13 completed. 13 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 13 |
| Phase 2 | 5 | Completed 5 |
Follow Acidosis: new trials by email Literature Review of Acidosis trials Research Report on Acidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis Plasma-Lyte 148, 0.9% sodium chloride - Diabetic Ketoacidosis | Phase 3 | Completed | The George Institute | 547 | 2024-03-14 | 2026-10-05 |
| Long-term Safety Extension to Study TRCA-301 TRC101, Placebo - Metabolic Acidosis | Phase 3 | Completed | Tricida, Inc. | 196 | 2017-12-20 | 2021-10-22 |
| Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease TRC101, Placebo - Metabolic Acidosis | Phase 3 | Completed | Tricida, Inc. | 217 | 2017-09-26 | 2021-04-26 |
| Alcohol: Thiamine and or Magnesium 1 Magnesium Sulfate, Pabrinex - Alcohol Withdrawal, Lactic Acidosis | Phase 2 / Phase 3 | Completed | Glasgow Royal Infirmary | 127 | 2016-12-16 | 2019-07-31 |
| FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study Treatment strategy: Non-invasive respiratory support delivered via high flow nasal cannula, Treatment strategy: Non-invasive respiratory support delivered via continuous positive airway pressure - Hypoxia, Respiratory Acidosis | Phase 2 / Phase 3 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 121 | 2015-11-01 | 2016-12-16 |
| Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill Sodium Bicarbonate - Metabolic Acidosis | Phase 3 | Completed | University Hospital, Montpellier | 400 | 2015-05-05 | 2026-06-15 |
| Alkali Therapy in Chronic Kidney Disease Sodium bicarbonate, Placebo - Chronic Kidney Disease, Metabolic Acidosis | Phase 2 / Phase 3 | Completed | Albert Einstein College of Medicine | 149 | 2011-10-01 | 2020-01-07 |
| Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis 0.45% saline replacement fluid, 0.9% saline replacement fluid, 0.45% saline intravenous fluid - Cerebral Edema, Diabetic Ketoacidosis | Phase 3 | Completed | University of California, Davis | 1389 | 2010-11-01 | 2018-06-25 |
| Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects Sodium bicarbonate, Placebos - Chronic Kidney Disease | Phase 2 / Phase 3 | Completed | Albert Einstein College of Medicine | 20 | 2009-03-01 | 2022-08-30 |
| Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural potassium citrate - Healthy | Phase 3 | Completed | Kantonsspital Baselland Bruderholz | 202 | 2007-07-01 | 2012-04-24 |
| Internet Administration of the Modified Atkins Diet for Adults With Intractable Epilepsy Dietary management of seizures - Epilepsy | Phase 3 | Completed | Johns Hopkins University | 30 | 2007-02-01 | 2015-09-02 |
| D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE) d4T, Abacavir, Riboflavin and Thiamine (Supplementation) - Acidosis, Lactic | Phase 2 / Phase 3 | Completed | University of British Columbia | 80 | 2001-08-01 | 2008-09-25 |
| Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis sodium dichloroacetate - Lactic Acidosis | Phase 3 | Completed | University of Florida | 45 | 1998-10-01 | 2015-03-25 |
Acidosis, Lactic (3) · Kidney Diseases (3) · Diabetic Ketoacidosis (2) · Renal Insufficiency, Chronic (2) · Acidosis, Respiratory (1) · Beriberi (1) · Brain Edema (1) · Dyspnea (1) · Epilepsy (1) · Hypertension (1) · Hypoxia (1) · Ketosis (1) · Lymphoma, Follicular (1) · Magnesium Deficiency (1)
Acid-Base Imbalance (13) · Metabolic Diseases (13) · Nutritional and Metabolic Diseases (13) · Pathological Conditions, Signs and Symptoms (7) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Male Urogenital Diseases (4) · Nervous System Diseases (4) · Pathologic Processes (4) · Urogenital Diseases (4) · Urologic Diseases (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Disease Attributes (3)
Sodium Bicarbonate (3) · veverimer (2) · Dichloroacetic Acid (1) · Dietary Supplements (1) · Magnesium Sulfate (1) · Plasma-lyte 148 (1) · Potassium Citrate (1) · Riboflavin (1) · Saline Solution (1) · Sodium Chloride (1) · Stavudine (1) · Thiamine (1) · abacavir (1)
Albert Einstein College of Medicine (2) · Tricida, Inc. (2) · Glasgow Royal Infirmary (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Johns Hopkins University (1) · Kantonsspital Baselland Bruderholz (1) · The George Institute (1) · University Hospital, Montpellier (1) · University of British Columbia (1) · University of California, Davis (1) · University of Florida (1)
United States (6) · Bulgaria (2) · Georgia (2) · Hungary (2) · Serbia (2) · Slovenia (2) · Ukraine (2) · United Kingdom (2) · Australia (1) · Canada (1) · Croatia (1) · France (1) · Switzerland (1)
Thomas Hostetter, MD (2) · Donogh Maguire, MB BCh (1) · Eric H Kossoff, MD (1) · Julio Montaner, MD (1) · Nathan Kuppermann, MD, MPH (1) · Nicole S Glaser, MD (1) · Padmanabhan Ramnarayan (1) · Peter W. Stacpoole (1) · Reto Krapf, MD (1)
PMID 23393105, PMID 28606907, PMID 29866165, PMID 29910040, PMID 30857647, PMID 31248662, PMID 31699517, PMID 34784301, PMID 35216581, PMID 35484175
2016 (1), R01DK087783 (1), U01HD062417 (1)