55 completed, 22 unknown, 8 terminated, 6 withdrawn. 96 Phase 2, 15 Phase 3, 9 Phase 1.
Follow Angina Pectoris: new trials by email Literature Review of Angina Pectoris trials Research Report on Angina Pectoris
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina. XC001, Sham (No Treatment) - Refractory Angina, Coronary Artery Disease | Phase 2 | Recruiting | XyloCor Therapeutics, Inc. | 106 | 2025-07-08 | 2026-09-11 |
| The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina Pectoris Vericiguat - Vasospastic Angina | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 57 | 2025-02-10 | 2026-07-29 |
| Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm Endothelin Receptor Antagonist, Placebo control - Coronary Spasm | Phase 2 / Phase 3 | Enrolling by invitation | Radboud University Medical Center | 100 | 2024-11-11 | 2024-11-18 |
| Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries Amlodipine, Nebivolol, Placebo - Angina Pectoris, Microvascular Angina | Phase 2 / Phase 3 | Recruiting | Stanford University | 150 | 2024-10-10 | 2024-11-27 |
| Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina Bone marrow aspiration and a single intracoronary infusion of autologous bone marrow-derived mononuclear cells., Sham bone marrow aspiration and sham cell infusion (insertion of vascular access sheath). - Refractory Angina Pectoris, Refractory Angina | Phase 2 | Recruiting | Barts & The London NHS Trust | 110 | 2024-03-01 | 2026-01-07 |
| Allopurinol in Patients With Refractory Angina to Improve Ischemic Symptoms Allopurinol 300 MG, Placebo oral tablet - Refractory Angina | Phase 2 / Phase 3 | Unknown | Ministry of Health, Brazil | 40 | 2021-03-03 | 2021-02-24 |
| A Placebo-Controlled Trial of CLBS16 in Subjects With Coronary Microvascular Dysfunction CLBS16, Placebo - Coronary Microvascular Dysfunction, Coronary Microvascular Disease | Phase 2 | Terminated | Lisata Therapeutics, Inc. | 34 | 2020-10-29 | 2026-05-04 |
| BuqitongluO Granule for Qi Deficiency and Blood Stasis Syndrome Buqitongluo Granule, Buqitongluo Granule Placebo, Standard care - Stroke, Ischemic, Coronary Artery Disease | Phase 2 | Unknown | Dongzhimen Hospital, Beijing | 432 | 2020-07-22 | 2021-04-01 |
| A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Refractory Angina IMB-1018972, Placebo oral tablet - Refractory Angina | Phase 2 | Withdrawn | Imbria Pharmaceuticals, Inc. | 2020-05-01 | 2025-11-10 | |
| Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial) AdVEGFXC1 - Coronary Artery Disease, Ischemia | Phase 1 / Phase 2 | Completed | XyloCor Therapeutics, Inc. | 41 | 2020-01-24 | 2024-01-30 |
| Rhodiola Rosea for Coronary Microvascular Disease Rhodiola Rosea Capsules, Placebo - Coronary Microvascular Disease | Phase 2 / Phase 3 | Unknown | Qilu Hospital of Shandong University | 114 | 2020-01-01 | 2020-01-06 |
| Adenovirus Vascular Endothelial Growth Factor D (AdvVEGF-D) Therapy for Treatment of Refractory Angina Pectoris AdvVEGF-D, Control Rx - Refractory Angina Pectoris, Gene Transfer | Phase 2 | Completed | Kuopio University Hospital | 63 | 2019-10-19 | 2025-01-13 |
| Precision Medicine With Zibotentan in Microvascular Angina Zibotentan, Placebo oral tablet - Microvascular Angina | Phase 2 | Completed | NHS Greater Glasgow and Clyde | 225 | 2019-10-18 | 2023-08-04 |
| The Randomized OPTIMAL-ACT Trial Unfractionated heparin - Coronary Artery Disease, Ischemic Heart Disease | Phase 2 | Completed | Mayo Clinic | 180 | 2019-02-08 | 2023-04-04 |
| Efficacy and Safety of Xuesaitong Soft Capsule for Coronary Heart Disease Unstable Angina Xuesaitong soft capsule, Placebo oral capsule - Coronary Heart Disease, Unstable Angina | Phase 2 | Unknown | Jie Wang | 70 | 2017-03-20 | 2017-03-17 |
| Crushed Ticagrelor Versus Eptifibatide Bolus + Clopidogrel Ticagrelor, Eptifibatide, Clopidogrel - Acute Coronary Syndrome, Angina, Unstable | Phase 2 | Completed | University of Alabama at Birmingham | 100 | 2016-11-01 | 2020-05-04 |
| Safety and Efficacy Study of the Amaranth Medical MAGNITUDE Bioresorbable Drug-Eluting Coronary Stent (RENASCENT III) AmM MAGNITUDE Bioresorbable Drug-Eluting Coronary Scaffold - Coronary Artery Disease, Myocardial Ischemia | Phase 2 | Unknown | Amaranth Medical Inc. | 70 | 2016-10-01 | 2016-11-25 |
| Citalopram for Sx/Util in Acute Coronary Syndrome Patients Citalopram - Acute Coronary Syndrome | Phase 1 / Phase 2 | Withdrawn | Henry Ford Health System | 2016-01-01 | 2022-12-09 | |
| Hierarchical Treatment Based on Somatization Symptom Checklist Deanxit, Prozac, coronary artery disease treatment - Syndrome X | Phase 1 / Phase 2 | Unknown | RenJi Hospital | 200 | 2015-12-01 | 2020-03-04 |
| Treadmill Cardiovascular Safety Study of Erenumab (AMG 334) Erenumab, Placebo - Stable Angina | Phase 2 | Completed | Amgen | 89 | 2015-11-23 | 2018-08-24 |
Showing 20 of 96. Sign in to see all of them.
Angina, Stable (27) · Coronary Artery Disease (27) · Angina, Unstable (24) · Myocardial Infarction (20) · Myocardial Ischemia (20) · Coronary Disease (9) · Acute Coronary Syndrome (8) · Heart Failure (7) · Microvascular Angina (7) · Cardiovascular Diseases (5) · Chest Pain (5) · Non-ST Elevated Myocardial Infarction (5) · Angina Pectoris, Variant (4) · Atherosclerosis (2)
Vascular Diseases (95) · Heart Diseases (94) · Neurologic Manifestations (93) · Pathological Conditions, Signs and Symptoms (93) · Signs and Symptoms (93) · Pain (92) · Cardiovascular Diseases (91) · Chest Pain (88) · Myocardial Ischemia (76) · Pathologic Processes (30) · Arterial Occlusive Diseases (27) · Arteriosclerosis (27) · Infarction (25) · Ischemia (25)
Clopidogrel (5) · Aspirin (4) · Ranolazine (4) · Ticagrelor (4) · Eptifibatide (3) · Abciximab (2) · Amlodipine (2) · Atorvastatin (2) · Heparin (2) · Influenza Vaccines (2) · STA 2 (2) · Sugars (2) · Tirofiban (2) · eleclazine (2) · 1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one (1)
Amaranth Medical Inc. (4) · AstraZeneca (2) · Cardium Therapeutics (2) · Gilead Sciences (2) · Lisata Therapeutics, Inc. (2) · Medispec (2) · North Florida Foundation for Research and Education (2) · Shahid Beheshti University of Medical Sciences (2) · Sinphar Pharmaceutical Co., Ltd (2) · Takeda (2) · XyloCor Therapeutics, Inc. (2) · ARCA Biopharma, Inc. (1) · Ablynx, a Sanofi company (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Affiliated Hospital to Academy of Military Medical Sciences (1)
United States (36) · United Kingdom (12) · Netherlands (10) · Belgium (9) · Germany (9) · Canada (7) · China (7) · Italy (6) · Poland (6) · Czechia (5) · Israel (5) · Russia (5) · South Korea (5) · Sweden (5) · Brazil (4)
Antonio Colombo, MD (3) · Ali Eskandari, MD (2) · Anthony A Bavry, MD, MPH (2) · Chuen-Den Tseng, MD, Ph.D (2) · Hossein Vakili, M.D. (2) · Maryam Keshtkar-Jahromi, M.D.; M.P.H. (2) · Paul Foster, MD (2) · Seyed Mostafa Razavi, MD (2) · Sharareh Gholamin, MD (2) · Alan S Lader, PhD (1) · Alexander Lind, MD (1) · Alexandra Lucas, MD (1) · Amrita Ahluwalia, PhD (1) · Andrew A Wolff, MD, FACC (1) · Annapoorna S Kini, MD MRCP (1)
PMID 17825712, PMID 21079055, PMID 22212857, PMID 22795280, PMID 16990385, PMID 17174178, PMID 17320744, PMID 17599602, PMID 17631219, PMID 18188136, PMID 19608137, PMID 19608488, PMID 19923168, PMID 20194878, PMID 20226548, PMID 20620737, PMID 20863951, PMID 21062996, PMID 21411144, PMID 21737787, PMID 22027731, PMID 22447880, PMID 22964356, PMID 23137499, PMID 23394404, PMID 23413981, PMID 23957447, PMID 24497345, PMID 24934484, PMID 25136078, PMID 25453536, PMID 25651246, PMID 25760881, PMID 26995378, PMID 27151378, PMID 27730819, PMID 27903568, PMID 27998900, PMID 28325638, PMID 28480650, PMID 28887315, PMID 31141104, PMID 31277053, PMID 31535314, PMID 31766977, PMID 32719097, PMID 33272036, PMID 33579317, PMID 34066713, PMID 34224684
2014 (2), 2008 (1), 2015 (1), 2018 (1), U01HL087318 (1)