113 completed, 33 unknown, 12 terminated, 8 recruiting. 180 Phase 1, 63 Phase 2.
Follow Atherosclerosis: new trials by email Literature Review of Atherosclerosis trials Research Report on Atherosclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease FGF-1, Placebo - Peripheral Arterial Disease, Stenosis | Phase 1 / Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 24 | 2028-10-15 | 2026-08-19 |
| A Bioequivalence and Safety Study of AJU-B718 and B718R in Healthy Adult Volunteers Under Fasting Conditions Test Drug, Reference Drug - Peripheral Arterial Disease | Phase 1 | Not yet recruiting | AJU Pharm Co., Ltd. | 40 | 2026-11-01 | 2026-10-28 |
| A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C) STX-1150 - Elevated LDL-C and High Cholesterol | Phase 1 | Recruiting | Monash University | 64 | 2026-06-30 | 2026-09-21 |
| A Phase 1b Study to Evaluate the PK of CSL300 (Clazakizumab) in Chinese Subjects With End Stage Kidney Disease (ESKD) CSL300, Placebo - End Stage Kidney Disease (ESKD) | Phase 1 | Recruiting | CSL Behring | 24 | 2026-06-17 | 2026-07-07 |
| Cell Therapy for Lower Limb Ulcers in Patients With Critical Limb Ischemia CELULAS TRONCO, CONVENTIONAL DRESSING - Peripheral Arterial Disease, Leg Ulcer | Phase 1 / Phase 2 | Not yet recruiting | UPECLIN HC FM Botucatu Unesp | 40 | 2026-06-01 | 2026-05-06 |
| The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants CG-0255 Besylate for Injection, CG-0255 Besylate Capsule, Clopidogrel - Acute Coronary Syndromes (ACS), Recent Myocardial Infarction | Phase 1 | Recruiting | Shanghai CureGene Pharmaceutical Co., Ltd. | 136 | 2026-06-01 | 2026-06-29 |
| TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD TB-500, Placebo - Atherosclerotic Cardiovascular Diseases, Endothelial Dysfunction | Phase 1 / Phase 2 | Recruiting | Hudson Biotech | 80 | 2026-02-05 | 2026-11-12 |
| A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease Yiyang Huoluo Decoction, conventional western medicine treatment - Coronary Heart Disease, Coronary Artery Disease | Phase 1 / Phase 2 | Recruiting | Xia Liang | 30 | 2026-01-16 | 2026-03-25 |
| Fish Oil, Metformin and Heart Health in PCOS Fish oil, Metformin, Fish Oil and Metformin - PCOS, Cardiovascular Disease | Phase 1 | Recruiting | University of Alberta | 146 | 2025-11-01 | 2025-12-12 |
| Effects of Carnosine In Patients With Peripheral Arterial Disease Patients Carnosine - Peripheral Arterial Disease | Phase 1 / Phase 2 | Recruiting | Shahid Baba | 144 | 2025-05-20 | 2025-05-29 |
| A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With Obesity AZD4144, Placebo - Healthy Participants | Phase 1 | Completed | AstraZeneca | 28 | 2025-04-22 | 2025-10-07 |
| Tolerance Study of Allogeneic of Adipose Tissue Derived Mesenchymal Stroma/Stem Cells (AdMSC) Transplantation in Patients With Critical Limb Ischemia. Adipose tissue derived mesenchymal Stroma/stem Cells transplantation - Critical Limb Ischemia | Phase 1 | Not yet recruiting | University Hospital, Toulouse | 10 | 2025-01-01 | 2025-01-28 |
| A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease. AZD4144, Placebo - Chronic Kidney Disease, Atherosclerotic Cardiovascular Disease | Phase 1 | Completed | AstraZeneca | 29 | 2024-12-09 | 2025-11-25 |
| Effect of Single-versus Double-limb Cycling Exercise on Blood Flow in Patients With Peripheral Artery Disease Cycle - Peripheral Arterial Disease | Phase 1 / Phase 2 | Unknown | Cairo University | 75 | 2024-07-01 | 2024-07-24 |
| Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Critical Limb Ischemia EPCs, Clinical standard treatment (CST) - Critical Limb Ischemia | Phase 1 | Unknown | Allife Medical Science and Technology Co., Ltd. | 27 | 2024-04-01 | 2024-04-11 |
| BE Study of Once Daily PMR Compared to Twice Daily Cilostazol Tablets in Healthy Volunteers Cilostazol Tablet 100 mg, PMR Tablet 145 mg - Intermittent Claudication | Phase 1 | Completed | Genovate Biotechnology Co., Ltd., | 40 | 2023-11-28 | 2024-02-23 |
| YN001 in Healthy Subjects and Patients With Coronary Atherosclerosis YN001, Placebo for YN001, rosuvastatin calcium tablets - Atherosclerotic Cardiovascular Disease | Phase 1 / Phase 2 | Completed | Beijing Inno Medicine Co., Ltd. | 144 | 2023-10-08 | 2026-09-22 |
| A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease Home-based leg heat therapy - Peripheral Arterial Disease, Intermittent Claudication | Phase 1 | Completed | Purdue University | 6 | 2023-05-30 | 2025-08-15 |
| Carnosine for Peripheral Arterial Disease Patients Carnosine - Peripheral Arterial Disease | Phase 1 / Phase 2 | Unknown | Shahid Baba | 20 | 2023-03-01 | 2024-07-22 |
| NAD Supplementation and Vascular Health in PAD Nicotinamide riboside - Peripheral Artery Disease | Phase 1 / Phase 2 | Completed | University of Oklahoma | 8 | 2023-02-27 | 2026-04-06 |
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Peripheral Arterial Disease (78) · Chronic Limb-Threatening Ischemia (49) · Peripheral Vascular Diseases (25) · Intermittent Claudication (21) · Cardiovascular Diseases (16) · Inflammation (10) · Hypercholesterolemia (8) · Diabetes Mellitus (7) · Ischemia (6) · Vascular Diseases (6) · Arterial Occlusive Diseases (5) · Coronary Artery Disease (5) · Diabetic Foot (5) · Hypertension (5)
Arteriosclerosis (177) · Arterial Occlusive Diseases (175) · Vascular Diseases (174) · Cardiovascular Diseases (164) · Pathological Conditions, Signs and Symptoms (90) · Peripheral Vascular Diseases (87) · Pathologic Processes (67) · Disease Attributes (54) · Chronic Disease (53) · Ischemia (48) · Peripheral Arterial Disease (34) · Signs and Symptoms (25) · Nutritional and Metabolic Diseases (22) · Metabolic Diseases (20)
darapladib (13) · Cilostazol (6) · Atorvastatin (3) · Rosuvastatin Calcium (3) · Saline Solution (3) · Standard of Care (3) · cholesterol-binding protein (3) · rilapladib (3) · 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylprpyl)-3-pyridinecarboxamide (2) · Carnosine (2) · Cell- and Tissue-Based Therapy (2) · Clopidogrel (2) · Granulocyte Colony-Stimulating Factor (2) · Lipectomy (2) · Sodium Chloride (2)
GlaxoSmithKline (19) · National Heart, Lung, and Blood Institute (NHLBI) (6) · Genovate Biotechnology Co., Ltd., (5) · Losordo, Douglas, M.D. (4) · Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud (3) · Bristol-Myers Squibb (3) · First Affiliated Hospital of Harbin Medical University (3) · MedImmune LLC (3) · Proteon Therapeutics (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Ajou University School of Medicine (2) · Alucent Biomedical (2) · AstraZeneca (2) · Heinrich-Heine University, Duesseldorf (2) · Hoffmann-La Roche (2)
United States (86) · China (14) · Germany (10) · Netherlands (6) · South Korea (6) · United Kingdom (6) · Australia (5) · Canada (5) · India (5) · Israel (4) · Italy (4) · Russia (4) · Brazil (3) · France (3) · Japan (3)
Michael P Murphy, MD (3) · Doo-Yeoun Cho, MD (2) · Heng-yan Qu (2) · Santiago A Garcia, MD (2) · Abdalla Awidi, MD (1) · Alexander Kharlamov, M.D., Ph.D. (1) · Alexander Reyzelman, MD (1) · Alisha Oropallo, MD (1) · Allan Gordon, MD, PhD (1) · Allan H Ropper, M.D. (1) · Amir Lerman, MD (1)
PMID 35802393, PMID 24475026, PMID 42573020, PMID 10777236, PMID 10805617, PMID 11581152, PMID 12473676, PMID 15324521, PMID 16449620, PMID 17223489, PMID 17353883, PMID 18779447, PMID 18783958, PMID 19050436, PMID 1917239, PMID 19301723, PMID 19711453, PMID 20097752, PMID 20832596, PMID 20940249, PMID 21160056, PMID 21594960, PMID 21901641, PMID 22003000, PMID 22020113, PMID 22145843, PMID 22852051, PMID 22875949, PMID 22877866, PMID 23192920, PMID 23278227, PMID 23375329, PMID 23670612, PMID 23727083, PMID 23758736, PMID 23797811, PMID 23899755, PMID 24070911, PMID 24218170, PMID 24333045, PMID 24456716, PMID 24552184, PMID 24613691, PMID 24650395, PMID 24990275, PMID 25239491, PMID 25287762, PMID 25567765, PMID 25578927, PMID 25908725
2009 (3), 2008 (1), 2023 (1), P01AT002034 (1), P01HL059407 (1), R01HL163419 (1), R21AG048001 (1)