237 completed, 25 unknown, 18 terminated, 12 recruiting. 92 Not applicable, 82 Phase 2, 50 Phase 3, 46 Phase 4, 24 Phase 1.
Follow Alcohol Dependence: new trials by email Literature Review of Alcohol Dependence trials Research Report on Alcohol Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence VR Cue-Exposure Including Olfactory Stimuli - Alcohol Dependence | Not applicable | Completed | Charite University, Berlin, Germany | 20 | 2026-03-07 | 2026-10-20 |
| Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD) Deep TMS (DTMS), Sham (No Treatment) - Alcohol Use Disorder, Alcoholism | Not applicable | Recruiting | Brainsway | 186 | 2025-11-07 | 2026-10-27 |
| Can Selfcompassion Training Reduce Alcohol Consumption in Patients With Alcohol Use Disosrder ? Mindful Self-Compassion program, Treatment As Usual (TAU) program - Addiction, Addiction Disorders | Not applicable | Not yet recruiting | Etablissement Public de Santé Barthélemy Durand | 152 | 2025-10-01 | 2025-08-20 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial Psilocybin, Ketamine - Alcohol Use Disorder, Alcohol Dependence | Phase 2 | Recruiting | University of Iowa | 80 | 2025-06-12 | 2025-11-28 |
| Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder Tirzepatide, Placebo - Alcohol Use Disorder, Alcohol Abuse/Dependence | Phase 2 | Recruiting | Anders Fink-Jensen, MD, DMSci | 108 | 2025-05-05 | 2026-02-10 |
| Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study Sham iTBS, Active iTBS, 10 Hz TMS - Alcohol Use Disorder, Alcohol Dependence | Not applicable | Completed | Wake Forest University Health Sciences | 5 | 2025-03-21 | 2026-10-16 |
| The Impact of Heavy Alcohol Use on Saliva and Oral Health Alcohol Use Disorder, Alcohol Dependence | Recruiting | National Institutes of Health Clinical Center (CC) | 72 | 2025-01-09 | 2026-08-28 | |
| Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS) French version PAWSS - Addiction, Substance, Alcohol Use Disorder | Recruiting | Etablissement Public de Santé Barthélemy Durand | 545 | 2024-11-11 | 2025-02-25 | |
| A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects. Vivitrol Injectable Product, IVL3004, IVL4002 - Opioid Dependence, Alcohol Dependence | Phase 1 | Recruiting | Inventage Lab., Inc. | 40 | 2024-09-11 | 2025-09-15 |
| Psilocybin-assisted Therapy for Alcohol Use Disorder Psilocybin, Niacin - Alcohol Use Disorder, Alcohol Dependence | Phase 2 | Unknown | University of Sydney | 90 | 2024-09-01 | 2024-06-10 |
| Virtual Incentive Treatment for Alcohol Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT) - Alcohol Use Disorder, Alcohol Drinking | Not applicable | Recruiting | Washington State University | 200 | 2024-06-18 | 2025-05-30 |
| Tracking Mood: The Effects of Daily Mood Tracking VAS on Alcohol Consumption in Adult Heavy Drinkers Intervention - Alcohol Abuse, Alcohol Drinking | Not applicable | Unknown | Ilona Myllyniemi | 2000 | 2024-05-01 | 2024-05-17 |
| Presence and Relapse Rates in Patients With Alcohol Use Disorder Using Virtual Reality VR Cue-Exposure Therapy - Alcohol Dependence | Completed | Charite University, Berlin, Germany | 60 | 2024-04-01 | 2026-01-21 | |
| Neuromodulation and Mindfulness Patients With AUD Transcutaneous vagus nerve stimulation, Closed-loop AM-tACS - Alcohol Dependence | Not applicable | Recruiting | Charite University, Berlin, Germany | 140 | 2024-03-20 | 2026-03-20 |
| Effects of Ketone Supplementation on Acute Alcohol Withdrawal Kenetik; Ketone Concentrate, Isocaloric dextrose placebo - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Enrolling by invitation | University of Pennsylvania | 50 | 2024-03-11 | 2026-04-06 |
| Telehealth Treatment for Alcohol Use Disorder Ria Treatment Platform - Alcohol Use Disorder, Alcohol Dependence | Not applicable | Active not recruiting | Ria Health | 135 | 2024-01-31 | 2026-06-30 |
| MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder Prolonged exposure therapy, MDMA, Niacin - PTSD, Alcohol Use Disorder | Phase 2 | Unknown | University of Sydney | 120 | 2023-09-19 | 2023-11-07 |
| Nitrate Modulates Cognitive Impairment Via Oral Microbiota. nitrate-rich beetroot juice, nitrate-depleted beetroot juice - Microtia, Alcohol Dependence | Not applicable | Completed | Peking University Sixth Hospital | 70 | 2023-09-10 | 2025-06-03 |
| Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity? Semaglutide Injectable Product, Placebo - Alcohol Abuse, Alcohol Addiction | Phase 2 | Completed | Psychiatric Centre Rigshospitalet | 108 | 2023-06-13 | 2025-08-05 |
| Study of the Neural Substrates of Alcohol Craving by High-resolution Electroencephalography Induction of alcohol craving, Questionnaires - Alcoholism, Alcohol Dependence | Not applicable | Withdrawn | Rennes University Hospital | 2023-05-01 | 2023-12-04 |
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Alcoholism (307) · Substance-Related Disorders (38) · Alcohol Drinking (22) · Stress Disorders, Post-Traumatic (17) · Alcohol-Related Disorders (16) · Behavior, Addictive (15) · Anxiety Disorders (12) · Bipolar Disorder (11) · Depression (10) · Tobacco Use Disorder (9) · Cocaine-Related Disorders (7) · Mental Disorders (7) · Schizophrenia (7) · Mania (5) · Psychotic Disorders (5)
Chemically-Induced Disorders (305) · Mental Disorders (300) · Alcohol-Related Disorders (291) · Substance-Related Disorders (269) · Behavior (61) · Drinking Behavior (23) · Pathological Conditions, Signs and Symptoms (23) · Trauma and Stressor Related Disorders (17) · Nervous System Diseases (16) · Stress Disorders, Traumatic (16) · Compulsive Behavior (15) · Impulsive Behavior (14) · Mood Disorders (13) · Pathologic Processes (12) · Signs and Symptoms (12)
Naltrexone (31) · Ethanol (18) · Topiramate (15) · Sugars (14) · Acamprosate (11) · Cognitive Behavioral Therapy (11) · nalmefene (11) · vivitrol (11) · Motivational Interviewing (10) · Baclofen (7) · Varenicline (7) · Crisis Intervention (6) · Gabapentin (6) · Practice Management, Medical (5) · Transcranial Magnetic Stimulation (5)
Yale University (22) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (19) · Medical University of South Carolina (18) · University of Pennsylvania (7) · Alkermes, Inc. (6) · Charite University, Berlin, Germany (6) · H. Lundbeck A/S (6) · UConn Health (6) · University of North Carolina, Chapel Hill (6) · Boston Medical Center (5) · NYU Langone Health (5) · South West Sydney Local Health District (5) · VA Office of Research and Development (5) · Brown University (4) · Centre for Addiction and Mental Health (4)
United States (196) · France (18) · Germany (16) · Australia (8) · Sweden (8) · United Kingdom (6) · Canada (4) · Japan (4) · Belgium (3) · Denmark (3) · Finland (3) · India (3) · Italy (3) · Austria (2) · Brazil (2)
Elizabeth Ralevski, Ph.D. (4) · Ismene L Petrakis, MD (4) · Ismene Petrakis, M.D. (4) · Kirsten C Morley, PhD (4) · Raymond F Anton, MD (4) · Lorenzo Leggio, M.D. (3) · Paul S Haber, MBBS (3) · Steven L Batki, MD (3) · Andrew Baillie, PhD (2) · Bankole Johnson, DSc, MD, PhD (2) · James C Garbutt, M.D. (2) · James C Garbutt, MD (2)
PMID 25227627, PMID 23873853, PMID 24190578, PMID 25832297, PMID 37142273, PMID 11153967, PMID 11468137, PMID 12637048, PMID 15908848, PMID 16012278, PMID 16129568, PMID 16300039, PMID 16905439, PMID 17113598, PMID 17283347, PMID 17663609, PMID 18614026, PMID 18636998, PMID 18819759, PMID 19309183, PMID 19560604, PMID 19593171, PMID 19593174, PMID 19926399, PMID 1992832, PMID 20331933, PMID 20363090, PMID 20402989, PMID 20921123, PMID 21124304, PMID 21389338, PMID 21454917, PMID 21491295, PMID 21620571, PMID 21631542, PMID 21631622, PMID 21787433, PMID 22234379, PMID 22234384, PMID 22480715, PMID 22551036, PMID 22651986, PMID 22722516, PMID 22954459, PMID 22985676, PMID 23131884, PMID 23134193, PMID 23218805, PMID 23237314, PMID 23276300
P60AA013759 (4), P50AA010761 (3), K01DA025073 (2), P60AA003510 (2), R01AA009568 (2), R01AA009892 (2), R37AA014028 (2), 1RC1AA019019-01 (1), 2009 (1), 2014 (1), 2018 (1), K23AA000222 (1), K23AA015616 (1), K23AA016340 (1), K23AA017508 (1)