33 completed, 21 recruiting, 21 unknown, 14 active not recruiting. 35 Not applicable, 16 Phase 4, 7 Phase 2, 5 Phase 3, 2 Phase 1.
Follow Microvascular Angina: new trials by email Literature Review of Microvascular Angina trials Research Report on Microvascular Angina
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI) Coronary angiogram with coronary reactivity testing (CRT) - Myocardial Infarction, Coronary Microvascular Disease | Not yet recruiting | Mayo Clinic | 52 | 2027-01-01 | 2026-08-31 | |
| Coronary MicrovAscular Diseases Intervention With Compound Danshen Dropping Pills Compound Danshen Dripping Pills, Placebo - Coronary Microvascular Disease | Phase 4 | Not yet recruiting | Qilu Hospital of Shandong University | 496 | 2026-10-01 | 2026-10-21 |
| Evaluation of the Systemic Microcirculation as a Surrogate for Coronary Microcirculation in Women With ANOCA Investigation of Systemic Endothelial Microvascular Function - Angina, Microvascular | Not yet recruiting | National Institute of Cardiology, Laranjeiras, Brazil | 60 | 2026-08-01 | 2026-05-05 | |
| Simultaneous Measurement of EpicArdial and Microvascular ResisTance Via Angiographic FLOW Study Patients with intermediate coronary artery stenosis with clinically indicated FFR assessment., Microvascular assessment - Non-obstructive Coronary Disease, Acute or Chronic Coronary Artery Disease | Enrolling by invitation | AngioInsight | 620 | 2026-07-28 | 2026-11-02 | |
| Self Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD) A-FLUX Reducer System - Angina Pectoris, Myocardial Ischemia | Not applicable | Suspended | VahatiCor, Inc. | 30 | 2026-04-07 | 2026-09-25 |
| Coronary Sinus Reducer in Coronary Microvascular Disease Coronary sinus reducer, Sham CSR procedure - Angina (Stable), Coronary Microvascular Disease | Not applicable | Enrolling by invitation | UMC Utrecht | 50 | 2025-11-20 | 2025-12-04 |
| The FLARE (Flurpiridaz vs. Rubidium Evaluation) Trial Coronary Artery Disease, Coronary Microvascular Disease | Enrolling by invitation | University of California, Los Angeles | 60 | 2025-08-13 | 2026-08-17 | |
| Study Targeting Myocardial Perfusion and Symptom Relief in Women With SGLT2 Inhibitors (STRONG) Brenzavvy (bexagliflozin), 20 mg Oral Tablet, Placebo - Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Disease | Phase 1 | Recruiting | University of Virginia | 150 | 2025-07-15 | 2026-09-09 |
| Comparative Study of Magnetocardiography and Emission Computed Tomography. Magnetocardiography examination - Myocardial Ischemia | Not yet recruiting | Yang Jing | 218 | 2025-07-01 | 2025-07-22 | |
| Self-Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD) (SERRA-I Study) A-FLUX Reducer System - Coronary Microvascular Dysfunction, Coronary Microvascular Disease | Not applicable | Active not recruiting | VahatiCor, Inc. | 30 | 2025-06-18 | 2026-08-26 |
| Clinical Evaluation of Aromatic Wentong in the Treatment of Coronary Microvascular Disease Kuangxiong Aerosol, Placebo Drug - Coronary Microvascular Disease | Phase 4 | Not yet recruiting | China-Japan Friendship Hospital | 528 | 2025-04-01 | 2025-04-11 |
| Nebivolol ANOCA Treatment Randomized Trial Nevibolol, Placebo - ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD) | Phase 3 | Not yet recruiting | Spanish Society of Cardiology | 150 | 2025-04-01 | 2025-01-01 |
| POLish Registry of CArdioneuroablation and CArdioneuromodulation cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation - Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS | Recruiting | SABAMED Medical Center Ltd. | 1000 | 2024-11-21 | 2025-09-29 | |
| The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI). Blood sampling, Ophthalmological examination, angina severity questionnaire - Microvascular Angina | Recruiting | Centre Hospitalier Universitaire Dijon | 52 | 2024-11-13 | 2026-10-22 | |
| Microvascular Coronary Rehabilitation For Improving Treatment - Feasibility Study MICROFIT - personalised high intensity interval training exercise rehabilitation and dietary advice - Microvascular Coronary Dysfunction, Microvascular Angina | Not applicable | Recruiting | Royal United Hospitals Bath NHS Foundation Trust | 40 | 2024-11-12 | 2026-08-14 |
| An Observational Study of Coronary Microvascular Disease of China Coronary Microvascular Disease | Recruiting | Henan Institute of Cardiovascular Epidemiology | 500 | 2024-11-11 | 2025-08-20 | |
| Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study Exercise training - Coronary Microvascular Disease, CMD | Not applicable | Recruiting | Bispebjerg Hospital | 100 | 2024-11-01 | 2025-02-21 |
| Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries Amlodipine, Nebivolol, Placebo - Angina Pectoris, Microvascular Angina | Phase 2 / Phase 3 | Recruiting | Stanford University | 150 | 2024-10-10 | 2024-11-27 |
| Angina After PCI: a Systems Medicine Study Cardiovascular magnetic resonance imaging, Coronary physiology - Angina (Stable), Ischemic Heart Disease (IHD) | Enrolling by invitation | NHS National Waiting Times Centre Board | 600 | 2024-09-17 | 2025-03-03 | |
| Insulin Resistance and Coronary Microvascular Dysfunction in Patients With Myocardial Ischemia and Non-obstructive Coronary Artery Disease Thermodilution based assessment of coronary microcirculation, Hyperinsulinemic-euglycemic Clamp test - Coronary Microvascular Dysfunction, Coronary Microvascular Disease | Not applicable | Active not recruiting | Azienda Ospedaliera Universitaria Integrata Verona | 40 | 2024-06-24 | 2026-10-27 |
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Angina Pectoris (25) · Coronary Artery Disease (23) · Myocardial Ischemia (15) · Angina Pectoris, Variant (10) · Angina, Stable (8) · Coronary Vasospasm (8) · Coronary Disease (7) · Chest Pain (6) · Heart Failure (5) · Ischemia (5) · Myocardial Infarction (5) · Heart Diseases (4) · Cardiovascular Diseases (3) · Hypertension (3)
Vascular Diseases (108) · Cardiovascular Diseases (106) · Heart Diseases (105) · Myocardial Ischemia (94) · Angina Pectoris (84) · Pathological Conditions, Signs and Symptoms (50) · Signs and Symptoms (39) · Neurologic Manifestations (38) · Pain (38) · Chest Pain (32) · Arterial Occlusive Diseases (23) · Arteriosclerosis (23) · Coronary Disease (23) · Pathologic Processes (17) · Angina, Unstable (10)
Adenosine (2) · Diltiazem (2) · Nebivolol (2) · Ranolazine (2) · Acupuncture Therapy (1) · Adrenergic beta-Antagonists (1) · Allopurinol (1) · Amlodipine (1) · Angiotensin-Converting Enzyme Inhibitors (1) · Bisoprolol (1) · Blood Specimen Collection (1) · Caloric Restriction (1) · Cardiac Rehabilitation (1) · Cardiotonic Agents (1) · Contrast Media (1)
Qilu Hospital of Shandong University (5) · NHS National Waiting Times Centre Board (4) · University Hospital, Grenoble (4) · Bispebjerg Hospital (3) · Samsung Medical Center (3) · Catharina Ziekenhuis Eindhoven (2) · CoreAalst BV (2) · Genetesis Inc. (2) · Imperial College London (2) · Johannes Gutenberg University Mainz (2) · Massachusetts General Hospital (2) · NHS Greater Glasgow and Clyde (2) · NYU Langone Health (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Ospedale San Giovanni Bellinzona (2)
United States (22) · United Kingdom (18) · China (13) · Germany (7) · Netherlands (7) · Denmark (6) · Spain (6) · France (5) · Switzerland (5) · Belgium (4) · Poland (4) · South Korea (4) · Italy (3) · Greece (2) · Serbia (2)
Colin Berry, MBChB, PhD (2) · Eva Prescott, MD, DMSc (2) · Katriona Brooksbank, PhD (2) · Mattia Cattaneo, MD (2) · A H Li, MD (1) · Alessandra Pia Porretta, MD (1) · Alexandra B Kimball, MD, MPH (1) · Alexandra Lansky, MD (1) · Ali Khavandi (1) · Anastasia Shchendrygina (1) · Andreas Seitz, MD (1) · Anthony Mathur (1) · Augusto Gallino, MD (1) · Augusto Gallino, Prof MD (1)
PMID 19433695, PMID 20220183, PMID 20579539, PMID 21911339, PMID 22322081, PMID 24563437, PMID 25082954, PMID 10675425, PMID 11320360, PMID 11788217, PMID 11991214, PMID 12147179, PMID 12914662, PMID 13394341, PMID 14981009, PMID 15007010, PMID 15020531, PMID 15313949, PMID 15671433, PMID 16368303, PMID 16458167, PMID 16720691, PMID 16923752, PMID 16988070, PMID 17314342, PMID 17430682, PMID 18188136, PMID 18370439, PMID 18427132, PMID 19151200, PMID 19231324, PMID 19351944, PMID 19712795, PMID 19833255, PMID 19878986, PMID 20075143, PMID 21105792, PMID 21450596, PMID 21561896, PMID 21586690, PMID 21861950, PMID 21982660, PMID 22007073, PMID 22236508, PMID 22496084, PMID 22952138, PMID 22958953, PMID 23281541, PMID 23432189, PMID 23558043
2016 (1), 2018 (1), K23HL119620 (1), R01HL124649 (1), R21NR017705 (1)