169 completed, 74 unknown, 12 terminated, 11 recruiting. 158 Not applicable, 53 Phase 4, 22 Phase 3, 16 Phase 2, 5 Phase 1.
Follow Anesthesia, Local: new trials by email Literature Review of Anesthesia, Local trials Research Report on Anesthesia, Local
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches Traditional adductor canal block, NVM (nerve to vastus medialis) targeted adductor canal block, Chloroprocaine Injection - Anesthesia, Local | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-08-27 |
| Bicarbonate Addition to Lidocaine-Epinephrine in Surgery Under WALANT Ambulatory surgery under Lidocaine with epinephrine alone, Ambulatory surgery under lidocaine with epinephrine plus bicarbonate - Anesthesia, Local, Hand Surgery | Phase 4 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 150 | 2026-02-01 | 2026-01-15 |
| Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty LIA with different doses of Diprospan - Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee | Not applicable | Recruiting | First Affiliated Hospital of Fujian Medical University | 120 | 2026-02-01 | 2026-01-13 |
| Rib Microtia and the Erector Spinae Plane (ESP) Block Erector Spinae Plane Block - Microtia, Congenital, Microtia | Not applicable | Withdrawn | Stanford University | 2025-11-01 | 2025-05-04 | |
| Electrical Epidural Stimulation Test for Detecting Epidural Catheter Reactivation in Obstetric Population Electrical Epidural Stimulation Test (EST) - Obstetric Pain, Anesthesia, Local | Not applicable | Not yet recruiting | Stanford University | 40 | 2025-11-01 | 2025-05-01 |
| The Use of Electrical Stimulation for Determination of Epidural Catheter Placement Electrical Epidural Stimulation Test - Obstetric Pain, Anesthesia, Local | Not applicable | Not yet recruiting | Stanford University | 50 | 2025-11-01 | 2025-05-01 |
| Conventional Versus Computer-Assisted Dental Anesthesia Computer-Controlled Local Anesthetic Delivery System, Conventional Aspirating Dental Syringe - Anesthesia, Local | Not applicable | Completed | University of Montemorelos | 29 | 2025-09-02 | 2026-07-28 |
| Ultrasonographic Optic Nerve Sheath Diameter in Postdural Puncture Headache Diagnosis Ultrasonographic Measurement of Optic Nerve Sheath Diameter (ONSD) - Anesthesia, Local, Headache | Completed | Ankara City Hospital Bilkent | 176 | 2025-08-08 | 2026-02-10 | |
| EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade 0.25% ropivacaine, 0.375% Ropivacaine, 0.5% Ropivacaine - Intercostal Nerve Block, Pulmonary Ventilation | Not applicable | Completed | Fudan University | 67 | 2025-07-25 | 2026-09-10 |
| Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements Buffered Lidocaine, Sham Comparator, Unbuffered lidocaine - Contraception, Pain, Acute | Not applicable | Recruiting | University of California, San Diego | 204 | 2025-06-04 | 2025-06-13 |
| Empathy Through Pain Control: Lidocaine Gel vs. Placebo Prior to IUD Placement Xylocaine jelly 2%, Surgilube - Contraception, Pain, Acute | Not applicable | Not yet recruiting | University of California, San Diego | 68 | 2025-06-01 | 2025-05-15 |
| Empathy Through Pain Control: Buffered Compared to Unbuffered 1% Lidocaine During IUD Placement Buffered Lidocaine, Lidocaine 1% Injectable Solution - Contraception, Pain, Acute | Not applicable | Not yet recruiting | University of California, San Diego | 68 | 2025-06-01 | 2025-05-15 |
| Preoperative Block for Anterior Cervical Spine Surgery Block for Anterior Cervical Spine Surgery, Saline (NaCl 0,9 %) (placebo) - Anesthesia, Local | Phase 3 | Not yet recruiting | Tanta University | 90 | 2025-04-01 | 2025-03-10 |
| Split Face Study of the Duration of Local Anesthetics - Fourth Arm 0.5 ml lidocaine + epinephrine 1:100,000, 1.0 ml lidocaine + epinephrine 1:100,000 - Anesthesia, Local | Phase 4 | Recruiting | Weill Medical College of Cornell University | 35 | 2025-01-21 | 2026-01-22 |
| Local Anesthetic Clinical Trial Lidocaine, Bupivacaine Hydrochloride, Mepivacaine Hydrochloride - Mohs Micrographic Surgery, Anesthesia, Local | Phase 4 | Enrolling by invitation | Baylor Research Institute | 400 | 2025-01-07 | 2026-05-22 |
| Soft Mist Nasal Administration Device for Topical Anaesthesia of the Nasal Cavity NAA for topical anaesthesia of the nasal cavity - Anesthesia, Local | Not applicable | Completed | Radboud University Medical Center | 20 | 2024-12-15 | 2025-04-29 |
| Interest of Soft Point Anesthesia in Association With Locoregional Anesthesia in Arthroscopic Shoulder Surgery Shoulder surgery - Anesthesia, Local | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 96 | 2024-12-01 | 2024-10-15 | |
| The Effect of Local Anesthetic Techniques on Hemodynamic Response and Postoperative Sore Throat in Double-Lumen Tubes Tracheo-Spray, Lidocaine Spray on DLT, Saline (Placebo) - Anesthesia, Local, Intubation, Intratracheal | Not applicable | Completed | V.K.V. American Hospital, Istanbul | 60 | 2024-11-06 | 2025-01-13 |
| A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults Open Inguinal Hernia Repair - Local Anesthesia, Inguinal Hernia Repair - General Anesthesia - Inguinal Hernia, Anesthesia, Local | Not applicable | Active not recruiting | University of Wisconsin, Madison | 18 | 2024-10-23 | 2026-10-02 |
| Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery Erector Spinae Plane Block, Subcutaneous Anesthesia - Fusion of Spine, Lumbar Region, Anesthesia, Local | Not applicable | Recruiting | University of Massachusetts, Worcester | 66 | 2024-09-13 | 2026-03-16 |
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Pain, Postoperative (55) · Agnosia (18) · Pain (18) · Acute Pain (16) · Breast Neoplasms (5) · Hip Fractures (5) · Neuralgia (5) · Child Behavior (4) · Hand Injuries (4) · Osteoarthritis, Knee (4) · Arm Injuries (3) · Carpal Tunnel Syndrome (3) · Chronic Pain (3) · Hernia, Inguinal (3) · Labor Pain (3)
Pathological Conditions, Signs and Symptoms (112) · Signs and Symptoms (105) · Neurologic Manifestations (104) · Pain (73) · Pathologic Processes (64) · Postoperative Complications (55) · Nervous System Diseases (39) · Wounds and Injuries (23) · Neurobehavioral Manifestations (21) · Perceptual Disorders (19) · Neoplasms (18) · Musculoskeletal Diseases (15) · Neoplasms by Site (15) · Cardiovascular Diseases (13) · Fractures, Bone (10)
Bupivacaine (33) · Lidocaine (32) · Ropivacaine (31) · Sodium Chloride (24) · Epinephrine (13) · Dexamethasone (9) · Anesthesia, General (8) · Anesthesia, Local (8) · Carticaine (8) · Acetaminophen (7) · Saline Solution (7) · Dexmedetomidine (6) · Fentanyl (5) · Mepivacaine (5) · Morphine (5)
Cairo University (12) · Stanford University (10) · Zealand University Hospital (8) · University of California, San Diego (7) · Istanbul University (6) · Alexandria University (5) · Jessa Hospital (5) · American Genomics, LLC (4) · Ain Shams University (3) · Başakşehir Çam & Sakura City Hospital (3) · Centre hospitalier de l'Université de Montréal (CHUM) (3) · Charite University, Berlin, Germany (3) · Hams Hamed Abdelrahman (3) · Lviv National Medical University (3) · Minia University (3)
United States (66) · Turkey (Türkiye) (31) · Egypt (29) · Canada (17) · Denmark (14) · France (12) · China (11) · Italy (8) · Belgium (7) · Greece (7) · Poland (6) · Brazil (5) · Netherlands (4) · Spain (4) · Germany (3)
Martin Uram, MD (4) · Ban Tsui, MD (3) · Ergun Mendes (3) · Mathias Maagaard, MD (3) · Sheila K Mody, MD, MPH (3) · Arshad Khanani, MD (2) · Brian M Ilfeld, MD, MS (2) · Dimitris Tousoulis, MD PhD (2) · Hielke Markerink (2) · Karolina Dobronska, MD (2)
PMID 25501494, PMID 37192994, PMID 1015603, PMID 11242725, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11472277, PMID 11765830, PMID 11871952, PMID 12148677, PMID 12411815, PMID 12548273, PMID 12560416, PMID 14622770, PMID 16343853, PMID 17138203, PMID 17413915, PMID 18021602, PMID 18165577, PMID 18327969, PMID 18547152, PMID 18573982, PMID 18682623, PMID 18682624, PMID 18686750, PMID 18762870, PMID 19119169, PMID 19157368, PMID 19174373, PMID 19690943, PMID 19840499, PMID 20592403, PMID 20783002, PMID 20831927, PMID 21102369, PMID 21702853, PMID 21739090, PMID 21881055, PMID 21924181, PMID 22067185, PMID 22143739, PMID 22287376, PMID 22506940, PMID 22771049, PMID 22886842, PMID 2322523, PMID 23295957, PMID 23330822, PMID 23522530
2016 (4), 2014 (1), 2018 (1), 2019 (1), K76AG068515 (1)