devices (20)  ·  C. R. Bard (20)  ·  National Heart, Lung, and Blood Institute (NHLBI) (18)  ·  Spectranetics Corporation (16)  ·  VA Office of Research and Development (16)  ·  Cook Group Incorporated (15)  ·  Boston Scientific Corporation (14)  ·  W.L.Gore & Associates (14)  ·  University of Nebraska (13)  ·  Bayer (12)  ·  Biotronik AG (12)

Countries

United States (674)  ·  Germany (232)  ·  France (174)  ·  China (119)  ·  United Kingdom (119)  ·  Belgium (112)  ·  Italy (110)  ·  Austria (97)  ·  Canada (79)  ·  Netherlands (72)  ·  Spain (67)  ·  South Korea (53)  ·  Brazil (51)  ·  Switzerland (47)  ·  Australia (46)

Top investigators

Marc Bosiers, MD (16)  ·  Koen Deloose, MD (14)  ·  Thomas Zeller, MD (13)  ·  Mary McDermott, MD (12)  ·  Dierk Scheinert, MD (11)  ·  Gunnar Tepe, MD (9)  ·  Marianne Brodmann, MD (9)  ·  Andrew Holden, MD (8)  ·  Jihad Mustapha, MD (8)  ·  Subhash Banerjee, MD (6)  ·  Kenneth Rosenfield, MD (5)  ·  Mary M McDermott, MD (5)  ·  Pierre Abraham, MD, PhD (5)

Results publications

PMID 42573020, PMID 42035974, PMID 31567024, PMID 33025243, PMID 35802393, PMID 36588397, PMID 36645250, PMID 30690141, PMID 31543165, PMID 36137674, PMID 37929840, PMID 39968829, PMID 17223489, PMID 18272892, PMID 21262997, PMID 23583245, PMID 23915883, PMID 25237048, PMID 25472980, PMID 26062950, PMID 31926836, PMID 34167675, PMID 40260835, PMID 41159585, PMID 16242558, PMID 16449620, PMID 17140820, PMID 17848483, PMID 18779447, PMID 20484101, PMID 21123095, PMID 21146749, PMID 21622669, PMID 21873417, PMID 21953370, PMID 22169682, PMID 22429908, PMID 22878166, PMID 23050152, PMID 23192918, PMID 23797811, PMID 24402764, PMID 24402839, PMID 25499305, PMID 25908725, PMID 26476467, PMID 26490645, PMID 26861113, PMID 27388828, PMID 27840332

NIH funding

2009 (5), 2017 (4), 2005 (3), 2014 (3), 2023 (3), 2025 (3), 2019 (2), R01AG006244 (2), R01HL075774 (2), R01HL098909 (2), 1IK2RX003546-01A2 (1), 1RC2HL101515-01 (1), 2004 (1), 2008 (1), 2016 (1)