72 completed, 21 unknown, 10 terminated, 5 withdrawn. 31 Phase 2, 28 Phase 4, 21 Phase 3, 17 Not applicable, 13 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biomarkers and Pharmacogenomics for Precision Depression Therapy Pharmacogenomic Testing, Antidepressant Agents - Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 220 | 2026-07-01 | 2026-07-31 |
| Repurposing Mirtazapine in Rett Syndrome mirtazapine - RETT Syndrome With Proven MECP2 Mutation | Phase 2 | Recruiting | University of Trieste | 54 | 2025-07-09 | 2026-02-24 |
| Neurobiological and Genomic Predictors of Relapse in Depression Antidepressant Medications - Healthy, Major Depressive Disorder (MDD) | Recruiting | Mehmet Kemal Arikan | 204 | 2025-01-01 | 2026-01-09 | |
| Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator Mirtazapine, Placebo - IBS - Irritable Bowel Syndrome, Diarrhea | Early Phase 1 | Recruiting | Mayo Clinic | 20 | 2024-12-19 | 2025-12-18 |
| Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment Mirtazapine, Placebo - Stimulant Use Disorder | Phase 2 | Recruiting | Washington State University | 60 | 2024-06-17 | 2026-07-02 |
| Trial of Mirtazapine for Depression in IBD Mirtazapine, Placebo - Major Depressive Disorder, Inflammatory Bowel Diseases | Phase 2 | Completed | King's College London | 76 | 2024-05-07 | 2026-08-19 |
| Mirtazapine for Acute and Chronic Post Mastectomy Pain Mirtazapine 30 MG, Placebo - Breast Cancer | Early Phase 1 | Completed | Assiut University | 62 | 2024-03-01 | 2026-01-22 |
| Improving Sleep After TKA Using Mirtazapine and Quetiapine Mirtazapine, Quetiapine, Placebo - Osteo Arthritis Knee, Insomnia | Not applicable | Not yet recruiting | St. Anna Ziekenhuis, Geldrop, Netherlands | 165 | 2024-01-01 | 2023-06-02 |
| Efficacy of Hydroxyzine for Patients With Panic Disorder Hydroxyzine, Escitalopram Oxalate - Panic Disorder | Phase 4 | Not yet recruiting | Sultan Qaboos University | 80 | 2023-12-30 | 2023-02-21 |
| Efficacy of Mirtazapine in Major Depressive Disorder With Insomnia Mirtazapine Tablets - Major Depressive Disorder With Insomnia | Phase 4 | Completed | National Institute of Mental Health, Dhaka | 135 | 2023-05-25 | 2024-04-02 |
| Prophylactic Mirtazapine and Different Doses of Intrathecal Morphine in Preventing Nausea and Vomiting After Cesarean Section Mirtazapine + Bupivacaine + Morphine, Placebo + Bupivacaine + Morphine, Placebo+ Bupivacaine + Morphine - Prophylactic, Mirtazapine | Not applicable | Completed | Kafrelsheikh University | 120 | 2023-01-01 | 2024-11-08 |
| Correlation of Genetic Variations With Clinical Response in Substance Use Disorder Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone - Substance Use Disorders, Substance Dependence | Unknown | Alexandria University | 200 | 2022-11-28 | 2023-04-27 | |
| Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder Antidepressant - Major Depressive Disorder | Completed | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 73336 | 2022-10-01 | 2023-08-18 | |
| Mirtazapine for Chronic Insomnia in Older Adults Mirtazapine 7.5 MG Oral Tablet once daily at bedtime, Placebo oral tablet once daily at bedtime - Chronic Insomnia | Phase 1 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 60 | 2022-10-01 | 2024-08-12 |
| Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea Escitalopram, Paroxetine, Fluoxetine - Major Depression | Completed | Pfizer | 370212 | 2022-07-04 | 2024-12-09 | |
| Endeavor to Stop Nausea/Vomiting Associated With Pregnancy (E-SNAP) Mirtazapine - Pregnancy, Severe Nausea and Vomiting | Phase 1 / Phase 2 | Withdrawn | Northwestern University | 2022-06-13 | 2024-12-11 | |
| Mirtazapine Versus Megestrol Acetate in Treatment of Anorexia-cachexia in Advanced Cancer Patients. Mirtazapine, Megestrol Acetate - Anorexia | Phase 2 | Unknown | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 80 | 2022-06-01 | 2022-05-18 |
| Evaluating the Effect of Mirtazapine on Anxiety in Parkinson's Disease Patients Mirtazapine 15 MG, Placebo - Parkinson Disease, Anxiety | Phase 2 | Unknown | Leila Dargahi. PharmD PhD | 64 | 2022-06-01 | 2025-05-21 |
| Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients with Advanced Stage Cancer Mirtazapine, Olanzapine - Anorexia Nervosa with Significantly Low Body Weight | Phase 2 | Enrolling by invitation | Englewood Hospital and Medical Center | 170 | 2022-01-20 | 2024-09-19 |
| Mirtazapine in Cancer-related Poly-symptomatology Mirtazapine, Escitalopram - Cancer, Neoplasms | Phase 3 | Terminated | Hospices Civils de Lyon | 1 | 2021-12-15 | 2023-06-08 |
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Depression (25) · Depressive Disorder, Major (21) · Sleep Initiation and Maintenance Disorders (11) · Mental Disorders (7) · Sleep Wake Disorders (7) · Anxiety Disorders (6) · Anorexia (5) · Substance-Related Disorders (5) · Alcoholism (4) · Depressive Disorder (4) · Dyssomnias (4) · Neoplasms (4) · Weight Loss (4) · Alzheimer Disease (3) · Amphetamine-Related Disorders (3)
Merck Sharp & Dohme LLC (10) · Ain Shams University (6) · Samsung Medical Center (6) · Capital Medical University (3) · New York State Psychiatric Institute (3) · University of Pittsburgh (3) · Actavis Inc. (2) · National Institute of Mental Health (NIMH) (2) · Peking University (2) · San Francisco Department of Public Health (2) · Shanghai Mental Health Center (2) · Teva Pharmaceuticals USA (2) · US Department of Veterans Affairs (2) · Universiti Sains Malaysia (2) · Ajay Wasan, MD, Msc (1)
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Doh Kwan Kim, M.D., Ph.D. (4) · Jack R Cornelius, M.D., M.P.H. (2) · James D. Carlson, Pharm. D. (2) · James D. Carlson,, Pharm.D, (2) · A. John Rush, MD (1) · Ahmed F El-Yazbi, PhD (1) · Ajay Wasan, MD, MSc (1) · Akshya Vasudev, MBBS, MD, MRCPsych (1) · Anne Ostenfeld, MD (1) · Aymen H Hamouri, MSc (1) · Boadie W Dunlop, MD (1)
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2004 (1), 2014 (1), 2018 (1), 2019 (1), N01MH090003 (1), P20DA024157 (1), P50DA009236 (1), R01DA022155 (1), R01DA034527 (1), R01MH076051 (1), R21AA022123 (1), R21HD105101 (1), R34MH091336 (1), U10MH066750 (1), U10MH066762 (1)