67 completed, 6 unknown, 4 terminated, 2 recruiting. 82 Phase 2, 14 Phase 3, 7 Phase 1.
Follow Alcohol Dependence: new trials by email Literature Review of Alcohol Dependence trials Research Report on Alcohol Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial Psilocybin, Ketamine - Alcohol Use Disorder, Alcohol Dependence | Phase 2 | Recruiting | University of Iowa | 80 | 2025-06-12 | 2025-11-28 |
| Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder Tirzepatide, Placebo - Alcohol Use Disorder, Alcohol Abuse/Dependence | Phase 2 | Recruiting | Anders Fink-Jensen, MD, DMSci | 108 | 2025-05-05 | 2026-02-10 |
| Psilocybin-assisted Therapy for Alcohol Use Disorder Psilocybin, Niacin - Alcohol Use Disorder, Alcohol Dependence | Phase 2 | Unknown | University of Sydney | 90 | 2024-09-01 | 2024-06-10 |
| Effects of Ketone Supplementation on Acute Alcohol Withdrawal Kenetik; Ketone Concentrate, Isocaloric dextrose placebo - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Enrolling by invitation | University of Pennsylvania | 50 | 2024-03-11 | 2026-04-06 |
| MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder Prolonged exposure therapy, MDMA, Niacin - PTSD, Alcohol Use Disorder | Phase 2 | Unknown | University of Sydney | 120 | 2023-09-19 | 2023-11-07 |
| Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity? Semaglutide Injectable Product, Placebo - Alcohol Abuse, Alcohol Addiction | Phase 2 | Completed | Psychiatric Centre Rigshospitalet | 108 | 2023-06-13 | 2025-08-05 |
| Varenicline and Bupropion for Alcohol Use Disorder Varenicline Tartrate 1 mg b.i.d, Bupropion Hydrochloride 150 mg b.i.d, Placebo for varenicline - Alcohol Use Disorder, Alcoholism | Phase 2 | Completed | Vastra Gotaland Region | 388 | 2019-03-04 | 2024-06-07 |
| The Efficacy and Neurobehavioural Mechanism of N-acetyl Cysteine (NAC) for Alcohol Dependence NAC 2400mg/day, Placebo - Alcohol Dependence | Phase 2 | Unknown | South West Sydney Local Health District | 40 | 2018-08-22 | 2019-03-19 |
| Progesterone Effect on Individuals Diagnoses With AD and PTSD. Progesterone, Placebo (for Progesterone) - Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD) | Phase 2 / Phase 3 | Completed | Yale University | 13 | 2016-09-01 | 2023-04-26 |
| 10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence Real cTBS, Sham cTBS - Cocaine Dependence, Alcohol Dependence | Phase 2 | Completed | Medical University of South Carolina | 84 | 2016-08-01 | 2020-03-12 |
| Oxytocin Treatment of Alcohol Dependence Intranasal Oxytocin, Placebo - Alcohol Dependence | Phase 2 | Completed | University of North Carolina, Chapel Hill | 22 | 2015-07-01 | 2017-08-15 |
| Glutamatergic Modulation of Disordered Alcohol Use CI-581a, CI-581b, Motivational Enhancement Therapy (MET) - Alcohol Dependence | Phase 2 / Phase 3 | Completed | New York State Psychiatric Institute | 50 | 2015-07-01 | 2020-02-11 |
| Safety and Pharmacodynamic Study of GET 73 in Alcohol Dependent GET 73, inactive ingredients capsule - Alcohol Dependence | Phase 1 / Phase 2 | Completed | Laboratorio Farmaceutico Ct S.r.l. | 25 | 2014-11-01 | 2019-04-10 |
| Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence aprepitant, Placebo, Manual-guided behavioral counseling - Cannabis Dependence, Alcohol Dependence | Phase 2 | Completed | The Scripps Research Institute | 20 | 2014-09-04 | 2017-08-02 |
| Mifepristone Treatment of Alcohol Use Disorder Mifepristone 1200 mg daily, Standardized behavioral therapy, Placebo - Alcohol Dependence, Alcohol Use Disorders | Phase 2 | Completed | The Scripps Research Institute | 103 | 2014-09-01 | 2022-10-06 |
| A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence Psilocybin, Diphenhydramine, Motivational Enhancement and Taking Action (META) - Alcohol Dependence | Phase 2 | Completed | NYU Langone Health | 95 | 2014-06-01 | 2022-11-08 |
| Use of Kudzu Extract in the Study of Its Ability to Reduce Alcohol Drinking in Treatment Seeking Alcohol Dependent Persons Kudzu extract, Placebo, Medical Management - Alcohol Abuse, Alcohol Dependence | Phase 2 | Withdrawn | Mclean Hospital | 2014-03-01 | 2015-10-07 | |
| Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence Enhanced-Cognitive Processing Therapy-C (E-CPT-C), Zonisamide, Placebo - Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD) | Phase 2 | Completed | Yale University | 24 | 2013-06-01 | 2020-03-16 |
| ABT-436 for Alcohol Dependence ABT-436, Matched Placebo - Sugar Pill - Alcohol Dependence, Alcohol Abuse | Phase 2 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 150 | 2013-02-01 | 2017-04-04 |
| Carisbamate as a Potential Treatment for Alcohol Dependence Carisbamate, Placebo - Alcohol Dependence, Alcohol Abuse | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 11 | 2013-02-01 | 2021-03-02 |
Showing 20 of 82. Sign in to see all of them.
Alcoholism (82) · Substance-Related Disorders (13) · Behavior, Addictive (7) · Stress Disorders, Post-Traumatic (7) · Tobacco Use Disorder (6) · Alcohol-Related Disorders (5) · Anxiety Disorders (5) · Cocaine-Related Disorders (5) · Alcohol Drinking (3) · Depression (3) · Smoking (3) · Bipolar Disorder (2) · Marijuana Abuse (2) · Alcoholic Intoxication (1) · Bulimia (1)
Chemically-Induced Disorders (82) · Mental Disorders (81) · Alcohol-Related Disorders (77) · Substance-Related Disorders (69) · Behavior (14) · Compulsive Behavior (7) · Stress Disorders, Traumatic (7) · Trauma and Stressor Related Disorders (7) · Impulsive Behavior (6) · Behavioral Symptoms (3) · Drinking Behavior (3) · Bipolar and Related Disorders (2) · Mood Disorders (2) · Nutritional and Metabolic Diseases (2) · Pathological Conditions, Signs and Symptoms (2)
Naltrexone (7) · Topiramate (7) · Sugars (6) · Varenicline (5) · Psilocybin (4) · Aprepitant (3) · Aripiprazole (3) · Baclofen (3) · Ethanol (3) · Gabapentin (3) · Ondansetron (3) · Practice Management, Medical (3) · Acamprosate (2) · LY686017 (2) · Mirtazapine (2)
National Institute on Alcohol Abuse and Alcoholism (NIAAA) (9) · Medical University of South Carolina (7) · Yale University (7) · University of Pennsylvania (5) · The Scripps Research Institute (4) · University of North Carolina, Chapel Hill (4) · Boston Medical Center (3) · University of Virginia (3) · Eli Lilly and Company (2) · Johns Hopkins University (2) · New York State Psychiatric Institute (2) · Sahlgrenska University Hospital (2) · University of Sydney (2) · Alkermes, Inc. (1) · Anders Fink-Jensen, MD, DMSci (1)
United States (67) · Sweden (3) · Australia (2) · Denmark (2) · Germany (2) · Brazil (1) · Thailand (1)
Ismene L Petrakis, MD (2) · James C Garbutt, MD (2) · Kirsten C Morley, PhD (2) · Lorenzo Leggio, M.D. (2) · Raymond F Anton, MD (2) · Aleksandra Zgierska, MD PhD (1) · Anders Fink-Jensen, MD, DMSc (1) · Anders Fink-Jensen, MD, DMSc, Professor (1) · Andreas Heinz, Prof., M.D. (1) · Andrew Baille, PhD (1) · Bankole A Johnson, MD (1) · Bankole Johnson, DSc, MD, PhD (1)
PMID 18636998, PMID 19593171, PMID 20921123, PMID 21631542, PMID 24190578, PMID 25409596, PMID 25419583, PMID 25427171, PMID 25586396, PMID 26243733, PMID 27627782, PMID 28029173, PMID 28440812, PMID 29281033, PMID 29324248, PMID 29960116, PMID 30055046, PMID 30217552, PMID 30280905, PMID 31786934, PMID 31894995, PMID 32445052, PMID 34120336, PMID 36001306, PMID 36332827, PMID 37142273, PMID 37276086, PMID 38147491, PMID 38206930, PMID 38326432, PMID 39102049, PMID 39741446, PMID 39779270, PMID 40123107, PMID 40487775, PMID 41128676, PMID 41329966, PMID 42070571, PMID 42409408
K01DA025073 (2), P50AA010761 (2), P60AA013759 (2), R37AA014028 (2), 1RC1AA019019-01 (1), 2009 (1), 2018 (1), K23AA017508 (1), K24DA000435 (1), P50DA012756 (1), R01AA012028 (1), R01AA012154 (1), R01AA012178 (1), R01AA015385 (1), R01AA015923 (1)